Publications by authors named "Shan Ren"

89 Publications

Colorectal Cancer, Gut Microbiota and Traditional Chinese Medicine: A Systematic Review.

Am J Chin Med 2021 Apr 6:1-24. Epub 2021 Apr 6.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Based on the study and research on the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and its role in guiding and regulating the occurrence and development of diseases, we have explored the mechanism of traditional Chinese medicine in the treatment of colorectal cancer by regulating the gut microbiota. Genetic variation, abnormal responses of innate and adaptive immunity, mucosal barrier dysfunction, imbalance of intestinal microbial colonization, personal and environmental risk factors are the main pathogenesis of colorectal cancer. The gut microbiota mainly includes (including , , and ) and (including and ), which have biological antagonism, nutrition for the organism, metabolic abilities, immune stimulation, and ability to shape cancer genes functions to body. The gut microbiota can be related to the health of the host. Current studies have shown that Chinese herbal compound, single medicinal materials, and monomer components can treat colorectal cancer by regulating the gut microbiota, such as Xiaoyaosan can increase the abundance of , , and and decrease the abundance of and . Therefore, studying the regulation and mechanism of gut microbiota on colorectal cancer is of great benefit to disease treatment.
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http://dx.doi.org/10.1142/S0192415X21500385DOI Listing
April 2021

Crumpled Versus Flat Gold Nanosheets: Temperature-Regulated Synthesis and Their Plasmonic and Catalytic Properties.

Langmuir 2021 Apr 31;37(14):4227-4235. Epub 2021 Mar 31.

Department of Chemistry and Chemical Engineering, Jining University, Qufu, Shandong 273115, P. R. China.

We report a high-yield synthesis of gold (Au) nanosheets with tunable size and surface morphology in the aqueous phase. In particular, crumpled and flat Au nanosheets with a thickness of ∼10 nm could be selectively produced in high purity when the reaction was conducted at room temperature and in an ice-water bath, respectively. Unlike Au nanoplates/nanoprisms in the form of well-defined triangles or hexagons documented in previous studies, the current products exhibit random in-plane branches or holes, together with wavy edges. Strong absorbance in the NIR region was observed for all the Au nanosheet products. When serving as electrocatalysts for the ethanol oxidation reaction, the current products exhibited an enhanced activity and operation stability, as compared to quasi-spherical counterparts.
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http://dx.doi.org/10.1021/acs.langmuir.1c00190DOI Listing
April 2021

[Mechanism of ursolic acid in regulating colorectal cancer cell HCT116 autophagy through hedgehog signaling pathway].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(5):1217-1223

Department of Pharmacology,School of Pharmacy,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.

To prove that ursolic acid(UA)could activate the autophagy of colorectal cancer HCT116 cells by inhibiting hedgehog signaling pathway. The effect of UA on the viability of HCT116 cells was determined by MTT assay. The effect of UA on the proliferation and migration of HCT116 cells was detected by crystal violet staining and scratch test. In the study on autophagy, the time points were screened out first: the autophagy fluorescence intensity of UA acting on HCT116 at different time points were detected by Cell Meter~(TM) Autophagy Assay Kit; Western blot was used to detect the expression of autophagy protein P62 at different time points. Then, Cell Meter~(TM) Autophagy Assay Kit was used to detect the effect of UA on autophagy fluorescence intensity of HCT116 cells. The effect of different doses of UA on the expressions of LC3Ⅱ and P62 proteins in HCT116 cells were detected by Western blot. Further, AdPlus-mCherry-GFP-LC3 B adenovirus transfection was used to detect the effects of UA on autophagy flux of HCT116 cells; UA combined with autophagy inhibitor chloroquine(CQ) was used to detect the expression of LC3Ⅱ by Western blot. In terms of mechanism, the effect of UA on hedgehog signaling pathway-related proteins in HCT116 cells was detected by Western blot. The results showed that UA inhibited the activity, proliferation and migration of HCT116 cells. UA enhanced the fluorescence intensity of autophagy in HCT116 cells, while promoting the expression of LC3Ⅱ and inhibiting the expression of P62, in a time and dose dependent manner. UA activated the autophagy in HCT116 cells, which manifested that UA resulted in the accumulation of fluorescence spots and strengthened the fluorescence intensity of autophagosomes; compared with UA alone, UA combined with autophagy inhibitor CQ promoted the expression of LC3Ⅱ. UA reduced the expressions of PTCH1, GLI1, SMO, SHH and c-Myc in hedgehog signaling pathway, while increased the expression of Sufu. In conclusion, our study showed that UA activated autophagy in colorectal cancer HCT116 cells, which was related to the mechanism in inhibiting hedgehog signaling pathway activity.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20201207.403DOI Listing
March 2021

A study on the characteristics of cognitive function in patients with multiple system atrophy in China.

Sci Rep 2021 Mar 2;11(1):4995. Epub 2021 Mar 2.

Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Fengtai District, Beijing, 100078, China.

Nonmotor symptoms in patients with multiple system atrophy (MSA) have received an increasing amount of attention in recent years, but no research on MSA patients' cognitive characteristics has been conducted in China. To evaluate the cognitive function of MSA patients in China. Using a case-control study design, 256 MSA patients and 64 controls were evaluated by the Montreal cognitive assessment (MoCA) scale to characterize their cognitive function. Like the controls, 60.5% of the patients with MSA had cognitive impairment, but the characteristics of cognitive impairment between the two groups were different. The cognitive impairment in MSA patients was prominent in the cognitive domains of visuospatial/executive functions, naming, attention, and orientation; particularly, the visuospatial/executive functions were the most significantly impaired, while impairment in language function was mainly seen in the controls. Besides, impairments in visuospatial/executive functions, attention, language, and orientation were more prominent in MSA-P (MSA with predominant Parkinsonism) patients than in MSA-C (MSA with predominant cerebellar ataxia). The cognitive impairments were more severe in patients with probable MSA than in patients with possible MSA. In addition, the results showed that the level of cognitive function was negatively correlated with the severity of MSA. This study, which characterized the cognitive function of MSA patients with the largest sample size known so far in China, found that patients with MSA do have cognitive impairment and display specific characteristics. Therefore, the cognitive impairment of MSA should be paid more attention.The study has been registered in the Chinese Clinical Trial Registry (ChiCTR) (Registration No: ChiCTR1900022462).
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http://dx.doi.org/10.1038/s41598-021-84393-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925668PMC
March 2021

Occurrence and trophic transfer of synthetic musks in the freshwater food web of a large subtropical lake.

Ecotoxicol Environ Saf 2021 Apr 22;213:112074. Epub 2021 Feb 22.

College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China; College of Environmental Science and Engineering, North China Electric Power University, Beijing 102206, China. Electronic address:

Synthetic musks (SMs) have drawn worldwide attention, as they are persistent, bioaccumulative, and toxic to many organisms. There is not enough information on the bioaccumulation and trophodynamic behavior of SMs in freshwater food webs to reliably understand the associated ecological risks. In this study, the concentrations of six SM congeners in fifteen aquatic species from Lake Chaohu, China, was investigated. The total concentrations of the six SMs ranged from 0.29 to 59.7 ng/g dry weight (median, 4.41) in fish muscle tissue and in the whole body tissues of small fish species and shrimps. Galaxolide (HHCB) and tonalide (AHTN) were the predominant congeners, accounting for 65.0% and 28.5% of the total SM concentration, respectively. On the whole, the total concentrations of SMs in livers and gills were 0.18-32.8 and 0.84-254 times higher than those in muscle tissues in fish species, respectively. In the food web of Lake Chaohu, cashmeran (DPMI) and HHCB showed a trend towards trophic magnification, and AHTN tended to show trophic dilution, but these trends were not statistically significant. This suggested that the trophic transfer of these chemicals through the food web was strongly influenced by many factors, including tissue-specific distribution within individuals at higher trophic levels. More investigation into the trophic transfer of SMs in aquatic ecosystems and the factors influencing uptake is needed.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112074DOI Listing
April 2021

Bioaccumulation and trophodynamics of cyclic methylsiloxanes in the food web of a large subtropical lake in China.

J Hazard Mater 2021 Feb 10;413:125354. Epub 2021 Feb 10.

College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China. Electronic address:

Available information on the bioaccumulation and trophodynamics of cyclic methylsiloxanes in aquatic food webs is insufficient for a reliable understanding of their toxicity and potential ecological harm. The concentrations of four cyclic methylsiloxanes in aquatic species collected from Lake Chaohu (China) were measured and the total concentration was in range of 2.01-36.1 ng/g dry weight. Dodecamethylcyclohexasiloxane (D6) represented 57.7% of the total measured methylsiloxane concentration. The distribution of these methylsiloxanes constitute the first tissue-specific record. The hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) tended to accumulate preferentially in fish muscles, while D6 was preferentially accumulated in fish liver and gills. In Lake Chaohu, significant trophic magnification of D3 (p < 0.01) and dilution of D6 (p < 0.05) were observed, and the trophic magnification factors (TMFs) were estimated at 4.94 and 0.68, respectively. No significant trends in D4 and D5 (p > 0.05) were observed within the food web. This study further confirmed the complexity of trophic transfer of the methylsiloxanes in the aquatic food web. The findings suggest that tissue-specific methylsiloxane distribution in aquatic species might also affect the observed TMFs. More research is required to investigate methylsiloxanes in additional species and their trophodynamics in different food webs.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125354DOI Listing
February 2021

A Robust Composite Proton Exchange Membrane of Sulfonated Poly (Fluorenyl Ether Ketone) with an Electrospun Polyimide Mat for Direct Methanol Fuel Cells Application.

Polymers (Basel) 2021 Feb 10;13(4). Epub 2021 Feb 10.

The Key Laboratory of Low-carbon Chemistry & Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China.

As a key component of direct methanol fuel cells, proton exchange membranes with suitable thickness and robust mechanical properties have attracted increasing attention. On the one hand, a thinner membrane gives a lower internal resistance, which contributes highly to the overall electrochemical performance of the cell, on the other hand, strong mechanical strength is required for the application of proton exchange membranes. In this work, a sulfonated poly (fluorenyl ether ketone) (SPFEK)-impregnated polyimide nanofiber mat composite membrane (PI@SPFEK) was fabricated. The new composite membrane with a thickness of about 55 μm exhibited a tensile strength of 35.1 MPa in a hydrated state, which is about 65.8% higher than that of the pristine SPFEK membrane. The antioxidant stability test in Fenton's reagent shows that the reinforced membrane affords better oxidation stability than does the pristine SPFEK membrane. Furthermore, the morphology, proton conductivity, methanol permeability, and fuel cell performance were carefully evaluated and discussed.
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http://dx.doi.org/10.3390/polym13040523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916468PMC
February 2021

Heterojunction interface of zinc oxide and zinc sulfide promoting reactive molecules activation and carrier separation toward efficient photocatalysis.

J Colloid Interface Sci 2021 Apr 2;588:826-837. Epub 2020 Dec 2.

State Key Laboratory of Mechanical Transmissions, College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China. Electronic address:

Heterojunction photocatalysts, which can alleviate the low carrier separation efficiency and insufficient light absorption capacity of a single catalyst, have received widespread attention. However, the specific interfacial structure of the heterojunction and its effect on the photocatalytic reaction is still unclear. Herein, a battery of zinc oxide/zinc sulfide (ZnO@ZnS) heterojunction microspheres with different degrees of sulfuration were successfully constructed via a facile hydrothermal method. The as-prepared photocatalysts shown decent aerobic nitric oxide (NO) oxidation performance under visible light irradiation, and the results of various characterization techniques illustrated that the superior photoactivity could be ascribed to the spatial separation of photoinduced electron-hole pairs due to the synergy of the internal electric field and the band offset. More importantly, density functional theory (DFT) calculations revealed that the heterojunction interface can significantly promote the generation of reactive oxygen species (ROS) and NO reaction intermediates and thus accelerate the photocatalytic reaction. Finally, in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) technology was used to time-dependently monitor the NO oxidation process, revealing the photocatalytic mechanism. This work investigated the role of the heterojunction interface in the gas-phase catalytic reaction, broadening the practical application of the ZnO@ZnS heterojunction.
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http://dx.doi.org/10.1016/j.jcis.2020.11.118DOI Listing
April 2021

Application of composite degradable modified starch-based flocculant on dewatering and recycling properties.

Water Sci Technol 2020 Nov;82(10):2051-2061

Sinocore Biotechnology (Qingdao) Co., Ltd, 53# Zhengzhou Road, Qingdao, 266042, China.

Sludge dewatering is an important step for wastewater treatment. Composite degradable flocculant (CDF) was prepared by cationic polyacrylamide (PAM) grafting onto modified starch with a novel initiator, and characterized by Fourier transform infrared spectroscopy. The microstructure of flocculated sludge was characterized by scanning electron microscopy. The study investigated the properties of CDF compared to PAM, which showed that the prepared CDF exhibited a highly effective flocculation on sludge dewatering, a higher transmittance and chemical oxygen demand removal rate, and a lower value of effluent ammonia nitrogen and total phosphorus. The fermentation process was also analyzed by testing the performance of dewatered sludge (temperature, pH, ammonia nitrogen, E4/E6 (humic acid absorbance at 465 nm (E4) and 665 nm (E6))). The dehydrated sludge with CDF could be easily compressed into cakes by belt-filter for easy transportation and storage. With the continuous addition of CDF and PAM, the corresponding index of capillary suction time (CST) increased. Moreover, the total value of CST with CDF was low, showing a good dewaterability. In addition, the sludge index of pumping time and moisture content with CDF were low in contrast with PAM. Fermentation experiments demonstrated that sludge with CDF had a comparatively high temperature and low value of E4/E6. Such novel CDF shows enormous potential in wastewater treatment and sludge fermentation.
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http://dx.doi.org/10.2166/wst.2020.464DOI Listing
November 2020

Synthetic musk fragrances in sediments from a subtropical river-lake system in eastern China: occurrences, profiles, and ecological risks.

Environ Sci Pollut Res Int 2021 Mar 20;28(12):14597-14606. Epub 2020 Nov 20.

College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China.

Synthetic musk fragrances (SMFs) in aquatic environments have been of increasing concern because of their potential characteristic of persistent, bioaccumulated, and ecological harm. However, little is known about the distribution of SMFs in river-lake systems. In this study, the occurrence and risks of six SMFs measured in sediments from Lake Chaohu (eastern China) and the rivers flowing into it were investigated. The total sedimentary SMF concentrations ranged from 2.43 to 15.5 ng/g in Lake Chaohu (median = 5.17 ng/g), and 2.34-104 ng/g in the rivers (median = 10.6 ng/g). Overall, moderate levels of SMFs were found in comparison with previous results from other areas. Galaxolide and tonalide dominated in the rivers whereas cashmeran was dominant in Lake Chaohu. A source assessment indicated that the discharge from industries contributed importantly to the pollution of SMFs in the studied waters, in addition to the inputs from domestic sewage. Our estimates suggested that the current sedimentary SMF concentrations were likely to pose extremely low ecological risk to aquatic organisms. However, more studies are needed to focus on the spatial and temporal trends in distribution as well as the ecotoxicological implications of SMFs in the Lake Chaohu area because there is a general lack of relevant information.
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http://dx.doi.org/10.1007/s11356-020-11486-5DOI Listing
March 2021

Exploring the decentralized treatment of sulfamethoxazole-contained poultry wastewater through vertical-flow multi-soil-layering systems in rural communities.

Water Res 2021 Jan 30;188:116480. Epub 2020 Sep 30.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, CEEER-URBNU, College of Environment, Beijing Normal University, Beijing, 100875, China.

Sulfamethoxazole (SMX) is the most widely distributed sulfonamide antibiotics detected in decentralized poultry wastewater in rural communities. As an economically-feasible and eco-friendly technology for decentralized wastewater treatment in rural areas, vertical-flow multi-soil-layering (MSL) system was promising to mitigate the ecological and human health risks from SMX in such areas. The treatment of SMX-contained poultry wastewater by using MSL systems was investigated for the first time, and the main and interactive effects of related multiple variables on system performance were explored through factorial analysis, including material of permeable layer, concentration of SMX, and pH of influent. Results indicated that SMX concentration and pH of influent showed significantly negative effects on SMX removal. Medical stone used in MSL systems with larger surface area could intensify the SMX removal compared to anthracite. MSL systems showed stable performances on SMX removal with the best SMX removal efficiency more than 91%. A novel stepwise-cluster inference (SCI) model was developed for the first time to map the multivariate numeric relationships between state variables and SMX removal under discrete and nonlinear complexities. It was demonstrated that the effect of SMX in wastewater with high concentration was significant on the differentiation of soil bacteria composition in MSL systems based on microbial diversity analysis. These results can help better understand the mechanism of SMX removal in MSL systems from perspectives of factorial analysis, numeric modeling, and microbiological change.
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http://dx.doi.org/10.1016/j.watres.2020.116480DOI Listing
January 2021

Efficacy of Getong Tongluo Capsule () for Convalescent-Phase of Ischemic Stroke and Primary Hypertension: A Multicenter, Randomized, Double-Blind, Controlled Trial.

Chin J Integr Med 2021 Apr 10;27(4):252-258. Epub 2020 Oct 10.

Department of Neurology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100078, China.

Objective: To evaluate whether the efficacy of Getong Tongluo Capsule (, GTC, consisted of total flavone of Radix Puerariae) on improving patients' quality of life and lowering blood pressure are superior to the extract of Ginkgo biloba (EGB) for patients with convalescent-phase ischemic stroke and primary hypertension.

Methods: This randomized, positive-drug- and placebo-controlled, double-blind trial was conducted from September 2015 to October 2017. Totally 477 eligible patients from 18 hospitals in China were randomly assigned in a 2:1:1 ratio to the following interventions, twice a day for 12 weeks: (1) GTC 250 mg plus EGB-matching placebo 40 mg (237 cases, GTC group), (2) EGB 40 mg plus GTC-matching placebo 250 mg (120 cases, EGB group) or (3) GTC-matching placebo 250 mg plus EGB-matching placebo 40 mg (120 cases, placebo group). Moreover, all patients were orally administered aspirin enteric-coated tablets 100 mg, once a day for 12 weeks. The primary outcome was the Barthel Index (BI). The secondary outcomes included the control rate of blood pressure and National Institutes of Health Stroke Scale (NIHSS) scores. The incidence and severity of adverse events (AEs) were calculated and assessed.

Results: The BI relative independence rates, the clinical recovery rates of NIHSS, and the total effective rates of NIHSS in the GTC and EGB groups were significantly higher than the placebo group at 12 weeks after treatment (P<0.05), and no statistical significance was found between the GTC and EGB groups (P>0.05). The control rate of blood pressure in the GTC group was significantly higher than the EGB and placebo groups at 12, 18 and 24 weeks after treatment (P<0.01). There were no statistically significant differences in the incidences of AEs, adverse drug reactions, or serious AEs among the 3 groups (P>0.05).

Conclusion: GTC exhibited significant efficacy in improving patients' quality of life as well as neurological function and controlling hypertension. (Registration No. ChiCTR1800016667).
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http://dx.doi.org/10.1007/s11655-020-3320-3DOI Listing
April 2021

Comparative Studies of Effects of Vapor- and Liquid-Phase AsO on Catalytic Behaviors of VO-WO/TiO Catalysts for NH-SCR.

ACS Omega 2020 Sep 18;5(38):24195-24203. Epub 2020 Sep 18.

Engineering Research Center for Energy and Environment of Chongqing, College of Materials Science and Engineering, Chongqing University, Chongqing 400044, P. R. China.

The role of vapor- and liquid-phase AsO in deactivating commercial VO-WO/TiO catalyst during the NH-selective catalytic reduction (SCR) process was explored and compared. AsO was loaded via vapor deposition (As(vap)) and the wet impregnation (As(imp)) method, respectively. Results demonstrated that the poisoning extent of vapor arsenic was much stronger than in the liquid state. Differences in As distribution on the catalyst surface was one of the main causes. Most vapor AsO could be oxidized to AsO, which underwent stacking and formed a dense covering layer on the catalyst surface. In comparison, liquid AsO could also be oxidized but distributed uniformly and did not change the catalyst pore structure. Loading arsenic would destroy the V-OH and V=O active sites of the catalyst, and less reactive As-OH was generated. Catalyst oxidizability was also enhanced, resulting in NH oxidation enhancement, decreased N selectivity, and a decline in SCR activity. Importantly, the intermediate of NH oxidation, NH-amide, also could react with NO + O, and more NO was generated on the poisoned catalyst during the SCR process, especially on As(imp). Finally, two mechanisms of arsenic poisoning were proposed, in which the role of vapor and liquid AsO over the VO-WO/TiO catalyst was compared.
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http://dx.doi.org/10.1021/acsomega.0c01734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528200PMC
September 2020

Comparison of the diagnostic efficacy between two PCR test kits for SARS-CoV-2 nucleic acid detection.

J Clin Lab Anal 2020 Oct 25;34(10):e23554. Epub 2020 Sep 25.

Department of Clinical Laboratory, Liuzhou People's Hospital, Liuzhou, China.

Background: To compare the diagnostic efficacy between two different real-time reverse transcription polymerase chain reaction (RT-PCR) test kits for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid detection and provide references for laboratories.

Methods: Throat swab samples from 18 hospitalized patients were clinically diagnosed with coronavirus disease 2019 (COVID-19) and 100 hospitalized patients without COVID-19 were collected. SARS-CoV-2 nucleic acid was detected in throat swab samples with RT-PCR test kits from Sansure Biotech Inc (Hunan, China) and Shanghai BioGerm Medical Biotechnology Co., Ltd.(Shanghai, China). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and kappa value were analyzed, and three parallel tests were performed with three weakly positive samples.

Results: The sensitivity, specificity, PPV, NPV, and kappa value of the Sansure PCR kit were 0.833, 1.000, 1.000, 0.971, and 0.894, respectively, and the sensitivity, specificity, PPV, NPV, and kappa value of the BioGerm PCR kit were 0.944, 1.000, 1.000, 0.990, and 0.966, respectively. For the three parallel tests, the coefficient of variation value of the BioGerm PCR kit in all three samples was the smallest for both the ORF1ab and N gene.

Conclusion: The detection efficacy of the BioGerm PCR kit for SARS-CoV-2 nucleic acid detection was relatively higher than that of the Sansure PCR kit.
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http://dx.doi.org/10.1002/jcla.23554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536918PMC
October 2020

Baseline resistance-associated substitutions may impact DAA response among treatment failure chronic hepatitis C patients with pegylated interferon and ribavirin in real life.

Antivir Ther 2020 Sep 16. Epub 2020 Sep 16.

Beijing Youan Hospital, Capital Medical University, Beijing, China.

Background: To evaluate the impact of baseline resistance-associated substitutions (RASs) on direct-acting antiviral (DAA) treatment response among pegylated interferon in combination with ribavirin (PR) failing patients in a real-life setting.

Methods: Blood samples and clinical data from 171 patients who failed PR treatment were collected. All of them received rescue DAA regimens. RAS identified in the NS3, NS5A and NS5B regions by Sanger sequencing method were compared by DAA regimen and HCV subtypes. We assessed sustained virological response at 12 weeks (SVR12) and evaluated the impact of baseline RASs on the effectiveness of DAA regimens in clinical practice.

Results: The overall SVR12 rates were: 89.47% (153/171), 92.1% (117/127) in patients without cirrhosis versus 81.8% (36/44) in those with cirrhosis, without significant difference (χ=3.69, P=0.08); 87.9% in genotype (GT)1b patients (n=116) versus 93.8% in GT2a (n=32) versus 90.5% in GT3 (n=21) versus 100% in GT6 (n=2), without significant difference (χ=1.02, P=0.84); 66.7% in asunaprevir (ASV) + daclatasvir (DCV) regimen (n=24) versus 94.0% in sofosbuvir (SOF)-based regimen (n=133), with significant difference (χ=19.7, P=0.001). Our results showed that the prevalence of NS3, NS5A, NS5B RASs was 45.02%, 39.76% and 71.34%, respectively, and higher incidence of RASs in cirrhosis than without cirrhosis (81.8% versus 63.8%), with a statistically significant difference (χ=4.92, P=0.03). In the ASV/DCV cohort (n=24), 4 of 11 patients (36.4%) with baseline NS3/NS5A RASs achieved SVR12, whereas 12 of 13 patients (92.3%) without RASs achieved SVR12, with significant difference (χ=8.39, P=0.008). However, this relationship was not seen in the SOF-based subgroup (94.6% versus 92.7%; χ=0.18, P=0.7). Treatment failure with DAAs occurred in 10.53% (n=18) of our study population, baseline NS5A substitution including L31M or Y93H (n=13) was the most frequently detected RAS, rescue regimen with velpatasvir (VEL)/SOF + ribavirin (RBV) for 12 weeks or 24 weeks was highly effective in patients who failed previous use of NS5A inhibitors, regardless of GT or cirrhosis.

Conclusions: Natural RASs are common in Chinese patients failing with PR treatment. High prevalence of clinically relevant RASs (such as L31M, Y93H) supports the appropriateness of HCV resistance tests to properly guide DAA-based therapy. These findings might be used to select salvage therapies.
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http://dx.doi.org/10.3851/IMP3369DOI Listing
September 2020

Abnormal static and dynamic functional connectivity of resting-state fMRI in multiple system atrophy.

Aging (Albany NY) 2020 08 27;12(16):16341-16356. Epub 2020 Aug 27.

Department of Radiology, Aerospace Center Hospital, Beijing 100049, China.

In order to explore the topological alterations in functional brain networks between multiple system atrophy (MSA) patients and healthy controls (HC), a new joint analysis method of static and dynamic functional connectivity (FC) is proposed in this paper. Twenty-four MSA patients and twenty HCs were enrolled in this study. We constructed static and dynamic brain networks from resting-state fMRI data and calculated four graph theory attributes. Statistical comparisons and correlation analysis were carried out for static and dynamic FC separately before combining both cases. We found decreased local efficiency (LE) and weighted degree (WD) in cerebellum from both static and dynamic graph attributes. For static FC alone, we identified increased betweenness centrality (BC) at left dorsolateral prefrontal cortex, left Cerebellum_Crus9 and decreased WD at Vermis_6. For dynamic FC alone, decreased BC, clustering coefficients and LE at several cortical regions and cerebellum were identified. All the features had significant correlation with total UMSARS scores. Receiver operating characteristic analysis showed that dynamic features had the highest area under the curve value. Our work not only added new evidence for the underlying neurobiology and disrupted dynamic disconnection syndrome of MSA, but also proved the possibility of disease diagnosis and progression tracking using rs-fMRI.
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http://dx.doi.org/10.18632/aging.103676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485713PMC
August 2020

A Highly Immobilized Organic Anode Material for High Performance Rechargeable Lithium Batteries.

ACS Appl Mater Interfaces 2020 Aug 3;12(32):36237-36246. Epub 2020 Aug 3.

The Key Laboratory of Low-carbon Chemistry & Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou 510275, China.

Organic conjugated carbonyl materials have attracted considerable attention in the field of high-capacity and green energy storage technologies. However, the high solubility in organic electrolyte restrains their further application. In this work, an organic terephthalate compound (LiM) with propargyl groups is synthesized innovatively and then used to prepare a highly cross-linked anode material (X-LiM) by simple hydrothermal treatment for rechargeable lithium batteries. The electrochemical properties are enhanced significantly by in situ constructing an interpenetrating network of X-LiM and the conductive carbon nanotubes (CNTs). The as-synthesized X-LiM@CNTs composite anode delivers a reversible capacity of ∼200 mAh g at 0.1 C after 200 cycles and exhibits excellent cycle stability at a high rate of 1 C with ∼150 mAh g retention capacity after 1000 cycles and nearly 100% average Coulombic efficiency. Additionally, the superior rate capability is obtained at the high rate of 2 and 10 C and with specific discharge capacities of 140 and 100 mAh g, respectively. Highly reversible redox reaction of the electrochemical active site carbonyl group (C═O) is ascertained by ex-situ infrared spectroscopy and X-ray photoelectron spectroscopy. The described approach provides a novel direction for the immobilization of organic electrode molecules and is intended to serve as a universal guide for the research and fabrication of high-performance organic batteries.
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http://dx.doi.org/10.1021/acsami.0c11241DOI Listing
August 2020

Different depths of sedation versus risk of delirium in adult mechanically ventilated patients: A systematic review and meta-analysis.

PLoS One 2020 16;15(7):e0236014. Epub 2020 Jul 16.

Department of Intensive Care Unit, Hebei General Hospital, Shijiazhuang City, Hebei Province, China.

Background: Delirium is multifactorial. This study aimed at determining the association between different depths of sedation and the risk of delirium in adult mechanically ventilated patients.

Methods: A systematic literature retrieval was conducted in databases including Cochrane Central Register of Controlled Trials, PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature for publications available till December 2019 without limitation in study type, and followed by a secondary retrieval for related literature. STATA15.1 and WinBugs 14.3 were used in statistical analyses for different sedation depths as the intervention. The main endpoint was delirium occurrence. Secondary endpoints were agitation-related adverse events and mortality.

Results: We included 18 studies comprising 8001 mechanically ventilated patients. Different sedation depths were not associated with the occurrence of delirium (OR = 1.00, 95%CI: 0.64-1.58, P = 0.993). Among the 18 enrolled studies, this finding was not confounded by the dosage of benzodiazepines (OR = 0.96, 95%CI: 0.79-1.17, P = 0.717) in eight randomized controlled trials(RCTs) or the patients' disease severity(OR 0.95, 95%CI: 0.79-1.13, P = 0.548) in 10 RCTs. However, contrasting results were found in non-RCTs. The deeper sedation group had a significantly increased risk for death(OR = 1.82, 95% CI: 1.23-2.69, P = 0.003), whereas lighter sedation seemed a potential risk for agitation-related adverse events (OR = 0.61, 95%CI: 0.45-0.84, P = 0.002).

Conclusions: It is inconclusive whether significantly different sedation depths would change the risk of delirium in adult mechanically ventilated patients.

Trial Registration Number: The study was registered in PROSPERO(http://www.crd.york.ac.uk/PROSPERO/) under registration number CRD42019145276.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236014PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365415PMC
September 2020

Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends.

Environ Geochem Health 2021 Mar 30;43(3):1177-1191. Epub 2020 Jun 30.

College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China.

Available information is still insufficient for a comprehensive understanding of the global distribution of polybrominated diphenyl ethers (PBDEs) in the environment. In particular, little is known about the changing trend of their distribution in urban soils. We conducted a survey of 21 PBDEs in urban soils from Tianjin, China. The chemicals were widely present in the area and summed concentrations ranged from 0.65 to 108 ng/g in soil, indicating low to moderate levels of pollution relative to other areas. BDE-209 was the predominant congener, contributing 88.9% of the concentrations of total soil PBDEs. Source assessment indicated that soil PBDEs in the area were mainly derived from the release of commercial deca-BDE from local industrial production processes and consumer products. We found that the soil concentrations of PBDEs appear to have declined in recent years, compared with other previous reports in this region. However, more studies are needed on this possible change trend of PBDE pollution, especially its impact on human health, although their calculated non-carcinogenic health risks in this study were low.
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http://dx.doi.org/10.1007/s10653-020-00645-9DOI Listing
March 2021

Cerebellar Atrophy in Multiple System Atrophy (Cerebellar Type) and Its Implication for Network Connectivity.

Cerebellum 2020 Oct;19(5):636-644

Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China.

We sought to assess structural and functional patterns of cerebellum in multiple system atrophy (cerebellar type), and investigate the associations of structural and functional cerebellar gray matter abnormalities. We collected magnetic resonance imaging data of 18 patients with multiple system atrophy (cerebellar type) and 18 health control subjects. The gray matter loss across the motor and cognitive cerebellar territories in patients was assessed using voxel-based morphometry. And change in the connectivity between the cerebellum and large-scale cortical networks was assessed using resting-state functional MRI analysis. Furthermore, we assessed the relationship between the extent of cerebellar atrophy and reduced-activation in the cerebellar-cortical and subthalamo-cerebellar functional connectivities. We confirmed the gray matter loss across the motor and cognitive cerebellar territories in patients and found that the extent of cerebellar atrophy was correlated with decreased connectivity between the cerebellum and large-scale cortical networks, including the default, frontal parietal, and sensorimotor networks. The volume reduction in the motor cerebellum was closely associated with the clinical motor severity. A post hoc analysis showed reduced-activation in the subthalamo-cerebellar functional connectivity without the subthalamic nucleus atrophy. These results emphasized significant atrophy in the cerebellar subsystem and its association with the large-scale cortical networks in multiple system atrophy (cerebellar type), which may improve our understanding of the neural pathophysiology mechanisms of disease.
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http://dx.doi.org/10.1007/s12311-020-01144-4DOI Listing
October 2020

[Exploration and practice of micro-video teaching of ].

Zhongguo Zhen Jiu 2020 Jan;40(1):103-5

School of Acupuncture-Moxibustion and Tuina, Henan University of CM, Zhengzhou 450003, China; Third Affiliated Hospital of Henan University of CM, Zhengzhou 450003.

In this paper, the micro-video teaching mode was explored in the course construction of . The micro-video teaching contents include the academic thought, experience in diagnosis and treatment, characteristic technology and clinical manipulation of famous acupuncture experts in the Henan University of CM. Each micro-video film is designed within 15-18 min, including three sections of knowledge, i.e. basic theory, technological application and clinical manipulation. Each section is designed within 5-6 min. The construction of the teaching course of is the innovation of practice mode of TCM and the new approach to the inheritance of the experience of experts. The construction of micro-video teaching course propels the reform of teaching mode, improves the learning initiative of students and clinical manipulative ability so as to improve the teaching effect and quality.
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http://dx.doi.org/10.13703/j.0255-2930.20190625-0001DOI Listing
January 2020

Corrigendum to "Bioinformatics Analysis Reveals the Altered Gene Expression of Patients with Postmenopausal Osteoporosis Using Liuweidihuang Pills Treatment".

Biomed Res Int 2019 20;2019:6897187. Epub 2019 Nov 20.

Department of Endocrinology, Third Affiliated Hospital of Hebei Medical University, China.

[This corrects the article DOI: 10.1155/2019/1907906.].
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http://dx.doi.org/10.1155/2019/6897187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935439PMC
November 2019

Promotional effects of nitrogen doping on catalytic performance over manganese-containing semi-coke catalysts for the NH-SCR at low temperatures.

J Hazard Mater 2020 Apr 17;387:121704. Epub 2019 Nov 17.

College of Materials Science and Engineering, Chongqing University, Chongqing, 400044, China; Chongqing Cheng Tou Road and Bridge Administration Co. Ltd, Chongqing, 400060, China.

A series of nitrogen-doped MnO/semi-coke catalysts were studied for low-temperature (LT) de-NO performance in the NH-SCR reaction. Changes in morphology, structure, and surface chemistry of the semi-coke catalysts were systematically investigated to analyze the promotional effects of nitrogen doping on catalytic performance. The catalytic activity of ASC-10U10 Mn was found to be enhanced significantly in a broad temperature range of 100-300 °C, improving 44.2 % at 150 °C-the largest jump in this temperature range-and reaching 94.5 % at 275 °C. Nitrogen doping results in aromatic pyridinic-N, pyrrolic-N, and quaternary-N; the unpaired electrons on these groups play a critical role in enhancing the adsorption and oxidation of NO. NH adsorption is enhanced due to numerous diverse Lewis acid sites on ASC-10U10 Mn. The electron distribution of MnO/semi-coke catalysts and the electron mobility between manganese and oxygen species are improved by nitrogen doping. The resulting nitrate intermediates, especially bridging nitrates, can be reduced by NH species at low temperatures. The increase in the number of oxygen vacancies improves oxidation of coordinated NH. In addition, DRIFTS results suggest that coordinated NH and intermediate -NH are much more active and make a considerable positive contribution to the LT SCR reaction.
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http://dx.doi.org/10.1016/j.jhazmat.2019.121704DOI Listing
April 2020

Hemodynamic effects of inotropic drugs in heart failure: A network meta-analysis of clinical trials.

Medicine (Baltimore) 2019 Nov;98(47):e18144

Department of Intensive Care Unit.

Background: There is currently no consensus on the appropriate selection of inotropic therapy in ventricular dysfunction. The objective of the study was to detect the effects of different inotropes on the hemodynamics of patients who developed low cardiac output.

Methods: PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched (all updated December 31, 2017). The inclusion criteria were as follows: low cardiac index (CI < 2.5 L/min/m) or New York Heart Association class II-IV, and at least 1 group receiving an inotropic drug compared to another group receiving a different inotropic/placebo treatment. The exclusion criteria were studies published as an abstract only, crossover studies, and studies with a lack of data on the cardiac index.

Results: A total of 1402 patients from 37 trials were included in the study. Inotropic drugs were shown to increase the cardiac index (0.32, 95%CI:0.25, 0.38), heart rate (7.68, 95%CI:6.36, 9.01), and mean arterial pressure (3.17, 95%CI:1.96, 4.38) than the placebo. Overall, the pooled estimates showed no difference in terms of cardiac index, heart rate, mean arterial pressure, systemic vascular resistance, and mean pulmonary arterial pressure among the groups receiving different inotropes.

Conclusions: Our systematic review found that inotrope therapy is not associated with the amelioration of hemodynamics. An accurate evaluation of the benefits and risks, and selection of the correct inotropic agent is required in all clinical settings.
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http://dx.doi.org/10.1097/MD.0000000000018144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882628PMC
November 2019

CO Nanoenrichment and Nanoconfinement in Cage of Imine Covalent Organic Frameworks for High-Performance CO Cathodes in Li-CO Batteries.

Small 2019 Dec 12;15(49):e1904830. Epub 2019 Nov 12.

The Key Laboratory of Low-Carbon Chemistry and Energy Conservation of Guangdong Province, State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China.

The Li-CO battery is an emerging green energy technology coupling CO capture and conversion. The main drawback of present Li-CO batteries is serious polarization and poor cycling caused by random deposition of lithium ions and big insulated Li CO formation on the cathode during discharge. Herein, covalent organic frameworks (COF) are identified as the porous catalyst in the cathode of Li-CO batteries for the first time. Graphene@COF is fabricated, graphene with thin and uniform imine COF loading, to enrich and confine CO in the nanospaces of micropores. The discharge voltage is raised by higher local CO concentration, which is predicted by the Nernst equation and realized by CO nanoenrichment. Moreover, uniform lithium ion deposition directed by the graphene@COF nanoconfined CO can produce smaller Li CO particles, leading to easier Li CO decomposition and thus lower charge voltage. The graphene@COF cathode with 47.5% carbon content achieves a discharge capacity of 27833 mAh g at 75 mA g , while retaining a low charge potential of 3.5 V at 0.5 A g for 56 cycles.
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http://dx.doi.org/10.1002/smll.201904830DOI Listing
December 2019

LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.

Yonsei Med J 2019 Nov;60(11):1081-1092

Department of Orthopedics, the Forth Hospital of Yulin (Xingyuan Hospital), West Yulin, Shaanxi, China.

Purpose: Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is a chronic progressive joint disease. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotes metastasis in cancers and functions as a sponge for miR-145. However, the role of MALAT1/miR-145 in OA pathogenesis has not yet been elucidated.

Materials And Methods: The expression of MALAT1 and miR-145 was examined by quantitative real-time PCR; the interaction between miR-145, MALAT1 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 5 was verified by luciferase reporter assay. Correlations among MALAT1, miR-145, and ADAMTS5 were analyzed by Spearman rank analysis. Chondrocytes viability and cartilage extracellular matrix (ECM) degradation were investigated with cell viability assay and Western blotting analyzing expression of ADAMTS5, collagen type 2 alpha 1 (COL2A1), aggrecan (ACAN), and cartilage oligomeric matrix protein (COMP).

Results: MALAT1 was upregulated, and miR-145 was downregulated in OA samples and IL-1β-induced chondrocytes. Mechanically, miR-145 could directly bind to MALAT1 and ADAMTS5. Moreover, miR-145 expression was negatively correlated with MALAT1 and ADAMTS5 expression in OA patients, whereas MALAT1 and ADAMTS5 expression was positively correlated. Functionally, overexpression of MALAT1 inhibited chondrocyte viability and promoted cartilage ECM degradation in IL-1β-induced chondrocytes. In support thereof, MALAT1 silencing and miR-145 upregulation exerted the opposite effect in IL-1β-induced chondrocytes. Moreover, the effect of MALAT1 was counteracted by miR-145 upregulation, and ADAMTS5 restoration could abate miR-145 effects.

Conclusion: An MALAT1/miR-145 axis contributes to ECM degradation in IL-1β-induced chondrocytes through targeting ADAMTS5, suggesting that MALAT1/miR-145/ADAMTS5 signaling may underlie human OA pathogenesis.
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http://dx.doi.org/10.3349/ymj.2019.60.11.1081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813144PMC
November 2019

Low-Carbon and Nanosheathed ZnCoO Spheroids with Porous Architecture for Boosted Lithium Storage Properties.

Research (Wash D C) 2019 21;2019:1354829. Epub 2019 Aug 21.

The Key Laboratory of Low-Carbon Chemistry & Energy Conservation of Guangdong Province, State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou 510275, China.

Multielectronic reaction electrode materials for high energy density lithium-ion batteries (LIBs) are severely hindered by their inherent sluggish kinetics and large volume variations, leading to rapid capacity fade. Here, a simple method is developed to construct low-carbon and nanosheathed ZnCoO porous spheroids (ZCO@C-5). In this micro/nanostructure, an ultrathin amorphous carbon layer (~2 nm in thickness) is distributed all over the primary nanosized ZCO particles (~20 nm in diameter), which finally self-assembles into porous core (ZCO)-shell(carbon) micron spheroids. The nanoencapsulation and macro/mesoporous architecture can not only provide facile electrolyte penetration and rapid ion/electron transfer but also better alleviate volumetric expansion effect to avoid pulverization of ZCO@C-5 spheroids during repeat charge/discharge processes. As expected, the three-dimensional porous ZCO@C-5 composites exhibit high reversible capacity of 1240 mAh g cycle at 500 mA g, as well as excellent long-term cycling stability and rate capability. The low-carbon and nanoencapsulation strategy in this study is simple and effective, exhibiting great potential for high-performance LIBs.
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http://dx.doi.org/10.34133/2019/1354829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753607PMC
August 2019

Spatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study.

Front Neurosci 2019 31;13:777. Epub 2019 Jul 31.

Department of Radiology, Aerospace Center Hospital, Beijing, China.

Multiple system atrophy (MSA) is a progressive neurodegenerative disease. However, little is known about the regional cerebral blood flow (rCBF) and functional connectivity changes in the disease. In this study, the magnetic resonance imaging (MRI) data including 24MSA-c-type patients and 20 healthy controls were collected by using voxel wise arterial spin labeling (ASL) perfusion analysis, several regions of the altered rCBF were identified in the MSA c-type patients. And then, the changes of the functional connectivities of identified rCBF regions were analyzed by using functional MRI (fMRI). Finally, rCBF value of cerebellum was extracted to differentiate the MSA c-type patients and controls. Compared with the controls, the MSA c-type patients showed distinct disruption of rCBF in the cerebellum. The disconnection of the identified cerebellar regions was revealed in several regions in the MSAc-type patients, including right middle frontal gyrus (MFG), right precuneus, left superior temporal gyrus (STG), right lingual gyrus, left postcentral gyrus (PoCG), right cerebellum 7b, right cerebellum 8, and left cerebellum 4,5. These regions were involved in the default mode network (DMN), sensorimotor network, visual associated cortices, and cerebellum. Using the rCBF value of vermis as biomarker, the two groups can be differentiated and reached a sensitivity of 95.8% and specificity of 100%. This is the first study to demonstrate the MSA-specific rCBF abnormalities using the ASL method, which are closely associated with several functional networks on resting state fMRI. The rCBF of vermis might be used as the potential imaging biomarker for the early diagnosis of MSA c-type.
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http://dx.doi.org/10.3389/fnins.2019.00777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685442PMC
July 2019

Lithium Borate Containing Bifunctional Binder To Address Both Ion Transporting and Polysulfide Trapping for High-Performance Li-S Batteries.

ACS Appl Mater Interfaces 2019 Aug 2;11(32):28968-28977. Epub 2019 Aug 2.

The Key Laboratory of Low-carbon Chemistry & Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering , Sun Yat-Sen University , Guangzhou 510275 , P. R. China.

A slightly cross-linked lithium borate containing single ion-conducting polymer (LBSIP) as a bifunctional binder for lithium sulfur batteries is designed and fabricated via a one-step thiol-ene click reaction. The LBSIP binder exhibits a maximum peeling strength of over 600 mN mm between the sulfur cathode and aluminum foil, together showing a high lithium ion diffusion coefficient of 2.1 × 10 cm s. Owing to the unique electron-donating groups, the binder can provide a good ionic conductive network and a dramatically enhanced polysulfide-trapping feature. The strong interaction between electron-donating groups of LBSIP with LiS was confirmed by the Li-NMR analysis and density-functional theory calculation. The cathode using the LBSIP binder exhibited a high Coulombic efficiency of ∼100% and an initial specific capacity of 712 mAh g with a capacity fading rate of 0.06% per cycle after 500 cycles at 0.5 C. Even at a high current rate of 2 C, a reversible capacity of over 500 mAh g was still obtained. However, the capacity of the cathode using the PVDF binder decreased to 331 mAh g after 180 cycles at 0.5 C. This work is very attractive for the rational design of functional binders for Li-S batteries with both ion-transporting and polysulfide-trapping features.
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http://dx.doi.org/10.1021/acsami.9b09604DOI Listing
August 2019

Performance analysis and life cycle greenhouse gas emission assessment of an integrated gravitational-flow wastewater treatment system for rural areas.

Environ Sci Pollut Res Int 2019 Sep 4;26(25):25883-25897. Epub 2019 Jul 4.

MOE Key Laboratory of Resourcces and Environmental Systems Optimization, North China Electric Power University, Beijing, 102206, China.

Due to the lack of appropriate wastewater treatment facility in rural areas, the discharging of wastewater without sufficient treatment results in many environmental issues and negative impact on the local economy. In this study, a novel integrated gravitational-flow wastewater treatment system (IGWTS) for treating domestic wastewater in rural areas was developed and evaluated. As the core module of IGWTS, the multi-soil-layering (MSL) system showed good performances for removing organic matters and nutrients in lab-scale experiments. Aeration was found to be the dominant positive factor for contaminant removal in factorial analysis, while bottom submersion had the most negative effect. Based on the critical operational factors obtained from lab-scale tests, the full-scale IGWTS consisting of multifunctional anaerobic tank (MFAT), MSL, and subsurface flow constructed wetland (SFCW) was designed, constructed, and operated successfully in the field application. The final effluent concentrations of COD, BOD, TP, NH-N, and TN reached 22.0, 8.0, 0.3, 4.0, and 11.0 mg/L, with removal rates of 92, 93, 92, 86, and 76%, respectively. The feasibility of IGWTS was also quantitatively evaluated from the perspectives of resource consumption, economic costs, water environment impact, and life cycle greenhouse gas (GHG) emissions. IGWTS has been proved to be a sound approach to mitigate GHG emissions compared with centralized wastewater treatment plant. It can also be featured as an eco-friendly technology to improve rural water environment, and an economic scenario with low construction and operation costs. Graphical abstract.
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http://dx.doi.org/10.1007/s11356-019-05746-2DOI Listing
September 2019