Publications by authors named "Shan Cong"

73 Publications

Experimental Study on the Resistance of Synthetic Penicillin Solid Lipid Nanoparticles to Clinically Resistant Staphylococcus aureus.

Comput Math Methods Med 2021 11;2021:9571286. Epub 2021 Nov 11.

Department of Oncology Surgery, The Second Affiliated Hospital of Qiqihaer Medical College, Qiqihar, Heilongjiang Province, China.

Background: With the increasing resistance of antibiotics to bacteria, new and effective methods are needed to transform existing antibiotics to solve the problem of long development cycles for new drugs. The antibiotic nanodelivery system has proven to be a promising strategy.

Aim: The purpose of this study is to synthesize penicillin solid lipid nanoparticles (penicillin SLNs) to enhance the antibacterial activity of penicillin against drug-resistant Staphylococcus aureus.

Materials And Methods: Penicillin SLNs were synthesized. And particle size, the polydispersity index (PI), and zeta potential (ZP) of penicillin SLNs were measured. The surface morphology of penicillin SLNs was observed using a transmission electron microscope.

Results: The particle size of penicillin SLNs is 112.3 ± 11.9 nm, the polydispersity index (PI) and zeta potential (ZP) of penicillin SLNs are 0.212 ± 0.03 and -27.6 ± 5.5 mV. The encapsulation efficiency and drug loading were 98.31 ± 1.2% and 4.98 ± 0.05 (%/), respectively. Penicillin SLNs had a more significant inhibitory effect on the growth of methicillin-sensitive Staphylococcus aureus (MSSA) after the drug and the bacteria were incubated for 12 hours. The number of MRSA colonies in the penicillin group increased after 12 hours, while the number of MRSA colonies in the penicillin SLNs group did not change significantly.

Conclusion: Penicillin SLNs enhance the ability of penicillin to enter cells and increase the concentration of penicillin in the cell and also extend the residence time of penicillin in the cell. Our findings indicated that penicillin SLNs enhance the inhibitory effect of penicillin on drug-resistant Staphylococcus aureus.
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http://dx.doi.org/10.1155/2021/9571286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601793PMC
November 2021

Surface Enhanced Raman Scattering Revealed by Interfacial Charge-Transfer Transitions.

Innovation (N Y) 2020 Nov 13;1(3):100051. Epub 2020 Oct 13.

Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou 215123, China.

Surface enhanced Raman scattering (SERS) is a fingerprint spectral technique whose performance is highly dependent on the physicochemical properties of the substrate materials. In addition to the traditional plasmonic metal substrates that feature prominent electromagnetic enhancements, boosted SERS activities have been reported recently for various categories of non-metal materials, including graphene, MXenes, transition-metal chalcogens/oxides, and conjugated organic molecules. Although the structural compositions of these semiconducting substrates vary, chemical enhancements induced by interfacial charge transfer are often the major contributors to the overall SERS behavior, which is distinct from that of the traditional SERS based on plasmonic metals. Regarding charge-transfer-induced SERS enhancements, this short review introduces the basic concepts underlying the SERS enhancements, the most recent semiconducting substrates that use novel manipulation strategies, and the extended applications of these versatile substrates.
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http://dx.doi.org/10.1016/j.xinn.2020.100051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454671PMC
November 2020

A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.

Hum Brain Mapp 2021 Sep 8. Epub 2021 Sep 8.

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology], Emory University, Atlanta, Georgia, USA.

Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
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http://dx.doi.org/10.1002/hbm.25625DOI Listing
September 2021

Electrochromic Metamaterials of Metal-Dielectric Stacks for Multicolor Displays with High Color Purity.

Nano Lett 2021 08 6;21(16):6891-6897. Epub 2021 Aug 6.

Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou 215123, China.

Inorganic electrochromic (EC) materials with vibrant multicolor change that are compatible with large-scale processing have been at the forefront of EC technology and are crucial in a wide range of applications, such as displays and camouflage. However, limited strategies are available to realize such inorganic materials, and challenges such as low color purity are yet to be overcome. Here, we demonstrate multilayered metal-dielectric metamaterials (MMDMs) as a new family of inorganics-based EC materials to achieve dynamic alternation among multicolors with high contrast and high color purity, which are structurally realized by significantly enhancing the confinement of the incident light in specific optical frequencies. This multilayer structure renders high reflectivity (75%), high quality factor (7.4), and a full width at half-maximum of 60 nm before coloration and presents a color gamut at least 40% wider than that of previously reported metamaterials after coloration, indicating good color quality.
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http://dx.doi.org/10.1021/acs.nanolett.1c02030DOI Listing
August 2021

Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis.

Sci Rep 2021 07 8;11(1):14141. Epub 2021 Jul 8.

Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.

In order to explore the role of exosomal circRNAs in the occurrence and development of sepsis, we looked for potential diagnostic markers to accurately identify sepsis and to lay a molecular basis for precise treatment. Ultracentrifugation was used to extract exosomes from the serum of patients with sepsis and healthy individuals. Then, changes in circRNA expression in exosomes were studied by circRNA microarray analysis. Gene ontology (GO) analysis and Kyoto City Encyclopaedia of Genes and Genomes (KEGG) pathway analysis were used to annotate the biological functions and pathways of genes, and a circRNA-miRNA-mRNA regulatory network was constructed. In the microarray analysis, 132 circRNAs were significantly differentially expressed, including 80 and 52 that were upregulated and downregulated, respectively. RT-qPCR verified the results of microarray analysis: hsa_circRNA_104484 and hsa_circRNA_104670 were upregulated in sepsis serum exosomes. ROC analysis showed that hsa_circRNA_104484 and hsa_circRNA_104670 in serum exosomes have the potential to be used as diagnostic markers for sepsis. The circRNA-miRNA-mRNA network predicted the potential regulatory pathways of differentially expressed circRNAs. There are differences in the expression of circRNA in serum exosomes between patients with sepsis and healthy individuals, which may be involved in the occurrence and development of the disease. Among them, elevations in hsa_circRNA_104484 and hsa_circRNA_104670 could be used as novel diagnostic biomarkers and molecular therapeutic targets.
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http://dx.doi.org/10.1038/s41598-021-93246-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266806PMC
July 2021

Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach.

Respir Res 2021 Jun 28;22(1):188. Epub 2021 Jun 28.

School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Xuan-bai-cheng-qi decoction (XCD), a traditional Chinese medicine (TCM) prescription, has been widely used to treat a variety of respiratory diseases in China, especially to seriously infectious diseases such as acute lung injury (ALI). Due to the complexity of the chemical constituent, however, the underlying pharmacological mechanism of action of XCD is still unclear. To explore its protective mechanism on ALI, firstly, a network pharmacology experiment was conducted to construct a component-target network of XCD, which identified 46 active components and 280 predicted target genes. Then, RNA sequencing (RNA-seq) was used to screen differentially expressed genes (DEGs) between ALI model rats treated with and without XCD and 753 DEGs were found. By overlapping the target genes identified using network pharmacology and DEGs using RNA-seq, and subsequent protein-protein interaction (PPI) network analysis, 6 kernel targets such as vascular epidermal growth factor (VEGF), mammalian target of rapamycin (mTOR), AKT1, hypoxia-inducible factor-1α (HIF-1α), and phosphoinositide 3-kinase (PI3K) and gene of phosphate and tension homology deleted on chromsome ten (PTEN) were screened out to be closely relevant to ALI treatment. Verification experiments in the LPS-induced ALI model rats showed that XCD could alleviate lung tissue pathological injury through attenuating proinflammatory cytokines release such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Meanwhile, both the mRNA and protein expression levels of PI3K, mTOR, HIF-1α, and VEGF in the lung tissues were down-regulated with XCD treatment. Therefore, the regulations of XCD on PI3K/mTOR/HIF-1α/VEGF signaling pathway was probably a crucial mechanism involved in the protective mechanism of XCD on ALI treatment.
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http://dx.doi.org/10.1186/s12931-021-01781-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237774PMC
June 2021

T-614 attenuates knee osteoarthritis via regulating Wnt/β-catenin signaling pathway.

J Orthop Surg Res 2021 Jun 22;16(1):403. Epub 2021 Jun 22.

Department of Rheumatism and Immunology, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, 830017, P.R. China.

Background: The aim of this study was to investigate the effect of Iguratimod (T-614) on rat knee osteoarthritis (KOA) and further to explore its underlying mechanism.

Methods: In this study, papain-induced KOA model was constructed. Hematoxylin and eosin (H&E) staining was conducted to observe the pathological changes of cartilage tissue and Mankin scoring principle was used for quantitative scoring. Transmission electron microscopy (TEM) was applied to observe the ultrastructure of cartilage tissue. ELISA was used to measure the levels of matrix metalloproteinase 13 (MMP-13) and inflammatory factors (interleukin (IL)-6 and tumor necrosis factor a (TNF-a)) in serum. RT-qPCR and immunohistochemistry were conducted to detect mRNA expression and protein expression of key genes in Wnt/β-catenin pathway.

Results: H&E, Mankin scoring, and TEM data confirmed that compared with model group, T-614 significantly improved the degeneration of articular cartilage. Besides, we observed that low, middle, and high doses of T-614 could decrease the levels of MMP13, TNF-α, and IL-6 in serum to different degrees. Mechanically, T-614 downregulated the mRNA and protein expression of β-catenin and MMP13 in cartilage tissue via a dose-dependent manner, and on the contrary upregulated the mRNA and protein expression of glucogen synthase kinase-3 beta (GSK-3β).

Conclusion: Our results suggested that T-614 can reduce the level of its downstream target gene MMP-13 and downregulate the expression of inflammatory cytokines TNF-α and IL-6 by regulating the Wnt/β-catenin signaling pathway, thereby inhibiting joint inflammation and controlling KOA degeneration of articular cartilage.
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http://dx.doi.org/10.1186/s13018-021-02530-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220752PMC
June 2021

Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis.

BMC Infect Dis 2021 Apr 26;21(1):384. Epub 2021 Apr 26.

Department of Respiratory Medicine, The Second Hospital of Jilin University, 218 Ziqiang Street, Nanguan District, Changchun, 130041, Jilin Province, China.

Background: The aim of the study was to conduct a meta-analysis to evaluate the accuracy of neutrophil CD64, procalcitonin (PCT), and interleukin-6 (IL-6) as markers for the diagnosis of sepsis in adult patients.

Methods: Various databases were searched to collect published studies on the diagnosis of sepsis in adult patients using neutrophil CD64, PCT, and IL-6 levels. Utilizing the Stata SE 15.0 software, forest plots and the area under the summary receiver operating characteristic curves were drawn. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve (AUC) were calculated.

Results: Fifty-four articles were included in the study. The pooled sensitivity, specificity, and AUC of neutrophil CD64 for the diagnosis of sepsis were 0.88 (95% confidence interval [CI], 0.81-0.92), 0.88 (95% CI, 0.83-0.91), and 0.94 (95% CI, 0.91-0.96), respectively. The pooled sensitivity, specificity, and AUC of PCT for the diagnosis of sepsis were 0.82 (95% CI, 0.78-0.85), 0.78 (95% CI, 0.74-0.82), and 0.87 (95% CI, 0.83-0.89), respectively. Subgroup analysis showed that the AUC for PCT diagnosis of intensive care unit (ICU) sepsis was 0.86 (95% CI, 0.83-0.89) and the AUC for PCT diagnosis of non-ICU sepsis was 0.82 (95% CI, 0.78-0.85). The pooled sensitivity, specificity, and AUC of IL-6 for the diagnosis of sepsis were 0.72 (95% CI, 0.65-0.78), 0.70 (95% CI, 0.62-0.76), and 0.77 (95% CI, 0.73-0.80), respectively.

Conclusions: Of the three biomarkers studied, neutrophil CD64 showed the highest diagnostic value for sepsis, followed by PCT, and IL-6. On the other hand, PCT showed a better diagnostic potential for the diagnosis of sepsis in patients with severe conditions compared with that in patients with non-severe conditions.
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http://dx.doi.org/10.1186/s12879-021-06064-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072745PMC
April 2021

Mimicking Nature's Butterflies: Electrochromic Devices with Dual-Sided Differential Colorations.

Adv Mater 2021 Apr 26;33(14):e2007314. Epub 2021 Feb 26.

Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.

Some butterfly species such as the orange oakleaf (Kallima inachus) have strikingly different colors on the dorsal (front) sides of their wings compared to those on the ventral (back) sides of their wings, which helps camouflage the butterflies from predators and attract potential mates. However, few human-made materials, devices, and technologies can mimic such differential coloring for a long time. Here, a new type of Janus-structured two-sided electrochromic device is developed that, upon application of different voltages, exhibits a coloration state on one side that is distinctly different from that on the other side. This is achieved by inserting an optically thin (4-8 nm) metallic layer with a complex refractive index, such as a layer composed of tungsten, titanium, copper or silver, into typical electrochromic structures.
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http://dx.doi.org/10.1002/adma.202007314DOI Listing
April 2021

Ultrathin Two-Dimensional Nanostructures: Surface Defects for Morphology-Driven Enhanced Semiconductor SERS.

Angew Chem Int Ed Engl 2021 Mar 19;60(10):5505-5511. Epub 2021 Jan 19.

School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, 230026, China.

Two-dimensional (2D) semiconductors have recently become attractive candidate substrates for surface-enhanced Raman spectroscopy, exhibiting good semiconductor-based SERS sensing for a wider variety of application scenarios. However, the underlying mechanism remains unclear. Herein, we propose that surface defects play a vital role in the magnification of the SERS performances of 2D semiconductors. As a prototype material, ultrathin WO nanosheets is used to demonstrate that surface defect sites and the resulting increased charge-carrier density can induce strong charge-transfer interactions at the substrate-molecule interface, thereby improving the sensitivity of the SERS substrate by 100 times with high reproducibility. Further work with other metal oxides suggests the reduced dimension of 2D materials can be advantageous in promoting SERS sensing for multiple probe molecules.
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http://dx.doi.org/10.1002/anie.202015306DOI Listing
March 2021

iTRAQ-Based Proteomics Reveals Potential Anti-Virulence Targets for ESBL-Producing .

Infect Drug Resist 2020 19;13:2891-2899. Epub 2020 Aug 19.

Department of Respiratory and Critical Care Medicine., The Second Hospital of Jilin University, Changchun, People's Republic of China.

Purpose: Treatment of infections with strains producing extended-spectrum beta-lactamases (ESBLs) is challenging due to the coexistence of multiple resistance mechanisms and the hypervirulent variant. Therefore, new targets or more effective treatment options aimed at ESBL-producing are urgently needed.

Materials And Methods: Here, we collected ESBL-producing and non-ESBL isolates and studied their differences from a proteomic point of view.

Results: We revealed treA, wza, gnd, rmlA, rmlC, rmlD, galE, aceE, and sucD as important virulence-related proteins in ESBL-producing , distinct from those in non-ESBL strains.

Conclusion: Our findings provide plausible anti-virulence targets and suggest new therapeutic avenues against ESBL-producing .
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http://dx.doi.org/10.2147/IDR.S259894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445504PMC
August 2020

Mechanism of miRNA-based Aconitum leucostomum Worosch. Monomer inhibition of bone marrow-derived dendritic cell maturation.

Int Immunopharmacol 2020 Nov 29;88:106791. Epub 2020 Aug 29.

The First Affiliated Hospital of Xinjiang Medical University, Xinjiang 301617, China. Electronic address:

Delvestidine (DLTD) is a monomeric compound isolated from Aconitum leucostomum Worosch, a widely used medicine for local treatment of rheumatoid arthritis (RA). Studies have shown that Aconitum leucostomum Worosch. can inhibit maturation of bone marrow-derived dendritic cells (BMDCs). Further, microRNAs (miRNAs) have regulatory effects on DC maturity and function. However, the mechanism underlying DLTD effects on DC maturity and RA remains to be elucidated. This study investigated whether DLTD-mediated inhibition of DC maturation is regulated by miRNAs. LPS-induced mature BMDCs were treated with DLTD for 48 h. CD80 and CD86 expression on BMDCs was detected by flow cytometry, and levels of inflammatory factors IL-6, IL-23, IL-1β, and TNF-α were detected by ELISA and PCR. Further, gene expression and miRNA expression profiles were investigated by bioinformatics analysis and verified by PCR. DLTD was found to inhibit CD80 and CD86 expression on the surface of BMDCs and secretion of inflammatory factors IL-6, IL-23, IL-1β, and TNF-α. In total, 54 differentially expressed miRNAs were detected, including 29 up-regulated and 25 down-regulated miRNAs after DLTD treatment. Analysis of biological information revealed that the differentially expressed target genes mainly regulated biological processes, including cell differentiation, cell cycle, and protein kinase complexes. Additionally, miR-511-3p downstream targets Calcr, Fzd10, and Eps8, were closely related to BMDCs maturation. DLTD may induce BMDCs maturity through regulation of miRNAs that affect Calcr, Fzd10, and Eps8 gene signals.
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http://dx.doi.org/10.1016/j.intimp.2020.106791DOI Listing
November 2020

Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data.

Neurobiol Aging 2020 11 14;95:81-93. Epub 2020 Jul 14.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Medial temporal lobe (MTL) consists of hippocampal subfields and neighboring cortices. These heterogeneous structures are differentially involved in memory, cognitive and emotional functions, and present nonuniformly distributed atrophy contributing to cognitive disorders. This study aims to examine how genetics influences Alzheimer's disease (AD) pathogenesis via MTL substructures by analyzing high-resolution magnetic resonance imaging (MRI) data. We performed genome-wide association study to examine the associations between 565,373 single nucleotide polymorphisms (SNPs) and 14 MTL substructure volumes. A novel association with right Brodmann area 36 volume was discovered in an ERC1 SNP (i.e., rs2968869). Further analyses on larger samples found rs2968869 to be associated with gray matter density and glucose metabolism measures in the right hippocampus, and disease status. Tissue-specific transcriptomic analysis identified the minor allele of rs2968869 (rs2968869-C) to be associated with reduced ERC1 expression in the hippocampus. All the findings indicated a protective role of rs2968869-C in AD. We demonstrated the power of high-resolution MRI and the promise of fine-grained MTL substructures for revealing the genetic basis of AD biomarkers.
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http://dx.doi.org/10.1016/j.neurobiolaging.2020.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609616PMC
November 2020

Identification of Biomarkers for Sarcoidosis and Tuberculosis of the Lung Using Systematic and Integrated Analysis.

Med Sci Monit 2020 Jul 23;26:e925438. Epub 2020 Jul 23.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Sarcoidosis (SARC) is a multisystem inflammatory disease of unknown etiology and pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis. Both of these diseases affect lungs and lymph nodes and share similar clinical manifestations. However, the underlying mechanisms for the similarities and differences in genetic characteristics of SARC and PTB remain unclear. MATERIAL AND METHODS Three datasets (GSE16538, GSE20050, and GSE19314) were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in SARC and PTB were identified using GEO2R online analyzer and Venn diagram software. Functional enrichment analysis was performed using Database for Annotation, Visualization and Integrated Discovery (DAVID) and R packages. Two protein-protein interaction (PPI) networks were constructed using Search Tool for the Retrieval of Interacting Genes database, and module analysis was performed using Cytoscape. Hub genes were identified using area under the receiver operating characteristic curve analysis. RESULTS We identified 228 DEGs, including 56 common SARC-PTB DEGs (enriched in interferon-gamma-mediated signaling, response to gamma radiation, and immune response) and 172 SARC-only DEGs (enriched in immune response, cellular calcium ion homeostasis, and dendritic cell chemotaxis). Potential biomarkers for SARC included CBX5, BCL11B, and GPR18. CONCLUSIONS We identified potential biomarkers that can be used as candidates for diagnosis and/or treatment of patients with SARC.
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http://dx.doi.org/10.12659/MSM.925438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397754PMC
July 2020

Remarkable Near-Infrared Electrochromism in Tungsten Oxide Driven by Interlayer Water-Induced Battery-to-Pseudocapacitor Transition.

ACS Appl Mater Interfaces 2020 Jul 15;12(30):33917-33925. Epub 2020 Jul 15.

Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.

Near-infrared (NIR) electrochromism is of academic and technological interest for a variety of applications in advanced solar heat regulation, photodynamic therapy, optical telecommunications, and military camouflage. However, inorganic materials with outstanding NIR modulation capability are quite few. Herein, we propose a promising strategy for achieving strong NIR electrochromism in tungsten oxide that is closely related to its electrochemical transformation from battery-type behavior to pseudocapacitance, induced by introducing an interlayer space with water molecules within tungsten oxide. Further evidence demonstrates that the interlayer water molecules significantly reduced the energy barrier to ion diffusion and increased the ion flux in tungsten oxide. As a result, compared with anhydrous WO, the as-synthesized WO·2HO nanoplates exhibited remarkably improved NIR electrochromic properties, including a large transmittance modulation (90.4%), high coloration efficiency (322.6 cm C), and high cyclic stability (maintaining 93.7% after 500 cycles), which were comparable to those of the best reported NIR electrochromic materials. Moreover, the application of the WO·2HO nanoplate-based electrochromic device resulted in a temperature difference of 11.9 °C, indicating good solar thermal regulation ability.
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http://dx.doi.org/10.1021/acsami.0c08270DOI Listing
July 2020

A Dopant Replacement-Driven Molten Salt Method toward the Synthesis of Sub-5-nm-Sized Ultrathin Nanowires.

Small 2020 Jun 7;16(23):e2001098. Epub 2020 May 7.

Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou, 215123, China.

The high-temperature molten-salt method is an important inorganic synthetic route to a wide variety of morphological phenotypes. However, its utility is limited by the fact that it is typically incapable of producing ultrathin (<5 nm diameter) nanowires, which have a crucial role in novel nanotechnology applications. Herein, a rapid molten salt-based synthesis of sub-5-nm-sized nanowires of hexagonal tungsten oxide (h-WO ) that is critically dependent on a substantial proportion of molybdenum (Mo) dopant is described. This dopant-driven morphological transition in tungsten oxide (WO ) may be attributable to the collapse of layered structure, followed by nanocluster aggregation, coalescence, and recrystallization to form ultrathin nanowires. Interestingly, due to the structural properties of h-WO , the thus-formed ultrathin nanowires are demonstrated to be excellent photocatalysts for the production of ammonia (NH ) from nitrogen (N ) and water. The ultrathin nanowires exhibit a high photocatalytic NH -production activity with a rate of 370 µmol g h and an apparent quantum efficiency of 0.84% at 420 nm, which is more than twice that obtained from the best-performing Mo-doped W O nanowire catalysts. It is envisaged that the dopant replacement-driven synthetic protocol will allow for rapid access to a series of ultrathin nanostructures with intriguing properties and increase potential applications.
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http://dx.doi.org/10.1002/smll.202001098DOI Listing
June 2020

Surface-Modified Two-Dimensional Titanium Carbide Sheets for Intrinsic Vibrational Signal-Retained Surface-Enhanced Raman Scattering with Ultrahigh Uniformity.

ACS Appl Mater Interfaces 2020 May 11;12(20):23523-23531. Epub 2020 May 11.

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

Surface-enhanced Raman scattering (SERS) employing a non-noble substrate in comparison with conventional noble-metal ones offers advantages of low cost and rich selection of candidates; however, its application has been seriously hindered by its unsatisfactory detection sensitivity, poor uniformity, and undesirable modification of vibrational signals via changing the orientation and/or polarizability of probe molecules. Here, an unusually sensitive but nonselective enhancement was achieved by employing titanium carbide sheets modified with aluminum oxyanions in situ as active supports for Raman measurement. The analyte molecules adopted a conformation similar to what they adopt on a bare substrate, while closely interacting with the aluminum oxyanion surface, which leads to the rare observation of highly sensitive but nonselective enhancement with a detection limit close to the pM level. With the substrate surface roughness in the nanometer region, an outstanding uniformity with a relative standard deviation of less than 4.3% was achieved. In addition, the SERS effect on the modified titanium carbide sheets was shown to be applicable to a wide range of analyte molecules, including both organic dyes and trace harmful compounds. The success of the work demonstrates the feasibility of surface tuning to improve the SERS effect, and it introduces a new window for two-dimensional materials in SERS applications.
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http://dx.doi.org/10.1021/acsami.0c00908DOI Listing
May 2020

Correction to: Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway.

Inflamm Res 2020 07;69(7):711

Clinical Pharmacokinetic Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

In the original publication of the article.
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http://dx.doi.org/10.1007/s00011-020-01344-yDOI Listing
July 2020

Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway.

Inflamm Res 2020 Apr 4;69(4):365-373. Epub 2020 Mar 4.

Clinical Pharmacokinetic Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective And Design: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway.

Subjects: Wistar rats and RAW264.7 cells were studied.

Treatment: LPS was used to induce inflammation in rats or RAW264.7 cells and emodin was given once a day before LPS stimulation and continued for a certain number of days.

Methods: Lung tissues and bronchoalveolar lavage fluid (BALF) were collected for the in vivo experiment, while cells and supernatant were collected for the in vitro experiment. Pathological changes in the lung tissues were assessed by hematoxylin and eosin staining. The levels of inflammatory factors, including TNF-α, IL-1β, and IL-6, were determined by enzyme-linked immunosorbent assay. The expression levels of p-mTOR, HIF-1α, and VEGF proteins were measured by Western blot analysis and immunohistochemistry. The mRNA levels of p70S6K, eIF4E-BP1, and eIF4E were measured by quantitative polymerase chain reaction.

Results: Emodin ameliorated pathological changes and infiltrated inflammatory cells in LPS-induced ALI. It also significantly reduced the expression of inflammatory factors, including TNF-α, IL-1β, and IL-6, in BALF and downregulated the expression of p-mTOR, HIF-1α, and VEGF proteins in the lung tissues. Similar anti-inflammatory effects and the downregulation of the mTOR/HIF-1α/VEGF signaling pathway were found in RAW264.7 cells. The mRNA levels of p70S6K, eIF4E-BP1, and eIF4E also decreased in the macrophages.

Conclusion: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1α/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.
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http://dx.doi.org/10.1007/s00011-020-01331-3DOI Listing
April 2020

Fabry-Perot Cavity-Type Electrochromic Supercapacitors with Exceptionally Versatile Color Tunability.

Nano Lett 2020 Mar 26;20(3):1915-1922. Epub 2020 Feb 26.

School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230000, China.

Electrochromic supercapacitors that can change their appearances according to their charged states are presently attracting significant interest from both academia and industry. Tungsten oxide is often used in electrochromic supercapacitors because it can serve as an active material for both benchmarking electrochromic devices and high-performance supercapacitor electrodes. Despite this, acceptable visual aesthetics in electrochromic supercapacitors have almost never been achieved using tungsten oxide, because, in its pure form, this compound only displays a 1-fold color modulation from transparent to blue. Herein, we defy this trend by reporting the first ever Fabry-Perot (F-P) cavity-type electrochromic supercapacitors based only on a tungsten oxide material. The devices were sensitively changeable according to their charge/discharge states and displayed a wide variety of fantastic patterns consisting of different, vivid colors, with both simple and complex designs being achieved. Our findings suggested a novel direction for the aesthetic design of intelligent, multifunctional electrochemical energy storage devices.
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http://dx.doi.org/10.1021/acs.nanolett.9b05152DOI Listing
March 2020

Towards full-colour tunability of inorganic electrochromic devices using ultracompact fabry-perot nanocavities.

Nat Commun 2020 Jan 16;11(1):302. Epub 2020 Jan 16.

Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou, 215123, P. R. China.

Intercalation-based inorganic materials that change their colours upon ion insertion/extraction lay an important foundation for existing electrochromic technology. However, using only such inorganic electrochromic materials, it is very difficult to achieve the utmost goal of full-colour tunability for future electrochromic technology mainly due to the absence of structural flexibility. Herein, we demonstrate an ultracompact asymmetric Fabry-Perot (F-P) nanocavity-type electrochromic device formed by using partially reflective metal tungsten as the current collector and reflector layer simultaneously; this approach enables fairly close matching of the reflections at both interfaces of the WO thin layer in device form, inducing a strong interference. Such an interference-enhanced device that is optically manipulated at the nanoscale displays various structural colours before coloration and, further, can change to other colours including blue, red, and yellow by changing the optical indexes (n, k) of the tungsten oxide layer through ion insertion.
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http://dx.doi.org/10.1038/s41467-019-14194-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965179PMC
January 2020

Regional imaging genetic enrichment analysis.

Bioinformatics 2020 04;36(8):2554-2560

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Motivation: Brain imaging genetics aims to reveal genetic effects on brain phenotypes, where most studies examine phenotypes defined on anatomical or functional regions of interest (ROIs) given their biologically meaningful interpretation and modest dimensionality compared with voxelwise approaches. Typical ROI-level measures used in these studies are summary statistics from voxelwise measures in the region, without making full use of individual voxel signals.

Results: In this article, we propose a flexible and powerful framework for mining regional imaging genetic associations via voxelwise enrichment analysis, which embraces the collective effect of weak voxel-level signals and integrates brain anatomical annotation information. Our proposed method achieves three goals at the same time: (i) increase the statistical power by substantially reducing the burden of multiple comparison correction; (ii) employ brain annotation information to enable biologically meaningful interpretation and (iii) make full use of fine-grained voxelwise signals. We demonstrate our method on an imaging genetic analysis using data from the Alzheimer's Disease Neuroimaging Initiative, where we assess the collective regional genetic effects of voxelwise FDG-positron emission tomography measures between 116 ROIs and 565 373 single-nucleotide polymorphisms. Compared with traditional ROI-wise and voxelwise approaches, our method identified 2946 novel imaging genetic associations in addition to 33 ones overlapping with the two benchmark methods. In particular, two newly reported variants were further supported by transcriptome evidences from region-specific expression analysis. This demonstrates the promise of the proposed method as a flexible and powerful framework for exploring imaging genetic effects on the brain.

Availability And Implementation: The R code and sample data are freely available at https://github.com/lshen/RIGEA.

Supplementary Information: Supplementary data are available at Bioinformatics online.
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http://dx.doi.org/10.1093/bioinformatics/btz948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178438PMC
April 2020

Mining Regional Imaging Genetic Associations via Voxel-wise Enrichment Analysis.

IEEE EMBS Int Conf Biomed Health Inform 2019 May 12;2019. Epub 2019 Sep 12.

Biostatistics, Epidemiology and Informatics University of Pennsylvania, Philadelphia, PA.

Brain imaging genetics aims to reveal genetic effects on brain phenotypes, where most studies examine phenotypes defined on anatomical or functional regions of interest (ROIs) given their biologically meaningful annotation and modest dimensionality compared with voxel-wise approaches. Typical ROI-level measures used in these studies are summary statistics from voxel-wise measures in the region, without making full use of individual voxel signals. In this paper, we propose a flexible and powerful framework for mining regional imaging genetic associations via voxel-wise enrichment analysis, which embraces the collective effect of weak voxel-level signals within an ROI. We demonstrate our method on an imaging genetic analysis using data from the Alzheimers Disease Neuroimaging Initiative, where we assess the collective regional genetic effects of voxel-wise FDGPET measures between 116 ROIs and 19 AD candidate SNPs. Compared with traditional ROI-wise and voxel-wise approaches, our method identified 102 additional significant associations, some of which were further supported by evidences in brain tissue-specific expression analysis. This demonstrates the promise of the proposed method as a flexible and powerful framework for exploring imaging genetic effects on the brain.
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http://dx.doi.org/10.1109/BHI.2019.8834450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860973PMC
May 2019

Photodegradable CuS SERS Probes for Intraoperative Residual Tumor Detection, Ablation, and Self-Clearance.

ACS Appl Mater Interfaces 2019 Jul 18;11(26):23436-23444. Epub 2019 Jun 18.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry , Chinese Academy of Sciences , Beijing 100190 , P. R. China.

Surface-enhanced Raman scattering (SERS) probes have exhibited great potential in biomedical applications. However, currently reported SERS probes are mainly fabricated by nondegradable Au or Ag nanostructures, which are not favorably cleared from the imaged tissues. This bottleneck hinders their in vivo applications. We herein explore a degradable SERS probe consisting of hollow CuS nanoparticles (NPs) to circumvent the current limitation. We identify, for the first time, the Raman enhancement effects of hollow CuS NPs as a SERS probe for Raman imaging of residual tumor lesions. Uniquely, CuS SERS probes are degradable, which stems from laser-induced photothermal effects of CuS NPs, leading to their disintegration from shell structures into individual crystals, thus facilitating their self-clearance from imaged tissues. This novel CuS SERS probe with photodegradation characteristics opens avenues for applying Raman imaging toward a myriad of biomedical applications.
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http://dx.doi.org/10.1021/acsami.9b00469DOI Listing
July 2019

Ultraflexible and Lightweight Bamboo-Derived Transparent Electrodes for Perovskite Solar Cells.

Small 2019 Aug 28;15(33):e1902878. Epub 2019 Jun 28.

School of Energy, Soochow Institute for Energy and Materials Innovations & Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou, 215006, China.

Wearable devices are mainly based on plastic substrates, such as polyethylene terephthalate and polyethylene naphthalate, which causes environmental pollution after use due to the long decomposition periods. This work reports on the fabrication of a biodegradable and biocompatible transparent conductive electrode derived from bamboo for flexible perovskite solar cells. The conductive bioelectrode exhibits extremely flexible and light-weight properties. After bending 3000 times at a 4 mm curvature radius or even undergoing a crumpling test, it still shows excellent electrical performance and negligible decay. The performance of the bamboo-based bioelectrode perovskite solar cell exhibits a record power conversion efficiency (PCE) of 11.68%, showing the highest efficiency among all reported biomass-based perovskite solar cells. It is remarkable that this flexible device has a highly bendable mechanical stability, maintaining over 70% of its original PCE during 1000 bending cycles at a 4 mm curvature radius. This work paves the way for perovskite solar cells toward comfortable and environmentally friendly wearable devices.
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http://dx.doi.org/10.1002/smll.201902878DOI Listing
August 2019

The Oncogene IARS2 Promotes Non-small Cell Lung Cancer Tumorigenesis by Activating the AKT/MTOR Pathway.

Front Oncol 2019 14;9:393. Epub 2019 May 14.

Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, China.

A limited number of studies have indicated an association between isoleucyl-tRNA synthetase 2 (IARS2) and tumorigenesis. We evaluated IARS2 protein expression in lung tumor tissues and paired non-tumor tissues. We found higher IARS2 expression in the tumor tissues, which was associated with the late Tumor and Node stages of the Tumor, Node, Metastasis staging system. Silencing IARS2 inhibited the activity of A549 and H1299 cells, resulting in G0/G1 stasis of A549 cells and mitochondrial apoptosis. IARS2 silencing was also found to inhibit NSCLC tumor growth in nude mice. Complementary DNA microarray analysis revealed 742 differentially expressed genes (507 upregulated and 235 downregulated) in IARS2-silenced A549 cells compared to controls. Ingenuity Pathway Analysis of the differential expression data suggested that multiple pathways are associated with IARS2 silencing in NSCLC cells; upstream analysis predicted the activation or inhibition of transcriptional regulators. Correlation analysis revealed that AKT and MTOR activities were significantly inhibited in IARS2-silenced cells, but were partially restored by the AKT-stimulating agent SC79. IARS2 appears to regulate lung cancer cell proliferation via the AKT/MTOR pathway. Our results help clarify the complex roles of IARS2 in tumorigenesis and suggest that it may be a novel regulator of lung cancer development.
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http://dx.doi.org/10.3389/fonc.2019.00393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528107PMC
May 2019

Off-centered-symmetry-based band structure modulation of hexagonal WO.

J Phys Condens Matter 2019 Sep 20;31(35):355501. Epub 2019 May 20.

Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application, School of Mathematics and Physics, Suzhou University of Science and Technology, Suzhou 215009, People's Republic of China.

The accurate band gap of 2.24 eV for hexagonal WO is obtained by adopting the revised Heyd-Scuseria-Ernzerhof screened hybrid functional. The large band gap is a result of the off-centered symmetry where the W atom forms two short and two long bonds with four neighboring in-plane O atoms. By adding/removing electrons into/from the crystal, the effect of charge doping is investigated. With introducing electrons, the off-centered symmetry gets weakened with a slight narrowing in band gap. However, the doping lifts the Fermi level into the conduction band, inducing an increase in transition energy for electrons. Similarly, the hole doping also results in a remarkable increase in the transition energy. Such band structure modulation can be used in high efficient photoabsorption, photocatalysis and surface-enhanced Raman spectroscopy.
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http://dx.doi.org/10.1088/1361-648X/ab2327DOI Listing
September 2019

Fabrication of Nickel Oxide Nanopillar Arrays on Flexible Electrodes for Highly Efficient Perovskite Solar Cells.

Nano Lett 2019 06 2;19(6):3676-3683. Epub 2019 May 2.

Department of Physics, Institute of Advanced Materials, State Key Laboratory of Environmental and Biological Analysis , Hong Kong Baptist University (HKBU) , Kowloon Tong , Hong Kong SAR , China.

Semiconductor nanomaterials with controlled morphologies and architectures are of critical importance for high-performance optoelectronic devices. However, the fabrication of such nanomaterials on polymer-based flexible electrodes is particularly challenging due to degradation of the flexible electrodes at a high temperature. Here we report the fabrication of nickel oxide nanopillar arrays (NiO NaPAs) on a flexible electrode by vapor deposition, which enables highly efficient perovskite solar cells (PSCs). The NiO NaPAs exhibit an enhanced light transmittance for light harvesting, prohibit exciton recombination, promote irradiation-generated hole transport and collection, and facilitate the formation of large perovskite grains. These advantageous features result in a high efficiency of 20% and 17% for the rigid and flexible PSCs, respectively. Additionally, the NaPAs show no cracking after 500 times of bending, consistent with the mechanic simulation results. This robust fabrication opens a new opportunity for the fabrication of a large area of high-performance flexible optoelectronic devices.
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http://dx.doi.org/10.1021/acs.nanolett.9b00760DOI Listing
June 2019

RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway.

J Cell Mol Med 2019 06 6;23(6):3897-3904. Epub 2019 Apr 6.

Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.

Initial functional studies have demonstrated that RNA-binding motif protein 10 (RBM10) can promote apoptosis and suppress cell proliferation; however, the results of several studies suggest a tumour-promoting role for RBM10. Herein, we assessed the involvement of RBM10 in lung adenocarcinoma cell proliferation and explored the potential molecular mechanism. We found that, both in vitro and in vivo, RBM10 overexpression suppresses lung adenocarcinoma cell proliferation, while its knockdown enhances cell proliferation. Using complementary DNA microarray analysis, we previously found that RBM10 overexpression induces significant down-regulation of RAP1A expression. In this study, we have confirmed that RBM10 decreases the activation of RAP1 and found that EPAC stimulation and inhibition can abolish the effects of RBM10 knockdown and overexpression, respectively, and regulate cell growth. This effect of RBM10 on proliferation was independent of the MAPK/ERK and P38/MAPK signalling pathways. We found that RBM10 reduces the phosphorylation of CREB via the AKT signalling pathway, suggesting that RBM10 exhibits its effect on lung adenocarcinoma cell proliferation via the RAP1/AKT/CREB signalling pathway.
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http://dx.doi.org/10.1111/jcmm.14263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533519PMC
June 2019

Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3.

J Biochem Mol Toxicol 2019 May 22;33(5):e22301. Epub 2019 Feb 22.

Department of Pediatrics, Jining No.1 People's Hospital, Jining, China.

Schizandrin is a major bioactive constituent of Schisandra chinensis (Turcz.) Baill with antioxidant and anti-inflammatory properties. The objective of this study was to explore the potential effects of schizandrin on a cell model of myocarditis. The H9c2 cells were treated with schizandrin alone or in combination with lipopolysaccharide (LPS), after which, cell survival, migration, and the release of inflammatory cytokines were assessed. Moreover, downstream effectors and signaling pathways were studied to reveal the possible underlying mechanism. As a result, LPS stimulation induced significant cell damage as cell viability was repressed and the apoptosis was induced. In the meantime, LPS promoted the release of proinflammatory cytokines including interleukin 1β (IL-1β), IL-8, IL-6, and tumor necrosis factor (TNF-α) while repressing the release of the anti-inflammatory cytokine IL-10. Schizandrin could promote H9c2 cell migration and long-term treatment (7 days) enhanced cell viability. More interestingly, pretreatment with schizandrin attenuated LPS-induced cell loss and inflammatory response. Besides this, Smad3 was a downstream effector of schizandrin. The beneficial effects of schizandrin on the H9c2 cells were attenuated when Smad3 was overexpressed. Moreover, the silencing of Smad3 deactivated c-Jun N-terminal kinase (JNK) and nuclear factor κB (NF-κB) pathways. This study preliminarily demonstrated that schizandrin prevented LPS-induced injury in the H9c2 cells and promoted the recovery of myocardial tissues by enhancing cell viability and migration. Schizandrin conferred its beneficial effects possibly by downregulating Smad3 and inhibiting the activation of JNK and NF-κB pathways.
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http://dx.doi.org/10.1002/jbt.22301DOI Listing
May 2019
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