Shan Cen

Shan Cen

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High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses.

J Virol 2019 Jun 29;93(12). Epub 2019 May 29.

NHC Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China

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http://dx.doi.org/10.1128/JVI.00023-19DOI Listing
June 2019

Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands.

Bioorg Med Chem Lett 2019 Jun 3;29(12):1541-1545. Epub 2019 Apr 3.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.03.049DOI Listing
June 2019

Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1.

Cell Rep 2019 Jun;27(11):3295-3304.e4

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.036DOI Listing
June 2019

APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.

Antiviral Res 2019 May 9;165:23-33. Epub 2019 Mar 9.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2019.03.005DOI Listing
May 2019

Self-assembled nanovehicle-mediated co-encapsulation of inactivated EV71 virus and CpG oligonucleotides elicits potent anti-EV71 humoral and cellular immune protective responses.

Biochem Biophys Res Commun 2019 Apr 16;511(2):253-259. Epub 2019 Feb 16.

College of Life Science and Bioengineering, Beijing University of Technology, NO. 100 Pingleyuan, Chaoyang District, Beijing, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193019
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http://dx.doi.org/10.1016/j.bbrc.2019.02.014DOI Listing
April 2019

Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist.

Eur J Med Chem 2019 Mar 26;166:232-242. Epub 2019 Jan 26.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.036DOI Listing
March 2019

Synthesis and Biological Evaluation of Substituted Indole and Its Analogs as Influenza A Virus Inhibitors.

Chem Biodivers 2019 Feb 28;16(2):e1800577. Epub 2019 Jan 28.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, P. R. China.

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http://dx.doi.org/10.1002/cbdv.201800577DOI Listing
February 2019

MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.

Biochem J 2019 Feb 5;476(3):467-481. Epub 2019 Feb 5.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China

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http://dx.doi.org/10.1042/BCJ20180754DOI Listing
February 2019

CRISPR/Cas9 Inhibits Multiple Steps of HIV-1 Infection.

Hum Gene Ther 2018 Nov 9;29(11):1264-1276. Epub 2018 May 9.

1 MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China .

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http://dx.doi.org/10.1089/hum.2018.018DOI Listing
November 2018

Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site.

Front Pharmacol 2018 30;9:1419. Epub 2018 Nov 30.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua, China.

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https://www.frontiersin.org/article/10.3389/fphar.2018.01419
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http://dx.doi.org/10.3389/fphar.2018.01419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284051PMC
November 2018

Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786.

J Antibiot (Tokyo) 2018 10 5;71(10):905-907. Epub 2018 Jul 5.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/s41429-018-0077-4DOI Listing
October 2018

Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque.

J Cardiovasc Transl Res 2018 08 23;11(4):285-291. Epub 2018 Jul 23.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, 100050, China.

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http://dx.doi.org/10.1007/s12265-018-9817-xDOI Listing
August 2018

Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein.

Antiviral Res 2018 07 27;155:1-11. Epub 2018 Apr 27.

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.04.020DOI Listing
July 2018

Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus.

Viruses 2018 06 16;10(6). Epub 2018 Jun 16.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China.

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http://www.mdpi.com/1999-4915/10/6/330
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http://dx.doi.org/10.3390/v10060330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024364PMC
June 2018

[Molecular mechanisms of genetic transposition inhibition by piRNA].

Yi Chuan 2018 Jun;40(6):445-450

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.16288/j.yczz.18-072DOI Listing
June 2018

Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis.

PLoS One 2018 8;13(2):e0191930. Epub 2018 Feb 8.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191930PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805253PMC
March 2018

Progress in the Rational Design for Polypharmacology Drug.

Curr Pharm Des 2016 ;22(21):3182-9

.

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November 2017

The poly-proline tail of SIVmac Vpx provides gain of function for resistance to a cryptic proteasome-dependent degradation pathway.

Virology 2017 11 10;511:23-29. Epub 2017 Aug 10.

Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.07.022DOI Listing
November 2017

Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities.

J Nat Prod 2017 10 10;80(10):2595-2601. Epub 2017 Oct 10.

Institute of Medicinal Biotechnology, Academy of Medical Science & Peking Union Medical College , Beijing 100050, China.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00878DOI Listing
October 2017

MTLD, a Database of Multiple Target Ligands, the Updated Version.

Molecules 2017 Sep 6;22(9). Epub 2017 Sep 6.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.

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http://dx.doi.org/10.3390/molecules22091375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151691PMC
September 2017

A highly conserved amino acid in VP1 regulates maturation of enterovirus 71.

PLoS Pathog 2017 Sep 22;13(9):e1006625. Epub 2017 Sep 22.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, PR China.

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http://dx.doi.org/10.1371/journal.ppat.1006625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634653PMC
September 2017

The function of LINE-1-encoded reverse transcriptase in tumorigenesis.

Yi Chuan 2017 05;39(5):368-376

Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.16288/j.yczz.17-047DOI Listing
May 2017

Anti-influenza triterpenoid saponins (saikosaponins) from the roots of Bupleurum marginatum var. stenophyllum.

Bioorg Med Chem Lett 2017 04 7;27(8):1654-1659. Epub 2017 Mar 7.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmcl.2017.03.015DOI Listing
April 2017

BST-2 restricts IAV release and is countered by the viral M2 protein.

Biochem J 2017 02 20;474(5):715-730. Epub 2017 Feb 20.

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China

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http://dx.doi.org/10.1042/BCJ20160861DOI Listing
February 2017

Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528.

J Nat Prod 2017 02 24;80(2):371-376. Epub 2017 Jan 24.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Tian Tan Xi Li, Beijing 100050, People's Republic of China.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00829DOI Listing
February 2017

Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities.

J Antibiot (Tokyo) 2017 01 15;70(1):105-108. Epub 2016 Jun 15.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/ja.2016.63DOI Listing
January 2017

Insights into the Phosphoryl Transfer Mechanism of Human Ubiquitous Mitochondrial Creatine Kinase.

Sci Rep 2016 12 2;6:38088. Epub 2016 Dec 2.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.1038/srep38088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133464PMC
December 2016

Identification of Triptophenolide from as a Pan-antagonist of Androgen Receptor.

ACS Med Chem Lett 2016 Dec 28;7(12):1024-1027. Epub 2016 Sep 28.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.6b00180
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http://dx.doi.org/10.1021/acsmedchemlett.6b00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150686PMC
December 2016

Phage Display-Derived Cross-Reactive Neutralizing Antibody against Enterovirus 71 and Coxsackievirus A16.

Jpn J Infect Dis 2016 12;69(1):66-74. Epub 2015 Jun 12.

College of Life Science and Bioengineering, Beijing University of Technology.

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http://dx.doi.org/10.7883/yoken.JJID.2015.060DOI Listing
October 2016

Citron kinase enhances ubiquitination of HIV-1 Gag protein and intracellular HIV-1 budding.

Arch Virol 2016 Sep 23;161(9):2441-8. Epub 2016 Jun 23.

Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1007/s00705-016-2933-5DOI Listing
September 2016

Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry.

Sci Rep 2016 09 9;6:33150. Epub 2016 Sep 9.

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for AIDS Research, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, P. R. China.

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http://dx.doi.org/10.1038/srep33150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016833PMC
September 2016

Establishment of a High-Throughput Assay to Monitor Influenza A Virus RNA Transcription and Replication.

PLoS One 2015 21;10(7):e0133558. Epub 2015 Jul 21.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133558PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511416PMC
May 2016

[Triterpenoid saponins from Bupleurum marginatum var. stenophyllum].

Zhongguo Zhong Yao Za Zhi 2016 Apr;41(7):1251-1256

Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029,China.

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http://dx.doi.org/10.4268/cjcmm20160716DOI Listing
April 2016

CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape.

Cell Rep 2016 Apr 7;15(3):481-489. Epub 2016 Apr 7.

McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal H3T 1E2, Canada; Departments of Medicine, Microbiology and Immunology, McGill University, Montreal H3A 2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.042DOI Listing
April 2016

[The sensitivity of transmitted/founder HIV-1 to anti-HIV drugs].

Yao Xue Xue Bao 2016 03;51(3):367-72

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March 2016

2-thio-6-azauridine inhibits Vpu mediated BST-2 degradation.

Retrovirology 2016 Mar 2;13:13. Epub 2016 Mar 2.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

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http://dx.doi.org/10.1186/s12977-016-0247-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776379PMC
March 2016

[The connection between LINE-1 retrotransposition and human tumorigenesis].

Yi Chuan 2016 02;38(2):93-102

Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences &

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http://dx.doi.org/10.16288/j.yczz.15-470DOI Listing
February 2016

EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge.

BMC Res Notes 2016 Jan 25;9:42. Epub 2016 Jan 25.

College of Life Science and Bioengineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, People's Republic of China.

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http://dx.doi.org/10.1186/s13104-015-1780-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724958PMC
January 2016

A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2.

Sci Rep 2015 Dec 16;5:18499. Epub 2015 Dec 16.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing 100050, China.

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http://dx.doi.org/10.1038/srep18499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680884PMC
December 2015

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.

PLoS Genet 2015 Jul 2;11(7):e1005367. Epub 2015 Jul 2.

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China.

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http://dx.doi.org/10.1371/journal.pgen.1005367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489885PMC
July 2015

[The mechanisms of drug resistance in prostate cancer].

Yao Xue Xue Bao 2015 Jul;50(7):797-801

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July 2015

Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1.

Biochem J 2015 Jun;468(2):303-13

*MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, P.R. China.

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http://www.biochemj.org/content/ppbiochemj/468/2/303.full.pd
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http://www.biochemj.org/content/ppbiochemj/early/2015/05/11/
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http://biochemj.org/lookup/doi/10.1042/BJ20141331
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http://dx.doi.org/10.1042/BJ20141331DOI Listing
June 2015

[Identification and characterization of HIV-1 transmitted /founder viruses].

Yi Chuan 2015 05;37(5):419-25

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China.

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http://dx.doi.org/10.16288/j.yczz.14-452DOI Listing
May 2015

Genetic variance in the HIV-1 founder virus Vpr affects its ability to induce cell cycle G₂arrest and cell apoptosis.

Yi Chuan 2015 05;37(5):480-6

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China.

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http://dx.doi.org/10.16288/j.yczz.15-004DOI Listing
May 2015

Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance.

Biochemistry 2015 Feb 30;54(5):1268-77. Epub 2015 Jan 30.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China 100050.

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http://dx.doi.org/10.1021/bi500602zDOI Listing
February 2015

Human APOBEC3F incorporation into human immunodeficiency virus type 1 particles.

Virus Res 2014 Oct 16;191:30-8. Epub 2014 Jul 16.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01681702140027
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http://dx.doi.org/10.1016/j.virusres.2014.07.011DOI Listing
October 2014

A cell-based high-throughput approach to identify inhibitors of influenza A virus.

Acta Pharm Sin B 2014 Aug 14;4(4):301-6. Epub 2014 Jul 14.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1016/j.apsb.2014.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629080PMC
August 2014

The roles of APOBEC3G complexes in the incorporation of APOBEC3G into HIV-1.

PLoS One 2013 2;8(10):e74892. Epub 2013 Oct 2.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China ; Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada ; Microbiology & Immunology, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074892PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788789PMC
June 2014

A novel peptide to disrupt the interaction of BST-2 and Vpu.

Biopolymers 2014 May;102(3):280-7

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.

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http://doi.wiley.com/10.1002/bip.22488
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http://dx.doi.org/10.1002/bip.22488DOI Listing
May 2014

Immunization of N terminus of enterovirus 71 VP4 elicits cross-protective antibody responses.

BMC Microbiol 2013 Dec 10;13:287. Epub 2013 Dec 10.

College of Life Science and Bioengineering, Beijing University of Technology, 100, Pingleyuan, Chaoyang District, Beijing 100124, PR China.

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http://dx.doi.org/10.1186/1471-2180-13-287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029445PMC
December 2013

Construction and characterization of an infectious cDNA clone of enterovirus type 71 subgenotype C4.

Virus Genes 2013 Oct 23;47(2):235-43. Epub 2013 Jul 23.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, No. 1 Tian Tan Xi Li, Beijing, 100050, People's Republic of China.

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http://dx.doi.org/10.1007/s11262-013-0955-6DOI Listing
October 2013

The interferon-inducible MxB protein inhibits HIV-1 infection.

Cell Host Microbe 2013 Oct 19;14(4):398-410. Epub 2013 Sep 19.

Lady Davis Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.chom.2013.08.015DOI Listing
October 2013

Identification of novel key amino acids at the interface of the transmembrane domains of human BST-2 and HIV-1 Vpu.

Retrovirology 2013 Aug 6;10:84. Epub 2013 Aug 6.

MOH Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Beijing 100730, P. R. China.

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http://dx.doi.org/10.1186/1742-4690-10-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751551PMC
August 2013

Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists.

PLoS One 2013 7;8(1):e53636. Epub 2013 Jan 7.

Zhejiang University-École Normale Supérieure Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053636PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538727PMC
July 2013

The MOV10 helicase inhibits LINE-1 mobility.

J Biol Chem 2013 Jul 10;288(29):21148-60. Epub 2013 Jun 10.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.

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http://dx.doi.org/10.1074/jbc.M113.465856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774381PMC
July 2013

In vitro antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic.

Chemotherapy 2012 14;58(3):175-84. Epub 2012 Jun 14.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.

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https://www.karger.com/Article/FullText/337084
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http://dx.doi.org/10.1159/000337084DOI Listing
January 2013

The role of the structural domains of human BST-2 in inhibiting the release of xenotropic murine leukemia virus-related virus.

Biochem Biophys Res Commun 2012 Nov 6;428(1):17-23. Epub 2012 Oct 6.

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X120191
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http://dx.doi.org/10.1016/j.bbrc.2012.10.001DOI Listing
November 2012

[Establishment of a high-throughput screening assay for interaction inhibitor between BST-2 and Vpu].

Bing Du Xue Bao 2012 Nov;28(6):633-8

Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

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November 2012

[Establishment of drug screening assay and pharmacodynamic evaluation method targeting influenza RNA polymerase].

Yao Xue Xue Bao 2012 Sep;47(9):1159-63

Department of lmmunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

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September 2012

Characterization of the interface of the bone marrow stromal cell antigen 2-Vpu protein complex via computational chemistry.

Biochemistry 2012 Feb 30;51(6):1288-96. Epub 2012 Jan 30.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.

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http://dx.doi.org/10.1021/bi2015986DOI Listing
February 2012

High-throughput assay to identify inhibitors of Vpu-mediated down-regulation of cell surface BST-2.

Antiviral Res 2011 Sep 14;91(3):321-9. Epub 2011 Jul 14.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.

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http://dx.doi.org/10.1016/j.antiviral.2011.07.007DOI Listing
September 2011

[The recent breakthroughs in the understanding of host factors contributing to hepatitis C virus].

Authors:
Xin Wang Shan Cen

Bing Du Xue Bao 2011 Sep;27(5):481-93

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September 2011

[Inhibition of HIV virus-like particles production by BST-2].

Bing Du Xue Bao 2011 Jul;27(4):319-25

State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

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July 2011

Functional analysis of the two cytidine deaminase domains in APOBEC3G.

Virology 2011 Jun 13;414(2):130-6. Epub 2011 Apr 13.

Institute of Medicinal Biotechnology, Beijing, China.

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http://dx.doi.org/10.1016/j.virol.2011.03.014DOI Listing
June 2011

[Establishment and drug susceptibility test of isoniazid resistant Mycobacterium smegmatis].

Yao Xue Xue Bao 2011 Apr;46(4):377-82

Laboratory of Immunobiology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China.

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April 2011

Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance.

Antiviral Res 2011 Mar 28;89(3):227-31. Epub 2011 Jan 28.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1016/j.antiviral.2011.01.005DOI Listing
March 2011

The cellular source for APOBEC3G's incorporation into HIV-1.

Retrovirology 2011 Jan 6;8. Epub 2011 Jan 6.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, PR China.

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http://dx.doi.org/10.1186/1742-4690-8-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024284PMC
January 2011

In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone.

J Antimicrob Chemother 2010 Nov 21;65(11):2411-5. Epub 2010 Sep 21.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.1093/jac/dkq341DOI Listing
November 2010

Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA.

Hepatology 2010 Sep;52(3):845-53

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/hep.23766DOI Listing
September 2010

[Establishment and application of a high-throughput screening assay for premature activation of HIV-1 precursors].

Yao Xue Xue Bao 2010 Feb;45(2):247-52

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

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February 2010

[Establishment and application of a screening anti-HIV-1 drug model targeted nuclear trafficking of virus RNA].

Yao Xue Xue Bao 2010 Feb;45(2):257-62

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

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February 2010

In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic.

Antimicrob Agents Chemother 2009 Oct 27;53(10):4525-8. Epub 2009 Jul 27.

Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.1128/AAC.00223-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764209PMC
October 2009

Methods for analysis of incorporation and annealing methods for analysis of tRNA(Lys) in HIV-1.

Methods Mol Biol 2009 ;485:223-32

Department of Medicine, McGill University, Lady Davis Institute for Medical Research Jewish General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-59745-170-3_16DOI Listing
March 2009

Interactions of reverse transcriptase sequences in Pol with Gag and LysRS in the HIV-1 tRNALys3 packaging/annealing complex.

Virology 2008 Oct 15;380(1):109-17. Epub 2008 Aug 15.

Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.virol.2008.07.015DOI Listing
October 2008

The incorporation of APOBEC3 proteins into murine leukemia viruses.

Virology 2008 Aug 24;378(1):69-78. Epub 2008 Jun 24.

Department of Virology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.

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http://dx.doi.org/10.1016/j.virol.2008.05.006DOI Listing
August 2008

[Advances in the study of molecular mechanism of APOBEC3G anti-HIV-1].

Yao Xue Xue Bao 2008 Jul;43(7):678-82

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

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July 2008

Function analysis of sequences in human APOBEC3G involved in Vif-mediated degradation.

Virology 2008 Jan 4;370(1):113-21. Epub 2007 Oct 4.

Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.virol.2007.08.027DOI Listing
January 2008

APOBEC3G inhibits DNA strand transfer during HIV-1 reverse transcription.

J Biol Chem 2007 Nov 12;282(44):32065-74. Epub 2007 Sep 12.

Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M703423200DOI Listing
November 2007

The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA.

J Virol 2007 Oct 1;81(20):11322-31. Epub 2007 Aug 1.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1128/JVI.00162-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045548PMC
October 2007

Inhibition of initiation of reverse transcription in HIV-1 by human APOBEC3F.

Virology 2007 Aug 24;365(1):92-100. Epub 2007 Apr 24.

Lady Davis Institute for Medical Research and McGill AIDS Center, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.virol.2007.03.022DOI Listing
August 2007

Inhibition of tRNA₃(Lys)-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication.

J Virol 2006 Dec 13;80(23):11710-22. Epub 2006 Sep 13.

Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St. Catherine Road, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1128/JVI.01038-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1642613PMC
December 2006

Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase.

J Biol Chem 2005 Jul 10;280(28):26018-23. Epub 2005 May 10.

Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M502454200DOI Listing
July 2005

Defective replication in human immunodeficiency virus type 1 when non-primers are used for reverse transcription.

J Virol 2005 Jul;79(14):9081-7

Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1128/JVI.79.14.9081-9087.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168737PMC
July 2005

The connection domain in reverse transcriptase facilitates the in vivo annealing of tRNALys3 to HIV-1 genomic RNA.

Retrovirology 2004 Oct 19;1:33. Epub 2004 Oct 19.

Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada.

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http://dx.doi.org/10.1186/1742-4690-1-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524520PMC
October 2004