Publications by authors named "Shalini Rawat"

3 Publications

  • Page 1 of 1

Epidemiological factors influencing gender preference among mothers attending under-five immunization clinic: A cross-sectional comparative study.

J Educ Health Promot 2021 31;10(1):190. Epub 2021 May 31.

Department of Community Medicine, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Background: Sex ratio is an important social indicator measuring the status and equality of female in society. The falling sex ratio of our country is a demographic disaster that is waiting to happen and is a matter of grave concern. Perception of gender by mothers or families has long-term implications on how children are nurtured during their lives. This study was done to understand mother's preference for the gender of the child and their concerns about the same.

Materials And Methods: An observational cross-sectional study was carried out using a semi-structured questionnaire. Two hundred and thirty-four mothers were interviewed. Frequencies and percentages were calculated. Pearson's Chi-square test was used to check the significance of the association.

Results: Study results depict that 26.47% of the mothers who were already having a male child still preferred son. Preference for son was 24.52% and 48.61% among earning mothers and nonearning mothers, respectively. Out of 206 mothers said that they would prefer male child. Reasons cited were as follows: sons carry family name forward (30.6%), having daughters leads to increased expenditure (20.9%), daughters are subjected to different problem in their lifetime mainly violence (11.7%), and sons supported their parents in old age (10.7%).

Conclusion: Preference for male child was found to be equally prevalent in both urban and rural areas. Mothers should be educated about the effect of declining sex ratio along with financial capacity building of women and providing social security to senior citizens which was the main reason for son preference. The impact of gender imbalance on individuals, families, and on society has to be emphasized at every possible point of contact with health-care delivery system.
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May 2021

"Silent sufferers: A study of domestic violence among pregnant women attending the ANC OPD at a Primary Health Care Centre".

J Family Med Prim Care 2021 Jan 30;10(1):232-236. Epub 2021 Jan 30.

Department of Community Medicine, Seth G.S. Medical College & KEM Hospital, Parel, Mumbai, Maharashtra, India.

Introduction: Domestic violence against women is one of the most pervasive abuses of human rights in the world. Violence during pregnancy leads to both acute injuries and profound long-term challenges to health and wellbeing. Pregnancy provides a good opportunity for healthcare personal to screen women for domestic violence.

Aim: To identify the pattern of domestic violence amongst pregnant women and to plan appropriate interventions.

Settings And Design: This cross-sectional study was carried out at Primary Health Care Centre.

Methods And Material: 90 pregnant women attending the ANC OPD and fulfilling the inclusion criteria were interviewed using a semi-structured questionnaire. Data were compiled and analyzed using SPSS version 24. Percentages were calculated and Chi-square test was used wherever applicable.

Results: Violence was mostly seen in the women who were married for five years (47.36%) and many among them experienced it within one year of marriage (34.28%). The most common violence faced by the women was verbal violence (44.73%), followed by financial violence (27.63%). Physical violence was experienced by 22.36% women. The Perceived risk factor for violence was mostly addiction of spouse in 26.31% of women and insufficient dowry and demand for male child in 19.73%.

Conclusions: As occurrence of violence was found to be significantly associated with duration of marriage, educational status, and earning status of women asking about intimate partner violence should be a part of routine antenatal care for early detection and identification of cases, their counseling, and appropriate interventions.
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January 2021

Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking.

PLoS Pathog 2018 07 16;14(7):e1007168. Epub 2018 Jul 16.

Bacterial Pathogenesis Lab, Dept. of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, INDIA.

Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies. This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored. In this study, we illustrated that heterogeneous expression of pneumolysin (Ply), a pore-forming toxin of the meningeal pathogen, S. pneumoniae (SPN) gives rise to stochastically different bacterial subpopulations with variable fate during passage across blood-brain barrier (BBB). We demonstrate that Ply mediated damage to pneumococcus containing vacuolar (PCV) membrane leads to recruitment of cytosolic "eat-me" signals, galectin-8 and ubiquitin, targeting SPN for autophagic clearance. However, a majority of high Ply producing subset extensively damages autophagosomes leading to pneumococcal escape into cytosol and efficient clearance by host ubiquitination machinery. Interestingly, a low Ply producing subset halts autophagosomal maturation and evades all intracellular defense mechanisms, promoting its prolonged survival and successful transcytosis across BBB, both in vitro and in vivo. Ply therefore acts as both, sword and shield implying that its smart regulation ensures optimal disease manifestation. Our elucidation of heterogeneity in Ply expression leading to disparate infection outcomes attempts to resolve the dubious role of Ply in pneumococcal pathogenesis.
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July 2018