Shairaz Baksh

Shairaz Baksh

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Shairaz Baksh

Publications by authors named "Shairaz Baksh"

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Erratum: Zare, A. et al. RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis. Cancers, 2018, 10, 184.

Cancers (Basel) 2018 11 7;10(11). Epub 2018 Nov 7.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 113 Street 87 Avenue, Edmonton, AB T6G 2E1, Canada.

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http://www.mdpi.com/2072-6694/10/11/425
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http://dx.doi.org/10.3390/cancers10110425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266786PMC
November 2018

RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.

Cancers (Basel) 2018 Jun 5;10(6). Epub 2018 Jun 5.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 113 Street 87 Avenue, Edmonton, AB T6G 2E1, Canada.

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http://dx.doi.org/10.3390/cancers10060184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025367PMC
June 2018

RACK1/TRAF2 regulation of modulator of apoptosis-1 (MOAP-1).

Biochim Biophys Acta Mol Cell Res 2018 May 19;1865(5):684-694. Epub 2018 Feb 19.

Department of Pediatrics, Faculty of Science, National University of Singapore, Singapore 117543, Singapore; Oncology, Faculty of Medicine and Dentistry, 3055, Katz Group Centre for Pharmacy and Health Research, 113 Street 87 Avenue, University of Alberta, Edmonton, AB T6G 2E1, Canada; Biochemistry, Faculty of Medicine and Dentistry, 3055 Katz Group Centre for Pharmacy and Health Research, 113 Street 87 Avenue, University of Alberta, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta, 4-120 Katz Group Centre for Pharmacy and Health Research, Edmonton, AB, T6G 2J7, Canada; Women and Children's Health Research Institute, University of Alberta, 5-083 Edmonton Clinic Health Academy (ECHA) 11405 87 Avenue NW, Edmonton, AB, T6G 1C9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2018.02.006DOI Listing
May 2018

Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.

J Pharmacol Exp Ther 2018 05 19;365(2):354-367. Epub 2018 Mar 19.

Departments of Biochemistry (M.S., G.I.D., A.S., J.M., V.P., I.S.G., P.H., S.B.), Pediatrics (A.Z., R.M., S.F., S.B.), Pharmacology (K.S.B., B.P.H.), Oncology (S.B.) Medicine (Y.F., H.V., P.H.), and Faculty of Pharmacy and Pharmaceutical Sciences (R.A.-O., D.B., C.A.-V.M.), University of Alberta, Edmonton, Alberta, Canada; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Mexico City, Mexico (R.A.-O.); Departments of Biochemistry and Medical Genetics and Immunology, University of Manitoba, Winnipeg, Manitoba, Canada (A.R.B., S.B.G.); Breakthrough Breast Cancer Research Center Chester Beatty Laboratories, London, United Kingdom (L.R.G., P.M.); Cancer Research Institute of Northern Alberta, Edmonton, Alberta, Canada (S.B.); and Women and Children's Health Research Institute, Edmonton, Alberta, Canada (S.B.)

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.117.24
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http://dx.doi.org/10.1124/jpet.117.247163DOI Listing
May 2018

Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?

Int J Dev Biol 2015 ;59(7-9):367-77

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1387/ijdb.140336lfDOI Listing
October 2016

RASSF1A Site-Specific Methylation Hotspots in Cancer and Correlation with RASSF1C and MOAP-1.

Cancers (Basel) 2016 Jun 10;8(6). Epub 2016 Jun 10.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 113 Street 87 Avenue, Edmonton, AB T6G 2E1, Canada.

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http://dx.doi.org/10.3390/cancers8060055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931620PMC
June 2016

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.

Cell Rep 2016 06 16;16(1):174-185. Epub 2016 Jun 16.

Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.068DOI Listing
June 2016

Design and synthesis of resveratrol-salicylate hybrid derivatives as CYP1A1 inhibitors.

J Enzyme Inhib Med Chem 2015 Dec 19;30(6):884-95. Epub 2014 Nov 19.

a Faculty of Pharmacy and Pharmaceutical Sciences , University of Alberta , Edmonton , Alberta , Canada .

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http://dx.doi.org/10.3109/14756366.2014.979347DOI Listing
December 2015

Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.

J Biol Chem 2015 Oct 12;290(40):24100-18. Epub 2015 Aug 12.

From the Departments of Biochemistry and Pediatrics, the Department of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta T6G 1Z2, Canada, and the Cancer Research Institute of Northern Alberta, Edmonton, Alberta T6G 1Z2, Canada, the Alberta IBD Consortium, Edmonton, Alberta T6G 2X8, Canada, and the Women and Children's Health Research Institute, Edmonton, Alberta T6G 1C9, Canada

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http://dx.doi.org/10.1074/jbc.M115.648345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591801PMC
October 2015

TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.

World J Gastroenterol 2015 Sep;21(36):10358-66

Natalia Volodko, Hien Q Huynh, Shairaz Baksh, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.

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http://dx.doi.org/10.3748/wjg.v21.i36.10358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579882PMC
September 2015

Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease.

Gastroenterology 2014 Sep 12;147(3):680-689.e2. Epub 2014 Jun 12.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.06.005DOI Listing
September 2014

RASSF tumor suppressor gene family: biological functions and regulation.

FEBS Lett 2014 Aug 4;588(16):2671-84. Epub 2014 Mar 4.

Department of Pediatrics, Faculty of Medicine and Dentistry, 113 St. 87 Ave., University of Alberta, Edmonton, AB T6G 2E1, Canada; Department of Biochemistry, Faculty of Medicine and Dentistry, 113 St. 87 Ave., University of Alberta, Edmonton, AB T6G 2E1, Canada; Department of Oncology, Faculty of Medicine and Dentistry, 113 St. 87 Ave., University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.02.041DOI Listing
August 2014

Tumor suppression.

FEBS Lett 2014 Aug 14;588(16):2557. Epub 2014 May 14.

Translational Oncogenomic Unit, Regina Elena Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.05.001DOI Listing
August 2014

Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

Clin Transl Gastroenterol 2014 Jan 16;5:e46. Epub 2014 Jan 16.

1] SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [2] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada [3] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ctg.2013.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912315PMC
January 2014

Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines.

J Biol Chem 2013 Aug 9;288(33):24104-15. Epub 2013 Jul 9.

Departments of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada.

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http://dx.doi.org/10.1074/jbc.M113.455832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745353PMC
August 2013

RASSF Family Proteins.

Mol Biol Int 2012 10;2012:938916. Epub 2012 Dec 10.

JG Brown Cancer Center, University of Louisville, 417 CTR Building, 505 S. Hancock Street, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1155/2012/938916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523567PMC
January 2013

RASSF1 Polymorphisms in Cancer.

Mol Biol Int 2012 31;2012:365213. Epub 2012 May 31.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 3-055 Katz Group Centre for Pharmacy and Health Research, 113 Street 87 Avenue, Edmonton, AB, Canada T6G 2E1.

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http://dx.doi.org/10.1155/2012/365213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371342PMC
August 2012

Modulator of Apoptosis 1: A Highly Regulated RASSF1A-Interacting BH3-Like Protein.

Mol Biol Int 2012 14;2012:536802. Epub 2012 Jun 14.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 3055 Katz Group Centre for Pharmacy and Health Research, 113 Street 87 Avenue, Edmonton, AB, Canada T6G 2E1.

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http://dx.doi.org/10.1155/2012/536802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382356PMC
August 2012

RASSF1A: Not a prototypical Ras effector.

Small GTPases 2011 May;2(3):148-157

Department of Pediatrics; Faculty of Medicine and Dentistry; University of Alberta; Edmonton, AB Canada.

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http://dx.doi.org/10.4161/sgtp.2.3.16286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136945PMC
May 2011

Nicotine-mediated signals modulate cell death and survival of T lymphocytes.

Toxicol Appl Pharmacol 2010 Feb 4;242(3):299-309. Epub 2009 Nov 4.

Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA.

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http://dx.doi.org/10.1016/j.taap.2009.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813922PMC
February 2010

14-3-3 mediated regulation of the tumor suppressor protein, RASSF1A.

Apoptosis 2010 Feb;15(2):117-27

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2N8, Canada.

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http://dx.doi.org/10.1007/s10495-009-0451-6DOI Listing
February 2010

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

J Biol Chem 2008 Aug 18;283(35):24194-201. Epub 2008 Jun 18.

Cardiovascular Research Group and the Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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http://www.jbc.org/content/283/35/24194.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M802869200
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http://dx.doi.org/10.1074/jbc.M802869200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259789PMC
August 2008

Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.

J Biol Chem 2008 Aug 27;283(35):23505-9. Epub 2008 Jun 27.

Cancer Institute, NYU School of Medicine, New York University, New York, NY 10016, USA.

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http://dx.doi.org/10.1074/jbc.C800087200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259758PMC
August 2008

Dynamics of RASSF1A/MOAP-1 association with death receptors.

Mol Cell Biol 2008 Jul 12;28(14):4520-35. Epub 2008 May 12.

Division of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1128/MCB.02011-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447132PMC
July 2008

Calreticulin inhibits commitment to adipocyte differentiation.

J Cell Biol 2008 Jul 7;182(1):103-16. Epub 2008 Jul 7.

Department of Laboratory Medicine and Pathobiology, Institute of Medical Sciences, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1083/jcb.200712078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447897PMC
July 2008

Mitotic regulation of CDK4 by the serine/threonine phosphatase, calcineurin.

Biochem Biophys Res Commun 2007 Nov 17;363(3):506-12. Epub 2007 Sep 17.

Department of Pediatrics, University of Alberta, Room B066, Dentistry/Pharmacy Centre, Edmonton, Alta, Canada T6G 2N8.

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http://dx.doi.org/10.1016/j.bbrc.2007.08.197DOI Listing
November 2007

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.

Mol Cell 2005 Jun;18(6):637-50

Cancer Biology Program, Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 1038 NRB, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650501316
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http://dx.doi.org/10.1016/j.molcel.2005.05.010DOI Listing
June 2005

Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.

J Pharmacol Exp Ther 2004 Nov 1;311(2):758-69. Epub 2004 Jul 1.

Integrated Department of Immunology, University of Colorado Health Sciences Center, AMC Cancer Center, 2-Diamond Building, 1600 Pierce Street, Denver, CO 80214, USA.

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http://dx.doi.org/10.1124/jpet.104.070060DOI Listing
November 2004

Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.

Cancer Res 2004 Jan;64(1):102-7

Section of Medical and Molecular Genetics, Department of Reproductive and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham, United Kingdom.

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January 2004

NFATc2-mediated repression of cyclin-dependent kinase 4 expression.

Mol Cell 2002 Nov;10(5):1071-81

Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00701-3DOI Listing
November 2002

Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin.

J Cell Biochem 2002 ;84(3):460-71

Laboratory of Lymphocyte Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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March 2002

Effect of anti-IL-2Ralpha antibody on IL-2-induced Jak/STAT signaling.

Am J Transplant 2002 Jan;2(1):31-40

Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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January 2002