Shai Izraeli

Shai Izraeli

UNVERIFIED PROFILE

Are you Shai Izraeli?   Register this Author

Register author
Shai Izraeli

Shai Izraeli

Publications by authors named "Shai Izraeli"

Are you Shai Izraeli?   Register this Author

100Publications

3135Reads

35Profile Views

Poorer outcome of childhood acute lymphoblastic leukemia in the Bedouin population: A report from the Berlin-Frankfurt-Muenster-based Israeli national protocols.

Pediatr Blood Cancer 2020 Jan 8;67(1):e28024. Epub 2019 Oct 8.

Division of Pediatric Hematology/Oncology, Schneider Children's Medical Center of Israel, Petah Tiqwa, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.28024DOI Listing
January 2020

The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns.

Blood 2019 10;134(16):1355-1358

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019002215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005361PMC
October 2019

Genes driving bad luck.

Blood 2019 10;134(15):1199-1200

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019002619DOI Listing
October 2019

JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility.

Leukemia 2019 09 9;33(9):2331-2335. Epub 2019 Apr 9.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Düsseldorf, Medical Faculty, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-019-0459-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756027PMC
September 2019

Mechanisms of Leukemia Evolution: Lessons from a Congenital Syndrome.

Cancer Cell 2019 Aug;36(2):115-117

Division of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel; Sackler Medical School, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.07.004DOI Listing
August 2019

Need for new thinking: Treatment of relapsed leukemia in children with Down syndrome.

Pediatr Blood Cancer 2019 06 5;66(6):e27644. Epub 2019 Feb 5.

Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27644DOI Listing
June 2019

Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia.

Br J Haematol 2019 03 10;184(6):994-998. Epub 2019 Jan 10.

Department of Paediatric Haematology and Oncology, Schneider Children's Medical Centre of Israel, Petach Tivka, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.15752DOI Listing
March 2019

American Funding Cutback to East Jerusalem Hospitals: A Blow to the Health of the City.

Am J Public Health 2018 12;108(12):1624-1625

A. Mark Clarfield, Shimon M. Glick, and Rivka Carmi are with the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-shev, Israel. Karl Skorecki, Rafi Beyar, Ziv Gil, Salem Billan, Zaher Azzam, and Fuad Basis are with Technion-Israel Institute of Technology, Haifa. Ora Paltiel is with the Department of Hematology, Hadassah-Hebrew University, Jerusalem, Israel. Dina Ben Yehuda is with the Hematology Department, Hadassah Medical Center, Jerusalem. Ephrat Levy-Lahad, Dan Turner, and Yonatan Halevy are with the Shaare Zedek Medical Center, Hebrew University of Jerusalem. Amnon Lahad is with the Department of Family Medicine, Hebrew University of Jerusalem. Shai Izraeli is with the Rina Zaizov Pediatric Hematology Oncology Division, Schneider Children's Medical Center of Israel, Petach Tiqva.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2105/AJPH.2018.304792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236734PMC
December 2018

Genomic precision medicine: on the TRK.

Blood 2018 08;132(8):773-774

Schneider Children's Medical Center of Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-06-857540DOI Listing
August 2018

Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group.

Pediatr Hematol Oncol 2017 Sep - Oct;34(6-7):355-364. Epub 2017 Nov 30.

h Division of Pediatric Hematology and Oncology, Department of Pediatrics and OHSU Knight Cancer Institute , Oregon Health and Sciences University , Portland , OR , USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08880018.2017.1
Publisher Site
http://dx.doi.org/10.1080/08880018.2017.1395937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191173PMC
July 2018

IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

J Clin Oncol 2018 04 2;36(12):1240-1249. Epub 2018 Mar 2.

Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School; Petra Dörge, German Center for Infection Research, Hannover; Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein; Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel; Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital; Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin; Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg; Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany; Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic; Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo; Maria Grazia Valsecchi, University of Milano-Bicocca, Monza; Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy; Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland; Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel; Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria; Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France; and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.74.3617DOI Listing
April 2018

Rac1 functions downstream of miR-142 in regulation of erythropoiesis.

Haematologica 2017 12 14;102(12):e476-e480. Epub 2017 Sep 14.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2017.171736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709115PMC
December 2017

Targeted therapy of CNS leukemia?

Blood 2017 08;130(5):562-563

CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-06-788430DOI Listing
August 2017

Down syndrome, RASopathies, and other rare syndromes.

Semin Hematol 2017 04 28;54(2):123-128. Epub 2017 Apr 28.

The Genes, Development and Environment Institute for Pediatric Research, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2017.04.008DOI Listing
April 2017

BCR-ABL (Ph)-like acute leukemia-Pathogenesis, diagnosis and therapeutic options.

Blood Rev 2017 03 16;31(2):11-16. Epub 2016 Sep 16.

Department of Pediatric Hemato-Oncology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel; Department of Human Molecular Genetics And Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.blre.2016.09.001DOI Listing
March 2017

Interleukin-7 signaling as a therapeutic target in acute lymphoblastic leukemia.

Expert Rev Hematol 2017 03 17;10(3):183-185. Epub 2017 Feb 17.

b Sackler Faculty of Medicine , Tel Aviv University , Ramat Aviv , Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17474086.2017.1292121DOI Listing
March 2017

Exclusive destruction of mitotic spindles in human cancer cells.

Oncotarget 2017 Mar;8(13):20813-20824

The Neufeld Cardiac Research Institute, Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.15343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400547PMC
March 2017

Advances in understanding the pathogenesis of CNS acute lymphoblastic leukaemia and potential for therapy.

Br J Haematol 2017 Jan 21;176(2):157-167. Epub 2016 Oct 21.

Childhood Leukaemia Research Section, Department of Paediatric Oncology and the Cancer Research Centre, Safra Children Hospital and Sheba Medical Centre, Tel Hashomer, Ramat Gan, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.14411DOI Listing
January 2017

Targeting hedgehog in T-ALL.

Authors:
Shai Izraeli

Blood 2016 12;128(23):2589-2590

EDMOND AND LILY SAFRA CHILDREN'S HOSPITAL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-10-743872DOI Listing
December 2016

UMI-4C for quantitative and targeted chromosomal contact profiling.

Nat Methods 2016 08 4;13(8):685-91. Epub 2016 Jul 4.

Department of Computer Science and Applied Mathematics, Weizmann Institute, Rehovot, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3922DOI Listing
August 2016

Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein.

Chem Sci 2016 Jul 4;7(7):4140-4147. Epub 2016 Mar 4.

Institute of Chemistry , Hebrew University of Jerusalem , Safra Campus, Givat Ram , Jerusalem 91904 , Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c6sc00115gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014068PMC
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

Deciphering "B-others": Novel fusion genes driving B-cell acute lymphoblastic leukemia.

Authors:
Shai Izraeli

EBioMedicine 2016 Jun 2;8:8-9. Epub 2016 Jun 2.

Department of Pediatric Hematology and Oncology, Leukemia Research Section, Edmond and Lily Children's Hospital, Sheba Medical Center, Ramat Gan 52621, Israel; Department of Molecular Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919499PMC
June 2016

The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.

Blood 2016 Apr 11;127(16):1998-2006. Epub 2016 Feb 11.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-08-665034DOI Listing
April 2016

On mice and humans: the role of thymic stromal lymphopoietin in human B-cell development and leukemia.

Haematologica 2016 Apr;101(4):391-3

Leukemia Research Section, Edmond and Lily Safra Children Hospital, Sheba Medical Center, Tel Hashomer, IsraelDepartment of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Israel

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.142448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004386PMC
April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.

Sci Rep 2016 Apr 14;6:24296. Epub 2016 Apr 14.

Sheba Cancer Research Center and the Edmond and Lily Safra Children Hospital, Sheba Medical Center, Tel-Hashomer 52621, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep24296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830966PMC
April 2016

The acute lymphoblastic leukemia of Down Syndrome - Genetics and pathogenesis.

Authors:
Shai Izraeli

Eur J Med Genet 2016 Mar 26;59(3):158-61. Epub 2015 Nov 26.

Functional Genomics and Leukemia Research, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmg.2015.11.010DOI Listing
March 2016

Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets.

Nucleic Acids Res 2015 Sep 10;43(16):7779-89. Epub 2015 Aug 10.

The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkv810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652780PMC
September 2015

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2938-48. Epub 2015 Aug 24.

Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel; Gabriele Escherich, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Andrea Biondi, Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Monza, Italy; Ajay Vora, Children's Cancer Group, School of Cancer, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; André Baruchel, Hôpital Robert Debré and University of Paris Diderot, Paris, France; Lewis B. Silverman, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; Kjeld Schmiegelow, Institute of Clinical Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark; Keizo Horibe, Nagoya Medical Center, Clinical Research Center, Nagoya, Japan; Yves C.M. Benoit, Universiteit Gent, Gent, Belgium; Shai Izraeli, Chaim Sheba Medical Center and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Allen Eng Juh Yeoh, Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore; and Der-Cherng Liang, Mackay Memorial Hospital, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59
Web Search
http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-01.pd
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1636
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567699PMC
September 2015

Lack of centrioles and primary cilia in STIL(-/-) mouse embryos.

Cell Cycle 2014 ;13(18):2859-68

a Sheba Cancer Research Center and the Edmond and Lily Safra Children's Hospital; Sheba Medical Center ; Tel-Hashomer, Ramat Gan , Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/15384101.2014.946830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615128PMC
August 2015

Central nervous system acute lymphoblastic leukemia: role of natural killer cells.

Blood 2015 May 20;125(22):3420-31. Epub 2015 Apr 20.

Childhood Leukemia Research Section, Department of Pediatric Oncology and the Cancer Research Center, Edmond and Lily Safra Children Hospital and Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-08-595108DOI Listing
May 2015

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Blood 2015 Feb 22;125(8):1292-301. Epub 2014 Dec 22.

Childhood Leukemia Research Institute, Cancer Research Center, Sheba Medical Center, Ramat-Gan, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-06-581892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335082PMC
February 2015

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Br J Haematol 2015 Jan 26;168(2):230-8. Epub 2014 Sep 26.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Haematology, UCL Cancer Institute, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303513PMC
January 2015

Haematopoietic development and leukaemia in Down syndrome.

Br J Haematol 2014 Dec 22;167(5):587-99. Epub 2014 Aug 22.

Paediatrics and Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13096DOI Listing
December 2014

Epidemiology of childhood leukemia in the presence and absence of Down syndrome.

Cancer Epidemiol 2014 Oct 10;38(5):479-89. Epub 2014 Aug 10.

Department of Epidemiology, UCLA Fielding School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canep.2014.07.006DOI Listing
October 2014

Towards precision medicine in childhood leukemia--insights from mutationally activated cytokine receptor pathways in acute lymphoblastic leukemia.

Cancer Lett 2014 Sep 22;352(1):15-20. Epub 2014 Feb 22.

Childhood Leukemia Research Section, Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Department of Molecular Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel; Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043835140010
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2014.02.009DOI Listing
September 2014

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.

Blood 2014 Jul 1;124(1):106-10. Epub 2014 May 1.

Childhood Leukemia Research Institute, Edmond and Lily Safra Children Hospital, Sheba Medical Center, Ramat Gan, Israel; Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-10-529685DOI Listing
July 2014

Beyond Philadelphia: 'Ph-like' B cell precursor acute lymphoblastic leukemias - diagnostic challenges and therapeutic promises.

Authors:
Shai Izraeli

Curr Opin Hematol 2014 Jul;21(4):289-96

aChildhood Leukemia Research Center, Department of Pediatric Hematology Onclology, Edmond and Lily Safra Children Hospital bSheba Medical Center, Tel Hashomer, Ramat Gan cDepartment of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0000000000000050DOI Listing
July 2014

The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions.

Chem Commun (Camb) 2014 May 11;50(40):5245-7. Epub 2013 Sep 11.

Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3cc45096aDOI Listing
May 2014

Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.

Cell Mol Life Sci 2014 Feb 27;71(3):365-78. Epub 2013 Apr 27.

Cancer Research Center, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, Tel Hashomer, 52621, Ramat Gan, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-013-1337-xDOI Listing
February 2014

How I treat ALL in Down's syndrome: pathobiology and management.

Blood 2014 Jan 14;123(1):35-40. Epub 2013 Nov 14.

Department of Pediatric Hemato-Oncology, Edmond and Lily Safra Children's Hospital, Sheba Medical Centre, Tel-Hashomer, Ramat Gan, and Tel Aviv University Medical School, Tel Aviv, Israel;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-07-453480DOI Listing
January 2014

Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002.

J Clin Oncol 2014 Jan 16;32(3):174-84. Epub 2013 Dec 16.

Jan Stary, Jan Trka, and Ondrej Hrusak, Charles University and University Hospital Motol, Prague; Yahia Jabali, Regional Hospital, Ceske Budejovice, Czech Republic; Martin Zimmermann and Hansjörg Riehm, Medical School Hannover, Hannover; Martin Schrappe, University Hospital Schleswig-Holstein, Kiel, Germany; Myriam Campbell, Roberto del Rio Hospital, Universidad de Chile, Santiago, Chile; Luis Castillo, Hospital Pereira Rossell, Montevideo, Uruguay; Eduardo Dibar, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Svetlana Donska, Regional Oncologic Hospital, Kiev, Ukraine; Alejandro Gonzalez, Institute of Hematology and Immunology, La Habana, Cuba; Shai Izraeli, Sheba Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Tel Hashomer; Batia Stark, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel; Dragana Janic, University Children's Hospital, University of Belgrade, Belgrade, Serbia; Janez Jazbec, University Children's Hospital, Ljubljana, Slovenia; Josip Konja, University Hospital Centre Rebro, Zagreb, Croatia; Emilia Kaiserova, University Children's Hospital, Bratislava, Slovakia; Jerzy Kowalczyk, University of Lublin, Lublin, Poland; Gabor Kovacs and Edina Magyarosy, Semmelweis University, Budapest, Hungary; Chi-Kong Li, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region, People's Republic of China; Alexander Popa, N.N. Blokhin Russian Cancer Research Center, Moscow, Russia; and Giuseppe Masera, Ospedale S. Gerardo, University of Milano-Bicocca, Monza, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2013.48.6522DOI Listing
January 2014

Spontaneous remission of childhood acute marrow fibrosis and megakaryoblastic leukemia.

J Pediatr Hematol Oncol 2012 Oct;34(7):565-8

Department of Pediatric Hemato-Oncology, Tel Aviv Medical Center, Tel Aviv University, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0b013e318257a172DOI Listing
October 2012

STIL is required for centriole duplication in human cells.

J Cell Sci 2012 Mar 20;125(Pt 5):1353-62. Epub 2012 Feb 20.

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.104109DOI Listing
March 2012

DYRK1A in Down syndrome: an oncogene or tumor suppressor?

J Clin Invest 2012 Mar 22;122(3):807-10. Epub 2012 Feb 22.

Functional Genomics and Department of Pediatric Hemato-Oncology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

View Article

Download full-text PDF

Source
http://www.jci.org/articles/view/62372
Publisher Site
http://dx.doi.org/10.1172/JCI62372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287238PMC
March 2012

A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.

BMC Cancer 2011 Sep 26;11:412. Epub 2011 Sep 26.

The Neufeld Cardiac Research Institute, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, 69978, Tel-Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-11-412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204305PMC
September 2011

The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

J Cell Sci 2011 Feb 18;124(Pt 4):532-9. Epub 2011 Jan 18.

Sheba Cancer Research Center and Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer 52621, Ramat Gan, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.079731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031367PMC
February 2011

Therapy-related acute myeloid leukemia with t(2;11)(q37;q23) after treatment for osteosarcoma.

Cancer Genet Cytogenet 2010 Dec;203(2):288-91

Department of Pediatric Hematology-Oncology, Safra Children's Hospital, Tel-Hashomer, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergencyto.2010.08.002DOI Listing
December 2010

Application of genomics for risk stratification of childhood acute lymphoblastic leukaemia: from bench to bedside?

Authors:
Shai Izraeli

Br J Haematol 2010 Oct;151(2):119-31

Functional Genomics and Leukaemia Research Laboratory, Edmond and Lily Safra Children's Hospital and Cancer Research Centre, Sheba Medical Centre and Tel Aviv University, Israel.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2141.2010.08312.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2010.08312.xDOI Listing
October 2010

Similar yet different.

Authors:
Shai Izraeli

Blood 2010 Aug;116(7):1019-20

Sheba Medical Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-05-285197DOI Listing
August 2010

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors.

Breast Cancer Res 2009 9;11(6):R78. Epub 2009 Nov 9.

The Neufeld Cardiac Research Institute and Dept, of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/bcr2445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815540PMC
July 2010

A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21.

Pediatr Blood Cancer 2010 Jul;54(7):1048-9

Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pbc.22331
Publisher Site
http://dx.doi.org/10.1002/pbc.22331DOI Listing
July 2010

Where can biology of childhood ALL be attacked by new compounds?

Cancer Treat Rev 2010 Jun 12;36(4):298-306. Epub 2010 Mar 12.

University Children's Hospital Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctrv.2010.02.005DOI Listing
June 2010

ERG is a megakaryocytic oncogene.

Cancer Res 2009 Jun;69(11):4665-73

Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-0075DOI Listing
June 2009

Constitutional aneuploidy and cancer predisposition.

Hum Mol Genet 2009 Apr;18(R1):R84-93

Sackler School of Medicine, Tel Aviv University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddp084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657942PMC
April 2009

Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.

Br J Haematol 2009 Mar 20;144(6):930-2. Epub 2008 Dec 20.

Division of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2141.2008.07552.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724897PMC
March 2009

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.

Blood 2009 Mar 12;113(12):2619-28. Epub 2009 Jan 12.

Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-11-16
Publisher Site
http://dx.doi.org/10.1182/blood-2008-11-163501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661853PMC
March 2009

Trisomy 21 tilts the balance.

Authors:
Shai Izraeli

Blood 2008 Dec;112(12):4361-2

Sheba Medical Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-09-176719DOI Listing
December 2008

The mitotic checkpoint gene, SIL is regulated by E2F1.

Int J Cancer 2008 Oct;123(7):1721-5

Department of Pediatric Hemato-Oncology and the Sheba Cancer Research Center, Tel-Hashomer, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.23665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693309PMC
October 2008

Integration of a palliative and terminal care center into a comprehensive pediatric oncology department.

Pediatr Blood Cancer 2008 May;50(5):949-55

Department of Pediatric Hematology-Oncology, Marion and Elie Wiesel Children's Pavilion, Chaim Sheba Medical Center, Tel-Aviv University Sackler School of Medicine, Ramat Gan, Israel.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pbc.21476
Publisher Site
http://dx.doi.org/10.1002/pbc.21476DOI Listing
May 2008

Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.

BMC Mol Biol 2007 Nov 29;8:109. Epub 2007 Nov 29.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2199-8-109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2231382PMC
November 2007