Publications by authors named "Shahrokh Bagheri"

63 Publications

The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes.

Arch Physiol Biochem 2021 Feb 1:1-9. Epub 2021 Feb 1.

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

This study was conducted to evaluate the anti-diabetic and antioxidant effects of hydroalcoholic pomegranate peel extract (APE) in alloxan-induced diabetes rat models. We divided 60 rats into the following six equal groups ( = 10): Healthy control; diabetic control (100 mg/kg alloxan); sham + glibenclamide (10 mg/kg); diabetic + glibenclamide (10 mg/kg); sham + APE (200 mg/kg) and diabetic + APE (200 mg/kg). After 8 weeks, kidneys were taken out for biochemical and molecular studies. Following APE treatment, biochemical parameters including malondialdehyde (MDA), and glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) significantly induced in the treated group as compared with the control group ( < 0.05). Also, gene expression of (3-fold), (2.6-fold), and (1.5-fold) were increased as compared to controls ( < 0.05). Overall, our results indicated that pomegranate can be used as an antioxidant agent to reduce complications from diseases associated with oxidative stress.
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http://dx.doi.org/10.1080/13813455.2021.1877308DOI Listing
February 2021

Management of the Cephalic Positioning of the Lower Lateral Cartilage in Modern Rhinoplasty: An Algorithmic Approach.

Oral Maxillofac Surg Clin North Am 2021 Feb;33(1):131-141

private practice, No. 11, 2nd floor, sepehr build.(1425), shariati Av., Gholhak, Tehran, Iran.

Cephalic positioning of lateral cruras literally means that the cartilage does not support the nasal rim. Cephalic positioning is a relatively common anatomic variant of lower lateral cartilages that shows an extremely vulnerable rhinoplasty patient. In these patients, any reductive technique, such as cephalic trimming without compensation, worsens the situation and may lead to esthetic failures and airway compromise. True cephalic malpositioning needs to be diagnosed from pseudomalpositions preoperatively. The presence of the pseudomalposition does not mean that it can be ignored. Either malposition or pseudomalposition is best diagnosed and considered in the treatment plan.
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http://dx.doi.org/10.1016/j.coms.2020.09.008DOI Listing
February 2021

New Concepts in Dorsal Nasal Augmentation.

Oral Maxillofac Surg Clin North Am 2021 Feb 5;33(1):39-50. Epub 2020 Nov 5.

Department of Oral and Maxillofacial surgery, Istanbul Aydin university, Beşyol Mahallesi, İnönü Caddesi & Akasya Sk. No:6, 34295 Küçükçekmece/İstanbul, Turkey.

Dorsal augmentation is commonly indicated in many primary and secondary aesthetic nose surgeries. Throughout the history, various synthetic and autogenous materials have been used for dorsal augmentation. In this article, we give an overview of basic concepts of cartilage grafting, review new concepts of dorsal augmentation, and discuss some emerging engineering modalities.
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http://dx.doi.org/10.1016/j.coms.2020.09.007DOI Listing
February 2021

Modern Rhinoplasty and the Management of Its Complications.

Oral Maxillofac Surg Clin North Am 2021 Feb 4;33(1):xiii-xiv. Epub 2020 Nov 4.

Department of Oral and Maxillofacial Surgery, University of Toronto, 124 Edward Street, Toronto ON M5G 1G6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.coms.2020.09.009DOI Listing
February 2021

Incidence of Pre-Existing Lingual Cortex Perforation Before Removal of Mandibular Third Molars.

J Oral Maxillofac Surg 2020 Dec 14;78(12):2129-2137. Epub 2020 Aug 14.

Georgia Oral & Facial Reconstructive Surgery, Attending Oral and Maxillofacial Surgeon, Northside Hospital, Director of Fellowship Program in Facial Cosmetic and Reconstructive Surgery, Atlanta, GA.

Purpose: The objective of this study was to determine the relationship between the mandibular third molar tooth (Md3) and the adjacent lingual cortical bone and determine the incidence of lingual cortex perforation by Md3s.

Patients And Methods: This retrospective study was designed and implemented from 100 cone-beam computed tomographic scans (CBCTs) of patients with age ranging from 18 to 65 years old. The primary outcome was to assess the incidence of mandibular third molars (Md3s) with existing lingual cortex perforation by their roots. Perforation was assessed at the level of root apex and the most lingual portion on the apical half of the root. Other outcome variables included average thickness of covering lingual bone in the nonperforation group, lingual cortex morphology, impaction, and demographics. Descriptive statistics were computed.

Results: More than half the radiographs showed lingual cortex perforation at the level of root apex and most lingual portion on the apical one half of the root (51.2% and 52.8%, respectively). The average thickness of the covering lingual bone was 1.25 mm around the root apex and 0.93 mm around the most lingual portion on the apical half of the root. The most common lingual cortex morphology was the undercut shape. There was statistically significant association between the presence of Md3 impaction and perforation at both root levels [(P value < .001, Effect size = 0.378) and (P value < .001, Effect size = 0.445)].

Conclusions: Perforation of the lingual cortex by Md3s, whether erupted or impacted, was found in >50% of patients as determined by a preoperative CBCT scan. Therefore, the finding of lingual cortex perforation after removal of Md3s is likely to be evidence of a pre-existing condition rather than a result of surgery.
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http://dx.doi.org/10.1016/j.joms.2020.08.010DOI Listing
December 2020

Oral Surgeons as Cosmetic Surgeons and Their Scope of Practice.

Plast Reconstr Surg 2020 01;145(1):218e

Northside Hospital and, Augusta University Georgia Oral and Facial Reconstructive Surgery, Atlanta, Ga.

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http://dx.doi.org/10.1097/PRS.0000000000006357DOI Listing
January 2020

Effects of Pistacia atlantica on Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats.

J Am Coll Nutr 2019 Mar-Apr;38(3):267-274. Epub 2019 Feb 4.

e Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Diabetes mellitus (DM) affects many patients all over the world. It involves different parts of the body, such as brain, eyes, kidneys, vessels, and so on. The lack of balance between free radicals and antioxidants is a possible mechanism involved in the pathogenesis of diabetes. Antioxidant treatment, especially natural forms, can be a beneficial solution. Therefore, we evaluated the effects of Pistacia atlantica oleoresin (PAO) on oxidative stress markers and antioxidant enzymes expression in diabetic rats.

Method: Fifty adult male Wistar rats were allotted randomly into five groups as follow: control group, diabetic control group, glibenclamide control group, diabetic glibenclamide group, diabetic treated group with 200 mg/kg PAO. Then PAO was prepared and analyzed by gas chromatography/mass spectroscopy (GC/MS). LD50 was also estimated for essential oil. Oxidative stress markers and antioxidant enzyme including malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were also measured. The expression of GPx, CAT, and SOD genes was investigated using real-time polymerase chain reaction (PCR).

Results: The main constituents of essential oil gum were beta-pinene (29.38%), followed by alpha-pinene (18.15%), myrcene (7.36%), trans-pinocarveol (7.15%), and camphene (4.12%). Diabetes induced an increased level of MDA (69.92 ± 3.92 vs. 43.76 ± 3.73) and decreased levels of GSH (2.57 ± 0.40 vs. 7.05 ± 1.59), GPx (11.66 ± 2.2 vs. 16.38 ± 2.1), CAT (12.17 ± 3.38 vs. 18.7 ± 2.66), and SOD (0.78 ± 0.67 vs. 2.41 ± 0.46). In contrast, PAO treatment significantly decreased MDA (54.59 ± 12.54 vs. 69.92 ± 3.92) and increased GSH (4.5 ± 0.89 vs. 2.57 ± 0.40), GPx (25.86 ± 5.37 vs. 11.66 ± 2.2), CAT (22.69 ± 0.36 vs. 12.17 ± 3.38), and SOD (3.65 ± 1.08 vs. 0.78 ± 0.67) (p < 0.05). Moreover, our results indicated that both GPx and CAT mRNA levels significantly increased approximately 4.46 and 6.23 times in rats fed with 200 mg/kg of PAO, more than that of the healthy control group, respectively (p < 0.01 and p < 0.001, respectively). Also, the average expression level of SOD was also significantly 1.57 higher in rats fed with 200 mg/kg of PAO in comparison to the diabetic control group (p < 0.05).

Conclusion: The results indicated that PAO could be propose as an agent that protects the body against diseases that are associated with oxidative stress.
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http://dx.doi.org/10.1080/07315724.2018.1482577DOI Listing
July 2020

The effects of dietary polyunsaturated fatty acids on miR-126 promoter DNA methylation status and VEGF protein expression in the colorectal cancer cells.

Genes Nutr 2018 18;13:32. Epub 2018 Dec 18.

5Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: There is increasing evidence indicating an aberrant expression of miRNAs in colorectal cancer (CRC) development. Growing evidence has suggested that polyunsaturated fatty acids (PUFAs) could modulate the remodeling of the epigenome. No study has yet been published to examine the direct effect of PUFA on the promoter methylation of miRNAs. This study aimed to examine the potential clinical application of PUFA on the promoter DNA methylation of miR-126 and its angiogenic target molecule (VEGF) in the CRC cells.

Methods: We investigated the direct effect of 100 μM EPA, DHA, and LA for 24 h on promoter methylation status of miR-126 in a panel of five CRC cell lines (HCT116, HT29/219, Caco2, SW742, and LS180) by methylation-specific PCR (MSP). We also quantified the miR-126 and VEGF transcript expression levels in five CRC cell lines affected by PUFA by real-time PCR. Moreover, we analyzed the protein expression level of VEGF, as a target of miR-126, by western blotting assay.

Results: MSP analysis showed extensive DNA methylation of the miR-126 promoter in all five CRC cell lines, and among all three PUFAs, only DHA completely demethylated the promoter of miR-126 in HCT116 and Caco2 cell lines. We found that only DHA significantly induces the expression level of miR-126 in HCT116 and Caco2 cell lines, respectively, by 20.1-fold and 1.68-fold ( < 0.05). Our finding indicates that the downregulation of VEGF protein level is also effectively observed only in DHA-treated HCT116 and Caco2 cells compared to control cells ( < 0.05).

Conclusions: Our results provide evidence that -3 PUFAs are able to modulate cellular miR-126 DNA methylation and inhibit VEGF expression level in a cell-type specific manner in colorectal cancer cells. DHA always showed higher efficacy than EPA and LA in our experiment. Overall, our results suggest a potential clinical application of -3 PUFAs as anti-angiogenic agents in CRC therapy.
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http://dx.doi.org/10.1186/s12263-018-0623-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299631PMC
December 2018

Current Techniques in Fat Grafting.

Atlas Oral Maxillofac Surg Clin North Am 2018 Mar 8;26(1):7-13. Epub 2017 Dec 8.

Division of Oral and Maxillofacial Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.cxom.2017.11.001DOI Listing
March 2018

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study.

J Nephropathol 2017 Jul 20;6(3):204-209. Epub 2017 Feb 20.

Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: Oleuropein is a potent antioxidant and free-radical scavenger with antiinflammatory properties.

Objectives: In the present study, we evaluated the protective effects of oleuropein on myeloperoxidase (MPO) activity, nitrite, urea, creatinine and glomerulosclerosis in alloxan-induced type 1 diabetic rats.

Materials And Methods: Thirty Sprague-Dawley male rats were randomly divided into 3 groups: group 1 as control; group 2 as untreated diabetic; and group 3 as treated with oleuropein 15 mg/kg i.p daily. Diabetes was induced in the second and third groups by subcutaneous alloxan injection. After 48 days, the animals were anaesthetized and then the livers and kidneys were removed immediately and used fresh or kept frozen until MPO activity analysis. Blood samples were also collected before sacrificing to measure nitrite, urea, and creatinine. Kidney paraffin sections were prepared to estimate glomerular volume, leukocyte infiltration, and glomerulosclerosis.

Results: Oleuropein significantly decreased leukocyte infiltration and glomerulosclerosis in the treated group compared with the diabetic untreated group. Oleuropein significantly decreased the levels of urea, nitrite, and creatinine in the treated group compared with the diabetic untreated group. Moreover, oleuropein significantly decreased MPO activity in the treated group compared with the diabetic untreated group.

Conclusions: Oleuropein has antioxidative and antiatherogenic activities and exerts beneficial effects on inflammation and kidney function test and decreases diabetic complication in diabetic rats.
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http://dx.doi.org/10.15171/jnp.2017.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607984PMC
July 2017

Biochemical effects of oleuropein in gentamicin-induced nephrotoxicity in rats.

ARYA Atheroscler 2016 Mar;12(2):87-93

Department of Immunology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: Oleuropein is a natural antioxidant and scavenging free radicals. In the present study, we examined effect of oleuropein on the paraoxonase 1 (PON1) activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of PON1 activity by high-density lipoprotein-cholesterol (HDL-C) and atherogenic indices in gentamicin (GM)-induced nephrotoxicity in rats.

Methods: This is a lab trial study in Khorramabad, Lorestan province of Iran (2013). 30 Sprague-Dawley rats were divided into three groups to receive saline; GM, 100 mg/kg/day; and GM plus oleuropein by 15 mg/kg intraperitoneal daily, respectively. After 12 days, animals were anesthetized, blood samples were also collected before killing to measure the levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and very LDL (VLDL), HDL-C, atherogenic index, lipid peroxidation, and the activities of PON1 of all groups were analyzed. Data were analyzed, and P < 0.050 was considered significant.

Results: Oleuropein significantly decreased lipid peroxidation, TG, TC, LDL, VLDL, atherogenic index, atherogenic coefficient (AC), and cardiac risk ratio (CRR). HDL-C level was significantly increased when treated with oleuropein. The activity of PON1 in treated animals was (62.64 ± 8.68) that it was significantly higher than untreated animals (47.06 ± 4.10) (P = 0.047). The activity of PON1 in the untreated nephrotoxic rats was significantly lower than that of control animals (77.84 ± 9.43) (P = 0.030). Furthermore, the activity of PON1 correlated positively with HDL-C and negatively with AC, CRR 1, and CRR 2 in the treated group with oleuropein.

Conclusion: This study showed that oleuropein improves PON1 activity, lipid profile, and atherogenic index and can probably decrease the risk of cardiovascular death in nephrotoxic patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933747PMC
March 2016

Nerve Gap Reconstruction.

J Oral Maxillofac Surg 2015 Oct 14;73(10):1885. Epub 2015 Jun 14.

Marietta, GA.

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http://dx.doi.org/10.1016/j.joms.2015.04.046DOI Listing
October 2015

Authors' response.

J Am Dent Assoc 2015 Jan 18;146(1):7-8. Epub 2014 Dec 18.

Georgia Oral and Facial Reconstructive Surgery, Marietta, GA; Director, Maxillofacial Consultations, Greensboro, GA; Department of Surgery, Northside Hospital, Atlanta, GA; Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Georgia Regents University, Augusta, GA.

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http://dx.doi.org/10.1016/j.adaj.2014.11.004DOI Listing
January 2015

Amelioration of lipid peroxidation in vivo and in vitro by Satureja khozestanica essential oil in alloxan-induced diabetic rats.

J Diabetes Metab Disord 2014 13;13(1):119. Epub 2014 Dec 13.

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoram Abad, Iran.

Background: We examined possible protective effect of Satureja khozestanica essential oil (SKE) on in vivo and in vitro lipid peroxidation in alloxan-induced Type 1 diabetic rats.

Methods: Thirty Sprage-dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with SKE by 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized, livers and kidneys were then removed immediately and used fresh or kept frozen until their lipid peroxidation analysis. Lipid peroxidation was determined by measurement of thiobarbituric acid reactive substances (TBARS). Blood samples were also collected before killing to measure the levels of fasting blood suger (FBS) and lipid peroxidation.

Results: SKE significantly inhibited the levels of FBS, TBARS serum and kidney content in treated group compared with the diabetic untreated group. Also the levels of malonedialdehyde liver content unaltered in treated group. SKE significantly inhibited LDL oxidation in vitro.

Conclusions: The findings showed that SKE exerts beneficial effects on the lipid peroxidation in alloxan-induced Type 1 diabetic rats.
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http://dx.doi.org/10.1186/s40200-014-0119-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280039PMC
December 2014

Crisis or chronic complaint?

J Oral Maxillofac Surg 2014 Nov 21;72(11):2100. Epub 2014 Oct 21.

Marietta, GA.

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http://dx.doi.org/10.1016/j.joms.2014.06.462DOI Listing
November 2014

Inferior alveolar nerve function after sagittal split osteotomy.

J Oral Maxillofac Surg 2014 Nov 21;72(11):2098-9. Epub 2014 Oct 21.

Marietta, GA.

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http://dx.doi.org/10.1016/j.joms.2014.06.463DOI Listing
November 2014

Immediate effects of different steps of rhinoplasty on nasolabial angle and tip projection.

J Craniofac Surg 2014 Sep;25(5):e404-6

From the *Craniomaxillofacial Research Center and Department of Oral and Maxillofacial Surgery, Azad University of Medical Sciences, Tehran, Iran; †Department of Oral and Maxillofacial Surgery, Northside Hospital, Atlanta, Georgia; and ‡Department of Oral and Maxillofacial Surgery, Gazi University, Ankara, Turkey.

Nasolabial angle (NLA) and nasal tip projection (NTP) play an important role in aesthetic nose surgery. Little deviations can determine success and failure. The goal of this study was to analyze the immediate effect of different steps of open rhinoplasty on NLA and NTP. In this prospective single-blind study, 50 consecutive rhinoplasty cases were considered. The study consisted of 38 women and 12 men. The mean age was 28 years, ranging from 17 to 37 years. A standard life-size photograph was taken in each step of a classic open rhinoplasty during surgery. Nasolabial angle and NTP were measured and analyzed. Nasolabial angle: average increase after skeletonization (2.26 degrees), strut insertion (4 degrees), and tip spanning (0.17 degrees), whereas cephalic resection caused a decrease (1.9 degrees). Nasal tip projection: average increase after skeletonization (0.1 mm), strut insertion (0.31 mm), and tip spanning (0.84 mm), whereas cephalic resection caused a decrease (0.53 mm). Whereas strut insertion caused the highest mean increase in NLA, tip spanning was the most effective regarding change of NTP. Expectably cephalic resection was associated with decrease in NLA and NTP.
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http://dx.doi.org/10.1097/SCS.0000000000000601DOI Listing
September 2014

When to refer a patient with a nerve injury to a specialist.

J Am Dent Assoc 2014 Aug;145(8):859-61

Dr. Meyer was the chief, Division of Oral and Maxillofacial Surgery, Department of Surgery, Northside Hospital, Georgia Oral and Facial Reconstructive Surgery, Atlanta, when this article was written. He now is the director, Maxillofacial Consultations, Greensboro, Ga.; and a clinical associate professor, Department of Oral and Maxillofacial Surgery, Georgia Regents University, Augusta.

Background: Nerve injury is a known and accepted risk of many oral surgical and dental procedures. Such injuries may occur despite the practitioner's providing the best of care. Taking proactive measures during evaluation and surgery may reduce the incidence of nerve injury.

Results: Injuries to the peripheral branches of the trigeminal nerve can cause unfavorable effects on orofacial sensation and related functions such as eating, drinking, washing, speaking, shaving and kissing.

Conclusions: When nerve injuries secondary to dental or oral surgery procedures fail to resolve promptly and the resulting dysesthesia is unacceptable to the patient, timely treatment gives the patient the best chance of a favorable outcome. Treatment may involve surgical exploration and repair of the injured nerve.

Practical Implications: Recognition of and prompt referral for nerve injuries give the patient the best chance of achieving improvement or recovery of sensory function in the distribution of the injured nerve.
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http://dx.doi.org/10.14219/jada.2014.45DOI Listing
August 2014

Neuropathic pain after mandibular ramus sagittal split osteotomy.

J Oral Maxillofac Surg 2014 May;72(5):846

Marietta, GA.

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http://dx.doi.org/10.1016/j.joms.2014.01.018DOI Listing
May 2014

Management of the superficial musculo-aponeurotic system (SMAS).

Atlas Oral Maxillofac Surg Clin North Am 2014 Mar;22(1):17-23

Aesthetics International USA, 11975 Morris Rd, Suite 220, Alpharetta, GA 30005, USA.

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http://dx.doi.org/10.1016/j.cxom.2013.11.006DOI Listing
March 2014

Surgical anatomy of the superficial musculo-aponeurotic system (SMAS).

Atlas Oral Maxillofac Surg Clin North Am 2014 Mar;22(1):9-15

Aesthetics International USA, 11975 Morris Road, Suite 220, Alpharetta, GA 30005, USA.

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http://dx.doi.org/10.1016/j.cxom.2013.11.005DOI Listing
March 2014

Submental fat transfer: an approach to enhance soft tissue conditions in patients with submental lipomatosis after orthognathic surgery.

J Oral Maxillofac Surg 2014 Jan;72(1):164.e1-7

Chair, Department of Oral and Maxillofacial Surgery, Northside Hospital, Atlanta, GA; Private Practice, Georgia Oral and Facial Surgery, Marietta, GA; Clinical Associate Professor, Department of Oral and Maxillofacial Surgery, Medical College of Georgia, Augusta, GA; Clinical Assistant, Department of Surgery, Emory University School of Medicine, Atlanta, GA.

Soft tissue changes after orthognathic surgery and their effects on the esthetic appearance of the patient can be the most challenging and sometimes undesired parts of this procedure. Although the soft tissue profile is improved in many orthognathic surgeries, suboptimal soft tissue changes may necessitate some special interventions. To overcome these problems, the authors present a technique based on transferring the submental fat (in patients with submental lipomatosis) to the lips, paranasal areas, or other sites of the face instead of discarding it. According to this technique, in patients with submental lipomatosis, submental fat can be used not only to compensate some of the unpleasant soft tissue effects of orthognathic procedures (eg, thinning of the upper lip after mandibular setback), but also to improve pre-existing soft tissue problems, which may be worse after orthognathic surgeries (eg, a poor neck and chin profile). Although submental fat liposuction is a traditional technique to improve the neck and chin profile, the present technique is based on transferring the harvested fat to other sites of the face (lips, paranasal areas, etc) instead of discarding it.
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http://dx.doi.org/10.1016/j.joms.2013.08.032DOI Listing
January 2014

Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10.

Ren Fail 2014 Apr 9;36(3):413-8. Epub 2013 Dec 9.

Razi Herbal Researches Center, Lorestan University of Medical Sciences , Khoram Abad , Iran .

Coenzyme Q10 is a natural antioxidant and scavenger of free radicals. In the present study, we examined the effect of coenzyme Q10 on paraoxonase 1 (PON1) activity, lipid profile, atherogenic indexes and relationship of PON 1 activity by high-density lipoprotein (HDL) and atherogenic indexes in gentamicin (GM)-induced nephrotoxicity rats. Thirty Sprague-Dawley rats were divided into three groups to receive saline; GM, 100 mg/kg/d; and GM plus coenzyme Q10 by 15 mg/kg i.p daily, respectively. After 12 days, animals were anaesthetized, blood samples were also collected before killing to measure the levels of triglyceride (TG), cholesterol (C), low-density lipoprotein (LDL), very low density lipoprotein (VLDL), HDL, atherogenic indexes and the activities of PON1 of all groups were analyzed. Data were analyzed by non-parametric Mann-Whitney test (using SPSS 13 software). Coenzyme Q10 significantly decreased TG, C, LDL, VLDL, atherogenic index, atherogenic coefficient and cardiac risk ratio. HDL level and PON1 activity were significantly increased when treated with coenzyme Q10. Also, the activity of PON 1 correlated positively with HDL and negatively with atherogenic coefficient, cardiac risk ratio 1 and cardiac risk ratio 2. This study showed that coenzyme Q10 exerts beneficial effects on PON1 activity, lipid profile, atherogenic index and correlation of PON 1 activity with HDL and atherogenic index in GM -induced nephrotoxicity rats.
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http://dx.doi.org/10.3109/0886022X.2013.865154DOI Listing
April 2014

Management of perforations of the nasal septum: can extracorporeal septoplasty be an effective option?

J Oral Maxillofac Surg 2014 Feb 25;72(2):391-5. Epub 2013 Oct 25.

Chair, Department of Oral and Maxillofacial Surgery, Northside Hospital, Atlanta, GA; Private Practice, Georgia Oral and Facial Surgery, Marietta, GA; Clinical Associate Professor, Department of Oral and Maxillofacial Surgery, Medical College of Georgia, Augusta, GA; Clinical Assistant, Department of Surgery, Emory University School of Medicine, Atlanta, GA.

Purpose: Perforation of the nasal septum is a frustrating problem frequently reported in the literature. Surprisingly, in most reports, iatrogenic perforation during septoplasty and electrocautery are the leading causes of this complication. This article presents the management of septal perforations and the indications for an extracorporeal approach.

Materials And Methods: Fourteen patients with septal perforations were referred for treatment. Treatment was chosen based on defect size. Flaps, extracorporeal repair, or no treatment was used as indicated.

Results: Two of 14 perforations were small and were repaired by local flaps, 5 cases were treated by extracorporeal repair, and the 7 remaining cases required no surgical procedure.

Conclusions: The extracorporeal technique, when indicated, can be used effectively for the repair of nasal septum perforations in selected cases.
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http://dx.doi.org/10.1016/j.joms.2013.08.016DOI Listing
February 2014

Lateral crural suspension flap: a novel technique to modify and stabilize the nasolabial angle.

J Oral Maxillofac Surg 2013 Sep 14;71(9):1572-6. Epub 2013 Jun 14.

Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Buali Hospital, Azad University, Tehran, Iran.

The proper nasolabial angle is a determinant factor in achieving a pleasant result in esthetic rhinoplasty surgery. Nasal tip position depends on various interrelated elements. Its rotation should be analyzed by assessing the nasolabial angle. An increase in this angle results in an upward tilt of the base of the nose with a concomitant decrease in nasal length. Several methods have been advocated to improve this angle; unfortunately, these techniques have considerable limitations in modifying and stabilizing nasal tip rotation. The general principles for rotating the nasal tip include removing the factors that resist the rotation of the lower lateral cartilages, creating space to accommodate them, rotating the lower lateral cartilages into the desired position, and stabilizing the cartilages in the desired position. Resection of the cephalic margin of the lateral crura fulfills these goals. This report describes a straightforward and stable method that uses cephalic portions of the lower lateral crural cartilages as 2 flaps to suspend the nasal tip to the septum to modify and stabilize the nasolabial angle.
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http://dx.doi.org/10.1016/j.joms.2013.03.024DOI Listing
September 2013

Antioxidant properties and inhibitory effects of Satureja khozestanica essential oil on LDL oxidation induced-CuSO(4) in vitro.

Asian Pac J Trop Biomed 2013 Jan;3(1):22-7

Department of Biochemistry, Lorestan University of Medical Sciences, Khoramabad, Iran.

Objective: To assess various antioxidative activities of Satureja khozestanica essential oil (SKE) and its effect on oxidation of low density lipoprotein (LDL) induced by CuSO4 in vitro by monitoring the formation of conjugated dienes and malondialdehyde (MDA).

Methods: The formation of conjugated dienes, lag time and MDA were measured. Inhibition of this Cu-induced oxidation was studied in the presence of several concentrations of SKE. Also total antioxidant activity and free radical scavenging of SKE were determinated.

Results: It was demonstrated that SKE was able to inhibit LDL oxidation and decrease the resistance of LDL against oxidation. The inhibitory effects of SKE on LDL oxidation were dose-dependent at concentrations ranging from 50 to 200 µg/mL. Total antioxidant capacity of SKE was (3.20±0.40) nmol of ascorbic acid equivalents/g SKE. The SKE showed remarkable scavenging activity on 2, 2-diphenyl-picrylhydrazyl, IC50 (5.30±0.11) ng/mL.

Conclusions: This study shows that SKE is a source of potent antioxidants and prevents the oxidation of LDL in vitro and it may be suitable for use in food and pharmaceutical applications.
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http://dx.doi.org/10.1016/S2221-1691(13)60018-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609387PMC
January 2013

Microsurgical reconstruction of the trigeminal nerve.

Oral Maxillofac Surg Clin North Am 2013 May 16;25(2):287-302. Epub 2013 Mar 16.

Maxillofacial Consultations Ltd, 1021 Holt's Ferry, Greensboro, GA 30642, USA.

Head and neck tumor surgery or traumatic injuries in the maxillofacial region often result in discontinuity defects of peripheral branches of the trigeminal (fifth cranial) nerve, causing loss of sensation to those areas of the face, mouth, or jaws supplied by this important nerve. Injuries to the peripheral branches of the trigeminal nerve can be repaired by microsurgical techniques, either at the time of the original injury or ablative operation if conditions are favorable, or at a later date. Repair of a peripheral nerve injury has a good chance of a satisfactory outcome if done in a timely fashion.
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http://dx.doi.org/10.1016/j.coms.2013.01.002DOI Listing
May 2013

Lingual nerve repair.

J Oral Maxillofac Surg 2013 May 27;71(5):830. Epub 2013 Feb 27.

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http://dx.doi.org/10.1016/j.joms.2012.12.026DOI Listing
May 2013

Effects of olive leaves extract on LDL oxidation induced-CuSO(4) in vitro.

Pak J Pharm Sci 2012 Jul;25(3):571-5

Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran.

Oxidation of low-density lipoprotein (LDL) has been strongly implicated in the pathogenesis of atherosclerosis. The use of some natural antioxidant and herbal medicine may lead to the inhibition of production of oxidized LDL and may decrease both the development and the progression of atherosclerosis. The aim of this study was to investigate the effects of Olive leaves ethanol extract (OLE) on LDL oxidation induced-CuSO(4) quantitatively in vitro. Low-density lipoprotein was incubated with CuSO(4) and the formation of conjugated dienes and thiobarbituric acid reactive substances (TBARS). Inhibition of this Cu-induced oxidation was studied in the presence of vitamin E and various concentration of OLE. It was demonstrated that OLE reduced the formation of conjugated dienes and TBARS of LDL against oxidation in vitro (p<0.05). The inhibitory effects of the OLE on LDL oxidation were dose-dependent at concentrations ranging from (2μg/ml) to (200μg/ml). Moreover, we compared effects of OLE on LDL oxidation with vitamin E as positive control. This study showed that OLE is a source of potent antioxidants and prevented the oxidation of LDL in vitro and it may be suitable for use in food and pharmaceutical applications.
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July 2012