Shahab Asgharzadeh

Shahab Asgharzadeh

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Shahab Asgharzadeh

Shahab Asgharzadeh

Publications by authors named "Shahab Asgharzadeh"

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Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimens.

J Neurooncol 2019 Oct 16. Epub 2019 Oct 16.

Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, 4650 Sunset Boulevard, MS #54, Los Angeles, CA, 90027-6016, USA.

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http://dx.doi.org/10.1007/s11060-019-03307-8DOI Listing
October 2019

Rare MYC-amplified Neuroblastoma With Large Cell Histology.

Pediatr Dev Pathol 2018 Sep-Oct;21(5):461-466. Epub 2018 Feb 9.

1 Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1177/1093526617749670DOI Listing
June 2019

Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method.

Pharm Stat 2019 Jun 25. Epub 2019 Jun 25.

Department of Preventive Medicine, Keck School of Medicine, The University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/pst.1955DOI Listing
June 2019

Enhancing Natural Killer and CD8 T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 T Cells with HLA-E Monospecific Monoclonal Antibodies.

Monoclon Antib Immunodiagn Immunother 2019 Apr;38(2):38-59

4 Department of Pediatrics and Pathology, Children's Hospital, Keck School of Medicine, USC, Los Angeles, California.

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http://dx.doi.org/10.1089/mab.2018.0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634170PMC
April 2019

Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.

Oncotarget 2017 Oct 16;8(53):91516-91529. Epub 2017 Sep 16.

Children's Hospital Los Angeles, Children's Center for Cancer and Blood Diseases, Division of Hematology, Oncology and Blood & Marrow Transplantation, and The Saban Research Institute, Los Angeles, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.21066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710942PMC
October 2017

NK Cell-derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells.

J Immunother 2017 09;40(7):265-276

*Applied Cell Sciences and Tissue engineering Department, School of Advanced Technologies in Medicine †Hematology, Oncology and Stem cell Transplant Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran ‡Department of Pediatrics, Division of Hematology, Oncology and Blood & Marrow Transplantation, The Saban Research Institute, Children's Hospital Los Angeles §Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1097/CJI.0000000000000179DOI Listing
September 2017

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.

Cancer Res 2017 09 7;77(18):5142-5157. Epub 2017 Jul 7.

Division of Hematology, Oncology and Blood and Marrow Transplantation, Keck School of Medicine of the University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600847PMC
September 2017

BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.

PLoS One 2016 16;11(6):e0156907. Epub 2016 Jun 16.

Department of Radiology, The Saban Research Institute, Children's Hospital Los Angeles, and Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911170PMC
July 2017

More than the genes, the tumor microenvironment in neuroblastoma.

Cancer Lett 2016 09 17;380(1):304-14. Epub 2015 Nov 17.

Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558454PMC
September 2016

Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy.

Neuro Oncol 2016 Jan 8;18(1):126-31. Epub 2015 Aug 8.

Children's Hospital Los Angeles and The Saban Research Institute, Los Angeles, California (S.B., A.S.M., R.S., R.J.K., N.J.R., M.V., L.T.H., S.M., A.E-E., F.H.G., A.R.J., M.D.K., G.D., M.D.N., S.A.); Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California (S.B., M.D.N.); Rudi Schulte Research Institute, Santa Barbara, California (S.B., M.D.N.); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (R.S.); Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio (J.L.F.); Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California (A.E-E., F.H.G., A.R.J., S.A.); Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California (M.D.K.); Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (A.S.M., N.J.R., A.E-E., G.D., S.A.).

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http://dx.doi.org/10.1093/neuonc/nov097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677409PMC
January 2016

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.

Cancer Cell 2015 Nov 17;28(5):599-609. Epub 2015 Oct 17.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643330PMC
November 2015

Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia.

Front Oncol 2015 27;5:191. Epub 2015 Aug 27.

Division of Hematology-Oncology, Department of Pediatrics, Children's Hospital Los Angeles , Los Angeles, CA , USA ; Department of Pediatrics, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA ; Department of Pathology, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550790PMC
September 2015

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.

Cancer Res 2015 Aug 22;75(15):3155-66. Epub 2015 Jun 22.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526355PMC
August 2015

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy.

J Natl Cancer Inst 2015 Jul 13;107(7). Epub 2015 May 13.

Children's Center for Cancer and Blood Diseases and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA; and Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (KBC, PMW, PN, HC, MM, MF); Division of Medical Oncology, Department of Internal Medicine, University of Southern California Keck School of Medicine and Norris Comprehensive Cancer Center, Los Angeles, CA (TX, AG); Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA (RK, MH, AJ, RCS, SA); Departments of Experimental Therapeutics and Leukemia and The Center for RNA interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX (CI, GAC); Department of Gynecologic Oncology and Reproductive Medicine and The Center for RNA interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX (XZ); Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) s.r.l., IRCCS, Gene Therapy Unit, Meldola (FC) 47014, Italy (IV, FF, DA); Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA (HS, SA).

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http://dx.doi.org/10.1093/jnci/djv135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651042PMC
July 2015

Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration.

Exp Cell Res 2015 May 3;334(1):78-89. Epub 2015 Apr 3.

Cancer Center and Departments of Cell Biology & Biochemistry, Pharmacology & Neuroscience, Internal Medicine and Pediatrics, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144827150011
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http://dx.doi.org/10.1016/j.yexcr.2015.03.024DOI Listing
May 2015

Tumor-associated macrophages in SHH subgroup of medulloblastomas.

Clin Cancer Res 2015 Mar 24;21(6):1457-65. Epub 2014 Oct 24.

Children's Hospital Los Angeles and The Saban Research Institute, Los Angeles, California. Department of Pediatrics, Keck School of Medicine of University of Southern California, Los Angeles, California. Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1144DOI Listing
March 2015

Pediatric brain tumor cell lines.

J Cell Biochem 2015 Feb;116(2):218-24

Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, California, 90027.

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http://dx.doi.org/10.1002/jcb.24976DOI Listing
February 2015

MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival.

Cancer Res 2014 Nov 27;74(21):5999-6009. Epub 2014 Aug 27.

Division of Hematology-Oncology, Department of Pediatrics, University of Southern California, Los Angeles, California. The Saban Research Institute of Children's Hospital, Los Angeles, California. Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-2513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216758PMC
November 2014

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.

Clin Cancer Res 2014 Feb 3;20(4):827-36. Epub 2013 Dec 3.

Authors' Affiliations: Departments of Pediatrics, Pathology, Radiology, and Neurosurgery, at the Saban Research Institute at Children's Hospital Los Angeles, Norris Comprehensive Cancer Center; Departments of Preventive Medicine and Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California; Division of Pediatric Neurooncology at the German Cancer Research Center DKFZ; and Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962776PMC
February 2014

Trends in childhood brain tumor incidence, 1973-2009.

J Neurooncol 2013 Nov 8;115(2):153-60. Epub 2013 Aug 8.

Department of Preventive Medicine, University of Southern California Keck School of Medicine, 2001 N. Soto St., Los Angeles, CA, 90089, USA,

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http://dx.doi.org/10.1007/s11060-013-1212-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056769PMC
November 2013

Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells.

Clin Immunol 2013 Oct 18;149(1):55-64. Epub 2013 Jun 18.

Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15216616130017
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http://dx.doi.org/10.1016/j.clim.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809126PMC
October 2013

Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1.

Cancer Immunol Immunother 2013 Oct 27;62(10):1637-48. Epub 2013 Aug 27.

Division of Hematology/Oncology, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #57, Los Angeles, CA, 90027, USA.

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http://dx.doi.org/10.1007/s00262-013-1466-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907789PMC
October 2013

Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells.

J Immunother 2013 Jun;36(5):319-29

Division of Hematology/Oncology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1097/CJI.0b013e31829b4493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064791PMC
June 2013

TARGETgene: a tool for identification of potential therapeutic targets in cancer.

PLoS One 2012 31;7(8):e43305. Epub 2012 Aug 31.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432038PMC
February 2013

Copy number variation signature to predict human ancestry.

BMC Bioinformatics 2012 Dec 27;13:336. Epub 2012 Dec 27.

Department of Pediatrics, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/1471-2105-13-336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598683PMC
December 2012

IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.

J Clin Invest 2012 Jun 8;122(6):2221-33. Epub 2012 May 8.

Department of Pediatrics and Department of Pathology and Immunology, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1172/JCI59535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366399PMC
June 2012

Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors.

Stem Cells 2012 Apr;30(4):697-708

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1732, USA.

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http://dx.doi.org/10.1002/stem.1046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973153PMC
April 2012

Neuroblastoma: issues in transplantation.

Biol Blood Marrow Transplant 2012 Jan;18(1 Suppl):S92-100

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.bbmt.2011.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260463PMC
January 2012

Bioinformatics for copy number variation data.

Methods Mol Biol 2011 ;719:235-49

Department of Pediatrics and Pathology, Keck School of Medicine, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-027-0_11DOI Listing
June 2011

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Cell 2010 Jul;142(2):218-29

Divisions of Molecular Carcinogenesis and Molecular Genetics, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2010.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913027PMC
July 2010

Prediction of human functional genetic networks from heterogeneous data using RVM-based ensemble learning.

Bioinformatics 2010 Mar 4;26(6):807-13. Epub 2010 Feb 4.

Department of Biomedical Engineering, University of Southern California, Los Angeles, 90089, USA.

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http://dx.doi.org/10.1093/bioinformatics/btq044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832827PMC
March 2010

Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.

J Clin Invest 2009 Jun;119(6):1524-36

Division of Hematology-Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine, and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1172/JCI37869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689106PMC
June 2009

Joint estimation of copy number variation and reference intensities on multiple DNA arrays using GADA.

Bioinformatics 2009 May 10;25(10):1223-30. Epub 2009 Mar 10.

Signal and Image Processing Institute, Ming Hsieh Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, EEB 400, 3740 McClintock Ave, Los Angeles, CA 90089-2564, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732310PMC
May 2009

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

Cancer Cell 2009 Apr;15(4):328-40

Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ccr.2009.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693316PMC
April 2009

An integrated cross-platform prognosis study on neuroblastoma patients.

Genomics 2008 Oct 30;92(4):195-203. Epub 2008 Jul 30.

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20877, USA.

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http://dx.doi.org/10.1016/j.ygeno.2008.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562635PMC
October 2008

Sparse representation and Bayesian detection of genome copy number alterations from microarray data.

Bioinformatics 2008 Feb 18;24(3):309-18. Epub 2008 Jan 18.

Signal and Image Processing Institute, Ming Hsieh Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, EEB 400, 3740 McClintock Ave, Los Angeles, CA 90089-2564, USA.

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http://dx.doi.org/10.1093/bioinformatics/btm601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704547PMC
February 2008

Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification.

J Natl Cancer Inst 2006 Sep;98(17):1193-203

Department of Pediatrics, Division of Hematology-Oncology, Childrens Hospital Los Angeles and Saban Research Institute, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/jnci/djj330DOI Listing
September 2006

Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2.

J Exp Med 2004 May;199(9):1213-21

Department of Pediatrics, Division of Hematology-Oncology, MS #57, Childrens Hospital Los Angeles, 4650 Sunset Blvd., Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1084/jem.20031462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211904PMC
May 2004