Professor of Pharmac Shah Murad , MBBS, M.Phil, MA, MSc, MBA, PhD - Islamabad Medical & Dental College - Professor of Pharmacology

Professor of Pharmac Shah Murad

MBBS, M.Phil, MA, MSc, MBA, PhD

Islamabad Medical & Dental College

Professor of Pharmacology

Islamabad, Punjab | Pakistan

Main Specialties: Public Health

Additional Specialties: Pharmacology and Therapeutics

ORCID logohttps://orcid.org/0000-0003-0259-2524


Top Author

Professor of Pharmac Shah Murad , MBBS, M.Phil, MA, MSc, MBA, PhD - Islamabad Medical & Dental College - Professor of Pharmacology

Professor of Pharmac Shah Murad

MBBS, M.Phil, MA, MSc, MBA, PhD

Introduction

I am Professor of Pharmacology and Therapeutics at Islamabad Medical and Dental College, main Murree road, Islamabad-Pakistan.
I am author of more than 60 research articles published in National and International Research Journals. I have 23 years teaching experience in the subject of Pharmacology & Therapeutics to MBBS/BDS/Pharmacy/Nursing and allied health sciences students in Punjab/Sindh/KPK/Islamabad Universities. I am keenly interested in research activities in allopathic/herbal medicines.

Primary Affiliation: Islamabad Medical & Dental College - Islamabad, Punjab , Pakistan

Specialties:

Additional Specialties:

Research Interests:


View Professor of Pharmac Shah Murad ’s Resume / CV

Education

Nov 2006
Shah Abdul Latif University
MBA
Marketing and Management
Dec 2002
Karachi University, JPMC
M.Phil
Pharmacology (Minor: Biochemistry, Physiology)
Jun 1990
LUMS
MBBS
Surgery, Medicine, ENT, Eye, Gynaecology
Dec 1989
University of Sindh
Masters in Economics
Economics
Jan 2014
Islamabad Medical and Dental College
MBBS and M.Phil
Pharmacology

Experience

Apr 2012 - Dec 2013
Frontier Medical and Dental College
Professor
Pharmacology
Dec 1995
Professor of Pharmacology
Teached Pharmacology to MBBS/BDS/Pharm D/Nursing/DPT/MLT/Allied Health Sciences
Remain HOD Pharmacology and Therapeutics

Publications

158Publications

3351Reads

1192Profile Views

1084PubMed Central Citations

HOW TO GET ALONG WITH OTHER DISIPLINES OF THERAPEUTICS?

JUMDC 2018;12(2):22-7

JMUDC

Atherosclerosis is a disease in which plaques that are made up of fat, cholesterol, calcium and other substances, build up in artery walls. Over time, the plaques harden, narrow the opening of the arteries and restrict the blood flow. When these fatty plaques rupture, they form a thrombus (blood clot) that can further limit, or even block the flow of oxygen-rich blood to organs and other parts of the body. Atherosclerosis can occur in arteries anywhere in the body but is most serious when it leads to a reduced or blocked blood supply to the heart or to the brain. If it occurs in one of the two main coronary arteries that supply blood to the heart this results in a heart attack. When thrombosis occurs in one of the arteries to the brain, it causes a stroke. Isomer of Vitamin E alpha tocopherol has antioxidant effects like other hypolipidemic drugs used in allopathy. Ziziphus Jujube is medicinal plant having hypolipidemic potential. We conducted study on comparison of hypolipidemic effects of these two agents. Study was placebo-controlled conducted in Jinnah Hospital, Lahore from December 2015 to February 2016. Ninety hyperlipidemic patients were divided in three equal groups including 30 patients in each group. Their base line LDL-cholesterol and HDL-cholesterol was determined and kept in their personal file. Group-1 was on placebo, Group-2 was on Vitamin E 400 mg twice daily for two months. Group-3 was on half Kg Jujube per day for two months. After two months therapy their post treatment LDL and HDL-cholesterol was determined. When analyzed statistically, results showed non-significant effects of herbal fruit/drug Jujube on HDL-cholesterol but significant role on LDL-cholesterol reduction. While vitamin E has highly significant reduction potential in LDL-cholesterol and significant effects on HDL-cholesterol with p-value <0.01. We concluded from the study that Z. Jujube has antioxidant potential by lowering LDL-cholesterol in human plasma. But This effect is not comparable with hypolipidemic effects of Vitamin E as it also increases good cholesterol i.e. HDL-cholesterol.

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July 2018
11 Reads

Professor

Effects of Ginger on LDL-C, Total Cholesterol, and Body Weight

HOD

It was research work to see effects of medicinal plant Ginger on body weight, total cholesterol and LDL-Cholesterol in hyperlipidemic patients

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May 2018
10 Reads

Ethics and regulation of inter-country medically assisted reproduction: a call for action.

Isr J Health Policy Res 2016 7;5:59. Epub 2016 Dec 7.

Department of Gynecology, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1186/s13584-016-0117-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142386PMC
January 2018
17 Reads
3 Citations

Effects of butanol fraction of Ziziphus mucronata root ethanol extract on glucose homeostasis, serum insulin and other diabetes-related parameters in a murine model for type 2 diabetes.

Pharm Biol 2017 Dec;55(1):416-422

a School of Life Sciences, University of KwaZulu-Natal (Westville Campus) , Durban , South Africa.

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http://dx.doi.org/10.1080/13880209.2016.1242632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130741PMC
December 2017
26 Reads
1.340 Impact Factor

Expressing and negotiating face in community pharmacist-patient interactions.

Res Social Adm Pharm 2017 11 27;13(6):1110-1126. Epub 2016 Oct 27.

Faculty of Pharmacy and Pharmaceutical Sciences, 3-171, Edmonton Clinic Health Academy, 11405 87 Avenue, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.sapharm.2016.10.003DOI Listing
November 2017
10 Reads
1 Citation

Incidence of depression and anxiety among women newly diagnosed with breast or genital organ cancer in Germany.

Psychooncology 2017 Oct 24;26(10):1535-1540. Epub 2017 Jan 24.

IMS Health, Frankfurt, Germany.

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http://dx.doi.org/10.1002/pon.4328DOI Listing
October 2017
14 Reads
2 Citations
2.443 Impact Factor

Metabolic syndrome and sexual function in postmenopausal women.

Arch Endocrinol Metab 2016 Nov-Dec;60(6):545-553. Epub 2016 Aug 25.

Departamento de Endocrinologia, Ginecologia e Obstetrícia, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz (IFF/Fiocruz), Rio de Janeiro, RJ, Brasil.

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http://dx.doi.org/10.1590/2359-3997000000194DOI Listing
August 2017
11 Reads

Radiation dermatitis caused by a bolus effect from an abdominal compression device.

Med Dosim 2016 2;41(3):221-4. Epub 2016 Jun 2.

Department of Radiation Oncology, University of California, Irvine Medical Center, Orange, CA. Electronic address:

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http://dx.doi.org/10.1016/j.meddos.2016.02.003DOI Listing
August 2017
11 Reads
1 Citation

[Prevalence of thyroid dysfunction in patients with type 2 diabetes mellitus].

Medicina (B Aires) 2016;76(6):355-358

III Cátedra de Patología y Clínica Médica, Facultad de Medicina, Universidad Nacional de Tucumán, Hospital Centro de Salud Zenón J. Santillán, San Miguel de Tucumán, Tucumán, Argentina.

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August 2017
26 Reads
1 Citation
0.421 Impact Factor

Pineal cysts and other pineal region malignancies: determining factors predictive of hydrocephalus and malignancy.

J Neurosurg 2017 Aug 21;127(2):249-254. Epub 2016 Oct 21.

Department of Neurological Surgery, The George Washington University, Washington, DC.

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http://dx.doi.org/10.3171/2016.8.JNS16220DOI Listing
August 2017
23 Reads
1 Citation
3.740 Impact Factor

Risk of Venous Thromboembolism After Laparoscopic Surgery for Gynecologic Malignancy.

J Minim Invasive Gynecol 2016 Nov - Dec;23(7):1057-1062. Epub 2016 Jun 21.

Gynecologic Oncology Division, Ob/Gyn and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jmig.2016.06.011DOI Listing
July 2017
35 Reads
1.575 Impact Factor

Prevalence of molar incisor hypomineralization in school children aged 8-12 years in Chennai.

J Indian Soc Pedod Prev Dent 2016 Apr-Jun;34(2):134-8

Department of Pediatric and Preventive Dentistry, GSL Dental College and Hospital, Rajamundry, Andhra Pradesh, India.

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http://dx.doi.org/10.4103/0970-4388.180438DOI Listing
July 2017
35 Reads
4 Citations

Development of Eudragit RS 100 Microparticles Loaded with Ropinirole: Optimization and In Vitro Evaluation Studies.

AAPS PharmSciTech 2017 Jul 9;18(5):1810-1822. Epub 2016 Nov 9.

Department of Pharmacy, Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.

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http://dx.doi.org/10.1208/s12249-016-0653-5DOI Listing
July 2017
21 Reads
1.780 Impact Factor

[Fetal alloimmune thrombocytopenia in pregnant woman with anti-HPA-1a antibodies].

Ceska Gynekol Summer 2016;81(4):300-303

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June 2017
12 Reads

Oral Administration of Pentoxifylline Reduces Endometriosis-Like Lesions in a Nude Mouse Model.

Reprod Sci 2017 06 12;24(6):911-918. Epub 2016 Oct 12.

1 Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1933719116673198DOI Listing
June 2017
10 Reads
1 Citation
2.230 Impact Factor

Elastic-Net Copula Granger Causality for Inference of Biological Networks.

PLoS One 2016 28;11(10):e0165612. Epub 2016 Oct 28.

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085021PMC
June 2017
8 Reads
2 Citations
3.234 Impact Factor

Changes in Non-Diabetic Comorbid Disease Status Following Laparoscopic Vertical Sleeve Gastrectomy (LVSG) Versus Laparoscopic Roux-En-Y Gastric Bypass (LRYGB) Procedures: a Systematic Review of Randomized Controlled Trials.

Obes Surg 2017 05;27(5):1208-1221

School of Agricultural, Computational and Environmental Sciences, International Centre for Applied Climate Sciences and Centre for Health Sciences Research, University of Southern Queensland, Toowoomba, QLD, Australia.

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http://dx.doi.org/10.1007/s11695-016-2469-5DOI Listing
May 2017
15 Reads
2 Citations
3.750 Impact Factor

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.

Authors:
Christina Fitzmaurice Christine Allen Ryan M Barber Lars Barregard Zulfiqar A Bhutta Hermann Brenner Daniel J Dicker Odgerel Chimed-Orchir Rakhi Dandona Lalit Dandona Tom Fleming Mohammad H Forouzanfar Jamie Hancock Roderick J Hay Rachel Hunter-Merrill Chantal Huynh H Dean Hosgood Catherine O Johnson Jost B Jonas Jagdish Khubchandani G Anil Kumar Michael Kutz Qing Lan Heidi J Larson Xiaofeng Liang Stephen S Lim Alan D Lopez Michael F MacIntyre Laurie Marczak Neal Marquez Ali H Mokdad Christine Pinho Farshad Pourmalek Joshua A Salomon Juan Ramon Sanabria Logan Sandar Benn Sartorius Stephen M Schwartz Katya A Shackelford Kenji Shibuya Jeff Stanaway Caitlyn Steiner Jiandong Sun Ken Takahashi Stein Emil Vollset Theo Vos Joseph A Wagner Haidong Wang Ronny Westerman Hajo Zeeb Leo Zoeckler Foad Abd-Allah Muktar Beshir Ahmed Samer Alabed Noore K Alam Saleh Fahed Aldhahri Girma Alem Mulubirhan Assefa Alemayohu Raghib Ali Rajaa Al-Raddadi Azmeraw Amare Yaw Amoako Al Artaman Hamid Asayesh Niguse Atnafu Ashish Awasthi Huda Ba Saleem Aleksandra Barac Neeraj Bedi Isabela Bensenor Adugnaw Berhane Eduardo Bernabé Balem Betsu Agnes Binagwaho Dube Boneya Ismael Campos-Nonato Carlos Castañeda-Orjuela Ferrán Catalá-López Peggy Chiang Chioma Chibueze Abdulaal Chitheer Jee-Young Choi Benjamin Cowie Solomon Damtew José das Neves Suhojit Dey Samath Dharmaratne Preet Dhillon Eric Ding Tim Driscoll Donatus Ekwueme Aman Yesuf Endries Maryam Farvid Farshad Farzadfar Joao Fernandes Florian Fischer Tsegaye Tewelde G/Hiwot Alemseged Gebru Sameer Gopalani Alemayehu Hailu Masako Horino Nobuyuki Horita Abdullatif Husseini Inge Huybrechts Manami Inoue Farhad Islami Mihajlo Jakovljevic Spencer James Mehdi Javanbakht Sun Ha Jee Amir Kasaeian Muktar Sano Kedir Yousef S Khader Young-Ho Khang Daniel Kim James Leigh Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Wagner Marcenes Desalegn Markos Yohannes A Melaku Kidanu G Meles Walter Mendoza Desalegn Tadese Mengiste Tuomo J Meretoja Ted R Miller Karzan Abdulmuhsin Mohammad Alireza Mohammadi Shafiu Mohammed Maziar Moradi-Lakeh Gabriele Nagel Devina Nand Quyen Le Nguyen Sandra Nolte Felix A Ogbo Kelechi E Oladimeji Eyal Oren Mahesh Pa Eun-Kee Park David M Pereira Dietrich Plass Mostafa Qorbani Amir Radfar Anwar Rafay Mahfuzar Rahman Saleem M Rana Kjetil Søreide Maheswar Satpathy Monika Sawhney Sadaf G Sepanlou Masood Ali Shaikh Jun She Ivy Shiue Hirbo Roba Shore Mark G Shrime Samuel So Samir Soneji Vasiliki Stathopoulou Konstantinos Stroumpoulis Muawiyyah Babale Sufiyan Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bemnet Amare Tedla Gizachew Assefa Tessema J S Thakur Bach Xuan Tran Kingsley Nnanna Ukwaja Benjamin S Chudi Uzochukwu Vasiliy Victorovich Vlassov Elisabete Weiderpass Mamo Wubshet Terefe Henock Gebremedhin Yebyo Hassen Hamid Yimam Naohiro Yonemoto Mustafa Z Younis Chuanhua Yu Zoubida Zaidi Maysaa El Sayed Zaki Zerihun Menlkalew Zenebe Christopher J L Murray Mohsen Naghavi

JAMA Oncol 2017 Apr;3(4):524-548

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2016.5688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103527PMC
April 2017
175 Reads
281 Citations

Single temperature liquefaction process at different operating pHs to improve ethanol production from Indian rice and corn feedstock.

Prep Biochem Biotechnol 2017 Apr 13;47(4):342-348. Epub 2016 Oct 13.

b DuPont Industrial Sciences, Genencor (China) Bio-Products Co. Ltd, Wuxi , Peoples Republic of China.

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http://dx.doi.org/10.1080/10826068.2016.1244687DOI Listing
April 2017
11 Reads
0.700 Impact Factor

The epidemiology of spinal tuberculosis in the United States: an analysis of 2002-2011 data.

Authors:

J Neurosurg Spine 2017 Apr 16;26(4):507-512. Epub 2016 Dec 16.

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http://dx.doi.org/10.3171/2016.9.SPINE16174DOI Listing
April 2017
18 Reads
2 Citations

pH-switchable bacteria detection using zwitterionic fluorescent polymer.

Biosens Bioelectron 2017 Apr 7;90:394-402. Epub 2016 Dec 7.

Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea; Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2016.12.013DOI Listing
April 2017
15 Reads
6.410 Impact Factor

Development of horseradish peroxidase-based cross-linked enzyme aggregates and their environmental exploitation for bioremediation purposes.

J Environ Manage 2017 Mar 12;188:137-143. Epub 2016 Dec 12.

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

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http://dx.doi.org/10.1016/j.jenvman.2016.12.015DOI Listing
March 2017
36 Reads
1 Citation
2.723 Impact Factor

[Analysis of the workload and the use of the nursing resources in an intensive care unit].

Enferm Intensiva 2015 Apr-Jun;26(2):72-81. Epub 2015 Apr 14.

Unidad de Cuidados Intensivos, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, España.

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http://dx.doi.org/10.1016/j.enfi.2015.02.002DOI Listing
March 2017
12 Reads

Impact of the Nordic hamstring and hip extension exercises on hamstring architecture and morphology: implications for injury prevention.

Br J Sports Med 2017 Mar 22;51(5):469-477. Epub 2016 Sep 22.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1136/bjsports-2016-096130DOI Listing
March 2017
25 Reads
3 Citations
5.030 Impact Factor

Urinary tract infection in children after cardiac surgery: Incidence, causes, risk factors and outcomes in a single-center study.

J Infect Public Health 2016 Sep-Oct;9(5):600-10. Epub 2016 Jan 29.

Bioinformatics and Research Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1016/j.jiph.2015.12.017DOI Listing
February 2017
14 Reads
2 Citations

Acute and Long-term Responses to Different Rest Intervals in Low-load Resistance Training.

Int J Sports Med 2017 Feb 16;38(2):118-124. Epub 2016 Dec 16.

Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.

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http://dx.doi.org/10.1055/s-0042-119204DOI Listing
February 2017
13 Reads
2.065 Impact Factor

Impact of hyperlipidemia on alloimmunity.

Curr Opin Organ Transplant 2017 Feb;22(1):14-21

aDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Sackler School of Biomedical Sciences Programs in Immunology and Genetics, Boston, Massachusetts bDepartment of Medicine, MetroWest Medical Center, Framingham, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOT.0000000000000381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425814PMC
February 2017
22 Reads
2.880 Impact Factor

Latency to vaginal mesh exposure with mesh placed abdominally versus vaginally in pelvic floor surgery: A retrospective comparative study.

J Obstet Gynaecol 2017 Feb 14;37(2):238-242. Epub 2016 Dec 14.

a Department of Obstetrics & Gynecology, Oregon Health & Science University , Portland , OR , USA.

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http://dx.doi.org/10.1080/01443615.2016.1245716DOI Listing
February 2017
23 Reads
0.604 Impact Factor

Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study.

Aliment Pharmacol Ther 2017 02 15;45(4):501-509. Epub 2016 Dec 15.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.1111/apt.13895DOI Listing
February 2017
10 Reads
1 Citation
5.730 Impact Factor

Antidiabetic activity of Embelia ribes, embelin and its derivatives: A systematic review and meta-analysis.

Biomed Pharmacother 2017 Feb 13;86:195-204. Epub 2016 Dec 13.

Department of Pharmacology, D.S.T.S. Mandal's College of Pharmacy, Solapur 413004, Maharashtra, India.

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http://dx.doi.org/10.1016/j.biopha.2016.12.001DOI Listing
February 2017
16 Reads
2.023 Impact Factor

Molecular evidence on the protective effect of ellagic acid on phosalone-induced senescence in rat embryonic fibroblast cells.

Food Chem Toxicol 2017 Feb 11;100:8-23. Epub 2016 Dec 11.

Toxicology and Diseases Group, Pharmaceutical Sciences Research Group, Tehran University of Medical Sciences, Tehran, Iran; International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02786915163046
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http://dx.doi.org/10.1016/j.fct.2016.12.008DOI Listing
February 2017
26 Reads
1 Citation
2.900 Impact Factor

Special electrophysiological characteristics of pediatric idiopathic ventricular tachycardia.

Int J Cardiol 2017 Jan 29;227:595-601. Epub 2016 Oct 29.

Department of Pediatrics, National Taiwan University Hospital and National Taiwan University Children Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.10.092DOI Listing
January 2017
13 Reads
4.040 Impact Factor

Structural and functional annotation of human FAM26F: A multifaceted protein having a critical role in the immune system.

Gene 2017 Jan 23;597:66-75. Epub 2016 Oct 23.

Basic Sciences Research, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, 54000, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2016.10.029DOI Listing
January 2017
23 Reads
2.140 Impact Factor

Disordered ferromagnetism in HoNiMnO double perovskite.

J Phys Condens Matter 2017 Jan 14;29(2):025804. Epub 2016 Nov 14.

Department of Physics, Indian Institute of Science, Bangalore 560012, India.

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http://dx.doi.org/10.1088/0953-8984/29/2/025804DOI Listing
January 2017
32 Reads
2.350 Impact Factor

Composition of Unrecorded Distilled Alcohol (bai jiu) Produced in Small Rural Factories in Central China.

Alcohol Clin Exp Res 2017 01 16;41(1):207-215. Epub 2016 Dec 16.

Key Laboratory of Industrial Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, China.

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http://dx.doi.org/10.1111/acer.13280DOI Listing
January 2017
10 Reads
1 Citation
3.210 Impact Factor

Rapid drug-susceptibility testing of Mycobacterium tuberculosis clinical isolates to first-line antitubercular drugs by nitrate reductase assay: A comparison with proportion method.

Int J Mycobacteriol 2016 12 25;5(4):469-474. Epub 2016 Jun 25.

Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2016;v
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http://dx.doi.org/10.1016/j.ijmyco.2016.06.006DOI Listing
December 2016
16 Reads

Signatures of Size-Dependent Structural Patterns in Hydrated Copper(I) Clusters, Cu(HO).

J Phys Chem A 2016 Dec 16;120(51):10252-10263. Epub 2016 Dec 16.

Department of Chemistry, University of Utah , 315 South 1400 East, Salt Lake City, Utah 84112, United States and.

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http://dx.doi.org/10.1021/acs.jpca.6b10346DOI Listing
December 2016
4 Reads
2.693 Impact Factor

Atopy patch test in children with atopic dermatitis.

Ann Allergy Asthma Immunol 2016 12;117(6):668-673

Division of Allergy and Immunology, Faculty of Medicine, Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1016/j.anai.2016.09.446DOI Listing
December 2016
15 Reads
1 Citation
2.600 Impact Factor

Metal catalyst free cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines in TFA alone: a new synthesis of indolophenazines.

Org Biomol Chem 2016 Dec;15(1):82-87

Dr Reddy's Institute of Life Sciences, Hyderabad Central University, Campus, Gachibowli, Hyderabad-500 046, India.

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http://dx.doi.org/10.1039/c6ob02340aDOI Listing
December 2016
14 Reads
3.562 Impact Factor

Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.

Pharm Biol 2016 1;54(4):686-91. Epub 2015 Oct 1.

a Department of Pharmacognosy and Pharmaceutical Botany , Faculty of Pharmaceutical Sciences, Prince of Songkla University , Songkhla , Thailand and.

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http://dx.doi.org/10.3109/13880209.2015.1072566DOI Listing
December 2016
17 Reads
2 Citations
1.340 Impact Factor

Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb.

Fitoterapia 2016 12 28;115:165-172. Epub 2016 Oct 28.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2016.10.011DOI Listing
December 2016
20 Reads
2 Citations
2.220 Impact Factor

Idiomarina tyrosinivorans sp. nov., isolated from estuarine surface water.

Int J Syst Evol Microbiol 2016 Dec 26;66(12):5384-5391. Epub 2016 Sep 26.

1​Department of Soil and Environmental Sciences, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung 402, Taiwan, ROC 2​Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan, ROC.

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http://dx.doi.org/10.1099/ijsem.0.001525DOI Listing
December 2016
9 Reads
2.511 Impact Factor

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study.

Arthritis Res Ther 2016 12 3;18(1):288. Epub 2016 Dec 3.

Unit of Clinical Epidemiology (KEP), Department of Medicine, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13075-016-1174-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135751PMC
December 2016
23 Reads
1 Citation
3.753 Impact Factor

The Fate of Abstracts Presented at the 2013 and 2014 Annual Meetings of the Romanian Society of Gastroenterology and Hepatology.

J Gastrointestin Liver Dis 2016 Dec;25(4):533-536

St. Spiridon Emergency Hospital, Institute of Gastroenterology and Hepatology, Iasi, Romania.

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http://dx.doi.org/10.15403/jgld.2014.1121.254.chiDOI Listing
December 2016
21 Reads
1.850 Impact Factor

Factors associated with No-Shows and rescheduling MRI appointments.

BMC Health Serv Res 2016 12 1;16(1):679. Epub 2016 Dec 1.

King Abdullah International Medical Research Center (KAIMRC), College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1186/s12913-016-1927-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133747PMC
December 2016
12 Reads
1 Citation
1.660 Impact Factor

[Imaging Blood Flow and Pulsation of Retinal Vessels with Full-Field Swept-Source OCT].

Klin Monbl Augenheilkd 2016 Dec 16;233(12):1324-1330. Epub 2016 Dec 16.

Institut für Biomedizinische Optik, Universität zu Lübeck, Lübeck.

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http://dx.doi.org/10.1055/s-0042-120279DOI Listing
December 2016
9 Reads
0.665 Impact Factor

Draft Genome Sequence of Blautia faecis Strain Marseille-P328, Isolated from the Human Ascending Colon.

Genome Announc 2016 Dec 15;4(6). Epub 2016 Dec 15.

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, CNRS (UMR 7278), IRD (198), INSERM (U1095), AMU, UM63), Institut Hospitalo-Universitaire Méditerranée-Infection, Faculté de Médecine, Aix-Marseille Université, Marseille, France

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http://dx.doi.org/10.1128/genomeA.01383-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159572PMC
December 2016
51 Reads
1 Citation

Chlorhexidine-related refractory anaphylactic shock: a case successfully resuscitated with extracorporeal membrane oxygenation.

J Clin Anesth 2016 Nov 3;34:654-7. Epub 2016 Aug 3.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2016.07.002DOI Listing
November 2016
16 Reads
1.210 Impact Factor

The rising cost of hospital care for children with gastroparesis: 2004-2013.

Neurogastroenterol Motil 2016 Nov 25;28(11):1698-1704. Epub 2016 May 25.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, CA, USA.

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http://dx.doi.org/10.1111/nmo.12869DOI Listing
November 2016
13 Reads
1 Citation
3.590 Impact Factor

Spanish and English Language Symposia to Enhance Activation in Pediatric Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2016 11;63(5):508-511

Division of Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA.

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http://dx.doi.org/10.1097/MPG.0000000000001191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035176PMC
November 2016
12 Reads
2.625 Impact Factor

Zika Virus in Pakistan: A Looming Adversity?

J Coll Physicians Surg Pak 2016 Nov;26(11):943

Department of Cardiac Surgery, Civil Hospital, Karachi.

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http://dx.doi.org/2487DOI Listing
November 2016
14 Reads
0.320 Impact Factor

Adult Celiac Disease: Patients Are Shorter Compared with Their Peers in the General Population.

Middle East J Dig Dis 2016 Oct;8(4):303-309

PhD Candidate in Biostatistics, Department of Epidemiology and Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.15171/mejdd.2016.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145298PMC
October 2016
47 Reads

Optic Disc Drusen in a Pediatric Patient - Diagnosis and Counselling of Family.

J Coll Physicians Surg Pak 2016 Oct;26(10):873

Department of Ophthalmology, Jinnah Postgraduate Medical Centre (JPMC), Karachi.

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http://dx.doi.org/2465DOI Listing
October 2016
9 Reads
0.320 Impact Factor

In vitro effects of different sources of fibrinogen supplementation on clot initiation and stability in a model of dilutional coagulopathy.

Transfus Med 2016 Oct 9;26(5):373-380. Epub 2016 Aug 9.

Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Cologne, Germany.

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http://dx.doi.org/10.1111/tme.12333DOI Listing
October 2016
10 Reads
1 Citation
1.310 Impact Factor

Characterization of the response of taurine protons to PRESS at 9.4 T for Resolving choline and Determining taurine T2.

NMR Biomed 2016 10 5;29(10):1427-35. Epub 2016 Aug 5.

Department of Oncology, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1002/nbm.3588DOI Listing
October 2016
12 Reads
3.044 Impact Factor

Surgical Management of Stones: American Urological Association/Endourological Society Guideline, PART I.

J Urol 2016 Oct 27;196(4):1153-60. Epub 2016 May 27.

American Urological Association Education and Research, Inc., Linthicum, Maryland.

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http://dx.doi.org/10.1016/j.juro.2016.05.090DOI Listing
October 2016
9 Reads
21 Citations
4.471 Impact Factor

Clinically Profiling Pediatric Patients with Dengue.

J Glob Infect Dis 2016 Jul-Sep;8(3):115-20

Department of Microbiology, Indira Gandhi Medical College and Research Institute, Puducherry, India.

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http://dx.doi.org/10.4103/0974-777X.188596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997795PMC
September 2016
17 Reads
1 Citation

How to make stone soup: Is the "Paleo diet" a missed opportunity for anthropologists?

Evol Anthropol 2016 Sep;25(5):228-231

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http://dx.doi.org/10.1002/evan.21504DOI Listing
September 2016
9 Reads

Effects of Tocotrienols on Insulin Secretion-Associated Genes Expression of Rat Pancreatic Islets in a Dynamic Culture.

Front Pharmacol 2016 30;7:291. Epub 2016 Aug 30.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur Malaysia.

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http://dx.doi.org/10.3389/fphar.2016.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003849PMC
September 2016
13 Reads
2 Citations

DIAGNOSIS OF ENDOCRINE DISEASE: The diagnostic performance of adrenal biopsy: a systematic review and meta-analysis.

Eur J Endocrinol 2016 Aug 2;175(2):R65-80. Epub 2016 Jun 2.

Evidence-Based Practice CenterCenter for the Science of Healthcare Delivery, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1530/EJE-16-0297DOI Listing
August 2016
46 Reads
4 Citations
4.070 Impact Factor

Ozurdex in age-related macular degeneration as adjunct to ranibizumab (The OARA Study).

Can J Ophthalmol 2016 Aug 30;51(4):302-305. Epub 2016 Jun 30.

Eye Research Unit, Hamilton Regional Eye Institute, St. Joseph's Healthcare Hamilton, Department of Surgery, McMaster University, Hamilton, Ont.

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http://dx.doi.org/10.1016/j.jcjo.2016.04.020DOI Listing
August 2016
12 Reads
4 Citations
1.300 Impact Factor

Sequencing for LIPA mutations in patients with a clinical diagnosis of familial hypercholesterolemia.

Atherosclerosis 2016 08 9;251:263-265. Epub 2016 Jul 9.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.008DOI Listing
August 2016
15 Reads
1 Citation
3.994 Impact Factor

Impacts of Thermal Treatments on Major and Minor Allergens of Sea Snail, Cerithidea obtusa (Obtuse Horn Shell).

Iran J Allergy Asthma Immunol 2016 Aug;15(4):309-316

Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.

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August 2016
10 Reads
1.013 Impact Factor

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2016 07 13;375(4):311-22. Epub 2016 Jun 13.

From the University of Texas Southwestern Medical Center, Dallas (S.P.M.); Massachusetts General Hospital, Boston (G.H.D.); Novo Nordisk, Bagsvaerd, Denmark (K.B.-F., P.K., L.S.R., M.S.); Friedrich Alexander University of Erlangen, Erlangen (J.F.E.M.), and St. Josef Hospital, Ruhr University, Bochum (M.A.N.) - both in Germany; Cleveland Clinic, Cleveland (S.E.N.); London School of Hygiene and Tropical Medicine Medical Statistics Unit (S.P.) and Imperial College London (N.R.P.), London; George Washington University Medical Center, Washington, DC (W.M.S.); Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto (B.Z.); International Diabetes Center at Park Nicollet, Minneapolis (R.M.B.); and the University of North Carolina School of Medicine, Chapel Hill (J.B.B.).

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http://dx.doi.org/10.1056/NEJMoa1603827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985288PMC
July 2016
55 Reads
359 Citations
55.873 Impact Factor

Retinal Detachment Due to Retinal Dialysis: Surgical Outcome After Scleral Buckling.

Asia Pac J Ophthalmol (Phila) 2015 Sep-Oct;4(5):259-62

From the Department of Ophthalmology, Khyber Girls Medical College, Hayatabad Medical Complex, Peshawar, Pakistan.

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http://dx.doi.org/10.1097/APO.0000000000000084DOI Listing
July 2016
13 Reads
1 Citation

ROLE OF YOGA IN ALIENATING THE MEMORY DECLINE AND FRONTAL LOBE METABOLITE CHANGES IN TYPE 2 DIABETES.

Int J Res Ayurveda Pharm 2016 Jan-Feb;7(1):78-81

Department of Physiology, MediCiti Institute of Medical Sciences, Ghanpur, Medchal, Hyderabad, India.

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http://dx.doi.org/10.7897/2277-4343.07116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933304PMC
July 2016
17 Reads
2 Citations

Apremilast (Otezla). No progress in plaque psoriasis or psoriatic arthritis.

Authors:

Prescrire Int 2016 Jun;25(172):149-51

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June 2016
18 Reads

[Simple bone cyst of the jaw: a retrospective study of 11 cases].

Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Jun;34(3):272-6

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June 2016
12 Reads

Linking of Antitumor trans NHC-Pt(II) Complexes to G-Quadruplex DNA Ligand for Telomeric Targeting.

Bioconjug Chem 2016 06 17;27(6):1456-70. Epub 2016 May 17.

CNRS UMR9187/INSERM U1196, Institut Curie, Centre Universitaire Paris XI , Bâtiments 110-112, 91405 Orsay, France.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00079DOI Listing
June 2016
44 Reads
1 Citation
4.513 Impact Factor

Ameliorating effect of Allium Sativum on high-fat diet induced fatty liver in albino rats.

Pak J Med Sci 2016 Mar-Apr;32(2):403-7

Dr. Hemant Kumar, M Phil, Department of Anatomy, Hamdard University, Karachi - Pakistan.

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http://dx.doi.org/10.12669/pjms.322.9025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859032PMC
May 2016
23 Reads

[Establishment and validation of a neonatal pig model of hemolytic jaundice].

Zhongguo Dang Dai Er Ke Za Zhi 2016 May;18(5):431-4

Department of Neonatology, Suzhou Municipal Hospital, Suzhou, Jiangsu 215002, China.

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May 2016
8 Reads

Dental unit water treatment with hydrogen peroxide and monovalent silver ions artificially contaminated with freshly isolated pathogens.

Ann Ig 2015 Nov-Dec;27(6):789-98

Water Research Foundation (retired), Denver, CO, USA.

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http://dx.doi.org/10.7416/ai.2015.2072DOI Listing
May 2016
11 Reads
1 Citation

Effect of Prebiotic Galacto-Oligosaccharides on Serum Lipid Profile of Hypercholesterolemics.

Probiotics Antimicrob Proteins 2016 Mar;8(1):19-30

Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

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http://dx.doi.org/10.1007/s12602-016-9206-1DOI Listing
March 2016
19 Reads
2 Citations

Antioxidant and antiacetylcholine esterase potential of aerial parts of Conocarpus erectus, Ficus variegata and Ficus maclellandii.

Pak J Pharm Sci 2016 Mar;29(2):489-95

Sustainable Energy Technologies (SET), Center, College of Engineering, PO-Box 800, King Saud University, Riyadh, Saudi Arabia.

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March 2016
26 Reads
0.950 Impact Factor

Antimicrobial dressings for the prevention of catheter-related infections in newborn infants with central venous catheters.

Cochrane Database Syst Rev 2016 Mar 23;3:CD011082. Epub 2016 Mar 23.

Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia, 50603.

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http://dx.doi.org/10.1002/14651858.CD011082.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464939PMC
March 2016
35 Reads
2 Citations

Quality of care in university hospitals in Saudi Arabia: a systematic review.

BMJ Open 2016 Feb 25;6(2):e008988. Epub 2016 Feb 25.

Department of Primary Care and Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-008988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769408PMC
February 2016
24 Reads
1 Citation
2.063 Impact Factor

Predictors for Surgical Referral in Patients With Pancreatic Cystic Lesions Undergoing Endoscopic Ultrasound: Results From a Large Multicenter Cohort Study.

Pancreas 2016 Jan;45(1):51-7

From the *Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, †Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO; ‡Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO; §Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; ∥Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora; and ¶Division of Gastroenterology, Veterans Affairs Medical Center, Denver, CO.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPA.0000000000000386DOI Listing
January 2016
40 Reads
1 Citation
2.960 Impact Factor

The effect of high altitude on endothelial and vascular dysfunction markers in preeclamptic patients.

Acta Physiol Hung 2015 Dec;102(4):391-9

Department of Obstetrics and Gynecology, College of Medicine, King Khalid University , Abha , Saudi Arabia.

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http://dx.doi.org/10.1556/036.102.2015.4.6DOI Listing
December 2015
10 Reads
0.750 Impact Factor

Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents.

Bioorg Chem 2015 Dec 23;63:123-31. Epub 2015 Oct 23.

HEJ, Research Institute of Chemistry, ICCBS, University of Karachi, Karachi 75270, Pakistan.

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http://dx.doi.org/10.1016/j.bioorg.2015.10.005DOI Listing
December 2015
20 Reads
1 Citation
2.150 Impact Factor

Kinetic evaluation of low-grade gliomas in adults before and after treatment with CCNU alone.

J Neurosurg 2015 Nov 26;123(5):1244-6. Epub 2015 Jun 26.

Department of Neurosurgery, University Hospital Center "Mother Theresa," Tirana, Albania; and.

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http://dx.doi.org/10.3171/2014.12.JNS141068DOI Listing
November 2015
18 Reads
3.740 Impact Factor

The Swedish Early Psoriatic Arthritis Registry 5-year Followup: Substantial Radiographic Progression Mainly in Men with High Disease Activity and Development of Dactylitis.

J Rheumatol 2015 Nov 15;42(11):2110-7. Epub 2015 Oct 15.

From the Skåne University Hospital, Center for Medical Imaging and Physiology, Lund; Department of Rheumatology, Uppsala University, Uppsala; Falu Lasarett, Rheumatology, Falun; Umeå University, Public Health and Clinical Medicine/Rheumatology, Umeå; Karolinska University Hospital, Rheumatology, Stockholm; Spenshult Hospital, Rheumatology, Olofström; Lund University, Rheumatology, Skåne University Hospital, Malmö, Sweden.M. Geijer, MD, PhD, Skåne University Hospital Lund, Center for Medical Imaging and Physiology; U. Lindqvist, MD, PhD, Department of Rheumatology, Uppsala University; T. Husmark, MD, Falu Lasarett, Rheumatology; G.M. Alenius, MD, PhD, Umeå University, Public Health and Clinical Medicine/Rheumatology; P.T. Larsson, MD, PhD, Karolinska University Hospital, Rheumatology; A. Teleman, MD, Spenshult Hospital, Rheumatology; E. Theander, MD, PhD, Lund University, Rheumatology, Skåne University Hospital, Malmö.

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http://dx.doi.org/10.3899/jrheum.150165DOI Listing
November 2015
21 Reads
3.190 Impact Factor

Proteomics Insights into the Biomass Hydrolysis Potentials of a Hypercellulolytic Fungus Penicillium funiculosum.

J Proteome Res 2015 Oct 27;14(10):4342-58. Epub 2015 Aug 27.

Synthetic Biology and Biofuels Group, ‡Malaria Group, and §DBT-ICGEB Centre for Advanced Bioenergy Research, International Centre for Genetic Engineering and Biotechnology , Aruna Asaf Ali Marg, 110 067 New Delhi, India.

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http://dx.doi.org/10.1021/acs.jproteome.5b00542DOI Listing
October 2015
22 Reads
5 Citations
4.250 Impact Factor

Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis.

Gastroenterology 2015 Oct 16;149(4):958-70.e12. Epub 2015 Jun 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1053/j.gastro.2015.06.006DOI Listing
October 2015
35 Reads
20 Citations
16.720 Impact Factor

Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals.

Pharmacogn Mag 2015 Oct;11(Suppl 2):S251-7

King Fahad Medical Research center, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.4103/0973-1296.166017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653335PMC
October 2015
10 Reads
2 Citations
1.110 Impact Factor

Frequency and Appropriateness of Fasting Orders in the Hospital.

Mayo Clin Proc 2015 Sep;90(9):1225-32

Division of Hospital Internal Medicine, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2015.07.013DOI Listing
September 2015
13 Reads
6.260 Impact Factor

The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits.

J Pak Med Assoc 2015 Jun;65(6):620-2

Department of Pharmacology and Therapeutics, BMSI, Jinnah Postgraduate Medical Center (JPMC), Karachi.

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June 2015
22 Reads
6 Citations
0.400 Impact Factor

Male-predominant plasma transfusion strategy for preventing transfusion-related acute lung injury: a systematic review.

Crit Care Med 2015 Jan;43(1):205-25

1Multidisciplinary Epidemiology and Translational Research in Intensive Care (M.E.T.R.I.C.), Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. 2Harvard School of Public Health, Boston, MA. 3University Witten-Herdecke, Witten, Germany. 4Cliniques Universitaires Saint-Luc, Universite' Catholique de Louvain, Bruxelles, Belgium. 5School of Public Health, Imperial College, London, United Kingdom. 6Division of Neurosurgery, Dalhousie University, Halifax, Canada. 7Division of Preventive Medicine, Mayo Clinic, Rochester, MN. 8Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/CCM.0000000000000675DOI Listing
January 2015
31 Reads
5 Citations
6.310 Impact Factor

Recognizing rheumatoid arthritis: oncoprotein survivin opens new possibilities: a population-based case-control study.

Medicine (Baltimore) 2015 Jan;94(4):e468

From the Allergy and Immunology Research Center, Institute of Medical Research, Kuala Lumpur, Malaysia (TCL, SM, JSD); Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm (TCL); Department of Rheumatology and Inflammation Research, Institute of Medicine, the University of Gothenburg, Göteborg, Sweden (ME, MIB); Department of Medicine, Putrajaya Hospital, Putrajaya (HH); and Department of Medicine, Raja Perempuan Bainun Hospital, Ipoh, Perak, Malaysia (WS).

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http://dx.doi.org/10.1097/MD.0000000000000468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602940PMC
January 2015
18 Reads
8 Citations
5.720 Impact Factor

Dual resonant frequencies effects on an induction-based oil palm fruit sensor.

Sensors (Basel) 2014 Nov 19;14(11):21923-40. Epub 2014 Nov 19.

Faculty of Engineering, Shinshu University, Wakasato 4-17-1, Nagano 380-8553, Japan.

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http://dx.doi.org/10.3390/s141121923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279569PMC
November 2014
14 Reads
1 Citation
2.250 Impact Factor

Adult survivor with repaired complete pentalogy of Cantrell.

World J Pediatr Congenit Heart Surg 2014 Oct;5(4):586-8

Department of Pediatric Pulmonary/Sleep Medicine, Nationwide Children's Hospital, The Ohio State University Wexner Medical Center, Columbus, OH, USA

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http://dx.doi.org/10.1177/2150135114540181DOI Listing
October 2014
12 Reads

Frequency and determinants of intracranial atherosclerotic stroke in urban Pakistan.

J Stroke Cerebrovasc Dis 2014 Sep 1;23(8):2174-2182. Epub 2014 Aug 1.

Research Section, Center for Non-Communicable Diseases, Khalid Mehmood Department of Medicine, Dow University of Health Sciences, Civil Hospital, Karachi, Pakistan; Department of Public Health and Primary Care, University of Cambridge, UK; Department of Medicine, University of Pennsylvania, Philadelphia.

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https://linkinghub.elsevier.com/retrieve/pii/S10523057140018
Publisher Site
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.003DOI Listing
September 2014
76 Reads
1.990 Impact Factor

Mutagenic and cytotoxic potential of Endosulfan and Lambda-cyhalothrin - in vitro study describing individual and combined effects of pesticides.

J Environ Sci (China) 2014 Jul 21;26(7):1471-9. Epub 2014 Jun 21.

Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.

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http://dx.doi.org/10.1016/j.jes.2014.05.013DOI Listing
July 2014
10 Reads
2 Citations
2.000 Impact Factor

Off-hour presentation and outcomes in patients with acute ischemic stroke: a systematic review and meta-analysis.

Eur J Intern Med 2014 Apr 12;25(4):394-400. Epub 2014 Apr 12.

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2014.03.012DOI Listing
April 2014
13 Reads
7 Citations
2.300 Impact Factor

Stercoral perforation of the colon in sigmoid colostomy patients: Two case reports.

Int J Surg Case Rep 2013 16;4(11):1038-40. Epub 2013 Sep 16.

Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

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http://dx.doi.org/10.1016/j.ijscr.2013.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825961PMC
November 2013
10 Reads

Design and formulation of mucoadhesive microspheres of sitagliptin.

J Microencapsul 2013 28;30(3):257-64. Epub 2012 Nov 28.

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

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http://dx.doi.org/10.3109/02652048.2012.720722DOI Listing
September 2013
18 Reads
1 Citation
1.580 Impact Factor

Effects of ciprofloxacin and zinc chloride in adult albino rat and pre-natal conceptus.

J Ayub Med Coll Abbottabad 2012 Jan-Mar;24(1):55-8

Department of Anatomy, Shaheed Mohtarma Benazir Bhutto Medical College Lyari Karachi, Pakistan.

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August 2013
32 Reads

MELD-XI score and cardiac mortality or transplantation in patients after Fontan surgery.

Heart 2013 Apr 13;99(7):491-6. Epub 2013 Feb 13.

Department of Cardiology, Boston's Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1136/heartjnl-2012-303347DOI Listing
April 2013
93 Reads
12 Citations
5.590 Impact Factor

Meta-analyses of lightweight versus conventional (heavy weight) mesh in inguinal hernia surgery.

Hernia 2012 Oct 13;16(5):497-502. Epub 2012 Sep 13.

Sunnybank Obesity Centre, Suite 9, McCullough Centre, 259 McCullough Street, Sunnybank, QLD, Australia.

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http://dx.doi.org/10.1007/s10029-012-0987-1DOI Listing
October 2012
12 Reads
2 Citations

Prostate-specific antigen and long-term prediction of prostate cancer incidence and mortality in the general population.

J Clin Oncol 2012 Feb;30(5_suppl)

J. Clin. Oncol.

5 Background: It is largely unknown whether prostate-specific antigen at first date of testing predicts long-term risk of prostate cancer incidence and mortality in the general population. We tested the hypothesis that baseline prostate-specific antigen levels predict long-term risk of prostate cancer incidence and mortality.
Using a prospective study, we examined 4383 20-94 year old men from the Danish general population followed in the Copenhagen City Heart Study from 1981 through 2009. Prostate-specific antigen was measured in plasma samples obtained in 1981-83.
During 28 years of follow-up, 170 men developed prostate cancer and 94 died from prostate cancer. Median follow-up was 18 years (range 0.5-28 years). For prostate cancer incidence, the subhazard ratio was 3.0 (95% confidence interval (CI) 1.9-4.6) for a prostate-specific antigen level of 1.01-2.00 ng/ml, 6.8 (4.2-11) for 2.01-3.00 ng/ml, 6.6 (3.4-13) for 3.01-4.00 ng/ml, 16 (10.4-25) for 4.01-10.00 ng/ml, and 57 (32-104) for >10.00 ng/ml versus 0.01-1.00 ng/ml.. For prostate cancer mortality, corresponding subhazard ratios were 2.2 (1.3-3.9), 5.1 (2.8-9.0), 4.2 (1.8-10), 7.0 (3.8-14), and 14 (6.0-32). For men with prostate-specific antigen levels of 0.01-1.00 ng/ml, absolute 10-year risk of prostate cancer was 0.6% for age <45 years, 0.7% for 45-49 years, 1.1% for 50-54 years, 1.2% for 55-59 years, 1.3% for 60-64 years, 1.1% for 65-69 years, 1.3% for 70-74 years, and 1.5% for age≥75 years; corresponding values for prostate-specific antigen levels >10.00 ng/ml were 35%, 41%, 63%, 71%, 77%, 69%, 75%, and 88%, respectively.
Stepwise increases in prostate-specific antigen at first date of testing predicted a 3-57 fold increased risk of prostate cancer, a 2-16 fold increased risk of prostate cancer mortality, and a 35-88% absolute 10-year risk of prostate cancer in those with prostate-specific antigen levels >10.00 ng/ml. Equally important, absolute 10-year risk of prostate cancer in those with levels 0.01-1.00 ng/ml was only 0.6-1.5%.

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February 2012
10 Reads

Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix.

J Cytol 2012 Jan;29(1):20-5

Departemnt of Pathology, King Edward Medical University, Lahore, Pakistan.

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http://dx.doi.org/10.4103/0970-9371.93213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307446PMC
January 2012
9 Reads
3 Citations
0.410 Impact Factor

A systematic review and meta-analysis of randomized trials of carotid endarterectomy vs stenting.

J Vasc Surg 2011 Mar 8;53(3):792-7. Epub 2011 Jan 8.

Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, Minn 55905, USA.

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http://dx.doi.org/10.1016/j.jvs.2010.10.101DOI Listing
March 2011
12 Reads
8 Citations
3.020 Impact Factor

Phase II trial of bevacizumab (A), lenalidomide (R), docetaxel (D), and prednisone (P) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

J Clin Oncol 2011 Mar;29(7_suppl):138

J. Clin. Oncol.

138 Background: Angiogenesis appears to play critical role in the progression of mCRPC. Previously we have shown anti-tumor activity in mCRPC with the combination of D, thalidomide (T), A and P (Ning JCO 2010). We hypothesized that combining R, an analogue of T, with A, D and P would have a more favorable toxicity profile and similar anti-tumor activity.
All pts had chemotherapy-naïve progressive mCRPC. 6 pts were treated with R at 15 and 20 mg prior to doses at 25 mg. Treatment is 75 mg/m(2) D, 15 mg/kg A every 21 days as one cycle (C), plus 25 mg R for 14 days with daily 10 mg P and enoxaparin. After grade 3 neutropenia was seen in > 80% of pts in all cohorts, the protocol was amended to include prophylactic pegfilgrastim. PSA is tested each C with imaging after C2 and then every 3C. Dental exams with mandible CT's are at baseline, after C5, and then every 6C or earlier if needed.
28 of a planned 51 pts have been enrolled. Pt characteristics include: median age 65.5 [51-78], Gleason score 8 [67.9% 8-10, 32.1% 6-7], on-study PSA 94.3 ng/mL [9.2-3520], and pre-study PSA doubling time 1.43 months [0.52-4.07]. Median C number was 8 [1-21]. 2/28 pts were off study due to clinical or radiographic progression. 26 pts remain on study. 22/24 (91.7%) and 20/24 (83.3%) pts who have completed ≥ 4C had PSA- decline of ≥ 50% and ≥ 75%, respectively. 14 pts with measurable disease were evaluable with 2 CRs (1 unconfirmed), 9 PRs (2 unconfirmed), and 3 SDs (a 78.6% overall RR). Grade ≥ 3 toxicities include neutropenia (16/28), anemia (6/28), thrombocytopenia (3/28), hypertension (1/28), and infection (2/28). 1/28 pts had febrile neutropenia. 8/28 pts (28.6%) developed grade 2 osteonecrosis of the jaw (ONJ), defined as bone death on dental exam, higher than 18.3% as reported by Ning. 5/8 had concomitant and 2/8 pts had history of bisphosphonate use.
Combined therapy with anti-angiogenic agents R and A, plus D and P is associated with high response rates, 91.7% in PSA and 78.6% in measurable disease in mCRPC pts, with manageable toxicities. Further study is underway to characterize the activity and to explore the high incidence of ONJ, including the possibility of ascertainment bias. No significant financial relationships to disclose.

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March 2011
9 Reads

Efficacy and rectal toxicity of hypofractionated radiation therapy with daily image guidance.

J Clin Oncol 2011 Mar;29(7_suppl):85

J. Clin. Oncol.

85 Background: To assess the biochemical control rates and long-term rectal side effect profile of hypofractionated image guided radiation therapy for prostate cancer. We hypothesize that daily CT-based image guidance will allow a higher dose per fraction to be safely administered, shortening the overall treatment time from 8 weeks to 4-5.5 weeks.
160 patients were treated with image guided radiation therapy with or without adjuvant hormonal ablation between 2005 and 2009 for patients <= T3a N0 M0. Patients were classified into risk groups with 51 patients defined as low risk, 67 as intermediate risk, and 43 as high risk. Mean age was 70.2 years. All patients were treated with 60/67.6/70/70.2 Gy to the prostate divided into 20/26/28/27 fractions. 57% of patients received hormone therapy. Daily CT or fiducial-based image guidance was performed prior to each fraction. The median follow up was 34 months. Biochemical control was defined by the Phoenix definition. Rectal toxicity was graded by the CTCAE 4.0 scale. In general patients with rectal bleeding more than once per week were started on rectal steroids.
12/160 (7.5%) of patients had late grade 2 or worse rectal toxicity after radiation treatment. The Kaplan-Meier estimate for grade 2 rectal toxicity at 2 years was 6.9%. The crude rate of biochemical no evidence of disease was 96.3%. Kaplan Meier estimates for biochemical no evidence of disease at 3 and 5 years are 0.98/0.84, 0.97/0.97, and 1.0/0.67 for low, medium, and high-risk patients respectively. Log-rank analysis showed no statistically significant difference among the dosing regimens for toxicity-free survival (p=0.24).
With daily image guidance hypofractionated radiation therapy is clinically safe with moderate late rectal toxicity. Early follow-up suggests high efficacy. Ongoing and future randomized trials such as RTOG 0415 will be required to confirm these findings. No significant financial relationships to disclose.

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March 2011
9 Reads

Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population.

Int J Dermatol 2011 Feb;50(2):221-4

Department of Dermatology, Kuala Lumpur Hospital Allergy and Immunology Research Center, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1111/j.1365-4632.2010.04745.xDOI Listing
February 2011
24 Reads
30 Citations
1.230 Impact Factor

Nephrotoxicity of CDDP assessed estimating glomerular filtration rate with 99mTc-DTPA plasma sample method.

J Coll Physicians Surg Pak 2010 Feb;20(2):98-101

Department of Nuclear Medicine, Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN), Karachi.

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http://dx.doi.org/02.2010/JCPSP.98101DOI Listing
February 2010
12 Reads
1 Citation
0.320 Impact Factor

Toxic effects of multiple anticancer drugs on skin.

Pak J Pharm Sci 2010 Jan;23(1):7-14

Department of Pharmacology, Dow International Medical College & Institute of Basic Medical Sciences, Dow University of Health Sciences, Karachi, Pakistan.

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January 2010
11 Reads
4 Citations
0.950 Impact Factor

Health complaints among subjects involved in oil cleanup operations during oil spillage from a Greek tanker "Tasman Spirit".

Int J Occup Med Environ Health 2009 ;22(2):143-8

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.2478/v10001-009-0011-xDOI Listing
December 2009
19 Reads
7 Citations
1.090 Impact Factor

Clinical presentation and outcomes of patients with biliary malignancies: the Aga Khan University experience.

Asian Pac J Cancer Prev 2009 Jul-Sep;10(3):463-6

Liaqat National Hospital, Karachi, Pakistan.

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November 2009
12 Reads
1 Citation
1.500 Impact Factor

Knowledge and practice of healthy lifestyle and dietary habits in medical and non-medical students of Karachi, Pakistan.

J Pak Med Assoc 2009 Sep;59(9):650-5

Department of Community Health Sciences, The Aga Khan University, Karachi, Pakistan.

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September 2009
20 Reads
9 Citations
0.400 Impact Factor

A new and novel treatment of opioid dependence: Nigella sativa 500 mg.

J Ayub Med Coll Abbottabad 2008 Apr-Jun;20(2):118-24

Department of Pharmacology, Fatima Jinnah Dental College, Karachi.

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http://ayubmed.edu.pk/JAMC/PAST/20-2/Sangi.pdf
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August 2009
44 Reads
4 Citations

Gender differences on bioavailabity of ofloxacin.

J Ayub Med Coll Abbottabad 2008 Apr-Jun;20(2):114-7

Department of Pharmacology, Lahore Medical & Dental College, Lahore, Pakistan.

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August 2009
13 Reads

SLC26A4 mutation spectrum associated with DFNB4 deafness and Pendred's syndrome in Pakistanis.

J Hum Genet 2009 May 13;54(5):266-70. Epub 2009 Mar 13.

National Center of Excellence in Molecular Biology, Punjab University, Lahore, Pakistan.

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http://dx.doi.org/10.1038/jhg.2009.21DOI Listing
May 2009
12 Reads
23 Citations
2.460 Impact Factor

Activity of paclitaxel in radiation induced and other secondary angiosarcomas.

J Clin Oncol 2009 May;27(15_suppl):10578

J. Clin. Oncol.

10578 Background: Angiosarcomas (AS) represent 1-2% of adult soft tissue sarcomas and can arise anywhere in the body. Major predisposing factors are therapeutic radiation and chronic lymphedema. Paclitaxel has shown an exceptionally high activity of 75-89% in angiosarcomas of the face and scalp and to a lesser and less consitent degree of 15-58% in other disease locations. We report on a retrospectice single center experience with chemotherapy in 17 patients (pts.) with secondary angiosarcomas (SAS).
Data from 17 patients were analysed including 15 females and 2 males with a median age of 63 years (range 18-80 years). 12 female patients suffered from angiosarcoma of the breast/thoracic wall following operation and radiation + chemotherapy of a primary breast cancer with an interval of a median of 6 years (range 2-15 years). 1 patient developed a SAS 6 years after resection and radiation of a liposarcoma in the limb. 4 patients were diagnosed with SAS following chronic lymphedema (3 Steward-Treves-Syndrome, interval 8, 9 and 38 years, repectively and 1 connatal lymphedema, interval 18 years).
14/17 pts. received surgery as first treatment for SAS. 10 pts. developed a locoregional recurrence, 1 pt. distant metastases. 3 pts. remain free of disease. 3 pts. were diagnosed with locally advanced/metastatic SAS. Surgery for local recurrence after primary surgery resulted in further recurrence in all cases. All 14 patients with recurrent/metastatic disease were treated with chemotherapy. 12 pts. received paclitaxel at a dose of 175 mg/m(2) q3w or 50-70 mg/m(2) q1w as first- or second-line therapy. Responses were 8 PR with a median PFS of 6 months (range 3-23 months), and 1 SD (PFS 4 months) with a disease control rate of 75%. 2 pts. are too early to evaluate, 1 pt. showed PD. In only 3/11 cases, pts. responded to Anthracycline-based chemotherapy.
Paclitaxel shows high activity in SAS, comparable to the results in face and scalp angiosarcomas and can be considered a standard treatment option. No significant financial relationships to disclose.

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May 2009
10 Reads

Anti-Mullerian hormone (AMH) and ovarian function in young breast cancer (BC) women receiving adjuvant chemoterapy (CT).

J Clin Oncol 2009 May;27(15_suppl):e11544

J. Clin. Oncol.

e11544 Background: Fertility loss is a main side effect of adjuvant CT in young women with BC. AMH was evaluated as a potential marker of residual ovarian function after CT.
AMH (ng/mL), FSH (mIU/mL), E2 (pg/mL) and menstrual activity were evaluated before CT and every 3 months after CT in pre-menopausal BC patients ( pts ) enrolled in a phase III study evaluating the role of triptorelin in the prevention of CT-induced early menopause. Means were compared with Student t test for paired data, anova or ancova. The effect of age, CT regimen, FSH and AMH on time to menstrual resumption was investigated by means of the Cox's proportional hazards model.
Among 26 evaluable pts at baseline, mean age was 39 years (range 27-45). Baseline mean values were: FSH 5.67 (SD 4.88), E2 151.81 (SD 134.9), AMH 2.67 (SD 1.85). Levels of AMH were significantly lower (1.26) in old pts ( ≥ 41 yrs) as compared to younger ones (2.97 and 3.63 in 25-36 yrs and 37-40 yrs old women, respectively) (p=0.018). After CT, mean value of AMH significantly decreased from 2.04 ( SD 1.44 ) to 0.59 ( SD 0.59 ) (p=0.0003 ); FSH value increased, from of 8.64 (SD 12.99) to 23.13 (SD 25.80) (p=0.017) and E2 values decreased from 159.71 (SD 147.03) to 73.29 (SD 129.53) (p=0.02). The mean decrease of AMH levels was not affected by the type of CT regimens: -1.50, -1.52 and -1.33 after FEC ⋄ Paclitaxel, FEC ⋄ Taxotere and FEC/CMF, respectively (p=0.97). Among 10 pts with both early (0-5 months) and delayed (6-11 months) post-CT evaluations, no change in AMH values was observed with longer follow up: mean values were 1.49, 0.35 and 0.36, at baseline, after 0-5 months and after 6-11 months, respectively. Menstrual activity resumption occurred in 48% of patients. At multivariate analysis factors significantly associated with the lower probability of menstrual activity resumption after CT were: old age (p=0.05) and chemotherapy with FEC ⋄ docetaxel ( p=0.05 ). In this preliminary analysis baseline and after CT values of AMH were not significantly associated with menstrual resumption.
Adjuvant CT significantly affects the levels of AMH in young women with BC. Further studies are needed to assess the role of AMH as a surrogate of ovarian toxicity induced by CT. No significant financial relationships to disclose.

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May 2009
14 Reads

Randomized phase III comparison of paclitaxel/carboplatin/etoposide versus gemcitabine/irinotecan, both followed by gefitinib, in patients (pts) with carcinoma of unknown primary site (CUP).

J Clin Oncol 2009 May;27(15_suppl):4631

J. Clin. Oncol.

4631 Background: Empiric chemotherapy for pts with CUP has resulted in modest survival improvements. Several regimens have been active in phase II trials, but no randomized comparison of newer regimens have been completed. In this multicenter randomized phase III trial, we compared the efficacy and toxicity of 2 active regimens.
Previously untreated pts with CUP (adenocarcinoma, poorly differentiated adenocarcinoma, poorly differentiated carcinoma, poorly differentiated squamous carcinoma) were eligible. Pts with specific treatable syndromes were excluded. Additional eligibility: ECOG PS 0-2; controlled brain metastases; adequate organ function. Pts were randomized (1:1) to paclitaxel 200mg/m(2) day 1/carboplatin AUC 6.0 day 1/etoposide 50mg/100mg alternating po days 1-10 (PCE) or gemcitabine 1000mg IV days 1, 8/irinotecan 100mg/m(2) IV days 1, 8 (GI). Both regimens were repeated at 21-day intervals for 4-6 courses. Responding/stable pts then received gefitinib 250mg po qd until tumor progression. The primary endpoint was the 2-year survival rate. Initially, a total of 320 pts were planned, to allow detection of a 50% improvement in 2-year survival (from 20% to 30%). However, due to slow accrual, enrollment was stopped after 198 pts were randomized.
Between September 2003 and July 2008, 198 pts were randomized (PCE, 93 patients; GI 105 patients). Pt characteristics were similar in both groups. Median progression-free survival for PCE versus GI was 3.2 months versus 5.3 months, p=0.19. Median overall survivals were 7.4 months (PCE) versus 8.6 months (GI), p=0.34; 2-year survivals were 16% (PCE) and 19% (GI). Response rates were similar (PCE 19%, GI 20%). GI was less toxic, with lower rates of grade 3/4 neutropenia (11% vs. 35%; p< 0.01), febrile neutropenia (0% vs. 9%; p<0.01), thrombocytopenia (3% vs. 8%; p=.05), anemia (3% vs. 9%; p=0.05), and RBC transfusions (10% vs. 24%; p<0.01).
The PCE and GI regimens had comparable efficacy in the treatment of CUP, while the GI regimen was better tolerated. The 2-year survival was similar (16%, 19%). Better treatments are needed for pts with CUP. [Table: see text].

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May 2009
14 Reads

Phase II trial of pharmacodynamically (PDally)-guided optimal biologic dose titration (OBDT) of sorafenib (S) in combination with metronomic cyclophosphamide (mC) in advanced neuroendocrine tumors (aNET).

J Clin Oncol 2009 May;27(15_suppl):3526

J. Clin. Oncol.

3526 Background: There is a paucity of reliable PD assays for guiding individual OBDT. PD effects of kinase inhibitors have been previously measured in static tissues. We developed a dynamic flow-cytometric PD assay that quantitates RAF signal transduction capacity (STC) based on the differential MEK´s phosphor-status in stimulated vs. basal conditions (phosphor-shift [PS]) in PBMCs. In a pilot study of 7 patients (pt) with advanced solid tumors in a phase I trial (unpublished data) the % of PS inhibition (I) 7 days after starting S at 400 mg BID showed a 10-fold interpatient variation and correlation with TTP. PDGFR-B/VEGFR2 blockade plus mC showed synergistic effect in the RIP1-Tag2 mouse NET model (J Clin Oncol. 23:939) In this phase II trial of aNET a double antiagniogenic strategy is undertaken: PD-guided OBDT of S + mC.
Eligibility criteria included: unresectable NET with documented PD within 6 months prior to entry; ECOG 0-2; unlimited prior therapy but S; octreotide allowed.
pt start run-in phase with S at 200mg bid + 50 mg QD fixed dose of mC. After 7 d they escalate to 400 mg BID of S regardless of RAF STC assay results. RAF STC and toxicity are then assessed Q14d, escalating S at 200 mg BID increments until any of the following is achieved: a) 90% RAF STC I; b) maximum S dose of 800 mg BID; or c) intolerable Gr 2 or G3+ toxicity. Once S dose is determined based on these criteria, cycle 1 begins.
Simon 2-stage optimal; P0 = 0.05 P1 = 0.2; α =0.05 β = 0.1.
Accrual: 10 pt M:F = 6:4, islet cell:carcinoid = 5:5, age median 56 (40-79), ECOG 0:1 = 5:5. S doses (mg BID) at cycle 1 were 200 (2 pt)/400 (5)/600 (2)/800 (1); corresponding cycle 1 day 1RAF STC I (%) were 5, 53/94, 100, 95, 16, 65/25, 41/71, respectively (R(2) = 0.13 p = 0.72) Most frequent Gr 3 non-hematologic possibly related adverse events in 30 cycles: hand-foot (2 pt), hypertension, abdominal pain, diarrhea, vomiting, lipase, ileal perforation (1 each). Disease control rate (9 evaluable pt): 78% (95% CI: 52-100%) (1PR, 6 SD).
This approach appears feasible/safe. Large interpatient S dose differences are needed to achieve RAF SCT I/toxicity balance. No S dose-RAF SCT I relation is shown. Disease control rate is promising. No significant financial relationships to disclose.

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May 2009
13 Reads

A randomized phase II trial of two different four-drug combinations in advanced pancreatic adenocarcinoma: Cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel.

J Clin Oncol 2009 May;27(15_suppl):4614

J. Clin. Oncol.

4614 Background: The combination of cisplatin (P), epirubicin (E), 5-fluorouracil (F) and gemcitabine (G) (PEFG regimen) yielded a progression-free survival at 6 months from treatment start (PFS6) of about 50% and a 1-year overall survival (OS) around 40% in patients with advanced pancreatic adenocarcinoma (PA). The current trial was aimed to assess whether the replacement of E with docetaxel (D) may improve PFS6.
Chemo-naive patients with stage III or metastatic PA, age 18-75y, Karnofsky performance status (PS) >50 received P (30 mg/m(2) day 1), G (800 mg/m(2) day 1) and capecitabine (1250 mg/m(2)/day days 1 to 14) and were randomized to receive either D at 25-30 mg/m(2) day 1 (arm A: PDXG regimen) or E at 30 mg/m(2) day 1 (arm B: PEXG regimen). Cycles were repeated every 14 days for a maximum of 6 months. Tumor was assessed by CT scan every 8 weeks. The Fleming design was used to calculate the sample size on the probability of being PFS6 (primary endpoint). Assuming P0=40% and P1=60%, α .05 and β.10, the study was to enroll 52 patients per arm. The regimen had to be considered of interest with > 26 patients being PFS6.
Between July 2005 and September 2008, 105 patients were enrolled at a single institution, stratified by stage and randomized (53 arm A). Patients' characteristics were (A/B): median age 61/59, PS > 70 92/88%, metastatic disease 66/65%; CA19.9 > upper limit of laboratory normal (ULN) 87/90%, median CA19.9 820/755 UI/mL. To date, 46 patients per arm are assessable for the primary endpoint: PFS6 was 58/54%. One- year OS was 41% in both arms. A partial response was observed in 61/37% of patients. Among assessable patients with basal CA19.9 value > ULN (37 per arm), a major biochemical response (reduction >89%) was observed in 46/35% and a minor biochemical response (reduction between 50 and 89%) in 43/35% of patients. Main per cycle G3-4 toxicity was: neutropenia 4/13%, thrombocytopenia 3/2%, anemia 4/3%, fatigue 6/4%.
PEXG yielded similar results when compared to prior series treated by PEFG, suggesting that capecitabine may replace F. The inclusion of D instead of E seems to be promising. The present trial confirms the relevant impact on outcome of advanced PA of four-drug regimens. No significant financial relationships to disclose.

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May 2009
10 Reads

The reliability of HER2-status determination from core-needle-biopsies and surgical specimens: A comparison of two established test methods (IHC, CISH).

J Clin Oncol 2009 May;27(15_suppl):e22141

J. Clin. Oncol.

e22141 Background: A milestone of breast-cancer therapy was the discovery of HER-2 entailing special targeted therapy with improved prognosis. The HER-2-status is routinely assessed through immunohistochemistry (IHC; HercepTest) showing protein over-expression and is double-checked with in-situ-hybridisation (ISH) demonstrating gene amplification in equivocal cases. It is questioned whether these methods achieve identical results in core-needle-biopsies and in excisional tumor specimens.
We performed a retrospective comparative study in order to address these questions. From 01/03-06/08 we collected the HercepTest results from both core-needle-biopsy and surgical specimen of 109 breast cancer patients in our institute and compared these to newly evaluated chromogenic ISH (CISH) results for both specimen types in order to assess the reliability of HER-2- diagnosis of both methodological approaches and of specimen type.
We found no significant difference in the HER- 2-status determined from either needle-biopsies or surgical specimens irrespective of the test used. For the overall comparison (218 specimens) of HercepTest and CISH we found only slight, non-significant deviations. Four cases were CISH-negative in spite of HercepTest scoring of 3+. Vice versa, five out of the total of 38 (17.4%) CISH-positives did not correspond to the HercepTest results of 0 or 1+.
Though not significant, there is some inconsistency in the HER-2-determination depending on the test-method, leaving these cases equivocal. In accordance with the literature, we therefore recommend to at least double-check samples with 2+ in the HercepTest as it is the current standard. Our data support the use of core-needle-biopsy as a reliable tissue sample for HER-2-diagnosis. [Table: see text].

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May 2009
9 Reads

Oxaliplatin-based neoadjuvant chemoradiation for locally advanced rectal cancer.

J Clin Oncol 2009 May;27(15_suppl):e15102

J. Clin. Oncol.

e15102 Background: Preoperative chemoradiation improves local recurrence in patients with locally advanced rectal cancer(1). The survival benefit of 5-FU based chemotherapy with radiation has been questioned(2). Oxaliplatin based protocols have shown promise but the optimal regime remains to be defined(3,4). We report our experience with addition of Oxaliplatin to neoadjuvant chemoradiation for rectal cancer.
For this retrospective study, thirty-six consecutive patients referred for neoadjuvant chemoradiation for rectal cancer between May 2007 and March 2008 were identified. All patients had histologically proven adenocarcinoma, and were clinical stage T3/T4 or N+, except for one who was T2N0. Outcomes of interest were R0 resection rate and pathological complete response rate(pCR). Neoadjuvant treatment consisted of upto 4 cycles of CapOx(oxaliplatin 130 mg/m2, IV, D1, capecitabine (2,000 mg/m2/day, D1-14, q3 weeks), followed by capecitabine(1650mg/m2/day) with concurrent pelvic radiation(50.4Gy/28 fractions). Restaging to assess resectability was done at 4-6 weeks and definitive TME surgery was undertaken 6-8 weeks after end of chemoradiation Results: Thirty patients(oxaliplatin group) received at least 1 cycle of CapOx(range 1-8). Radical radiotherapy to 50.4Gy/28# was completed in 29/36 patients(81%). Surgical resection was undertaken in 24/36 patients(67%). Resection rate, R0 resection rate, pCR and local recurrence rate were 63%(19/30), 95%(18/19), 32%(6/19), and 5%(1/19) in the oxaliplatin group. In patients with low rectal cancer (0-5cm from anal verge), 16/26(62%) underwent resection. Sphincter sparing surgery was carried out in 7 patients, all of whom had received oxaliplatin, giving a sphincter sparing surgery rate of 64%(7/11) in the oxaliplatin group.
Addition of oxaliplatin to neoadjuvant chemoradiation results in a significant number of patients achieving R0 resection, pCR and sphincter sparing surgery, compared to historical controls. No significant financial relationships to disclose.

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May 2009
8 Reads

Effect of ciprofoxacin on growing cartilage in albino rat pups.

J Ayub Med Coll Abbottabad 2006 Jul-Sep;18(3):50-4

Department of Anatomy, Muhammad Medical College, Mirpurkhas.

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April 2007
16 Reads

Homer proteins control neuronal differentiation through IP(3) receptor signaling.

FEBS Lett 2006 Nov 17;580(26):6145-50. Epub 2006 Oct 17.

Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

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http://dx.doi.org/10.1016/j.febslet.2006.10.013DOI Listing
November 2006
10 Reads
2 Citations
3.170 Impact Factor

A randomized clinical trial comparing 50mCi and 100mCi of iodine-131 for ablation of differentiated thyroid cancers.

J Pak Med Assoc 2006 Aug;56(8):353-6

Karachi Institute of Radiotherapy and Neuclear Medicine, Jinnah Postgraduate Medical Centre.

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August 2006
12 Reads
2 Citations
0.400 Impact Factor

Seroprevalence of HBV, HCV and HIV infections among college going first time voluntary blood donors.

J Pak Med Assoc 2006 Jan;56(1 Suppl 1):S24-5

Blood Transfusion Service, Jinnah Postgraduate Medical Centre, Karachi.

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January 2006
11 Reads
3 Citations
0.400 Impact Factor

Clinical research, comparison of the subjective visual function in patients with epiphora and patients with second-eye cataract.

Orbit 2005 Mar;24(1):33-8

Buckinghamshire Hospitals NHS Trust, HP21 8AL, Aylesbury, UK.

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http://dx.doi.org/10.1080/01676830590897155DOI Listing
March 2005
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4 Citations

Simultaneous determination of ofloxacin, tetrahydrozoline hydrochloride, and prednisolone acetate by high-performance liquid chromatography.

J Chromatogr Sci 2002 Sep;40(8):429-33

Jamjoom Pharmaceuticals, Jeddah, Kingdom of Saudi Arabia.

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September 2002
19 Reads
3 Citations
1.360 Impact Factor

Safety of pharmacological (intravenous dipyridamole) stress for Thallium-201 perfusion imaging in patients with coronary artery disease unable to exercise.

J Pak Med Assoc 1994 Oct;44(10):237-9

Atomic Energy Medical Centre, Jinnah Postgraduate Medical Centre, Karachi.

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October 1994
12 Reads
0.400 Impact Factor

Rapid in-office and in-vivo desensitization of an injection phobia utilizing hypnosis.

Authors:
L K Daniels

Am J Clin Hypn 1976 Jan;18(3):200-3

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http://dx.doi.org/10.1080/00029157.1976.10403798DOI Listing
January 1976
12 Reads
1 Citation

Malathion A and B esterases of mouse liver-I.

Biochem Pharmacol 1975 Sep;24(18):1713-7

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September 1975
11 Reads
1 Citation
5.010 Impact Factor