Shad B Smith

Shad B Smith

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Shad B Smith

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Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.

PLoS Genet 2019 Jun 14;15(6):e1008226. Epub 2019 Jun 14.

Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615631PMC
June 2019

Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 Feb;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition.

Mol Pain 2017 Jan-Dec;13:1744806917729306

John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 7John T. Macdonald Foundation.

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http://dx.doi.org/10.1177/1744806917729306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584655PMC
September 2018

Genomics of Cardiovascular Measures of Autonomic Tone.

J Cardiovasc Pharmacol 2018 03;71(3):180-191

Department of Anesthesiology, Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC.

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http://dx.doi.org/10.1097/FJC.0000000000000559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839974PMC
March 2018

Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice.

Neuroreport 2017 Dec;28(18):1215-1220

aDepartment of Anesthesiology, Perioperative Medicine and Pain Management bJohn P. Hussman Institute for Human Genomics cJohn T. Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida dCenter for Pharmacogenetics and Individualized Therapy, University of North Caroline, Eshelman School of Pharmacy, Chapel Hill eDepartment of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1097/WNR.0000000000000872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685868PMC
December 2017

Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.

Mamm Genome 2017 Oct 25;28(9-10):407-415. Epub 2017 May 25.

Department of Pharmacology and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s00335-017-9694-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693610PMC
October 2017

Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification.

J Pain 2016 09;17(9 Suppl):T93-T107

Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.jpain.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193199PMC
September 2016

Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study.

Pain 2016 06;157(6):1266-78

aCenter for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Departments of bBiostatistics and cEndodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA dDepartment of Biostatistics, Harvard University, Boston, MA, USA Departments of eDental Ecology and fEpidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA gDepartment of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA hPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA iDepartment of Neural and Pain Sciences and Brotman Facial Pain Clinic, University of Maryland School of Dentistry, Baltimore, MD, USA jThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1097/j.pain.0000000000000518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949303PMC
June 2016

Modification of COMT-dependent pain sensitivity by psychological stress and sex.

Pain 2016 Apr;157(4):858-67

aThe Alan Edwards Centre for Research on Pain, McGill University, McGill University Genome Building, Montreal, QC, Canada bDepartment of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA cCenter for Pain Research and Innovation, University of North Carolina at Chapel Hill; Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA dDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA eCenter for Translational Pain Medicine, Duke University, Durham, NC, USA fDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA; Brotman Facial Pain Center, University of Maryland School of Dentistry, Baltimore, MD, USA gCenter for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA hDepartment of Community Dentistry and Behavioral Science, University of Florida, College of Dentistry, and Pain, Research and Intervention Center of Excellence, Gainesville, FL, USA iDepartment of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA.

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http://pdfs.journals.lww.com/pain/2016/04000/Modification_of
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/j.pain.0000000000000449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794347PMC
April 2016

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.

PLoS One 2015 3;10(3):e0118273. Epub 2015 Mar 3.

Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, Florida, United States of America; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America; John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America; Bruce W. Carter Miami Veterans Healthcare System, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118273PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347988PMC
January 2016

Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.

J Med Genet 2015 Nov 2;52(11):762-9. Epub 2015 Sep 2.

Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina, USA Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA Department of Orthopedics, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1136/jmedgenet-2015-103142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864963PMC
November 2015

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.

Pain 2014 Nov 16;155(11):2390-9. Epub 2014 Sep 16.

Center for Pain Research and Innovation, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253645PMC
November 2014

Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions.

J Pain 2013 Dec;14(12 Suppl):T116-24

Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2013.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857103PMC
December 2013

Study protocol, sample characteristics, and loss to follow-up: the OPPERA prospective cohort study.

J Pain 2013 Dec;14(12 Suppl):T2-19

Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.jpain.2013.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855654PMC
December 2013

Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study.

J Pain 2013 Dec;14(12 Suppl):T91-101.e1-3

Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.jpain.2013.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855664PMC
December 2013

Facial pain with localized and widespread manifestations: separate pathways of vulnerability.

Pain 2013 Nov 16;154(11):2335-43. Epub 2013 Jul 16.

Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2013.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808468PMC
November 2013

The phenotypic and genetic signatures of common musculoskeletal pain conditions.

Nat Rev Rheumatol 2013 Jun 2;9(6):340-50. Epub 2013 Apr 2.

Regional Center for Neurosensory Disorders, Koury Oral Health Sciences Building, University of North Carolina, Chapel Hill, NC 27599-7455, USA.

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http://dx.doi.org/10.1038/nrrheum.2013.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991785PMC
June 2013

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Authors:
Keri L Monda Gary K Chen Kira C Taylor Cameron Palmer Todd L Edwards Leslie A Lange Maggie C Y Ng Adebowale A Adeyemo Matthew A Allison Lawrence F Bielak Guanjie Chen Mariaelisa Graff Marguerite R Irvin Suhn K Rhie Guo Li Yongmei Liu Youfang Liu Yingchang Lu Michael A Nalls Yan V Sun Mary K Wojczynski Lisa R Yanek Melinda C Aldrich Adeyinka Ademola Christopher I Amos Elisa V Bandera Cathryn H Bock Angela Britton Ulrich Broeckel Quiyin Cai Neil E Caporaso Chris S Carlson John Carpten Graham Casey Wei-Min Chen Fang Chen Yii-Der I Chen Charleston W K Chiang Gerhard A Coetzee Ellen Demerath Sandra L Deming-Halverson Ryan W Driver Patricia Dubbert Mary F Feitosa Ye Feng Barry I Freedman Elizabeth M Gillanders Omri Gottesman Xiuqing Guo Talin Haritunians Tamara Harris Curtis C Harris Anselm J M Hennis Dena G Hernandez Lorna H McNeill Timothy D Howard Barbara V Howard Virginia J Howard Karen C Johnson Sun J Kang Brendan J Keating Suzanne Kolb Lewis H Kuller Abdullah Kutlar Carl D Langefeld Guillaume Lettre Kurt Lohman Vaneet Lotay Helen Lyon Joann E Manson William Maixner Yan A Meng Kristine R Monroe Imran Morhason-Bello Adam B Murphy Josyf C Mychaleckyj Rajiv Nadukuru Katherine L Nathanson Uma Nayak Amidou N'diaye Barbara Nemesure Suh-Yuh Wu M Cristina Leske Christine Neslund-Dudas Marian Neuhouser Sarah Nyante Heather Ochs-Balcom Adesola Ogunniyi Temidayo O Ogundiran Oladosu Ojengbede Olufunmilayo I Olopade Julie R Palmer Edward A Ruiz-Narvaez Nicholette D Palmer Michael F Press Evandine Rampersaud Laura J Rasmussen-Torvik Jorge L Rodriguez-Gil Babatunde Salako Eric E Schadt Ann G Schwartz Daniel A Shriner David Siscovick Shad B Smith Sylvia Wassertheil-Smoller Elizabeth K Speliotes Margaret R Spitz Lara Sucheston Herman Taylor Bamidele O Tayo Margaret A Tucker David J Van Den Berg Digna R Velez Edwards Zhaoming Wang John K Wiencke Thomas W Winkler John S Witte Margaret Wrensch Xifeng Wu James J Yang Albert M Levin Taylor R Young Neil A Zakai Mary Cushman Krista A Zanetti Jing Hua Zhao Wei Zhao Yonglan Zheng Jie Zhou Regina G Ziegler Joseph M Zmuda Jyotika K Fernandes Gary S Gilkeson Diane L Kamen Kelly J Hunt Ida J Spruill Christine B Ambrosone Stefan Ambs Donna K Arnett Larry Atwood Diane M Becker Sonja I Berndt Leslie Bernstein William J Blot Ingrid B Borecki Erwin P Bottinger Donald W Bowden Gregory Burke Stephen J Chanock Richard S Cooper Jingzhong Ding David Duggan Michele K Evans Caroline Fox W Timothy Garvey Jonathan P Bradfield Hakon Hakonarson Struan F A Grant Ann Hsing Lisa Chu Jennifer J Hu Dezheng Huo Sue A Ingles Esther M John Joanne M Jordan Edmond K Kabagambe Sharon L R Kardia Rick A Kittles Phyllis J Goodman Eric A Klein Laurence N Kolonel Loic Le Marchand Simin Liu Barbara McKnight Robert C Millikan Thomas H Mosley Badri Padhukasahasram L Keoki Williams Sanjay R Patel Ulrike Peters Curtis A Pettaway Patricia A Peyser Bruce M Psaty Susan Redline Charles N Rotimi Benjamin A Rybicki Michèle M Sale Pamela J Schreiner Lisa B Signorello Andrew B Singleton Janet L Stanford Sara S Strom Michael J Thun Mara Vitolins Wei Zheng Jason H Moore Scott M Williams Shamika Ketkar Xiaofeng Zhu Alan B Zonderman Charles Kooperberg George J Papanicolaou Brian E Henderson Alex P Reiner Joel N Hirschhorn Ruth J F Loos Kari E North Christopher A Haiman

Nat Genet 2013 Jun 14;45(6):690-6. Epub 2013 Apr 14.

The Center for Observational Research, Amgen, Inc. Thousand Oaks, California, USA.

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http://dx.doi.org/10.1038/ng.2608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694490PMC
June 2013

Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.

Pain 2006 Dec 13;126(1-3):24-34. Epub 2006 Jul 13.

Department of Psychology and Centre for Research on Pain, McGill University, Montreal, Que., Canada.

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http://dx.doi.org/10.1016/j.pain.2006.06.004DOI Listing
December 2006

Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse.

Pain 2006 Sep 11;124(1-2):50-8. Epub 2006 May 11.

Department of Psychology and Centre for Research on Pain, McGill University, Montreal, Que., Canada H3A 1B1.

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http://dx.doi.org/10.1016/j.pain.2006.03.023DOI Listing
September 2006

Social modulation of pain as evidence for empathy in mice.

Science 2006 Jun;312(5782):1967-70

Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1128322
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http://dx.doi.org/10.1126/science.1128322DOI Listing
June 2006

Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains.

Anesthesiology 2005 Oct;103(4):751-8

Department of Psychology and Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/00000542-200510000-00013DOI Listing
October 2005

Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains.

Life Sci 2004 Apr;74(21):2593-604

Department of Psychology Centre for Research on Pain, McGill University, 1205 Dr. Penfield Ave., Montreal QC, Canada H3A 1B1.

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http://dx.doi.org/10.1016/j.lfs.2004.01.002DOI Listing
April 2004

The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.

J Pharmacol Exp Ther 2003 Feb;304(2):547-59

Department of Psychology and Program in Neuroscience, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.

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http://dx.doi.org/10.1124/jpet.102.041889DOI Listing
February 2003