Publications by authors named "Shaban R M Sayed"

4 Publications

  • Page 1 of 1

Green catalyst Cu(II)-enzyme-mediated eco-friendly synthesis of 2-pyrimidinamines as potential larvicides against Culex quinquefasciatus mosquito and toxicity investigation against non-target aquatic species.

Bioorg Chem 2021 Apr 8;109:104697. Epub 2021 Feb 8.

Research Department of Chemistry, Nehru Memorial College (Affiliated to Bharathidasan University), Puthanampatti 621007, Tiruchirappalli District, Tamil Nadu, India. Electronic address:

Novel one-pot multicomponent synthesis of 2-pyrimidinamine derivatives can be achieved via green chemistry, using Cu(II)-tyrosinase enzyme (Cu-Tyr) as a catalyst. This method offers mild reaction conditions and a high yield of derivatives. We synthesised several compounds in this manner and evaluated their larvicidal, and antifeedant activities. Out of the synthesised derivatives, compound 3, with a median lethal dose (LD) of 21.43 µg/mL, was highly active against Culex quinquefasciatus, compared to compounds 1a-m and 2, and the control, hydantocidin. Compounds 1j, 1d, and 1e were low active against C. quinquefasciatus with LD values of 78.46, 78.59, and 79.54 µg/mL, respectively. In antifeedant screening, compounds 1j, 1l, and 2 generated 100% mortality within 24 h against Oreochromis mossambicus at 100 µg/mL, where toxicity was determined as the ratio of the number of dead and live fingerlings (%) at 24 h. In contrast, compounds 1a-f, 1i, 1m, and 3 were less toxic to O. mossambicus as compared to the control, dibromoisophakellin. Therefore, compound 3 had high larvicidal activity against C. quinquefasciatus and was less toxic to non-target aquatic species. Molecular docking studies also supported the finding that compound 3 was an effective larvicide with more inhibition ability than the control hydantocidin (-9.6 vs. -6.1 kcal/mol).
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http://dx.doi.org/10.1016/j.bioorg.2021.104697DOI Listing
April 2021

Metagenomic analysis of microbial community and its role in bioelectrokinetic remediation of tannery contaminated soil.

J Hazard Mater 2021 Jan 21;412:125133. Epub 2021 Jan 21.

Electron Microscope Unit, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia.

Tanneries create a serious threat to the environment by generating a significant amount of toxic metal-containing solid waste. This study deals with the application of bio-electrokinetic remediation (Bio-EK) of tannery effluent contaminated soil (TECS). Metagenomes representing the TECS sample were sequenced using the Illumina HiSeq platform. The bioreduction of hexavalent chromium Cr(VI)to trivalent chromium Cr (III) was achieved by BIO-EK techniques. NGS-data (Next Generation Sequencing) analysis was revealed that Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria, and Planctomycetes were identified in the bio-electrokinetic system. Proteobacteria are responsible for the bioreduction of chromium hexavalent by the formation of FeS particles. The bio-generated FeS particles can be reduced the toxic chromium (VI) to non-toxic chromium (III) in soil. Simultaneously total chromium and organic content were significantly removed in BIO-EK (40 and 290 mg kg) when compared to control soil (182 and 240 mg kg). The presence of pollutant degrading microbes such as Desulfovibrio, Pseudomonas, Bacillus, Clostridium, Halanaerobium enhanced the bioreduction of the chromium during the electrokinetic remediation. This study can be claimed that the microbial cultures assisted electrokinetic remediation of total chromium, organic and iron in the tannery effluent contaminated soil was one of the suitable efficient techniques. In addition, the viability of the new combination technology developed (Electrokinetic + Bio) to treat low-permeability polluted soils was demonstrated.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125133DOI Listing
January 2021

Complete green synthesis of silver-nanoparticles applying seed-borne .

Saudi J Biol Sci 2020 May 19;27(5):1333-1339. Epub 2019 Dec 19.

Botany and Microbiology Department, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.

Seed-borne fungus was examined in this study to investigate its capability of synthesizing silver nanoparticles (Ag-NPs). experiments were conducted using corn-grain contaminating fungal isolate. Ag-NPs detection and characterization were assayed by the aid of spectroscopic techniques. Spectroscopy (energy dispersive), X-ray diffraction, transmission electron-microscope and optical absorption dimensions were employed. Ag-NPs with biosynthesized were used to test invitro against Bipolaris ; the cause of target leaf spot disease on sorghum plants. The myco-synthesis of Ag NPs using was proved in this study. Moreover, was successfully inhibited by such Ag NPs .
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http://dx.doi.org/10.1016/j.sjbs.2019.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182998PMC
May 2020

Bioengineered silver nanoparticles using and its fungicidal activity against .

Saudi J Biol Sci 2017 Nov 14;24(7):1522-1528. Epub 2016 Oct 14.

Chemistry Department, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.

Microorganisms based biosynthesis of nanomaterials has triggered significant attention, due to their great potential as vast source of the production of biocompatible nanoparticles (NPs). Such biosynthesized functional nanomaterials can be used for various biomedical applications. The present study investigates the green synthesis of silver nanoparticles (Ag NPs) using the fungus () which is isolated from cereals. The cell filtrate was used for the reduction of AgNO to Ag NPs. To the best of our knowledge is utilized first time for the preparation of Ag NPs. Several alkaloids and proteins present in the phytopathogenic fungus were mainly responsible for the formation of highly crystalline Ag NPs. The as-synthesized Ag NPs were characterized by using UV-Visible spectroscopy, X-ray diffraction and transmission electron microscopy (TEM). The TEM micrographs have revealed that spherical shaped Ag NPs with polydisperse in size were obtained. These results have clearly suggested that the biomolecules secreted by are mainly responsible for the formation and stabilization of nanoparticles. Furthermore, the antifungal activity of the as-prepared Ag NPs was tested against , which is the major cause of a serious plant disease, known as tomato leaf mold. The synthesized Ag NPs displayed excellent fungicidal activity against the tested fungal pathogen. The extreme zone of reduction occurred at 50 μL, whereas, an increase in the reduction activity is observed with increasing the concentration of Ag NPs. These encouraging results can be further exploited by employing the as synthesized Ag NPs against various pathogenic fungi in order to ascertain their spectrum of fungicidal activity.
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http://dx.doi.org/10.1016/j.sjbs.2016.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169509PMC
November 2017