Publications by authors named "Seyoung Oh"

6 Publications

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Symptom distress and quality of life among Black Americans with cancer and their family caregivers.

Psychooncology 2021 Apr 2. Epub 2021 Apr 2.

School of Nursing, University of Michigan, Ann Arbor, Michigan, USA.

Objective: Black Americans are disproportionately affected by cancer and chronic diseases. Black patients with cancer and their family caregivers may concurrently experience symptoms that influence their wellbeing. This study investigates the influence of mental and physical symptom distress on quality of life (QOL) among Black Americans with cancer and their family caregivers from a dyadic perspective.

Methods: One hundred and fifty-one dyads comprised of a Black American with breast, colorectal, lung or prostate cancer and a Black family caregiver were included in this secondary analysis of pooled baseline data from three studies. Self-reports of problems managing 13 symptoms were used to measure mental and physical symptom distress. Descriptive statistics and the actor-partner interdependence model were used to examine symptom prevalence and the influence of each person's symptom distress on their own and each other's QOL.

Results: Fatigue, sleep problems, pain and mental distress were prevalent. Patients and caregivers reported similar levels of mental distress; however, patients reported higher physical distress. Increased patient mental distress was associated with decreased patient QOL (overall, emotional, social, functional). Increased patient physical distress was associated with decreased patient QOL (overall, physical, emotional, functional) and decreased caregiver emotional wellbeing. Increased caregiver mental distress was associated with decreased caregiver QOL (overall, emotional, social, functional) and decreased patient overall QOL. Increased caregiver physical distress was associated with decreased caregiver QOL (overall, physical, functional), decreased patient emotional wellbeing, and better patient social wellbeing.

Conclusions: Supporting symptom management in Black patient/caregiver dyads may improve their QOL.
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http://dx.doi.org/10.1002/pon.5691DOI Listing
April 2021

Chronic Disease Among African American Families: A Systematic Scoping Review.

Prev Chronic Dis 2020 12 31;17:E167. Epub 2020 Dec 31.

University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Health Behavior, Chapel Hill, North Carolina.

Introduction: Chronic diseases are common among African Americans, but the extent to which research has focused on addressing chronic diseases across multiple members of African American families is unclear. This systematic scoping review summarizes the characteristics of research addressing coexisting chronic conditions among African American families, including guiding theories, conditions studied, types of relationships, study outcomes, and intervention research.

Methods: The literature search was conducted in PsycInfo, PubMed, Social Work Abstracts, Sociological Abstracts, CINAHL, and Family and Society Studies Worldwide to identify relevant articles published from January 2000 through September 2016. We screened the title and abstracts of 9,170 articles, followed by full-text screening of 530 articles, resulting in a final sample of 114 articles. Fifty-seven percent (n = 65) of the articles cited a guiding theory/framework, with psychological theories (eg, social cognitive theory, transtheoretical model) being most prominent. The most common conditions studied in families were depression (70.2%), anxiety (23.7%), and diabetes (22.8%), with most articles focusing on a combination of physical and mental health conditions (47.4%).

Results: In the 114 studies in this review, adult family members were primarily the index person (71.1%, n = 81). The index condition, when identified (79.8%, n = 91), was more likely to be a physical health condition (46.5%, n = 53) than a mental health condition (29.8%, n = 34). Among 343 family relationships examined, immediate family relationships were overwhelmingly represented (85.4%, n = 293); however, extended family (12.0%, n = 41) and fictive kin (0.6%, n = 2) were included. Most (57.0%, n = 65) studies focused on a single category of outcomes, such as physical health (eg, obesity, glycemic control), mental health (eg, depression, anxiety, distress), psychosocial outcomes (eg, social support, caregiver burden), or health behaviors (eg, medication adherence, disease management, health care utilization); however, 43.0% (n = 49) of studies focused on outcomes across multiple categories. Sixteen intervention articles (14.0%) were identified, with depression the most common condition of interest.

Conclusion: Recognizing the multiple, simultaneous health issues facing families through a lens of family comorbidity and family multimorbidity may more accurately mirror the lived experiences of many African American families and better elucidate intervention opportunities than previous approaches.
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http://dx.doi.org/10.5888/pcd17.190431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784550PMC
December 2020

Improvement of the Bias Stress Stability in 2D MoS and WS Transistors with a TiO Interfacial Layer.

Nanomaterials (Basel) 2019 Aug 12;9(8). Epub 2019 Aug 12.

Department of Advanced Material Engineering, Chungbuk National University, Chungdae-ro 1, Seowon-Gu, Cheongju, Chungbuk 28644, Korea.

The fermi-level pinning phenomenon, which occurs at the metal-semiconductor interface, not only obstructs the achievement of high-performance field effect transistors (FETs) but also results in poor long-term stability. This paper reports on the improvement in gate-bias stress stability in two-dimensional (2D) transition metal dichalcogenide (TMD) FETs with a titanium dioxide (TiO) interfacial layer inserted between the 2D TMDs (MoS or WS) and metal electrodes. Compared to the control MoS, the device without the TiO layer, the TiO interfacial layer deposited on 2D TMDs could lead to more effective carrier modulation by simply changing the contact metal, thereby improving the performance of the Schottky-barrier-modulated FET device. The TiO layer could also suppress the Fermi-level pinning phenomenon usually fixed to the metal-semiconductor interface, resulting in an improvement in transistor performance. Especially, the introduction of the TiO layer contributed to achieving stable device performance. Threshold voltage variation of MoS and WS FETs with the TiO interfacial layer was ~2 V and ~3.6 V, respectively. The theoretical result of the density function theory validated that mid-gap energy states created within the bandgap of 2D MoS can cause a doping effect. The simple approach of introducing a thin interfacial oxide layer offers a promising way toward the implementation of high-performance 2D TMD-based logic circuits.
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http://dx.doi.org/10.3390/nano9081155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724147PMC
August 2019

Image-Guided Neutron Capture Therapy Using the Gd-DO3A-BTA Complex as a New Combinatorial Treatment Approach.

Contrast Media Mol Imaging 2018 1;2018:3727109. Epub 2018 Nov 1.

Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 700-721, Republic of Korea.

Gadolinium-neutron capture therapy (Gd-NCT) is based on the nuclear capture reaction that occurs when Gd is irradiated with low energy thermal neutrons to primarily produce gamma photons. Herein, we investigated the effect of neutron capture therapy (NCT) using a small molecular gadolinium complex, Gd-DO3A-benzothiazole (Gd-DO3A-BTA), which could be a good candidate for use as an NCT drug due to its ability to enter the intracellular nuclei of tumor cells. Furthermore, MRI images of Gd-DO3A-BTA showed a clear signal enhancement in the tumor, and the images also played a key role in planning NCT by providing accurate information on the uptake time and duration of Gd-DO3A-BTA. We injected Gd-DO3A-BTA into MDA-MB-231 breast tumor-bearing mice and irradiated the tumors with cyclotron neutrons at the maximum accumulation time (postinjection 6 h); then, we observed the size of the growing tumor for 60 days. Gd-DO3A-BTA showed good therapeutic effects of chemo-Gd-NCT for the tumor models. Simultaneously, the Gd-DO3A-BTA groups ([Gd-DO3A-BTA(+), NCT(+)]) showed a significant reduction in tumor size ( < 0.05), and the inhibitory effect on tumor growth was exhibited in the following order: [Gd-DO3A-BTA(+), NCT(+)] > [Gd-DO3A-BTA(+), NCT(-)] > [Gd-DO3A-BTA(-), NCT(+)] > [Gd-DO3A-BTA(-), NCT(-)]. On day 60, the [Gd-DO3A-BTA(+), NCT(+)] and [Gd-DO3A-BTA(-), NCT(-)] groups exhibited an approximately 4.5-fold difference in tumor size. Immunohistochemistry studies demonstrated that new combinational therapy with chemo-Gd-NCT could treat breast cancer by both the inhibition of tumor cell proliferation and induction of apoptosis-related proteins, with tumor monitoring by MRI.
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http://dx.doi.org/10.1155/2018/3727109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236812PMC
May 2019

Development of a disposable kit with fully automatic self-shielding reactor for [F]FDG synthesis.

Appl Radiat Isot 2018 Jan 26;131:23-29. Epub 2017 Oct 26.

College of Information and Communication Engineering, SungKyunKwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, Republic of Korea. Electronic address:

A self-shielding device for the synthesis of radiopharmaceuticals was developed and fabricated in this study. Radiation exposure was minimized by the self-shielding of the kit, installation of the disposable kit in the auxiliary chamber while in a shielded state, and discharge of the kit into a radioactive waste container upon completion of the synthesis process. The developed self-shielding synthesis kit was tested by synthesizing 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) in order to verify its performance.
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http://dx.doi.org/10.1016/j.apradiso.2017.10.044DOI Listing
January 2018

Development of an 83.2 MHz, 3.2 kW solid-state RF amplifier using Wilkinson power divider and combiner for a 10 MeV cyclotron.

Rev Sci Instrum 2017 Mar;88(3):034706

College of Information and Communication Engineering, Sungkyunkwan University, Suwon 16419, South Korea.

We design a stripline-type Wilkinson power divider and combiner for a 3.2 kW solid-state radio frequency (RF) amplifier module and optimize this setup. A Teflon-based printed circuit board is used in the power combiner to transmit high RF power efficiently in the limited space. The reflection coefficient (S) and insertion loss (S) related to impedance matching are characterized to determine the optimization process. The resulting two-way divider reflection coefficient and insertion loss were -48.00 dB and -3.22 dB, respectively. The two-way power combiner reflection coefficient and insertion loss were -20 dB and -3.3 dB, respectively. Moreover, the 3.2 kW solid-state RF power test results demonstrate that the proposed power divider and combiner exhibit a maximum efficiency value of 71.3% (combiner loss 5%) at 48 V supply voltage.
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http://dx.doi.org/10.1063/1.4978652DOI Listing
March 2017