Publications by authors named "Seyfettin Erdem"

19 Publications

  • Page 1 of 1

Examination of the effects of COVID 19 on corneal endothelium.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 7. Epub 2021 Jun 7.

Department Ophthalmology, Dicle University Medical Faculty, 21280, Sur/Dıyarbakır, Turkey.

Purpose: To demonstrate the effects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy.

Methods: Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining visual acuity, refractive defect detection, anterior and posterior segment examinations, and specular microscopy measurements were calculated from images with at least 100 cells. The mean cell density (CD), mean coefficient of variation (CV), mean hexagonal cell percentage, mean cell area (AVG), and central corneal thickness (CCT) were evaluated.

Results: The mean time from diagnosis of the disease in group 1 was 54.25 ± 6.36 days. The mean time elapsed since the PCR test became negative was 38.45 ± 6.87 days. Only four were treated in the hospital. Specular microscopy data showed that the CD was 2713.56 ± 246.25 and 2845.80 ± 299.27 in groups 1 and 2, respectively (p = 0.003). The CV values were 42.92 ± 6.79 and 40.16 ± 5.97, respectively (p = 0.009). The hexagonality were 46.51 ± 7.35 and 49.12 ± 6.87, respectively (p = 0.024). The AVG was 371.60 ± 34.64 and 353.16 ± 35.29, respectively (p = 0.007). The CCT values were 553.00 ± 73.2, and 526.84 ± 33.57, respectively (p = 0.005).

Conclusion: A decrease in the number of endothelial cells and hexagonal cells (polymorphism) as well as an increase in the cell area change coefficient (polymegatism) and the average cell area were observed from corneal specular microscopic examination of individuals recovering from COVID-19 in the early period of the disease. These results may be important in understanding the systemic effects of the disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-021-05259-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181541PMC
June 2021

Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211010550. Epub 2021 Apr 27.

Department of Ophthalmology, School of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD).

Methods: In this retrospective study, patients were divided into three groups: wet-type AMD ( = 60), dry-type AMD ( = 60), and healthy controls ( = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually.

Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group ( < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group ( < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group ( = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively.

Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/25158414211010550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082999PMC
April 2021

Autonomic dysfunction detection by an automatic pupillometer as a non-invasive test in patients recovered from COVID-19.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: To recognize dysfunctions in the autonomic nervous system (ANS) with changes in dynamic and static pupillary responses in patients who recovered from coronavirus disease-2019 (COVID-19) METHODS: One month after recovery from COVID-19, patients were subjected to eye examinations. Pupillary responses were measured using a pupillometry system. Dynamic pupil parameters (i.e., pupil contraction amplitude, pupil dilatation latency, pupil contraction latency, pupil dilatation duration, pupil dilatation velocity, pupil contraction duration, pupil contraction velocity, resting pupil diameter [PD]) and static pupil parameters (i.e., mesopic PD, scotopic PD, high photopic PD, and low photopic PD) were registered.

Results: Although high photopic and scotopic PDs were significantly higher in patients recovering from COVID-19 than in healthy controls (P = 0.04 and P = 0.002), no statistically significant difference was found in mesopic and low photopic PD (P = 0.19 and P = 0.41). Regarding dynamic pupillometry parameters, resting PD and pupil contraction velocity (P = 0.04 and P = 0.02, respectively) were significantly higher in patients recovering from COVID-19 than in healthy controls (P < 0.001 and P < 0.001, respectively), whereas pupil dilatation latency and pupil contraction duration were lower in these patients than in healthy controls (P = 0.01 and P = 0.008, respectively). No significant differences in pupil contraction amplitude, pupil dilatation duration, pupil contraction latency, and pupil dilatation velocity were found between the study groups (P = 0.93, P = 0.91, P = 0.42, and P = 0.48, respectively).

Conclusion: Pupil responses, which are controlled by the ANS, were impaired in patients recovering from COVID-19. Pupillometry shows promise as a non-invasive, easy-to-apply diagnostic technology for detecting autonomic dysfunction in patients recovering from COVID-19.

Clinical Trial Registration: Not applicable.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-021-05209-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078384PMC
April 2021

Long-term effects of trabeculectomy in primary open-angle glaucoma on segmented macular ganglion cell complex alterations.

Int Ophthalmol 2021 Jun 21;41(6):2249-2263. Epub 2021 Apr 21.

Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: The aim of this study is to compare, using optical coherence tomography (OCT), the changes in the thickness of the macular nerve fiber layer (mNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL) and peripapillary global retinal nerve fiber layer (gRNFL) (in a span of 3 years) in surgically treated eyes with primary open-angle glaucoma (POAG).

Methods: The medical records of 32 consecutive POAG patients who underwent trabeculectomy with mitomycin-C, between January 2013 and December 2014, were retrospectively reviewed. Pre- and postoperative measurements of IOP and OCT were analyzed 1, 2 and 3 years after the operation.

Results: Among all patients, no significant changes in the thickness of the mNFL, mGCL or mIPL were found, with a significant reduction observed only in the IOP values and peripapillary gRNFL thickness during the 3-year postoperative period. In a subgroup analysis based on the preoperative peak IOPs (median value:41 mmHg), the thickness of the mNFL, mGCL and mIPL in the 3-year postoperative period increased significantly in the lower preoperative peak IOP group (IOP < 41 mmHg), whereas the macular OCT parameters in the 3-year postoperative period decreased in the higher preoperative peak IOP group.

Conclusions: Eyes exhibiting lesser preoperative peak IOP demonstrated greater preservation of the layer-by-layer segmented macular ganglion cell complex thickness as compared to eyes exhibiting greater preoperative peak IOP; also when the IOPs determined for the two groups in the period of follow-up were quite comparable.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-021-01840-yDOI Listing
June 2021

Crystalline gene mutations in Turkish children with congenital cataracts.

Int Ophthalmol 2021 Apr 16. Epub 2021 Apr 16.

Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: To detect crystallin gene mutations in Turkish children with congenital cataracts.

Methods: The present study included 56 children (38 males and 18 females) who were diagnosed with congenital cataract in our ophthalmology clinic. The patients' blood samples were collected and sent to the medical genetics laboratory. The samples were assessed using the sequence analysis method, which covered all exons of CRYAA, CRYAB, CRYBB1, CRYBB2, CRYBB3, CRYGC and CRYGD.

Results: In total, 56 patients with congenital cataracts were included in the present study. Of these, 68% were male and 32% were female. The age range of the patients was 2 months to 5 years. The mean age of onset was 21.08 ± 15.15 months. All the patients had bilateral congenital cataracts. The female-to-male ratio was 1:2.1. Mutation analysis was performed to detect possible mutations in CRYAA, CRYAB, CRYBB1, CRYBB2, CRYBB3, CRYGC and CRYGD. Of the four mutations detected, one was novel (c.383A > T in CRYGD) and three were known (c.592C > T in CRYBB2, c.164A > G in CRYGC and c.592C > T in CRYBB2). Two of these three mutations were detected in the same gene (CRYBB2). Crystallin gene mutations were detected in 7% of patients with congenital cataracts (four out of 56 patients) in the present study.

Conclusions: We think that mutations in crystallin genes are responsible for 7% of congenital cataract cases in our country. The detection of these mutations may help in the molecular diagnosis of congenital cataracts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-021-01843-9DOI Listing
April 2021

Retinal Vasculitis Case Developing in the Early Period after COVID-19.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Ophthalmology, Dicle University, Dicle üniversitesi tip fakültesi Göz Hastaliklari Anabilim dali, Sur, Diyarbakir, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1363-1326DOI Listing
April 2021

Macular vessel density in patients recovered from COVID 19.

Photodiagnosis Photodyn Ther 2021 Mar 27;34:102267. Epub 2021 Mar 27.

Dicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey.

Purpose: The purpose is to evaluate macular vascular densities (VDs) using optical coherence tomography angiography (OCTA) in patients effected by coronavirus disease-2019 (COVID-19).

Methods: The superficial (SF) and deep macular VD of 50 patients with SARS CoV2 pneumonia who had positive polymerase chain reaction (PCR) tests and who recovered after receiving treatment and 55 healthy age- and gender-matched controls were compared using OCTA. Blood inflammation parameters were also recorded.

Results: There was no statistically significant difference between the two groups in terms of age and gender (p = 0.147 and p = 0.504, respectively). Nor was there a difference with respect to smokers between the two groups (p = 0.231). In COVID-19 patients, the VDs in superior hemi quadrant, superior quadrant and inferior quadrant, were significantly lower (p = 0.033, p = 0.029 and p = 0.042, respectively) in superficial plexus. It was also significantly lower in parafovea, superior hemi and superior quadrants (p = 0.026, p < 0.001 and p = 0.004, respectively) in deep plexus. In addition, white blood cell and neutrophil counts were significantly negatively correlated with the VD of the deep parafovea, deep superior quadrant and deep superior hemi quadrant (p < 0.05). There was no difference between the patient and control groups in both superficial and deep foveal avascular zone (FAZ) (p = 0.101 and p = 0.691 respectively).

Conclusion: In COVID-19 disease, VD is low in some sectors in both SF and deep layers, but no change in FAZ. The effect of COVID 19 disease on the retina and whether it makes the retina sensitive to damage can only be understood with long-term follow-up.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2021.102267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999941PMC
March 2021

Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?

Int Ophthalmol 2021 Mar 24. Epub 2021 Mar 24.

Department Ophthalmology, Dicle University Medical Faculty, 21280, Diyarbakir, Turkey.

Purpose: We aimed to reveal whether static and dynamic pupillary responses can be used for the detection of autonomic nervous system (ANS) dysfunction in patients with obstructive sleep apnea syndrome (OSAS).

Methods: We included in this study patients with OSAS, who were divided into three groups according to the apnea-hypopnea index (AHI) (group 1, mild [n = 20]; group 2, moderate [n = 20]; and group 3, severe [n = 20]), and healthy controls (group 4, n = 20). Pupillary responses were measured using a pupillometry system.

Results: Static (mesopic PD, P = 0.0019; low photopic PD, P = 0.001) and dynamic pupil responses (resting diameter, P = 0.004; amplitude of pupil contraction, P < 0.001; duration of pupil contraction, P = 0.022; velocity of pupil contraction, P = 0.001; and velocity of pupil dilation, P = 0.012) were affected in patients with different OSAS severities. Also, AHI was negatively correlated with mesopic PD (P = 0.008), low photopic PD (P = 0.003), resting diameter (P = 0.001), amplitude of pupil contraction (P < 0.001), duration of pupil contraction (P = 0.011), velocity of pupil contraction (P < 0.001), and velocity of pupil dilation (P = 0.001).

Conclusion: We detected pupil responses innervated by the ANS were affected in the OSAS patients. This effect was more significant in the severe OSAS patients. Therefore, the pupillometry system can be an easily applicable, noninvasive method to detect ANS dysfunction in the OSA patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-021-01814-0DOI Listing
March 2021

Genetic analysis of patients with primary congenital glaucoma.

Int Ophthalmol 2021 Mar 21. Epub 2021 Mar 21.

Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: To determine the common gene mutation in patients with primary congenital glaucoma (PCG) in the Southeast region of Turkey via genetic analysis and to evaluate whether there were other gene mutations in these patients.

Methods: A total of 25 patients with PCG were included in this study. We performed sequence analysis including all exons of cytochrome p450 1B1 (CYP1B1), myocilin (MYOC), forkhead box C1 (FOXC1), and paired-like homeodomain 2 (PITX2) genes of the obtained samples. Further, we analyzed the results using the Nextgen analysis program.

Results: The CYP1B1 gene mutation was detected in 20 (80%) of 25 patients, and FOXC1 gene mutation was detected in one (4%) patient. The mutation site of nine (45%) of the 20 CYP1B1 genes was found in the second exon. The pathogenic variant (p.Gly61Glu) was observed in 12 (60%) patients (in the first and second exons); the mutation type of six (50%) of these patients was homozygous. The mutation site of one patient with FOXC1 gene mutation was found to be in the first exon; its pathogenic variant was p.Met400lle. The mutation type in this gene was observed to be heterozygous. Lastly, there were no mutations in the MYOC, FOXC1, and PITX2 genes in combination with the CYP1B1 gene mutation.

Conclusion: The most common cause of PCG in our region is the CYP1B1 gene mutation, and the most frequent pathogenic variant is c.182G > A (p.Gly61Glu). We also determined that the CYP1B1 gene mutation was alone and did not occur with other gene mutations (MYOC, FOXC1, and PITX2).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-021-01815-zDOI Listing
March 2021

Bilateral Central Retinal Artery Occlusion Secondary to SARS-CoV-2 Infection in the Early and Late Periods: A Case Report.

Klin Monbl Augenheilkd 2021 Feb 19. Epub 2021 Feb 19.

Ophthalmology, Dicle Üniversitesi Tip Fakültesi, Diyarbakir, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1353-5915DOI Listing
February 2021

Evaluation of anterior segment parameters with Pentacam in children with poorly-controlled type 1 Diabetes Mellitus without diabetic retinopathy.

Photodiagnosis Photodyn Ther 2021 Mar 5;33:102206. Epub 2021 Feb 5.

Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

Purpose: To determine the effect of abnormal glucose metabolism on the cornea, lens, anterior chamber volume (ACV), and anterior chamber depth (ACD) in children with poorly-controlled type 1 diabetes mellitus (DM) without diabetic retinopathy (DR).

Methods: After the complete ophthalmologic examination of children with poorly-controlled (glycosylated hemoglobin [HbA1c] >7.0 %) type 1 DM without DR and age-matched healthy subjects (control group), the central corneal thickness (CCT), keratometry (K) values (Kmean front and back, and Kmax), radius (R) values (Rmin front and back), corneal volume (CV), ACD, ACV, pupil diameter, mean lens density (MLD), lens density standard deviation (LD SD), and maximum lens density (LD max) were measured using Pentacam High Resolution. Endothelial cell density was measured using a specular microscope. The results were assessed and compared between the two groups.

Results: There were 60 patients (38 boys and 22 girls) in the DM group and 30 (14 boys, 16 girls) in the control group. There were considerable differences between the groups in terms of CCT, CV, ACD, MLD, LD SD and LD max, and Kmean back. Further, there was a positive correlation between HbA1c and MLD, LD SD, CV, and CCT in patients with DM.

Conclusion: The results of our study demonstrate that poorly-controlled type 1 DM without DR affects the cornea, ACD, and LD based on anterior segment measurements taken with a Scheimpflug camera. CCT, CV, LD SD, and MLD values may be parameters that can be used to follow-up patients with type 1 DM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2021.102206DOI Listing
March 2021

Evaluation of Ocular Hypoperfusion in Patients with Acromegaly by Using Optical Coherence Tomography Angiography.

Curr Eye Res 2021 Jan 22:1-5. Epub 2021 Jan 22.

Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

: This study aimed to evaluate the retinal blood vessel parameters and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with acromegaly in comparison with healthy controls.: A total of 45 patients with acromegaly and 45 healthy controls were included in this study. In all patients, the vessel density (VD) of the deep and superficial macular vascular networks and the foveal avascular zone (FAZ) were measured using OCTA. The correlation of insulin-like growth factor 1 (IGF-1) level and disease duration with deep macular VD and FAZ values was analyzed. All parameters were registered. Results were assessed and compared between the two groups.: Deep macular plexus VD values were lower in patients with acromegaly compared to the control group. No significant differences in VD values in the superficial segment, except for that in the inferior parafovea ( = .01) were found between the two groups. Furthermore, patients with acromegaly showed enlargement in the superficial ( = .30) and deep FAZ areas ( < .001). IGF-1 level and disease duration showed a significant negative correlation with the deep whole image ( = -0.216, = .041, = -0.339, = .001, respectively), deep parafovea ( = -0.271, = .01; = -0.372, < .001, respectively), deep parafovea superior hemi ( = -0.342, = .001; = -0.350, = .001, respectively), deep parafovea temporal ( = -0.224, = .034; = -0.234, = .026, respectively), deep parafovea nasal ( = -0.320, = .002; = -0.361, < .001, respectively), and deep parafovea superior VD values ( = -0.293, = .005; = -0.307, = .003, respectively) and a significant positive correlation with the deep FAZ area values ( = 0.244, = .02; = 0.329, = .002, respectively).: VD values in the deep macular capillary plexus were lower in patients with acromegaly, and the superficial and deep FAZ area enlarged. Patients with acromegaly may have an increased risk of developing ocular vascular complications. OCTA can be used to evaluate retinal blood VD in patients with acromegaly.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2021.1877311DOI Listing
January 2021

Effect of fasting on diurnal fluctuation of parafoveal and peripapillary vessel density and related oculodynamic and haemodynamic parameters.

Photodiagnosis Photodyn Ther 2021 Mar 28;33:102160. Epub 2020 Dec 28.

Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

Purpose: To investigate the effects of Ramadan fasting on diurnal superficial-deep parafoveal vessel density (pfVD) and nerve head (NH)-radial peripapillary capillary (RPC) peripapillary vessel density (ppVD) using optical coherence tomography angiography (OCTA), as well as other related oculodynamic and haemodynamic parameters, and to compare these findings with those in the nonfasting period in healthy individuals.

Methods: A total of 105 healthy individuals, 42 women and 63 men, were included in this prospective study. OCTA was used to examine the superficial-deep pfVD and NH-RPC ppVD. In the third week of Ramadan, OCTA readings were obtained twice daily at 08:00 and 16:00 hour (h) under fasting conditions and compared with nonfasting values 2 weeks after Ramadan. Both intraocular pressure (IOP) and blood pressure values were assessed accordingly.

Results: The mean age (23-51) of individuals was 34.37 ± 7.04 years. In comparison with the 08:00 -h values, the 16:00 -h IOPs, superficial-deep pfVDs and RPC ppVDs were substantially reduced both during the fasting and nonfasting periods (P = 0.001, P = 0.009, P = 0.006, P = 0.006, P = 0.004, P = 0.004, P = 0.41, P = 0.032 and P = 0.021). No differences were found in the diurnal change of superficial-deep pfVDs, NH-RPC ppVDs, IOPs and mean ocular perfusion pressures (MOPPs) between the fasting and nonfasting periods, whereas the same was not true for mean arterial blood pressures (MABPs) (P = 0.049).

Conclusions: The parafoveal and peripapillary VDs (except for NHpp-VD) and IOPs were found to have decreased significantly throughout the day both in fasting and nonfasting periods. Our study confirms the diurnal changes in the IOPs, MOPPs, superficial-deep pfVDs and NH-RPC ppVDs under dehydration and normal terms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2020.102160DOI Listing
March 2021

The effectiveness of automatic pupillometry as a screening method to detect diabetic autonomic neuropathy.

Int Ophthalmol 2020 Nov 4;40(11):3127-3134. Epub 2020 Jul 4.

Department Ophthalmology, Dicle University Medical Faculty, 21280, Diyarbakır, Turkey.

Purpose: This study aimed to compare static and dynamic pupil responses of diabetic patients with and without nonproliferative diabetic retinopathy (DR) and normal healthy individuals under different lighting conditions via quantitative automated pupillometry.

Methods: Forty patients with DM with nonproliferative DR (group 1), 40 patients with DM without DR (group 2), and 40 healthy controls (group 3) underwent a complete ophthalmologic examination. Static pupillometry [scotopic pupil diameter (PD), mesopic PD, low photopic PD, and high photopic PD] and dynamic pupillometry (resting PD, contraction amplitude, latency, duration, velocity of contraction, dilatation latency, and duration and velocity at rest) were measured via automatic quantitative pupillometry.

Results: Analysis of variance revealed that scotopic PD [F(2, 117) = 6.42; p = 0.02], mesopic PD [F(2, 117) = 3.20; p = 0.04], and low photopic PD [F(2, 117) = 4.86; p = 0.009] were significantly different among the groups. Scotopic PD and low photopic PD were significantly lower in group 1 than in group 2 (p = 0.03 and p = 0.03, respectively). Meanwhile, the resting diameter, velocity of pupil contraction, and velocity of pupil dilatation were found to be significantly lower (p = 0.02, p = 0.01, and p = 0.008, respectively), and the duration of pupil contraction was significantly higher in group 1 than in group 3 (p = 0.03).

Conclusion: Both DM patients with and without nonproliferative DR exhibited pupillary involvement. Automated pupillometry may be an easily applicable, noninvasive screening option for reducing mortality and morbidity rates associated with diabetic autonomic neuropathy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-020-01499-xDOI Listing
November 2020

Is there an association between congenital nasolacrimal duct obstruction and cesarean delivery?

Eur J Ophthalmol 2020 Nov 19;30(6):1228-1231. Epub 2019 Nov 19.

Department of Endocrinology and Metabolic Diseases, Diyarbakır Gazi Yasargil Training and Research Hospital, Diyarbakır, Turkey.

Purpose: The aim of this study was to research the relationship between types of birth and congenital nasolacrimal duct obstruction.

Method: The study enrolled 665 infantile patients with prediagnosis of congenital nasolacrimal duct obstruction due to associated ophthalmic symptoms. Age, gender, family history, delivery type, and patient medical records were investigated. Patients were grouped and compared according to their birth type and whether it was the first birth.

Results: The number of the infants with and without congenital nasolacrimal duct obstruction was 227 (34.1%) and 438 (65.9%), respectively. Comparison of the congenital nasolacrimal duct obstruction and non-congenital nasolacrimal duct obstruction groups according to the first births showed that ratio of cesarean section was significantly higher in the congenital nasolacrimal duct obstruction group than the non- congenital nasolacrimal duct obstruction group (58.7% and 20.7%, respectively). Number with positive family history also was significantly higher in the congenital nasolacrimal duct obstruction group.

Conclusion: Cesarean section in first birth and positive family history of congenital nasolacrimal duct obstruction appear to be important risk factors in the etiopathogenesis of congenital nasolacrimal duct obstruction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672119889522DOI Listing
November 2020

Causes of Blindness among Syrian Refugees Living in Southeastern Turkey.

Authors:
Seyfettin Erdem

Ophthalmic Epidemiol 2019 12 5;26(6):416-419. Epub 2019 Jul 5.

Department of Ophtalmology, Bismil State Hospital, Diyarbakır, Turkey.

This study was conducted to evaluate the causes of blindness in Syrian refugees living in southeastern Turkey. Another aim was to help the authorities determine strategies for dealing with blindness. A detailed ophthalmologic examination, including visual acuity and intraocular pressure, of 253 Syrian refugee patients complaining of visual impairment was conducted between January 2016 and January 2018 at our hospital's outpatient clinic. Of the 253 Syrian refugee patients who visited our outpatient clinic, 176 (69.6%) were female and 77 (30.4%) male. The mean age of the patients was 46.4 ± 20.8 years. 27.3% of the patients were blind (N = 69) and 5.9% of the patients had severe visual impairment (N = 15). The most common causes of blindness were cataract (N = 42, 60.8%), refractive error (N = 8, 11.6%), phthisis (N = 5, 7.3%) and corneal opacity (N = 5, 7.3%). The highest rate of blindness (21.3%) was observed in the subgroup of patients over 40 years of age. Our study showed that Syrian refugees living in southeastern Turkey have been affected by several causes of preventable blindness, although they had free access to public health services in the country. The possible reasons of this situation are difficulties associated with lack of knowledge regarding eye health services and challenges arising from organisational problems related to the delivery of health services. Providing regular eye disease screening programmes and rehabilitation services may be beneficial in preventing blindness in the refugee population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/09286586.2019.1639200DOI Listing
December 2019

Brimonidine-timolol versus brinzolamide-timolol for treatment of elevated intraocular pressure after phacoemulsification surgery.

Int Ophthalmol 2018 Aug 3;38(4):1583-1589. Epub 2017 Jul 3.

Dicle University Medical Faculty, Diyarbakir, Turkey.

Purpose: To compare the efficacy of the fixed combination of brimonidine-timolol (FCBT) and the fixed combination of brinzolamide-timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery.

Methods: A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used. IOP was recorded at preoperative and postoperative hours 6 and 24 and days 3 and 5.

Results: No statistical differences were observed among the groups regarding age, sex and baseline IOP levels (p > 0.05). Mean IOP levels were significantly lower in the treatment groups than in the control group at postoperative hours 6 and 24 and days 3 and 5 (p < 0.001). Administration of one drop of FCBT or FCBZT demonstrated similar effects on preventing IOP spikes within 24 h of phacoemulsification cataract surgery. FCBZT more effectively lowered IOP than FCBT at days 3 and 5 (p < 0.05).

Conclusions: We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-017-0626-zDOI Listing
August 2018

The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever.

Med Hypotheses 2012 Jun 10;78(6):717-20. Epub 2012 Mar 10.

Bitlis State Hospital, Physical Medicine and Rehabilitation Department, Bitlis, Turkey.

Patients with familial Mediterranean fever (FMF) have a susceptibility to the development of multiple sclerosis (MS). Here, we will propose the possible underlying pathophysiological mechanisms of this predisposition. Inflammation, disruption of blood-brain barrier (BBB), mitochondrial energy deficit, demyelination, and axonal damage, which play an important role in the pathogenesis of MS, may occur during the course of FMF. Most FMF patients have homozygous mutations in the MEFV gene that codes for the protein pyrin. Also, pyrin mutations were found about 3.5 times higher in the MS patients than the healthy control group. Pyrin is implicated in the maturation and secretion of the proinflammatory cytokine IL-1β. IL-1β is a major mediator of fever and systemic inflammation, and mononuclear cells from FMF patients release higher levels of IL-1β. Moreover, IL-1 plays a significant role in the regulation of the T-cells, and it is considered an essential cytokine for the Th cell differentiation that implicated in the MS pathogenesis. In addition, endothelial dysfunction and vasculitis in FMF may cause BBB breakdown that is the first step in the development of MS lesions. Apart from this, damage can occur in myelin and mitochondria proteins due to high body temperature that arises during the FMF attacks. Whereas the protein damage in myelin results in demyelination, and the protein damage in mitochondria causes lack of energy. Both situations play a part in the pathogenesis of MS. Due to mitochondrial energy deficit, remyelination may not be achieved, and therefore, axonal damage increases. Thus, at the end of these pathophysiological processes, MS findings may occur in the FMF patients especially with irregular use of colchicine.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2012.02.017DOI Listing
June 2012

Apert's syndrome: ophthalmic importance and clinical findings.

Ann Ophthalmol (Skokie) 2009 ;41(1):44-6

Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.

Apert's syndrome is a rare form of craniosynostosis that exhibits with many ocular manifestations. We present two cases of Apert's syndrome. Our first case is a 10-year-old girl admitted with exotropia, V pattern and proptosis on examination. Investigations revealed coronal craniosynostosis, cleft palate, vaginal atresia and syndactyly of the hands and feet. The second case is a 5-year-old boy presented with hypertelorism, exotropia, dissociated vertical deviation and proptosis. Investigations revealed coronal craniosynostosis, bifid uvula and syndactyly of the hands and feet.
View Article and Find Full Text PDF

Download full-text PDF

Source
June 2009