Publications by authors named "Seyed Mohammad Javad Mortazavi"

61 Publications

How Antivirals Might be Linked to the Emergence of New Variants of SARS-CoV-2.

J Biomed Phys Eng 2021 Apr 1;11(2):123-124. Epub 2021 Apr 1.

PhD, Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.31661/jbpe.v0i0.2101-1275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064135PMC
April 2021

Efficacy of 16S rRNA variable regions high-resolution melt analysis for bacterial pathogens identification in periprosthetic joint infections.

BMC Microbiol 2021 Apr 13;21(1):112. Epub 2021 Apr 13.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Accurate and rapid identification of microorganisms causing periprosthetic joint infections (PJIs) are necessary for choosing an appropriate antibiotic therapy. Therefore, molecular techniques are suggested for diagnosis in suspected PJIs. The Broad-range PCR and High-Resolution Melt Analysis (HRMA) were evaluated for the identification of causative organisms of PJIs in this study.

Results: For 47 of 63 specimens, both the culture and broad-range PCR were positive. The culture was found to be able of organism's detection in 74.6% (47/63) of patients. Of 47 positive cultures, 11 (23.4%) were polymicrobial and 36 (76.59%) were monomicrobial cultures, in which 34 (91.89%) cases were detected by HRM assay. The sensitivity, specificity of HRMA vs monomicrobial culture were 91.89, 93.75%, respectively. The sensitivity, specificity of total HRMA (mono + poly) vs culture were 82.92, 93.75%.

Conclusions: HRM assay coupled with broad-range PCR are effective screening, rapid, and relatively cost-effective methods for discrimination of PJIs especially in aiding culture method. Using computer programs such as the Matlab-2018b program for HRM data analysis is also valuable and helpful in diagnosis.
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http://dx.doi.org/10.1186/s12866-021-02164-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045251PMC
April 2021

Time from Injury Is the Key Predictor of Meniscal Injury in ACL-Deficient Knees.

J Knee Surg 2021 Feb 22. Epub 2021 Feb 22.

Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Science, Tehran, Iran.

The meniscus is one of the most important structures of the knee that needs to be saved if possible. Previous studies showed that increasing time from an anterior cruciate ligament (ACL) injury (TFI) could lead to a meniscal tear, especially medial meniscus (MM). We developed the present study to see if the TFI alone is a predictor of meniscal injury in ACL-deficient knees. We included 111 patients who had a reconstructed ACL injury at our institution from March 2015 to March 2016 in this retrospective cohort study. All demographic data, including age, gender, and body mass index (BMI), were collected. We also recorded the mechanism of injury and the TFI. We extracted the meniscal condition at the time of surgery from the surgical report. All patients were followed up for a mean of 23 months, and the Lysholm score and pain visual analog scale (VAS) score were obtained. The mean TFI of patients with MM tear was 17.4 ± 16.8 months, which was significant than the patients with lateral meniscal (LM) tear (9.3 ± 8.3 months) and intact meniscus (7.4 ± 8.1 months) ( = 0.001). Patients with TFI less than 6 months had a significantly lower rate of MM tear, and increasing TFI more than 6 months could increase the rate of MM tear ( = 0.001). We could not find any association between age, BMI, and gender and meniscal injury. At the latest follow-up, Lysholm and VAS scores in patients with and without meniscal tear were the same. Our study confirms that increasing time from the ACL injury would increase the risk of MM damage. The cutoff point for this risk factor is 6 months from initial injury; therefore, to save the meniscus, it might be better to perform ACL reconstruction within 6 months in ACL-deficient knees.
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http://dx.doi.org/10.1055/s-0040-1722324DOI Listing
February 2021

Cementless total hip arthroplasty in haemophilia patients through direct anterior approach.

Haemophilia 2021 Mar 2;27(2):e239-e244. Epub 2021 Feb 2.

Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Total hip arthroplasty (THA) has become the treatment of choice for patients with severe haemophilic arthropathy of the hip. However, the intraoperative and postoperative complications, including blood loss and infection, are significant concerns. Direct Anterior Approach (DAA) might be beneficial in THA of patients with haemophilia.

Aim: The present study was conducted to assess outcomes of THA using DAA in patients with haemophilia.

Methods: We retrospectively reviewed our joint replacement database. From January 2010 to December 2015, we had 12 patients with haemophilia who underwent 14 THAs by DAA and followed for an average of 69 months.

Results: All patients were male with a mean age of 36 ± 7 years at the time of THA. The mean Harris Hip Score improved from 46 preoperatively to 89 at the final follow-up visit. One dislocation and one infection occurred. Only one patient with simultaneous bilateral THA needed a transfusion. All components were radiologically well fixed at the final follow-up visit except one acetabular loosening that needed revision. All patients were satisfied with the outcome of the surgery at the final follow-up visit.

Conclusion: In this study, it was observed that complications of cementless THA using DAA in haemophilia patients with hip arthropathy are comparable to other surgical approaches. However, the complication of bleeding in this approach might be less.
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http://dx.doi.org/10.1111/hae.14224DOI Listing
March 2021

Contamination and Decontamination of Autologous Bone in the Operating Room: A Systematic Review.

J Orthop Trauma 2021 02;35(2):65-70

Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objective: To perform a systematic review of the literature to determine the rate of contamination of autologous bone fragments inadvertently dropped on the operating room floor, the microbial profile (contaminating organism), and the outcome of intraoperative decontamination techniques in terms of effectiveness and cellular toxicity.

Data Sources: PubMed, Medline, and Embase were searched for English literature published from 1990 through 2020 using terms such as "bone graft contamination," "dropped osteoarticular fragments," "autogenous bone decontamination," and similar interchangeable words.

Study Selection: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Inclusion criteria consisted of all studies on contamination of host bone fragments, means and/or rate of autologous bone contamination in operating rooms, microbial analysis of contaminated bone autograft, outcome of decontamination, and cellular viability after decontamination.

Data Extraction: All potentially eligible studies underwent a full-text review and cross-referencing after title and abstract screening. Data on authors, publication year, study type, means and rate of contamination, microbial profile, decontamination technique, and effectiveness and cellular toxicity outcomes were extracted.

Data Synthesis: Analysis and synthesis of data were performed on Microsoft Excel 2016.

Conclusion: The rate of contamination for dropped osteoarticular or osteochondral host fragment approached 40%. Staphylococcus epidermidis was the most common organism contaminating the bone graft when dropped on the operating room floor. A 5-minute bath in 10% povidone-iodine solution followed by 1-minute bulb syringe lavage with normal saline has proved successful in decontamination and maintenance of cellular viability.

Level Of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
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http://dx.doi.org/10.1097/BOT.0000000000001908DOI Listing
February 2021

Don't worry! The next generation would be more resistant to SARS-CoV-2.

Inflamm Res 2020 Dec 28;69(12):1159-1161. Epub 2020 Sep 28.

Medical Physics and Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1007/s00011-020-01405-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521771PMC
December 2020

Fracture Surgery in Known COVID-19 Infected Patients: What Are the Challenges?

Arch Bone Jt Surg 2020 May;8(3):378-382

Department of Orthopedic Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Surgery in the time of COVID-19 pandemic is a challenging issue while treatment of affected fracture patients is inevitable. The present study summarizes the challenges that an orthopedic surgeon is confronting during the surgical treatment of fracture patients with concomitant COVID-19 infection.

Methods: Demographic and fracture related data of 13 fracture patients with concomitant COVID-19 infection who were treated with surgery was collected from three trauma centers in Tehran and Kermanshah cities from 21, February 2020 to April 3, 2020.

Results: All patients were male with mean age of 38.6±19.5 years. Eight patients had high energy fracture and seven patients had multiple fractures and trauma. Wrist and hand were the common sites of fracture following hip and pelvis. The mean interval time period between the diagnosis of COVID-19 infection and surgery was 2.3±1.5 days. Before surgery, all patients except one had been admitted to the corona dedicated wards, while two patients were admitted to the intensive care unit (ICU). One of the ICU admitted patients died. All the 12 alive patients remained in home isolation after discharge.

Conclusion: Fracture surgery in COVID-19 patients has many challenges such as lack of medical resources, delay of surgery, medial staff fear, and patient isolation. However, a multidisciplinary approach using all potential hospital resources would lead to successful operation and acceptable outcome.
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http://dx.doi.org/10.22038/abjs.2020.47899.2372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358239PMC
May 2020

Total Knee Arthroplasty and Atypical Cartilaginous Tumor/Enchondroma of the Distal Femur.

Arthroplast Today 2020 Sep 22;6(3):521-525. Epub 2020 Jul 22.

Joint Reconstruction Research Center (JRRC), Tehran University of Medical Sciences, Tehran, Iran.

Enchondroma is a common benign chondrogenic tumor, which typically occurs in the short bones of hands and feet. However, when affecting the long bones, it is difficult to rule out the low-grade chondrosarcoma, called atypical cartilaginous tumor (ACT), because of the highly similar clinical and radiologic features. This study reports 2 patients with advanced knee osteoarthritis, scheduled for total knee arthroplasty, who had a distal femoral lesion on imaging suggestive of ACT/enchondroma. We believe that the treatment of these patients could be a challenge for arthroplasty surgeons. This is because it might be difficult to decide whether a periarticular chondral tumor of an osteoarthritic knee is malignant and changes the plan. In this report, we described our approach to address both knee osteoarthritis and ACT/enchondroma of the distal femur. To the best of our knowledge, this issue has not yet been discussed in the literature.
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http://dx.doi.org/10.1016/j.artd.2020.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387675PMC
September 2020

Late-Onset De Novo Genu Recurvatum after Primary Total Knee Arthroplasty: A Potential Indication for Isolated Polyethylene Exchange.

Arthroplast Today 2020 Sep 13;6(3):492-495. Epub 2020 Jul 13.

Joint Reconstruction Research Center (JRRC), Tehran University of Medical Sciences, Tehran, Iran.

Knee instability is the second most common cause of revision after total knee arthroplasty (TKA). Genu recurvatum (GR) is the rarest form of instability usually occurring in patients with underlying conditions such as neuromuscular disorders and fixed valgus deformities. The literature regarding de novo post-TKA GR and its treatment is scarce. In this case series and review of literature, we aimed to review the treatment strategies of post-TKA GR and to present our experience in the treatment of late-onset de novo GR after TKA by isolated polyethylene exchange. To our knowledge, isolated polyethylene exchange has not been so far described for GR correction after TKA. We found a unique wear pattern at the base of the liner post in all 3 patients. They showed a satisfactory outcome with no recurrence on a mean follow-up of 26.67 months.
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http://dx.doi.org/10.1016/j.artd.2020.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358988PMC
September 2020

Point/Counterpoint. Low-dose radiation as a treatment for COVID-19 pneumonia: A threat or real opportunity?

Med Phys 2020 09 19;47(9):3773-3776. Epub 2020 Jul 19.

Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.

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http://dx.doi.org/10.1002/mp.14367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362107PMC
September 2020

The Efficacy of Periodic Complete Blood Count Tests in Evaluation of the Health Status of Radiation Workers in Iran: A Systematic Review.

Iran J Public Health 2020 Apr;49(4):628-636

Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Periodic medical examinations of radiation workers are routinely conducted in many countries. Although low dose radiation (LDR) is not expected to cause a significant effect on blood count, the periodic examination usually includes reviewing the work history, general medical history, a physical examination and collecting a blood sample. Despite lymphocytes are the most sensitive cells to radiation, their counts do not show any significant change as long as the radiation level is less than a few hundreds of millisievert (mSv). In spite of this, in Iran, radiation workers, even those who work in diagnostic radiology departments, are regularly examined for blood count changes.

Methods: After a detailed search in PubMed, ISI, Scopus, SID and Google Scholar, only 12 out of 650 articles matched our criteria. A review of these 12 reports was conducted. The full texts were fully reviewed by the authors.

Results: The complete blood count (CBC) test has a very low efficacy in evaluation of the adverse health effects of ionizing radiation in radiation workers. Therefore, finding alternative methods with a higher efficacy is recommended.

Conclusion: CBC tests cannot be introduced as valid markers of potential radiation effects in most occupational exposures. Given this consideration, in periodic tests of radiation workers, cytogenetic tests can be the gold-standard method. In particular, due to its relatively low cost and good sensitivity and specificity, the dicentric assay can be promising. Moreover, the simple and rapid evaluation of micronuclei by fast automated scoring systems can be a good alternative for current low efficacy CBC tests.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283191PMC
April 2020

Femoral artery intimal injury following total hip arthroplasty through the direct anterior approach: a rare but potential complication.

Arthroplast Today 2019 Sep 27;5(3):288-291. Epub 2019 Jul 27.

Department of General Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Vascular injury following total hip arthroplasty (THA) is a rare but known complication. Various vascular lesions have been described in the literature, with arterial intimal damage being uncommon. Despite the recent popularity of the direct anterior approach in THA, only 1 case of iatrogenic vascular injury has been reported. We report 3 cases of common femoral artery intimal damage with thrombosis following direct anterior THA. We propose that misplacement of the anterior retractor in this approach, especially in certain susceptible patients, can lead to vascular damage. Therefore, maintaining a step-wise approach to placing the retractor with caution is essential. One of our cases had a delayed presentation of undetectable arterial pulse, highlighting the significance of regular postoperative vascular examinations.
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http://dx.doi.org/10.1016/j.artd.2019.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728615PMC
September 2019

The Utility of Leukocyte Esterase Strip Test in the Diagnosis of Pediatric Septic Arthritis.

J Pediatr Orthop 2020 Apr;40(4):e312-e316

Joint Reconstruction Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran.

Background: Most tests used to diagnose pediatric septic arthritis are either not accurate or do not produce rapid results. A leukocyte esterase (LE) strip test has previously been validated for the diagnosis of adult native and periprosthetic joint infections. The purpose of this prospective study was to: (1) evaluate the performance characteristics of the LE strip test in the diagnosis of pediatric septic arthritis and (2) determine the false positive rate of LE strip test on the aseptic synovial fluid (SF).

Methods: Between May 2016 and November 2018, SF was obtained from children who were hospitalized at our tertiary referral center on the basis of suspicion of septic arthritis. All patients underwent arthrocentesis, and the aspirate was tested with LE strip test, leukocyte count, and culture. Twenty-five patients satisfied the inclusion criteria. For the second part of the study, SF from 25 children undergoing surgery for developmental dysplasia of the hip was collected and tested with LE strip test, leukocyte count, and culture.

Results: In the first part of this study, 19 joints were classified as septic and 6 as aseptic. Considering a positive LE strip test ("++" and "+++" readings) indicative of septic arthritis yielded a sensitivity of 100%, specificity of 83%, positive predictive value of 95%, and negative predictive value of 100%. In the second part, all 25 patients with an aseptic SF had a negative test result ("-" and "+" readings).

Conclusions: The LE strip test seems to be a valuable additional tool in the diagnosis of pediatric septic arthritis. The LE strip test has the advantages of being inexpensive and simple, providing real-time results and having a perfect negative predictive value to rule out the diagnosis of septic arthritis.

Level Of Evidence: Level II-diagnostic.
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http://dx.doi.org/10.1097/BPO.0000000000001413DOI Listing
April 2020

Direct and indirect effects of exposure to 900 MHz GSM radiofrequency electromagnetic fields on CHO cell line: Evidence of bystander effect by non-ionizing radiation.

Environ Res 2019 07 26;174:176-187. Epub 2019 Apr 26.

Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran; Department of Diagnostic Imaging, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA. Electronic address:

Introduction: The rapid rise in global concerns about the adverse health effects of exposure to radiofrequency radiation (RFR) generated by common devices such as mobile phones has prompted scientists to further investigate the biological effects of these environmental exposures. Non-targeted effects (NTEs) are responses which do not need a direct exposure to be expressed and are particularly significant at low energy radiations. Although NTEs of ionizing radiation are well documented, there are scarcely any studies on non-targeted responses such as bystander effect (BE) after exposure to non-ionizing radiation. The main goal of this research is to study possible RFR-induced BE.

Material And Methods: Chinese hamster ovary cells were exposed to 900 MHz GSM RFR at an average specific absorption rate (SAR) of 2 W/kg for 4, 12 and 24 hours (h). To generate a uniformly distributed electromagnetic field and avoid extraneous RF exposures a cavity was desined and used. Cell membrane permeability, cell redox activity, metabolic and mitotic cell death and DNA damages were analyzed. Then the most effective exposure durations and statistically significant altered parameters were chosen to assess the induction of BE through medium transfer procedure. Furthermore, intra and extra cellular reactive oxygen species (ROS) levels were measured to assess the molecular mechanism of BE induced by non-ionizing radiation.

Results: No statistically significant alteration was found in cell membrane permeability, cell redox activity, metabolic cell activity and micronuclei (MN) frequency in the cells directly exposed to RFR for 4, 12, or 24 h. However, RFR exposure for 24 h caused a statistically significant decrease in clonogenic ability as well as a statistically significant increase in olive moment in both directly exposed and bystander cells which received media from RFR-exposed cells (conditioned culture medium; CCM). Exposure to RFR also statistically significant elevated both intra and extra cellular levels of ROS.

Conclusion: Our observation clearly indicated the induction of BE in cells treated with CCM. To our knowledge, this is the first report that a non-ionizing radiation (900 MHz GSM RFR) can induce bystander effect. As reported for ionizing radiation, our results proposed that ROS can be a potential molecule in indirect effect of RFR. On the other hand, we found the importance of ROS in direct effect of RFR but in different ways.
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http://dx.doi.org/10.1016/j.envres.2019.03.063DOI Listing
July 2019

Comments on 'Cardiovascular effects of space radiation: Implications for future human deep space exploration'.

Eur J Prev Cardiol 2019 11 18;26(17):1897-1898. Epub 2019 Apr 18.

Diagnostic Imaging Department, Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/2047487319840169DOI Listing
November 2019

Commentary regarding "Factors associated with mental health among high school students in Iran: Does mobile phone overuse associate with poor mental health?"

J Child Adolesc Psychiatr Nurs 2019 05 13;32(2):102-103. Epub 2019 Mar 13.

Department of Occupational Health, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1111/jcap.12226DOI Listing
May 2019

Comments on Ahmad, I.M. et al. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. , 2019, , 12.

Antioxidants (Basel) 2019 Feb 15;8(2). Epub 2019 Feb 15.

Medical Physics Department, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran.

This commentary is regarding the paper recently published by Ahmad et al [...].
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http://dx.doi.org/10.3390/antiox8020042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406610PMC
February 2019

Commentary regarding "on-orbit sleep problems of astronauts and countermeasures".

Mil Med Res 2018 10 30;5(1):38. Epub 2018 Oct 30.

Department of Electrical Engineering, Biophotonics Lab, University of Wisconsin Milwaukee, 3200 N Cramer St, Milwaukee, WI53211, USA.

This commentary addresses the article by Wu et al. entitled "On-orbit sleep problems of astronauts and countermeasures". In this article, the authors discussed the sleep problems of astronauts. Despite its challenging topic, the paper authored by Wu et al. has at least one major shortcoming. This issue is related to the observation that the sleep pattern of astronauts can be disturbed by light flash phenomenon. Since the first report by astronaut E.E. Aldrin in 1969, many astronauts have reported light flashes. These visually perceived flashes of light occurred in different shapes but they apparently moved across the visual field of astronauts and possibly caused, at least to some extent, sleep problems. Moreover, the countermeasures proposed by the authors may improve astronauts' sleep pattern, but they do not address the root cause of the light flashes (i.e., heavy ion interactions outside the shielding provided by the Earth's magnetosphere). A possible approach to reducing light flashes is available using the fact that much of the galactic cosmic radiation (GCR) spectrum is composed of ions that can be diverted from the spacecraft using electromagnetic fields. Possible design parameters and the requisite electric and magnetic field strengths to successfully deflect GCR radiation are outlined.
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http://dx.doi.org/10.1186/s40779-018-0185-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208067PMC
October 2018

Letter by Mortazavi Regarding Article, "Exposure to Low-Dose Ionizing Radiation From Cardiac Procedures and Malignancy Risk in Adults With Congenital Heart Disease".

Circulation 2018 09;138(13):1373-1374

Biophotonics Lab, Department of Electrical Engineering, University of Wisconsin Milwaukee. INIRPRC, Shiraz University of Medical Sciences, Iran.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033817DOI Listing
September 2018

Letter to the Editor Regarding "Wireless Phone Use and Risk of Adult Glioma: Evidence from a Meta-Analysis".

World Neurosurg 2018 11;119:449

Biophotonics Laboratory, Department of Electrical Engineering, University of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2018.06.128DOI Listing
November 2018

Effect of radiofrequency electromagnetic fields (RF-EMFS) from mobile phones on nickel release from orthodontic brackets: An in vitro study.

Int Orthod 2018 09 12;16(3):562-570. Epub 2018 Jul 12.

Ionizing and Non-ionizing Radiation protection Research Center (INIRpRC), Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The worldwide dramatic increase in the use of cell phones has generated great concerns about their potential adverse health effects.

Objective: The aim of the present study was to evaluate the effects of radiofrequency electromagnetic fields (RF-EMFs) emitted from mobile phones on the level of nickel release from orthodontic brackets.

Methods: Twenty stainless steel brackets were divided randomly into experimental and control groups (n=10). Brackets were immersed in artificial saliva at 37°C for 6 months. Experimental group were exposed to GSM 900MHz RF-EMFs emitted from a mobile phone stimulator for 4hours. The specific absorption rate (SAR) was 2.287W/kg. The concentration of nickel in the artificial saliva in both groups was evaluated by using the cold-vapour atomic absorption spectrometry. The Mann-Whitney test was used to assess significant differences in nickel release between the exposed and non-exposed groups.

Results: The mean nickel levels in the exposed and non-exposed groups were 11.95 and 2.89μg/l, respectively. This difference between the concentrations of nickel in the artificial saliva of these groups was statistically significant (P=0.001).

Conclusion: Exposure to RF-EMFs emitted from mobile phones can lead to human exposure to higher levels of nickel in saliva in patients with orthodontic appliances. As nickel exposure can lead to allergic reaction in humans and considering this point that about 10-20% of the population can be hypersensitive to nickel, further studies are needed to evaluate the effects of radiofrequency electromagnetic fields (RF-EMFs) emitted from common devices such as mobile phones or Wi-Fi routers on the level of nickel release from orthodontic brackets.
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http://dx.doi.org/10.1016/j.ortho.2018.06.013DOI Listing
September 2018

Effets des champs électromagnétiques de radiofréquences (CEM-RF) des téléphones mobiles sur la libération du nickel des attaches orthodontiques : étude in vitro.

Int Orthod 2018 09 12;16(3):562-570. Epub 2018 Jul 12.

Ionizing and Non-ionizing Radiation protection Research Center (INIRpRC), Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1016/j.ortho.2018.06.014DOI Listing
September 2018

Women with hereditary breast cancer predispositions should avoid using their smartphones, tablets, and laptops at night.

Iran J Basic Med Sci 2018 Feb;21(2):112-115

Department of Diagnostic Imaging, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

Breast cancer is the most common malignancy among women, both in the developed and developing countries. Women with mutations in the BRCA1 and BRCA2 genes have an increased risk of breast and ovarian cancers. Recent studies show that short-wavelength visible light disturb the secretion of melatonin and causes circadian rhythm disruption. We have previously studied the health effects of exposure to different levels of radiofrequency electromagnetic fields (RF-EMFs) such as mobile phones, mobile base stations, mobile phone jammers, laptop computers, and radars. Moreover, over the past several years, we investigated the health effects of exposure to the short wavelength visible light in the blue region emitted from digital screens. The reduction of melatonin secretion after exposure to blue light emitted from smartphone's screen has been reported to be associated with the negative impact of smartphone use at night on sleep. We have shown that both the blue light and RF-EMFs generated by mobile phones are linked to the disruption of the circadian rhythm in people who use their phones at night. Therefore, if women with hereditary breast cancer predispositions use their smartphones, tablets and laptops at night, disrupted circadian rhythms (suppression of melatonin caused by exposure to blue light emitted from the digital screens), amplifies the risk of breast cancer. It can be concluded that women who carry mutated BRCA1 or BRCA2, or women with family history of breast cancer should avoid using their smartphones, tablets and laptops at night. Using sunglasses with amber lenses, or smartphone applications which decrease the users' exposure to blue light before sleep, at least to some extent, can decrease the risk of circadian rhythm disruption and breast cancer.
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http://dx.doi.org/10.22038/IJBMS.2018.27711.6751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811748PMC
February 2018

Letter to the Editor (July 26, 2017) concerning the paper "Impact of electromagnetic radiation emitted by monitors on changes in the cellular membrane structure and protective antioxidant effect of vitamin A - study".

Int J Occup Med Environ Health 2018 01 5;31(3):371-372. Epub 2017 Dec 5.

Fox Chase Cancer Center, Philadelphia, USA (Department of Diagnostic Imaging).

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http://dx.doi.org/10.13075/ijomeh.1896.01245DOI Listing
January 2018

Comments on analysis of mobile phone use among young patients with brain tumors in Japan.

Bioelectromagnetics 2017 12 5;38(8):653-654. Epub 2017 Oct 5.

Diagnostic Imaging Center, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/bem.22082DOI Listing
December 2017

Development of a bioactive porous collagen/β-tricalcium phosphate bone graft assisting rapid vascularization for bone tissue engineering applications.

J Biomed Mater Res A 2018 Jan 26;106(1):73-85. Epub 2017 Sep 26.

Department of Biomedical Engineering, Islamic Azad University, Yazd Branch, Yazd, Iran.

We developed collagen (COL) and collagen/beta tricalcium phosphate (COL/β-TCP) scaffolds with a β-TCP/collagen weight ratio of 4 by freeze-drying. Mouse bone marrow-derived mesenchymal stem cells (BMMSCs) were cultured on these scaffolds for 14 days. Samples were characterized by physicochemical analyses and their biological properties such as cell viability and alkaline phosphatase (ALP) activity was, also, examined. Additionally, the vascularization potential of the prepared scaffolds was tested subcutaneously in Wistar rats. We observed a microporous structure with large porosity (∼95-98%) and appropriate pore size (120-200 µm). The COL/β-TCP scaffolds had a much higher compressive modulus (970 ± 1.20 KPa) than pure COL (0.8 ± 1.82 KPa). In vitro model of apatite formation was established by immersing the composite scaffold in simulated body fluid for 7 days. An ALP assay revealed that porous COL/β-TCP can effectively activate the differentiation of BMMSCs into osteoblasts. The composite scaffolds also promoted vascularization with good integration with the surrounding tissue. Thus, introduction of β-TCP powder into the porous collagen matrix effectively improved the mechanical and biological properties of the collagen scaffolds, making them potential bone substitutes for enhanced bone regeneration in orthopedic and dental applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 73-85, 2018.
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http://dx.doi.org/10.1002/jbm.a.36207DOI Listing
January 2018

Re: Are electromagnetic fields in incubators a risk factor for autism?

Acta Paediatr 2017 12 24;106(12):2063. Epub 2017 Sep 24.

Diagnostic Imaging Center, Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/apa.14055DOI Listing
December 2017

Association between electromagnetic field exposure and abortion in pregnant women living in Tehran.

Int J Reprod Biomed 2017 Feb;15(2):115-116

Dentomaxillofacial Radiology Department, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405225PMC
February 2017

Sensitivity to Antibiotics of Bacteria Exposed to Gamma Radiation Emitted from Hot Soils of the High Background Radiation Areas of Ramsar, Northern Iran.

Int J Occup Environ Med 2017 04;8(2):80-84

Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses.

Objective: To explore the bacterial susceptibility to antibiotics in samples of subsp. serovar Typhimurium (), , and after exposure to gamma radiation emitted from the soil samples taken from the high background radiation areas of Ramsar, northern Iran.

Methods: Standard Kirby-Bauer test, which evaluates the size of the zone of inhibition as an indicator of the susceptibility of different bacteria to antibiotics, was used in this study.

Results: The maximum alteration of the diameter of inhibition zone was found for when tested for ciprofloxacin. In this case, the mean diameter of no growth zone in non-irradiated control samples of was 20.3 (SD 0.6) mm; it was 14.7 (SD 0.6) mm in irradiated samples. On the other hand, the minimum changes in the diameter of inhibition zone were found for and when these bacteria were tested for nitrofurantoin and cephalexin, respectively.

Conclusion: Gamma rays were capable of making significant alterations in bacterial susceptibility to antibiotics. It can be hypothesized that high levels of natural background radiation can induce adaptive phenomena that help microorganisms better cope with lethal effects of antibiotics.
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http://dx.doi.org/10.15171/ijoem.2017.958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679611PMC
April 2017