Publications by authors named "Sevtap Savas"

53Publications

The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying effects.

BMC Med 2019 07 29;17(1):150. Epub 2019 Jul 29.

Discipline of Genetics, Faculty of Medicine, Memorial University, 300 Prince Philip Drive, New Medical Education Building, St. John's, NL, A1B 3V6, Canada.

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http://dx.doi.org/10.1186/s12916-019-1379-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661748PMC
July 2019

Correction to: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer.

BMC Cancer 2019 05 10;19(1):437. Epub 2019 May 10.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

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http://dx.doi.org/10.1186/s12885-019-5672-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511186PMC
May 2019

A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer.

BMC Cancer 2019 Feb 9;19(1):133. Epub 2019 Feb 9.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

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http://dx.doi.org/10.1186/s12885-019-5346-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368959PMC
February 2019

Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses.

Biomark Res 2018 13;6:17. Epub 2018 Jun 13.

1Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

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http://dx.doi.org/10.1186/s40364-018-0133-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998544PMC
June 2018

The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers.

Crit Rev Oncol Hematol 2018 Mar 6;123:114-131. Epub 2018 Feb 6.

Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada.

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http://dx.doi.org/10.1016/j.critrevonc.2018.01.009DOI Listing
March 2018

Validation of microRNA pathway polymorphisms in esophageal adenocarcinoma survival.

Cancer Med 2017 02 11;6(2):361-373. Epub 2017 Jan 11.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cam4.989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313634PMC
February 2017

Mitochondrial DNA polymorphisms, its copy number change and outcome in colorectal cancer.

BMC Res Notes 2015 Jun 27;8:272. Epub 2015 Jun 27.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, HSC, Room H4333, St. John's, NL, A1B 3V6, Canada.

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http://dx.doi.org/10.1186/s13104-015-1250-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482280PMC
June 2015

A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer.

Biomed Res Int 2015 12;2015:968743. Epub 2015 May 12.

Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada M5G 2M9 ; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7.

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http://www.hindawi.com/journals/bmri/2015/968743/
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http://dx.doi.org/10.1155/2015/968743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443940PMC
March 2016

Discovery and validation of vascular endothelial growth factor (VEGF) pathway polymorphisms in esophageal adenocarcinoma outcome.

Carcinogenesis 2015 Sep 25;36(9):956-62. Epub 2015 May 25.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre and University of Toronto, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1093/carcin/bgv073DOI Listing
September 2015

A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes.

Biomark Res 2015 19;3. Epub 2015 Mar 19.

Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL Canada A1B 3 V6 ; Discipline of Oncology, Faculty of Medicine, Memorial University, St. John's, NL Canada A1B 3 V6.

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http://dx.doi.org/10.1186/s40364-015-0031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393623PMC
April 2015

Biomarkers For Colon Cancer.

Biomark Cancer 2015 20;7(Suppl 1):49-50. Epub 2016 Apr 20.

Associate Professor of Genetics and Oncology, Memorial University of Newfoundland, St. John's, Canada.

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http://dx.doi.org/10.4137/BIC.S39882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839965PMC
April 2016

Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer.

PLoS One 2014 18;9(11):e113513. Epub 2014 Nov 18.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada; Discipline of Oncology, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113513PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236175PMC
January 2016

Inferring gene network from candidate SNP association studies using a Bayesian graphical model: application to a breast cancer case-control study from ontario.

Hum Hered 2014 23;78(3-4):140-52. Epub 2014 Oct 23.

Department of Computer and Mathematical Sciences, University of Toronto Scarborough, Scarborough, Ont., Canada.

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http://dx.doi.org/10.1159/000365923DOI Listing
September 2015

Special considerations in prognostic research in cancer involving genetic polymorphisms.

BMC Med 2013 Jun 17;11:149. Epub 2013 Jun 17.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St, John's, Newfoundland, Canada.

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http://dx.doi.org/10.1186/1741-7015-11-149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729672PMC
June 2013

Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2.

PLoS One 2013 21;8(5):e62468. Epub 2013 May 21.

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062468PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660339PMC
December 2013

Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients.

PLoS One 2012 24;7(7):e38953. Epub 2012 Jul 24.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404081PMC
April 2013

Vascular endothelial growth factor pathway polymorphisms as prognostic and pharmacogenetic factors in cancer: a systematic review and meta-analysis.

Clin Cancer Res 2012 Sep 25;18(17):4526-37. Epub 2012 Jun 25.

Ontario Cancer Institute; Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital/University Health Network and University of Toronto, Toronto, CA.

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http://clincancerres.aacrjournals.org/content/18/17/4526.ful
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http://clincancerres.aacrjournals.org/content/early/2012/06/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-1315DOI Listing
September 2012

A curated database of genetic markers from the angiogenesis/VEGF pathway and their relation to clinical outcome in human cancers.

Authors:
Sevtap Savas

Acta Oncol 2012 Feb 12;51(2):243-6. Epub 2011 Dec 12.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

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http://dx.doi.org/10.3109/0284186X.2011.636758DOI Listing
February 2012

Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival.

Clin Cancer Res 2012 Jan 10;18(1):196-206. Epub 2011 Nov 10.

Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-1759DOI Listing
January 2012

Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers.

Cancer 2012 Mar 25;118(6):1554-65. Epub 2011 Aug 25.

Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.26446DOI Listing
March 2012

Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines.

BMC Med Genomics 2011 Feb 11;4:18. Epub 2011 Feb 11.

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1755-8794-4-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050680PMC
February 2011

Useful genetic variation databases for oncologists investigating the genetic basis of variable treatment response and survival in cancer.

Authors:
Sevtap Savas

Acta Oncol 2010 Nov 29;49(8):1217-26. Epub 2010 Jul 29.

Memorial University of Newfoundland, St. John's, NL, Canada.

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http://dx.doi.org/10.3109/0284186X.2010.500297DOI Listing
November 2010

dbCPCO: a database of genetic markers tested for their predictive and prognostic value in colorectal cancer.

Hum Mutat 2010 Aug;31(8):901-7

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3V6.

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http://doi.wiley.com/10.1002/humu.21285
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http://dx.doi.org/10.1002/humu.21285DOI Listing
August 2010

Genetic variations as cancer prognostic markers: review and update.

Hum Mutat 2009 Oct;30(10):1369-77

Department of Medical Biophysics, Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/humu.21078
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http://dx.doi.org/10.1002/humu.21078DOI Listing
October 2009

Studying genetic variations in cancer prognosis (and risk): a primer for clinicians.

Oncologist 2009 Jul 6;14(7):657-66. Epub 2009 Jul 6.

Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada.

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http://dx.doi.org/10.1634/theoncologist.2009-0042DOI Listing
July 2009

A comprehensive catalogue of functional genetic variations in the EGFR pathway: protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research.

Int J Cancer 2009 Sep;125(6):1257-65

Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.24535DOI Listing
September 2009

Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.

Hum Mutat 2008 Apr;29(4):461-7

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.20732DOI Listing
April 2008

Biological implications of SNPs in signal peptide domains of human proteins.

Proteins 2008 Feb;70(2):394-403

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/prot.21548DOI Listing
February 2008

Human non-synonymous single nucleotide polymorphisms can influence ubiquitin-mediated protein degradation.

OMICS 2007 ;11(2):200-8

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/omi.2007.4324DOI Listing
September 2007

Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network.

Physiol Genomics 2007 Apr 26;29(2):109-17. Epub 2006 Dec 26.

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00226.2006DOI Listing
April 2007

Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations.

Hum Genomics 2006 Mar;2(5):287-96

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500178PMC
http://dx.doi.org/10.1186/1479-7364-2-5-287DOI Listing
March 2006

Human SNPs resulting in premature stop codons and protein truncation.

Hum Genomics 2006 Mar;2(5):274-86

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500177PMC
http://dx.doi.org/10.1186/1479-7364-2-5-274DOI Listing
March 2006

Genetic variation and the mitogen-activated protein kinase (MAPK) signaling pathway.

OMICS 2006 ;10(1):66-81

Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.

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http://dx.doi.org/10.1089/omi.2006.10.66DOI Listing
September 2006

Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs.

BMC Cancer 2005 Aug 19;5:107. Epub 2005 Aug 19.

Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, ON, Canada.

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http://dx.doi.org/10.1186/1471-2407-5-107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208866PMC
August 2005

Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins.

Proteins 2005 Feb;58(3):697-705

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/prot.20367DOI Listing
February 2005

The USH1C 216G-->A splice-site mutation results in a 35-base-pair deletion.

Hum Genet 2005 Feb 1;116(3):225-7. Epub 2004 Dec 1.

Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s00439-004-1217-4DOI Listing
February 2005

Genetic heterogeneity in Usher syndrome.

Am J Med Genet A 2004 Sep;130A(1):13-6

Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1002/ajmg.a.30052DOI Listing
September 2004

Identifying functional genetic variants in DNA repair pathway using protein conservation analysis.

Cancer Epidemiol Biomarkers Prev 2004 May;13(5):801-7

Fred A. Litwin Centre for Cancer Genetics, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 600 University Avenue Room 992A, Toronto, ON M5G 1X5, Canada.

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May 2004

Structure, diversity, and evolution of the 45-bp VNTR in intron 5 of the USH1C gene.

Genomics 2004 Mar;83(3):439-44

Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1016/j.ygeno.2003.09.006DOI Listing
March 2004

The USH1C 216G-->A mutation and the 9-repeat VNTR(t,t) allele are in complete linkage disequilibrium in the Acadian population.

Hum Genet 2002 Jan 6;110(1):95-7. Epub 2001 Dec 6.

Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1007/s00439-001-0653-7DOI Listing
January 2002