Publications by authors named "Sevgi Keles"

60Publications

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

Authors:
Qian Zhang Paul Bastard Zhiyong Liu Jérémie Le Pen Marcela Moncada-Velez Jie Chen Masato Ogishi Ira K D Sabli Stephanie Hodeib Cecilia Korol Jérémie Rosain Kaya Bilguvar Junqiang Ye Alexandre Bolze Benedetta Bigio Rui Yang Andrés Augusto Arias Qinhua Zhou Yu Zhang Fanny Onodi Sarantis Korniotis Léa Karpf Quentin Philippot Marwa Chbihi Lucie Bonnet-Madin Karim Dorgham Nikaïa Smith William M Schneider Brandon S Razooky Hans-Heinrich Hoffmann Eleftherios Michailidis Leen Moens Ji Eun Han Lazaro Lorenzo Lucy Bizien Philip Meade Anna-Lena Neehus Aileen Camille Ugurbil Aurélien Corneau Gaspard Kerner Peng Zhang Franck Rapaport Yoann Seeleuthner Jeremy Manry Cecile Masson Yohann Schmitt Agatha Schlüter Tom Le Voyer Taushif Khan Juan Li Jacques Fellay Lucie Roussel Mohammad Shahrooei Mohammed F Alosaimi Davood Mansouri Haya Al-Saud Fahd Al-Mulla Feras Almourfi Saleh Zaid Al-Muhsen Fahad Alsohime Saeed Al Turki Rana Hasanato Diederik van de Beek Andrea Biondi Laura Rachele Bettini Mariella D'Angio' Paolo Bonfanti Luisa Imberti Alessandra Sottini Simone Paghera Eugenia Quiros-Roldan Camillo Rossi Andrew J Oler Miranda F Tompkins Camille Alba Isabelle Vandernoot Jean-Christophe Goffard Guillaume Smits Isabelle Migeotte Filomeen Haerynck Pere Soler-Palacin Andrea Martin-Nalda Roger Colobran Pierre-Emmanuel Morange Sevgi Keles Fatma Çölkesen Tayfun Ozcelik Kadriye Kart Yasar Sevtap Senoglu Şemsi Nur Karabela Carlos Rodríguez-Gallego Giuseppe Novelli Sami Hraiech Yacine Tandjaoui-Lambiotte Xavier Duval Cédric Laouénan Andrew L Snow Clifton L Dalgard Joshua D Milner Donald C Vinh Trine H Mogensen Nico Marr András N Spaan Bertrand Boisson Stéphanie Boisson-Dupuis Jacinta Bustamante Anne Puel Michael J Ciancanelli Isabelle Meyts Tom Maniatis Vassili Soumelis Ali Amara Michel Nussenzweig Adolfo García-Sastre Florian Krammer Aurora Pujol Darragh Duffy Richard P Lifton Shen-Ying Zhang Guy Gorochov Vivien Béziat Emmanuelle Jouanguy Vanessa Sancho-Shimizu Charles M Rice Laurent Abel Luigi D Notarangelo Aurélie Cobat Helen C Su Jean-Laurent Casanova

Science 2020 10 24;370(6515). Epub 2020 Sep 24.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.abd4570DOI Listing
October 2020

Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency.

Pediatr Allergy Immunol 2020 Jul 11;31(5):515-527. Epub 2020 Mar 11.

Department of Pediatrics, Division of Immunology and Allergy, Ankara University Faculty of Medicine, Ankara, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228270PMC
July 2020

Hypomorphic DOCK8 deletion causes hypereosinophilic syndrome.

Pediatr Blood Cancer 2020 02 20;67(2):e28084. Epub 2019 Nov 20.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.28084DOI Listing
February 2020

Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1.

J Allergy Clin Immunol 2020 01 16;145(1):391-401.e8. Epub 2019 Oct 16.

Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961977PMC
January 2020

Intrauterine detection of DCLRE1C (Artemis) mutation by restriction fragment length polymorphism.

Pediatr Allergy Immunol 2019 09 26;30(6):668-671. Epub 2019 Jun 26.

Necmettin Erbakan University, Meram Medical Faculty, Department of Pediatric Allergy and Immunology, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13056DOI Listing
September 2019

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects.

J Allergy Clin Immunol 2019 06 20;143(6):2302-2305. Epub 2019 Feb 20.

Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.02.010DOI Listing
June 2019

Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency.

Int J Pediatr 2018 23;2018:3527480. Epub 2018 Apr 23.

Department of Pediatric Allergy and Immunology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/3527480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937368PMC
April 2018

DOCK8 Deficiency Presenting as an IPEX-Like Disorder.

J Clin Immunol 2017 Nov 23;37(8):811-819. Epub 2017 Oct 23.

Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Karp Family Building, Room 10-214. 1 Blackfan Street, Boston, MA, 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-017-0451-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691358PMC
November 2017

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 10;8:1244. Epub 2017 Oct 10.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
Publisher Site
http://dx.doi.org/10.3389/fimmu.2017.01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641412PMC
October 2017

Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency.

J Allergy Clin Immunol 2018 04 12;141(4):1450-1458. Epub 2017 Sep 12.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, and the University of Medical Science, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.06.049DOI Listing
April 2018

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 17;8:798. Epub 2017 Jul 17.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
Publisher Site
http://dx.doi.org/10.3389/fimmu.2017.00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511964PMC
July 2017

Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency.

Pediatr Transplant 2017 Nov 30;21(7). Epub 2017 Jun 30.

Faculty of Medicine, Department of Pediatric Bone Marrow Transplantation Unit, MedicalPark Antalya Hospital, Bahçeşehir University, Antalya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/petr.13015DOI Listing
November 2017

DOCK8 deficiency: Insights into pathophysiology, clinical features and management.

Clin Immunol 2017 08 15;181:75-82. Epub 2017 Jun 15.

Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555255PMC
August 2017

Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation.

J Allergy Clin Immunol 2018 03 7;141(3):1050-1059.e10. Epub 2017 Jun 7.

Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743769PMC
March 2018

Would mean platelet volume/platelet count ratio be used as a novel formula to predict 22q11.2 deletion syndrome?

Asian Pac J Allergy Immunol 2016 Jun;34(2):166-73

Baskent University Faculty of Medicine, Department of Pediatric Allergy and Immunology, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12932/AP0604.34.2.2016DOI Listing
June 2016

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

N Engl J Med 2015 Jun;372(25):2409-22

From the Division of Immunology (K.D., J.C., S.K., M.J.M., K.C., K.F., T.A.C., R.S.G., L.D.N.) and Manton Center for Orphan Disease Research (L.D.N.), Boston Children's Hospital, and Department of Molecular Biology, Massachusetts General Hospital (T.K.O.), Boston, Harvard Stem Cell Institute, Harvard University, Cambridge (L.D.N.), and Department of Pediatrics, University of Massachusetts Medical School, Worcester (A.M.C.) - all in Massachusetts; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (C.D.C., I.B., N.K.S., M.S., C.B., K.B.), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna (K.B.), and CeRUD Vienna Center for Rare and Undiagnosed Diseases (K.B.) - all in Vienna; St. Giles Laboratory of Human Genetics of Infectious Disease, Rockefeller Branch, Rockefeller University (S.-Y.Z., M.A., S.O., B.B., Y.I., L.A., J.-L.C.), and Institute for Genomic Medicine, Columbia University (S. Petrovski, D.B.G.) - both in New York; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM Unité 1163 (S.-Y.Z., V.P., L.A., J.-L.C.), Paris Descartes University, Sorbonne Paris Cité, Imagine Institute (S.-Y.Z., F.R., P.L., L.A., J.-L.C.), and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children (J.-L.C.) - all in Paris; Howard Hughes Medical Institute, Chevy Chase, MD (J.-L.C.); Department of Molecular and Translational Medicine, University of Brescia, Brescia (S. Parolini, O.P., G.T.), and Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genoa (A.M.) - both in Italy; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology (E.H.), Institute for Molecular Medicine Finland (J.S.), Children's Hospital (M.K.), Research Programs Unit, Diabetes and Obesity Research Program (M.K.), and Folkhälsan Research Center (M.K.), University of Helsinki and Helsinki University Central Hospital, Helsinki, Tampere Center

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1413462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480434PMC
June 2015

Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder.

Pediatr Nephrol 2015 Jul 25;30(7):1197-202. Epub 2015 Apr 25.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-015-3102-xDOI Listing
July 2015

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita.

Pediatr Dermatol 2015 May-Jun;32(3):e74-7. Epub 2015 Mar 17.

Department of Dermatology, School of Medicine, Boston University, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.12550DOI Listing
April 2016

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation.

Clin Respir J 2016 Mar 16;10(2):223-30. Epub 2014 Oct 16.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/crj.12209DOI Listing
March 2016

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy.

J Allergy Clin Immunol 2014 Jun 24;133(6):1753-5.e3. Epub 2014 Apr 24.

Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749140045
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2014.03.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052613PMC
June 2014

Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency.

Clin Immunol 2014 Jul 15;153(1):104-108. Epub 2014 Apr 15.

Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2014.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112510PMC
July 2014

Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities.

Hum Mutat 2013 Dec 18;34(12):1611-4. Epub 2013 Sep 18.

Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910166PMC
December 2013

Sublingual immunotherapy in children with allergic rhinoconjunctivitis mono-sensitized to house-dust-mites: a double-blind-placebo-controlled randomised trial.

Respir Med 2013 Sep 23;107(9):1322-9. Epub 2013 Jul 23.

Pediatric Allergy and Immunology, Marmara University Medical Faculty, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2013.06.021DOI Listing
September 2013

Variable presentation of primary immune deficiency: two cases with CD3 gamma deficiency presenting with only autoimmunity.

Pediatr Allergy Immunol 2013 May;24(3):257-62

Department of Pediatric Hematology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.12063DOI Listing
May 2013

Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder.

Gene 2013 Jan 2;512(2):189-93. Epub 2012 Nov 2.

Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2012.10.062DOI Listing
January 2013

A novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes.

J Allergy Clin Immunol 2011 Oct 8;128(4):808-815.e7. Epub 2011 Jun 8.

Division of Pediatric Allergy and Immunology, Marmara University, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2011.04.033DOI Listing
October 2011

Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells.

Pediatr Allergy Immunol 2010 Nov;21(7):1059-63

Pediatric Allergy & Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3038.2010.01051.xDOI Listing
November 2010

Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'.

Pediatr Allergy Immunol 2010 Aug 1;21(5):843-51. Epub 2010 Jul 1.

Selcuk University, Meram Medical Faculty, Division of Immunology and Allergy, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-3038.2010.01010.xDOI Listing
August 2010

A rare cause of preseptal cellulitis: anthrax.

Pediatr Dermatol 2007 May-Jun;24(3):330-1

Department of Peadiatrics, Selcuk University Meram Medical Facutly, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1525-1470.2007.00420.xDOI Listing
July 2007

Systemic onset juvenile rheumatoid arthritis presenting with absence of B lymphocytes.

Rheumatol Int 2007 Aug 25;27(10):981-3. Epub 2007 Jan 25.

Departments of Pediatrics, Pediatric Immunology and Allergy Division, Selcuk University Meram Medical Faculty, Beyşehir Yolu, 42080 Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-007-0316-7DOI Listing
August 2007

Late-presenting congenital diaphragmatic hernia associated with ectopic thoracic kidney.

Eur J Pediatr 2006 Aug 19;165(8):571-2. Epub 2006 Apr 19.

Department of Pediatrics, Selcuk University Meram Medical Faculty, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-006-0119-yDOI Listing
August 2006

Chilaiditi syndrome as a cause of respiratory distress.

Eur J Pediatr 2006 Jun 18;165(6):367-9. Epub 2006 Feb 18.

Department of Pediatrics, Selcuk University Meram Medical Faculty, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-005-0077-9DOI Listing
June 2006

Picture of the month: Coughing paroxysms associated with subconjunctival hemorrhage and dellen.

Arch Pediatr Adolesc Med 2006 Jan;160(1):53-5

Pediatric Immunology and Allergy Division and the Departments of Pediatrics and Ophthalmology, Selçuk University Meram Medical Faculty, 42080 Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archpedi.160.1.53DOI Listing
January 2006

Congenital aneurysm of the muscular interventricular septum in a child.

Turk J Pediatr 2005 Jan-Mar;47(1):82-4

Department of Pediatric Cardiology, Selçuk University Meram Faculty of Medicine, Konya, Turkey.

View Article

Download full-text PDF

Source
June 2005

Pulmonary vascular sling with aberrant right upper lobe pulmonary artery in a child.

Anadolu Kardiyol Derg 2003 Dec;3(4):370

Pediatric Cardiology Unit, Department of Pediatrics, Faculty of Medicine, Selçuk University, Konya, Turkey.

View Article

Download full-text PDF

Source
December 2003