Seth Love

Seth Love

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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Dear Reader: Data citation in changing times.

Brain Pathol 2019 03;29(2):153-154

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http://doi.wiley.com/10.1111/bpa.12702
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http://dx.doi.org/10.1111/bpa.12702DOI Listing
March 2019

VEGFR1 and VEGFR2 in Alzheimer's Disease.

J Alzheimers Dis 2018 ;61(2):741-752

Institute of Clinical Neurosciences, University of Bristol, School of Medicine, Level 2 Learning and Research, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-170745DOI Listing
January 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Cerebral Aβ and systemic hypertension.

J Cereb Blood Flow Metab 2018 Nov 7;38(11):1993-2005. Epub 2017 Aug 7.

1 School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://journals.sagepub.com/doi/10.1177/0271678X17724930
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http://dx.doi.org/10.1177/0271678X17724930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259324PMC
November 2018

Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease.

Brain Pathol 2018 09 6;28(5):603-610. Epub 2018 Feb 6.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1111/bpa.12567DOI Listing
September 2018

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease.

Acta Neuropathol Commun 2018 09 7;6(1):88. Epub 2018 Sep 7.

Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1186/s40478-018-0592-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127939PMC
September 2018

Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease.

J Alzheimers Dis 2017 ;60(4):1511-1524

MS and Stem Cell Group, Translational Health Sciences, Bristol Medical School, University of Bristol, UK.

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http://dx.doi.org/10.3233/JAD-170094DOI Listing
July 2018

A broader view of dementia: multiple co-pathologies are the norm.

Brain 2018 07;141(7):1894-1897

University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/brain/awy153DOI Listing
July 2018

Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life.

J Alzheimers Dis 2017 ;59(3):1123-1137

School of Clinical Sciences, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-170316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545905PMC
April 2018

A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination.

Forensic Sci Med Pathol 2018 03 25;14(1):106-108. Epub 2017 Nov 25.

Department of Neuropathology, North Bristol NHS Trust, Bristol, UK.

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http://dx.doi.org/10.1007/s12024-017-9933-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830465PMC
March 2018

Differing associations between Aβ accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease.

J Cereb Blood Flow Metab 2018 01 2;38(1):103-115. Epub 2017 Feb 2.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1177/0271678X17690761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757436PMC
January 2018

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism.

Neurochem Int 2018 01 9;112:49-58. Epub 2017 Nov 9.

Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2017.10.014DOI Listing
January 2018

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

Small vessel disease, neurovascular regulation and cognitive impairment: post-mortem studies reveal a complex relationship, still poorly understood.

Clin Sci (Lond) 2017 Jul 30;131(14):1579-1589. Epub 2017 Jun 30.

Dementia Research Group, School of Clinical Sciences, University of Bristol, Learning and Research Level 1, Southmead Hospital, Bristol BS10 5NB, U.K.

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http://dx.doi.org/10.1042/CS20170148DOI Listing
July 2017

The Vascular Impairment of Cognition Classification Consensus Study.

Alzheimers Dement 2017 Jun 10;13(6):624-633. Epub 2016 Dec 10.

Dementia Research Group, Faculty of Health Sciences, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.10.007DOI Listing
June 2017

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ.

Brain Pathol 2017 05 8;27(3):305-313. Epub 2016 Jul 8.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, United Kingdom.

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http://dx.doi.org/10.1111/bpa.12392DOI Listing
May 2017

Trigeminal Nerve Root Demyelination Not Seen in Six Horses Diagnosed with Trigeminal-Mediated Headshaking.

Front Vet Sci 2017 15;4:72. Epub 2017 May 15.

Department of Neuropathology, University of Bristol Institute of Clinical Neurosciences, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.3389/fvets.2017.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431280PMC
May 2017

Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.

J Neurochem 2017 04 29;141(2):275-286. Epub 2017 Mar 29.

Dementia Research Group, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/jnc.13974DOI Listing
April 2017

Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline.

Brain 2017 02 21;140(2):e13. Epub 2016 Dec 21.

Dementia Research Group, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Level 1, Learning & Research, Southmead Hospital, Bristol, BS10 5NB, UK

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http://dx.doi.org/10.1093/brain/aww305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841058PMC
February 2017

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment.

Brain 2016 11;139(11):2957-2969

Dementia Research Group, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Learning and Research Level 1, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1093/brain/aww214DOI Listing
November 2016

Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Acta Neuropathol 2016 11 15;132(5):753-755. Epub 2016 Sep 15.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Salford Royal Hospital, University of Manchester, Salford, Manchester, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-016-1617-2DOI Listing
November 2016

Cerebral Hypoperfusion and the Energy Deficit in Alzheimer's Disease.

Brain Pathol 2016 09;26(5):607-17

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, United Kingom.

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http://dx.doi.org/10.1111/bpa.12401DOI Listing
September 2016

Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease.

Brain Pathol 2016 07 9;26(4):533-41. Epub 2015 Nov 9.

Dementia Research Group, School of Clinical Sciences, Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/bpa.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982069PMC
July 2016

Cerebrovascular disease in ageing and Alzheimer's disease.

Acta Neuropathol 2016 May 28;131(5):645-58. Epub 2015 Dec 28.

Institute of Clinical Neurosciences, School of Clinical Sciences, Learning and Research Level 2, Southmead Hospital, University of Bristol, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1007/s00401-015-1522-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835514PMC
May 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

The concept of sporadic cerebral small vessel disease: A road map on key definitions and current concepts.

Int J Stroke 2016 Jan;11(1):6-18

Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1177/1747493015607485DOI Listing
January 2016

Paraneoplastic tumefactive demyelination with underlying combined germ cell cancer.

Pract Neurol 2015 Dec 18;15(6):451-5. Epub 2015 Jun 18.

Neuropathology Department, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1136/practneurol-2015-001146DOI Listing
December 2015

Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells.

Mol Biol Cell 2015 Dec 14;26(25):4552-61. Epub 2015 Oct 14.

School of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom

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http://dx.doi.org/10.1091/mbc.E15-05-0270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678014PMC
December 2015

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Authors:
Valentina Escott-Price Céline Bellenguez Li-San Wang Seung-Hoan Choi Denise Harold Lesley Jones Peter Holmans Amy Gerrish Alexey Vedernikov Alexander Richards Anita L DeStefano Jean-Charles Lambert Carla A Ibrahim-Verbaas Adam C Naj Rebecca Sims Gyungah Jun Joshua C Bis Gary W Beecham Benjamin Grenier-Boley Giancarlo Russo Tricia A Thornton-Wells Nicola Denning Albert V Smith Vincent Chouraki Charlene Thomas M Arfan Ikram Diana Zelenika Badri N Vardarajan Yoichiro Kamatani Chiao-Feng Lin Helena Schmidt Brian Kunkle Melanie L Dunstan Maria Vronskaya Andrew D Johnson Agustin Ruiz Marie-Thérèse Bihoreau Christiane Reitz Florence Pasquier Paul Hollingworth Olivier Hanon Annette L Fitzpatrick Joseph D Buxbaum Dominique Campion Paul K Crane Clinton Baldwin Tim Becker Vilmundur Gudnason Carlos Cruchaga David Craig Najaf Amin Claudine Berr Oscar L Lopez Philip L De Jager Vincent Deramecourt Janet A Johnston Denis Evans Simon Lovestone Luc Letenneur Isabel Hernández David C Rubinsztein Gudny Eiriksdottir Kristel Sleegers Alison M Goate Nathalie Fiévet Matthew J Huentelman Michael Gill Kristelle Brown M Ilyas Kamboh Lina Keller Pascale Barberger-Gateau Bernadette McGuinness Eric B Larson Amanda J Myers Carole Dufouil Stephen Todd David Wallon Seth Love Ekaterina Rogaeva John Gallacher Peter St George-Hyslop Jordi Clarimon Alberto Lleo Anthony Bayer Debby W Tsuang Lei Yu Magda Tsolaki Paola Bossù Gianfranco Spalletta Petra Proitsi John Collinge Sandro Sorbi Florentino Sanchez Garcia Nick C Fox John Hardy Maria Candida Deniz Naranjo Paolo Bosco Robert Clarke Carol Brayne Daniela Galimberti Elio Scarpini Ubaldo Bonuccelli Michelangelo Mancuso Gabriele Siciliano Susanne Moebus Patrizia Mecocci Maria Del Zompo Wolfgang Maier Harald Hampel Alberto Pilotto Ana Frank-García Francesco Panza Vincenzo Solfrizzi Paolo Caffarra Benedetta Nacmias William Perry Manuel Mayhaus Lars Lannfelt Hakon Hakonarson Sabrina Pichler Minerva M Carrasquillo Martin Ingelsson Duane Beekly Victoria Alvarez Fanggeng Zou Otto Valladares Steven G Younkin Eliecer Coto Kara L Hamilton-Nelson Wei Gu Cristina Razquin Pau Pastor Ignacio Mateo Michael J Owen Kelley M Faber Palmi V Jonsson Onofre Combarros Michael C O'Donovan Laura B Cantwell Hilkka Soininen Deborah Blacker Simon Mead Thomas H Mosley David A Bennett Tamara B Harris Laura Fratiglioni Clive Holmes Renee F A G de Bruijn Peter Passmore Thomas J Montine Karolien Bettens Jerome I Rotter Alexis Brice Kevin Morgan Tatiana M Foroud Walter A Kukull Didier Hannequin John F Powell Michael A Nalls Karen Ritchie Kathryn L Lunetta John S K Kauwe Eric Boerwinkle Matthias Riemenschneider Mercè Boada Mikko Hiltunen Eden R Martin Reinhold Schmidt Dan Rujescu Jean-François Dartigues Richard Mayeux Christophe Tzourio Albert Hofman Markus M Nöthen Caroline Graff Bruce M Psaty Jonathan L Haines Mark Lathrop Margaret A Pericak-Vance Lenore J Launer Christine Van Broeckhoven Lindsay A Farrer Cornelia M van Duijn Alfredo Ramirez Sudha Seshadri Gerard D Schellenberg Philippe Amouyel Julie Williams

PLoS One 2014 12;9(6):e94661. Epub 2014 Jun 12.

Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094661PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055488PMC
October 2015

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β.

Neuropathol Appl Neurobiol 2015 Jun;41(4):445-57

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.

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http://doi.wiley.com/10.1111/nan.12205
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http://dx.doi.org/10.1111/nan.12205DOI Listing
June 2015

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.

Neuropathol Appl Neurobiol 2015 Jun;41(4):428-44

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Level 1 Learning and Research, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1111/nan.12212DOI Listing
June 2015

Synaptic protein levels altered in vascular dementia.

Neuropathol Appl Neurobiol 2015 Jun 23;41(4):533-43. Epub 2015 Apr 23.

School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://doi.wiley.com/10.1111/nan.12215
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http://dx.doi.org/10.1111/nan.12215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471617PMC
June 2015

Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease.

J Pathol 2015 Apr 7;235(5):721-30. Epub 2015 Jan 7.

Alzheimer Clinical Centre, Lariboisiere FW Saint-Louis Hospital, AP-HP University of Paris Diderot, France; Department of Histology and Biology of Ageing, Lariboisiere FW Saint-Louis Hospital, AP-HP University of Paris Diderot, France; INSERM U942, Paris, France.

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http://dx.doi.org/10.1002/path.4491DOI Listing
April 2015

Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer's disease and vascular dementia.

Brain 2015 Apr 16;138(Pt 4):1059-69. Epub 2015 Feb 16.

Dementia Research Group, University of Bristol, Learning & Research level 1, Southmead Hospital, Bristol BS10 5NB, UK

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http://dx.doi.org/10.1093/brain/awv025DOI Listing
April 2015

White matter damage in dementia. Introduction.

Brain Pathol 2015 Jan;25(1):33-4

Dementia Research Group, Institute of Clinical Neurosciences, Southmead Hospital, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/bpa.12222DOI Listing
January 2015

White matter hypoperfusion and damage in dementia: post-mortem assessment.

Brain Pathol 2015 Jan;25(1):99-107

Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Learning and Research Level 2, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1111/bpa.12223DOI Listing
January 2015

Differential changes in Aβ42 and Aβ40 with age.

J Alzheimers Dis 2014 ;40(3):727-35

Dementia Research Group, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-132339DOI Listing
December 2014

Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy.

Acta Neuropathol 2014 Dec 7;128(6):777-89. Epub 2014 Sep 7.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1007/s00401-014-1340-9DOI Listing
December 2014

Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.

Alzheimers Res Ther 2014 1;6(5-8):77. Epub 2014 Dec 1.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1186/s13195-014-0077-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248436PMC
December 2014

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.

Front Aging Neurosci 2014 11;6:238. Epub 2014 Sep 11.

Dementia Research Group, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol Bristol, UK.

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http://dx.doi.org/10.3389/fnagi.2014.00238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160973PMC
October 2014

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging.

PLoS One 2013 21;8(10):e78806. Epub 2013 Oct 21.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078806PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804620PMC
August 2014

Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies.

Brain Pathol 2014 Jul 28;24(4):334-43. Epub 2014 Mar 28.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/bpa.12130DOI Listing
July 2014

Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia.

Brain 2014 May 10;137(Pt 5):1524-32. Epub 2014 Mar 10.

1 Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/brain/awu040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999715PMC
May 2014

Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations.

Brain Pathol 2014 Mar 11;24(2):117-27. Epub 2013 Sep 11.

Department of Neurosurgery, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.1111/bpa.12082DOI Listing
March 2014

Endothelin-converting enzyme-1 activity, endothelin-1 production, and free radical-dependent vasoconstriction in Alzheimer's disease.

J Alzheimers Dis 2013 ;36(3):577-87

University of Bristol, Dementia Research Group, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-130383DOI Listing
February 2014

Influence of LRP-1 and apolipoprotein E on amyloid-β uptake and toxicity to cerebrovascular smooth muscle cells.

J Alzheimers Dis 2013 ;33(1):95-110

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-121336DOI Listing
September 2013

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization.

Brain 2013 Sep 13;136(Pt 9):2677-96. Epub 2013 Aug 13.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 806, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1093/brain/awt210DOI Listing
September 2013

Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins.

J Cereb Blood Flow Metab 2013 Jul 27;33(7):1050-7. Epub 2013 Mar 27.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/jcbfm.2013.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705431PMC
July 2013

Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis.

Mult Scler 2013 Feb 21;19(2):153-61. Epub 2012 Jun 21.

MS Labs, Burden Centre, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, UK.

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http://dx.doi.org/10.1177/1352458512451661DOI Listing
February 2013

Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.

J Alzheimers Dis 2012 ;32(1):43-56

Functional Neurosurgery Research Group, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-120658DOI Listing
February 2013

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

J Neurochem 2012 Dec 1;123(6):997-1009. Epub 2012 Nov 1.

Faculty of Health and Life Sciences, University of the West of England, Bristol, UK.

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http://dx.doi.org/10.1111/jnc.12044DOI Listing
December 2012

A rare cause of neural foraminal widening.

J Radiol Case Rep 2012 Dec 1;6(12):1-8. Epub 2012 Dec 1.

Department of Neuroradiology, Frenchay Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.3941/jrcr.v6i12.1236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557120PMC
December 2012

The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro.

Int J Mol Epidemiol Genet 2011 30;2(4):409-15. Epub 2011 Nov 30.

Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Building, Frenchay Hospital Bristol, BS16 1LE, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243456PMC
October 2012

LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: relationship to cerebral amyloid angiopathy and APOE status.

Neurosci Lett 2012 Sep;525(2):123-8

Dementia Research Group, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, BS16 1LE, UK.

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http://dx.doi.org/10.1016/j.neulet.2012.07.065DOI Listing
September 2012

Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.

J Alzheimers Dis 2012 ;29(4):853-61

Dementia ResearchGroup, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2012-111760DOI Listing
August 2012

Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia.

Neurobiol Aging 2012 Jul 11;33(7):1345-55. Epub 2010 Nov 11.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.09.024DOI Listing
July 2012

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):377-87

MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.3233/JAD-2011-110824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118466PMC
May 2012

Clinicopathological review of patients with and without multiple sclerosis treated by partial sensory rhizotomy for medically refractory trigeminal neuralgia: a 12-year retrospective study.

Clin Neurol Neurosurg 2012 May 30;114(4):361-5. Epub 2011 Nov 30.

Department of Neurosurgery, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK.

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http://dx.doi.org/10.1016/j.clineuro.2011.11.018DOI Listing
May 2012

Clusterin mRNA and protein in Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):337-44

Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2011-110473DOI Listing
May 2012

Resistant to amyloid-β or just waiting for disease to happen?

Authors:
Seth Love

Alzheimers Res Ther 2012 May 30;4(3):19. Epub 2012 May 30.

Dementia Research Group, Institute of Clinical Neurosciences School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, BS16 1LE, UK.

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http://dx.doi.org/10.1186/alzrt122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506933PMC
May 2012

Activators and inhibitors of the plasminogen system in Alzheimer's disease.

J Cell Mol Med 2012 Apr;16(4):865-76

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Sciences at North Bristol, Bristol University, Bristol, UK.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01394.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822855PMC
April 2012

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

J Neuropathol Exp Neurol 2011 Nov;70(11):944-59

Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, UK.

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http://dx.doi.org/10.1097/NEN.0b013e3182345e46DOI Listing
November 2011

Neprilysin protects against cerebral amyloid angiopathy and Aβ-induced degeneration of cerebrovascular smooth muscle cells.

Brain Pathol 2011 Sep 3;21(5):594-605. Epub 2011 Apr 3.

Dementia Research Group, School of Clinical Sciences, Institute of Clinical Neurosciences, University of Bristol, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2011.00486.xDOI Listing
September 2011

Unpicking frontotemporal lobar degeneration.

Brain 2011 Sep 22;134(Pt 9):2453-5. Epub 2011 Aug 22.

Department of Neuropathology, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK.

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http://dx.doi.org/10.1093/brain/awr176DOI Listing
September 2011

Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro.

Int J Mol Epidemiol Genet 2011 25;2(2):156-62. Epub 2011 Mar 25.

Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Buildings, Frenchay Hospital Frenchay, Bristol, BS16 1LE, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110390PMC
July 2011

Endothelin receptor antagonists: potential in Alzheimer's disease.

Pharmacol Res 2011 Jun 27;63(6):525-31. Epub 2010 Dec 27.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, United Kingdom.

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http://dx.doi.org/10.1016/j.phrs.2010.12.008DOI Listing
June 2011

Accumulation of insoluble amyloid-β in down's syndrome is associated with increased BACE-1 and neprilysin activities.

J Alzheimers Dis 2011 ;23(1):101-8

Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.3233/JAD-2010-101395DOI Listing
May 2011

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Authors:
Paul Hollingworth Denise Harold Rebecca Sims Amy Gerrish Jean-Charles Lambert Minerva M Carrasquillo Richard Abraham Marian L Hamshere Jaspreet Singh Pahwa Valentina Moskvina Kimberley Dowzell Nicola Jones Alexandra Stretton Charlene Thomas Alex Richards Dobril Ivanov Caroline Widdowson Jade Chapman Simon Lovestone John Powell Petroula Proitsi Michelle K Lupton Carol Brayne David C Rubinsztein Michael Gill Brian Lawlor Aoibhinn Lynch Kristelle S Brown Peter A Passmore David Craig Bernadette McGuinness Stephen Todd Clive Holmes David Mann A David Smith Helen Beaumont Donald Warden Gordon Wilcock Seth Love Patrick G Kehoe Nigel M Hooper Emma R L C Vardy John Hardy Simon Mead Nick C Fox Martin Rossor John Collinge Wolfgang Maier Frank Jessen Eckart Rüther Britta Schürmann Reiner Heun Heike Kölsch Hendrik van den Bussche Isabella Heuser Johannes Kornhuber Jens Wiltfang Martin Dichgans Lutz Frölich Harald Hampel John Gallacher Michael Hüll Dan Rujescu Ina Giegling Alison M Goate John S K Kauwe Carlos Cruchaga Petra Nowotny John C Morris Kevin Mayo Kristel Sleegers Karolien Bettens Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Gill Livingston Nicholas J Bass Hugh Gurling Andrew McQuillin Rhian Gwilliam Panagiotis Deloukas Ammar Al-Chalabi Christopher E Shaw Magda Tsolaki Andrew B Singleton Rita Guerreiro Thomas W Mühleisen Markus M Nöthen Susanne Moebus Karl-Heinz Jöckel Norman Klopp H-Erich Wichmann V Shane Pankratz Sigrid B Sando Jan O Aasly Maria Barcikowska Zbigniew K Wszolek Dennis W Dickson Neill R Graff-Radford Ronald C Petersen Cornelia M van Duijn Monique M B Breteler M Arfan Ikram Anita L DeStefano Annette L Fitzpatrick Oscar Lopez Lenore J Launer Sudha Seshadri Claudine Berr Dominique Campion Jacques Epelbaum Jean-François Dartigues Christophe Tzourio Annick Alpérovitch Mark Lathrop Thomas M Feulner Patricia Friedrich Caterina Riehle Michael Krawczak Stefan Schreiber Manuel Mayhaus S Nicolhaus Stefan Wagenpfeil Stacy Steinberg Hreinn Stefansson Kari Stefansson Jon Snaedal Sigurbjörn Björnsson Palmi V Jonsson Vincent Chouraki Benjamin Genier-Boley Mikko Hiltunen Hilkka Soininen Onofre Combarros Diana Zelenika Marc Delepine Maria J Bullido Florence Pasquier Ignacio Mateo Ana Frank-Garcia Elisa Porcellini Olivier Hanon Eliecer Coto Victoria Alvarez Paolo Bosco Gabriele Siciliano Michelangelo Mancuso Francesco Panza Vincenzo Solfrizzi Benedetta Nacmias Sandro Sorbi Paola Bossù Paola Piccardi Beatrice Arosio Giorgio Annoni Davide Seripa Alberto Pilotto Elio Scarpini Daniela Galimberti Alexis Brice Didier Hannequin Federico Licastro Lesley Jones Peter A Holmans Thorlakur Jonsson Matthias Riemenschneider Kevin Morgan Steven G Younkin Michael J Owen Michael O'Donovan Philippe Amouyel Julie Williams

Nat Genet 2011 May 3;43(5):429-35. Epub 2011 Apr 3.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/ng.803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173PMC
May 2011

Overview and recent advances in neuropathology.

Pathology 2011 Feb;43(2):87

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http://dx.doi.org/10.1097/PAT.0b013e3283429f6cDOI Listing
February 2011

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

PLoS One 2010 Nov 15;5(11):e13950. Epub 2010 Nov 15.

Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981526PMC
November 2010