Seth L Alper

Seth L Alper

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Seth L Alper

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Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

Blood Cells Mol Dis 2019 11 17;79:102346. Epub 2019 Jul 17.

Renal Division and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA 02115, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2019.102346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744291PMC
November 2019

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.

Sci Signal 2019 Oct 15;12(603). Epub 2019 Oct 15.

Departments of Neurosurgery, Pediatrics, and Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/scisignal.aaw9315DOI Listing
October 2019

APOL1 Kidney Risk Variants Induce Cell Death Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.

J Am Soc Nephrol 2019 Sep 26. Epub 2019 Sep 26.

Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1681/ASN.2019020114DOI Listing
September 2019

Transmembrane insertases and -glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.

J Biol Chem 2019 Aug 2;294(34):12655-12669. Epub 2019 Jul 2.

Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215

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http://dx.doi.org/10.1074/jbc.RA119.008299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709635PMC
August 2019

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background.

Kidney Int 2019 Aug 1. Epub 2019 Aug 1.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.07.010DOI Listing
August 2019

The Peritoneal Surface Proteome in a Model of Chronic Peritoneal Dialysis Reveals Mechanisms of Membrane Damage and Preservation.

Front Physiol 2019 14;10:472. Epub 2019 May 14.

Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.3389/fphys.2019.00472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530346PMC
May 2019

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.

Proc Natl Acad Sci U S A 2019 02 7;116(9):3712-3721. Epub 2019 Feb 7.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1820414116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397558PMC
February 2019

Targeted Metabolomic Profiling of Peritoneal Dialysis Effluents Shows Anti-oxidative Capacity of Alanyl-Glutamine.

Front Physiol 2018 21;9:1961. Epub 2019 Jan 21.

Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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https://www.frontiersin.org/article/10.3389/fphys.2018.01961
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http://dx.doi.org/10.3389/fphys.2018.01961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348277PMC
January 2019

Modulation of tubular solute reuptake in UMOD knockout mice.

Am J Physiol Renal Physiol 2018 08 7;315(2):F238-F240. Epub 2018 Mar 7.

Division of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1152/ajprenal.00080.2018DOI Listing
August 2018

Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures.

Mol Cell Proteomics 2018 03 4;17(3):516-532. Epub 2017 Dec 4.

From the ‡Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria;

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http://dx.doi.org/10.1074/mcp.RA117.000186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836375PMC
March 2018

modifies -induced kidney disease risk.

Proc Natl Acad Sci U S A 2018 03 12;115(13):3446-3451. Epub 2018 Mar 12.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1716113115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879665PMC
March 2018

Revised prevalence estimate of possible Hereditary Xerocytosis as derived from a large U.S. Laboratory database.

Am J Hematol 2018 01 23;93(1):E9-E12. Epub 2017 Nov 23.

Quest Diagnostics, Marlborough, Massachusetts, 01752.

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http://dx.doi.org/10.1002/ajh.24923DOI Listing
January 2018

Genome-wide association study of erythrocyte density in sickle cell disease patients.

Blood Cells Mol Dis 2017 06 13;65:60-65. Epub 2017 May 13.

Faculty of Medicine, Program in Bioinformatics, Université de Montréal, Montreal, Quebec, Canada; Montreal Heart Institute, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.05.005DOI Listing
June 2017

Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis.

Clin Kidney J 2017 Feb 31;10(1):135-140. Epub 2016 Aug 31.

Division of Nephrology and Vascular Biology Research Center, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/ckj/sfw074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469557PMC
February 2017

Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and characterization for structural studies.

Biochem Biophys Rep 2016 Dec 26;8:184-191. Epub 2016 Aug 26.

Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.bbrep.2016.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613929PMC
December 2016

4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock.

Crit Care Med 2016 Nov;44(11):e1082-e1089

1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 2Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. 3Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. 4Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. 5Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. 6Department of Nephrology, Polyclinic Gentilly, Nancy, France. 7Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. 8Department of Biochemistry, Simmons College, Boston, MA. 9Division of Nephrology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA. 10Department of Biological Chemistry, Northeastern University, Boston, MA.

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http://dx.doi.org/10.1097/CCM.0000000000001822DOI Listing
November 2016

Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.

Cell Physiol Biochem 2014 27;33(3):605-20. Epub 2014 Feb 27.

Renal Division, Division of Molecular and Vascular Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1159/000358638DOI Listing
August 2016

Extracellular Cl(-) regulates human SO4 (2-)/anion exchanger SLC26A1 by altering pH sensitivity of anion transport.

Pflugers Arch 2016 08 29;468(8):1311-32. Epub 2016 Apr 29.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s00424-016-1823-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956541PMC
August 2016

Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia.

Haematologica 2016 08 5;101(8):909-17. Epub 2016 May 5.

Department of Molecular Medicine and Medical Biotechnologies, "Federico II" University of Naples, Italy CEINGE, Biotecnologie Avanzate, Naples, Italy.

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http://dx.doi.org/10.3324/haematol.2016.142372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967569PMC
August 2016

Atypical patterns of segregation of familial enlargement of the vestibular aqueduct.

Laryngoscope 2016 07 20;126(7):E240-7. Epub 2015 Oct 20.

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/lary.25737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838554PMC
July 2016

Copy Number Variation at the APOL1 Locus.

PLoS One 2015 1;10(5):e0125410. Epub 2015 May 1.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125410PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416782PMC
February 2016

The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity.

Antimicrob Agents Chemother 2016 01 12;60(1):613-6. Epub 2015 Oct 12.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

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http://dx.doi.org/10.1128/AAC.01668-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704178PMC
January 2016

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.

Proc Natl Acad Sci U S A 2016 Jan 23;113(4):830-7. Epub 2015 Dec 23.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215; Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1522913113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743809PMC
January 2016

Authors' response to "Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'".

Haematologica 2016 Jan;101(1):e39

Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center, Boston; Department of Medicine, Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.3324/haematol.2015.137810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697908PMC
January 2016

Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia.

Haematologica 2015 Dec 20;100(12):e483-5. Epub 2015 Aug 20.

Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.3324/haematol.2015.132449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666336PMC
December 2015

Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).

Am J Hematol 2015 Oct;90(10):921-6

Department Of Molecular Medicine And Medical Biotechnologies, "Federico II" University Of Naples, Naples, Italy.

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http://dx.doi.org/10.1002/ajh.24117DOI Listing
October 2015

K-Cl cotransporters, cell volume homeostasis, and neurological disease.

Trends Mol Med 2015 Aug 1;21(8):513-23. Epub 2015 Jul 1.

Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2015.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834970PMC
August 2015

Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.

Stroke 2015 Jul 11;46(7):1956-1965. Epub 2015 Jun 11.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, (G.B., H.Y., L.L., S.W., Y.S., D.S.); Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA (K.T.K.); Manton Center for Orphan Diseases, Harvard Medical School, MA (K.T.K.); Renal Division and Vascular Biology Center, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA (B.E.S., S.L.A); Division of Nephrology, Dept. of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (SS.Y., SH.L); Veterans Affairs Pittsburgh Health Care System, Geriatric Research, Educational and Clinical Center, Pittsburgh, PA (D.S).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643659PMC
http://dx.doi.org/10.1161/STROKEAHA.115.008939DOI Listing
July 2015

Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.

Front Physiol 2015 23;6:179. Epub 2015 Jun 23.

Renal Division, Beth Israel Deaconess Medical Center Boston, MA, USA ; Harvard Digestive Diseases Center, Harvard Medical School Boston, MA, USA ; Department of Medicine, Harvard Medical School Boston, MA, USA.

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http://dx.doi.org/10.3389/fphys.2015.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477073PMC
July 2015

Cesium-associated hypokalemia successfully treated with amiloride.

Clin Kidney J 2015 Jun 31;8(3):335-8. Epub 2015 Mar 31.

Beth Israel Deaconess Medical Center , Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.1093/ckj/sfv017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440464PMC
June 2015

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.

Kidney Int 2015 Feb 6;87(2):332-42. Epub 2014 Aug 6.

1] Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA [2] Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ki.2014.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312530PMC
February 2015

Hereditary xerocytosis revisited.

Am J Hematol 2014 Dec 21;89(12):1142-6. Epub 2014 Jul 21.

Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts; Dana-Farber Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237618PMC
December 2014

Pendrin, a novel transcriptional target of the uroguanylin system.

Cell Physiol Biochem 2013 18;32(7):221-37. Epub 2013 Dec 18.

Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1159/000356641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970214PMC
September 2014

Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger.

Pflugers Arch 2014 Aug 26;466(8):1605-18. Epub 2014 Mar 26.

Renal Division and Molecular and Vascular Medicine Division, Beth Israel Deaconess Medical Center; Department of Medicine, Harvard Medical School, 99 Brookline Ave. RN-380 F, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s00424-014-1494-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113327PMC
August 2014

Evolution of the primate trypanolytic factor APOL1.

Proc Natl Acad Sci U S A 2014 May 7;111(20):E2130-9. Epub 2014 May 7.

Department of Microbiology, New York University School of Medicine, New York, NY 10016;Department of Biological Sciences, Hunter College at City University of New York, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1400699111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034216PMC
May 2014

Short-term responses of the kidney to high altitude in mountain climbers.

Nephrol Dial Transplant 2014 Mar 22;29(3):497-506. Epub 2013 Mar 22.

Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/ndt/gft051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938295PMC
March 2014

TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.

Kidney Int 2014 Jan 31;85(1):72-81. Epub 2013 Jul 31.

Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/ki.2013.286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834073PMC
January 2014

Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report.

Blood Cells Mol Dis 2014 Jan 23;52(1):53-4. Epub 2013 Aug 23.

Renal Division and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10799796130019
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http://dx.doi.org/10.1016/j.bcmd.2013.07.015DOI Listing
January 2014

Association of hypermagnesemia and blood pressure in the critically ill.

J Hypertens 2013 Nov;31(11):2136-41; discussion 2141

aBeth Israel Deaconess Medical Center, Department of Medicine bHarvard-MIT Division of Health Sciences and Technology cSchool of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

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https://lcp.mit.edu/pdf/CeliJH13.pdf
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HJH.0b013e3283642f18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682028PMC
November 2013

Na+/H+ exchange is inactivated during mouse oocyte meiosis, facilitating glycine accumulation that maintains embryo cell volume.

J Cell Physiol 2013 Oct;228(10):2042-53

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/jcp.24370DOI Listing
October 2013

Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1.

J Physiol 2013 Oct 22;591(20):4963-82. Epub 2013 Jul 22.

G. Gros: Zentrum Physiologie, Vegetative Physiologie 4220, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. V. Endeward: Zentrum Physiologie 4220, Medizinische Hochschule Hannover, Germany. 

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http://dx.doi.org/10.1113/jphysiol.2013.251181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810803PMC
October 2013

The SLC26 gene family of anion transporters and channels.

Mol Aspects Med 2013 Apr-Jun;34(2-3):494-515

Renal Division and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.mam.2012.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602804PMC
September 2013

Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct.

JAMA Otolaryngol Head Neck Surg 2013 Sep;139(9):907-13

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamaoto.2013.4185DOI Listing
September 2013

Substitution of transmembrane domain Cys residues alters pH(o)-sensitive anion transport by AE2/SLC4A2 anion exchanger.

Pflugers Arch 2013 Jun 28;465(6):839-51. Epub 2012 Dec 28.

Renal Division and Molecular and Vascular Medicine Division, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, RN-380F, Boston, MA 02215, USA.

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http://dx.doi.org/10.1007/s00424-012-1196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083511PMC
June 2013

N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes.

Blood Cells Mol Dis 2013 Jun 6;51(1):9-16. Epub 2013 Mar 6.

Divisions of Nephrology and Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, USA.

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http://dx.doi.org/10.1016/j.bcmd.2013.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646938PMC
June 2013

Strain-specific variations in cation content and transport in mouse erythrocytes.

Physiol Genomics 2013 May 12;45(9):343-50. Epub 2013 Mar 12.

Department of Laboratory Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00143.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656420PMC
May 2013

mutation testing for hearing loss associated with enlargement of the vestibular aqueduct.

World J Otorhinolaryngol 2013 May;3(2):26-34

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, United States.

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http://dx.doi.org/10.5319/wjo.v3.i2.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423814PMC
May 2013

Harnessing red cell membrane pathophysiology towards point-of-care diagnosis for sickle cell disease.

Authors:
Seth L Alper

J Physiol 2013 Mar;591(6):1403-4

Beth Israel Deaconess Medical Center, Divisions of Nephrology and Molecular and Vascular Medicine, 330 Brookline Ave, Boston, MA 02215, USA.

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http://dx.doi.org/10.1113/jphysiol.2013.252429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607160PMC
March 2013

SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts.

Proc Natl Acad Sci U S A 2013 Feb 22;110(6):2163-8. Epub 2013 Jan 22.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1206392110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568349PMC
February 2013

Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK.

J Mol Med (Berl) 2012 Jun 7;90(6):707-18. Epub 2012 Jan 7.

Department of Pathology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.

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http://dx.doi.org/10.1007/s00109-011-0851-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986693PMC
June 2012

Transcriptional regulation of the pendrin gene.

Cell Physiol Biochem 2011 16;28(3):385-96. Epub 2011 Nov 16.

Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1159/000335100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709172PMC
March 2012

STAS domain structure and function.

Cell Physiol Biochem 2011 16;28(3):407-22. Epub 2011 Nov 16.

Molecular and Vascular Medicine Division, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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https://www.karger.com/Article/FullText/335104
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http://dx.doi.org/10.1159/000335104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709189PMC
March 2012

Pendrin function and regulation in Xenopus oocytes.

Cell Physiol Biochem 2011 16;28(3):435-50. Epub 2011 Nov 16.

Renal Division and Molecular and Vascular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1159/000335106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709188PMC
March 2012

SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct.

Cell Physiol Biochem 2011 18;28(3):545-52. Epub 2011 Nov 18.

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850-3320, USA.

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http://dx.doi.org/10.1159/000335119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709178PMC
March 2012

The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link.

Am J Physiol Renal Physiol 2012 Mar 30;302(5):F614-24. Epub 2011 Nov 30.

Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Haifa, Israel.

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http://dx.doi.org/10.1152/ajprenal.00189.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353648PMC
March 2012

Guanine nucleotides differentially modulate backbone dynamics of the STAS domain of the SulP/SLC26 transport protein Rv1739c of Mycobacterium tuberculosis.

FEBS J 2012 Feb 22;279(3):420-36. Epub 2011 Dec 22.

Division of Molecular and Vascular Medicine, Renal Division, and Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08435.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262594PMC
February 2012

SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization.

Am J Physiol Cell Physiol 2011 Aug 18;301(2):C289-303. Epub 2011 May 18.

Renal Division and Vascular Biology Center, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00089.2011
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http://dx.doi.org/10.1152/ajpcell.00089.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154555PMC
August 2011

Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1.

Biochem Cell Biol 2011 Apr;89(2):224-35

Renal and Molecular Vascular Medicine Divisions, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1139/o10-147DOI Listing
April 2011

Solution structure of the guanine nucleotide-binding STAS domain of SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.

J Biol Chem 2011 Mar 29;286(10):8534-44. Epub 2010 Dec 29.

Divison of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M110.165449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048736PMC
March 2011

Familial renal tubular acidosis.

Authors:
Seth L Alper

J Nephrol 2010 Nov-Dec;23 Suppl 16:S57-76

Renal Division and Molecular and Vascular Medicine Division, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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February 2011

Tubular transport: core curriculum 2010.

Am J Kidney Dis 2010 Dec 30;56(6):1202-17. Epub 2010 Oct 30.

Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1053/j.ajkd.2010.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018279PMC
December 2010