Seth F Harris

Seth F Harris

UNVERIFIED PROFILE

Are you Seth F Harris?   Register this Author

Register author
Seth F Harris

Seth F Harris

Publications by authors named "Seth F Harris"

Are you Seth F Harris?   Register this Author

39Publications

1490Reads

32Profile Views

Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.

J Mol Biol 2018 07 17;430(14):2139-2152. Epub 2018 May 17.

Banting and Best Department of Medical Research and Department of Medical Genetics, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00222836183043
Publisher Site
http://dx.doi.org/10.1016/j.jmb.2018.05.018DOI Listing
July 2018

VH-VL orientation prediction for antibody humanization candidate selection: A case study.

MAbs 2016 ;8(2):288-305

a Roche Pharmaceutical Research and Early Development, Large Molecule Research, Roche Innovation Center Penzberg , Nonnenwald 2, Penzberg , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19420862.2015.1117720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966660PMC
December 2016

Developments in the Implementation of Acoustic Droplet Ejection for Protein Crystallography.

J Lab Autom 2016 Feb 14;21(1):97-106. Epub 2015 Aug 14.

Department of Structural Biology, Genentech, Inc, South San Francisco, CA, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2211068215598938DOI Listing
February 2016

Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.

Structure 2015 Nov 17;23(11):2043-54. Epub 2015 Sep 17.

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2015.08.010DOI Listing
November 2015

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility.

Nature 2015 Mar 18;519(7544):425-30. Epub 2015 Mar 18.

Molecular Biology Department, Genentech, Inc., South San Francisco, California 94080, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14323DOI Listing
March 2015

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.

Bioorg Med Chem Lett 2014 Sep 2;24(18):4546-4552. Epub 2014 Aug 2.

Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.07.071DOI Listing
September 2014

Nanolitre-scale crystallization using acoustic liquid-transfer technology.

Acta Crystallogr D Biol Crystallogr 2012 Aug 17;68(Pt 8):893-900. Epub 2012 Jul 17.

Department of Discovery Technologies, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444912016617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413209PMC
August 2012

Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias.

Acta Crystallogr D Biol Crystallogr 2010 May 21;66(Pt 5):568-76. Epub 2010 Apr 21.

Department of Discovery Technologies, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444910005512DOI Listing
May 2010

Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.

Cell 2006 Oct;127(2):329-40

Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2006.09.027DOI Listing
October 2006

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site.

Structure 2004 Jun;12(6):1087-97

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S096921260400126
Publisher Site
http://dx.doi.org/10.1016/j.str.2004.03.020DOI Listing
June 2004