Seth B Herzon

Seth B Herzon

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Seth B Herzon

Publications by authors named "Seth B Herzon"

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Synthesis and reactivity of precolibactin 886.

Nat Chem 2019 Oct 23;11(10):890-898. Epub 2019 Sep 23.

Department of Chemistry, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41557-019-0338-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761996PMC
October 2019

Structure elucidation of colibactin and its DNA cross-links.

Science 2019 09 8;365(6457). Epub 2019 Aug 8.

Department of Chemistry, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/science.aax2685DOI Listing
September 2019

Programmable Synthesis of 2-Deoxyglycosides.

J Am Chem Soc 2019 May 9;141(20):8098-8103. Epub 2019 May 9.

Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.

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http://dx.doi.org/10.1021/jacs.9b03982DOI Listing
May 2019

Antibacterial properties and clinical potential of pleuromutilins.

Nat Prod Rep 2019 01 6;36(1):220-247. Epub 2018 Jul 6.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA. and Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1039/c8np00042eDOI Listing
January 2019

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.

ACS Chem Biol 2018 12 20;13(12):3286-3293. Epub 2018 Nov 20.

Department of Microbial Pathogenesis , Yale School of Medicine , New Haven , Connecticut 06536 , United States.

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http://pubs.acs.org/doi/10.1021/acschembio.8b00714
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http://dx.doi.org/10.1021/acschembio.8b00714DOI Listing
December 2018

Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening.

Biochemistry 2018 11 31;57(45):6391-6394. Epub 2018 Oct 31.

Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.8b01023
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http://dx.doi.org/10.1021/acs.biochem.8b01023DOI Listing
November 2018

Synthesis of Myrocin G, the Putative Active Form of the Myrocin Antitumor Antibiotics.

J Am Chem Soc 2018 11 16;140(47):16058-16061. Epub 2018 Nov 16.

Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.

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http://dx.doi.org/10.1021/jacs.8b10891DOI Listing
November 2018

Cobalt bis(acetylacetonate)--butyl hydroperoxide-triethylsilane: a general reagent combination for the Markovnikov-selective hydrofunctionalization of alkenes by hydrogen atom transfer.

Beilstein J Org Chem 2018 28;14:2259-2265. Epub 2018 Aug 28.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.3762/bjoc.14.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122341PMC
August 2018

Directed C-H Bond Oxidation of (+)-Pleuromutilin.

J Org Chem 2018 07 1;83(13):6843-6892. Epub 2018 May 1.

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http://dx.doi.org/10.1021/acs.joc.8b00462DOI Listing
July 2018

DNA Repair: Unconventional Lesions Require Unconventional Repair.

Authors:
Seth B Herzon

Biochemistry 2018 02 6;57(7):1057-1058. Epub 2018 Feb 6.

Department of Chemistry, Yale University , New Haven, Connecticut 06511, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b01241DOI Listing
February 2018

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.

J Am Chem Soc 2017 12 28;139(49):17719-17722. Epub 2017 Nov 28.

Department of Microbial Pathogenesis, Yale School of Medicine , New Haven, Connecticut 06536, United States.

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http://dx.doi.org/10.1021/jacs.7b09971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202678PMC
December 2017

Development of a Modular Synthetic Route to (+)-Pleuromutilin, (+)-12-epi-Mutilins, and Related Structures.

J Am Chem Soc 2017 11 2;139(45):16377-16388. Epub 2017 Nov 2.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.7b09869DOI Listing
November 2017

Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway.

ACS Chem Biol 2017 10 8;12(10):2598-2608. Epub 2017 Sep 8.

Department of Chemistry, University of Florida , Gainesville, Florida 32611, United States.

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http://dx.doi.org/10.1021/acschembio.7b00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830302PMC
October 2017

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.

J Am Chem Soc 2017 10 12;139(42):14817-14824. Epub 2017 Oct 12.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.7b07807DOI Listing
October 2017

The Mechanism of Action of (-)-Lomaiviticin A.

Authors:
Seth B Herzon

Acc Chem Res 2017 10 28;50(10):2577-2588. Epub 2017 Sep 28.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/acs.accounts.7b00347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874803PMC
October 2017

Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics.

Org Lett 2017 09 31;19(18):4980-4983. Epub 2017 Aug 31.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/acs.orglett.7b02476DOI Listing
September 2017

Introduction: Natural Product Synthesis.

Chem Rev 2017 09;117(18):11649-11650

University of California , Irvine.

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http://dx.doi.org/10.1021/acs.chemrev.7b00520DOI Listing
September 2017

A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A. Evidence for a structural revision.

Chem Sci 2017 Jul 4;8(7):4867-4871. Epub 2017 May 4.

Department of Chemistry , Yale University , New Haven , CT 06520 , USA . Email:

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http://dx.doi.org/10.1039/c7sc01127jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603897PMC
July 2017

A modular and enantioselective synthesis of the pleuromutilin antibiotics.

Science 2017 06;356(6341):956-959

Department of Chemistry, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/science.aan0003DOI Listing
June 2017

Hydroheteroarylation of Unactivated Alkenes Using N-Methoxyheteroarenium Salts.

J Am Chem Soc 2017 04 12;139(16):5998-6007. Epub 2017 Apr 12.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.7b02388DOI Listing
April 2017

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

J Am Chem Soc 2017 03 10;139(11):4195-4201. Epub 2017 Mar 10.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.7b00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831107PMC
March 2017

A Mechanistic Model for Colibactin-Induced Genotoxicity.

J Am Chem Soc 2016 12 28;138(48):15563-15570. Epub 2016 Nov 28.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.6b10354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359767PMC
December 2016

Mechanism of Nucleophilic Activation of (-)-Lomaiviticin A.

J Am Chem Soc 2016 12 28;138(48):15559-15562. Epub 2016 Nov 28.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.6b09657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339879PMC
December 2016

Synthesis of Ketones and Esters from Heteroatom-Functionalized Alkenes by Cobalt-Mediated Hydrogen Atom Transfer.

J Org Chem 2016 10 26;81(19):8673-8695. Epub 2016 Sep 26.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/acs.joc.6b01709DOI Listing
October 2016

Stereoselective Multicomponent Reactions Using Zincate Nucleophiles: β-Dicarbonyl Synthesis and Functionalization.

Org Lett 2016 10 27;18(19):4880-4883. Epub 2016 Sep 27.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://pubs.acs.org/doi/10.1021/acs.orglett.6b02320
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http://dx.doi.org/10.1021/acs.orglett.6b02320DOI Listing
October 2016

Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.

Bioorg Med Chem Lett 2016 07 30;26(13):3122-3126. Epub 2016 Apr 30.

Department of Chemistry, Yale University, New Haven, CT 06520, United States; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.04.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899226PMC
July 2016

Intermolecular Hydropyridylation of Unactivated Alkenes.

J Am Chem Soc 2016 07 12;138(28):8718-21. Epub 2016 Jul 12.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jacs.6b05271DOI Listing
July 2016

The pharmacology and therapeutic potential of (-)-huperzine A.

J Exp Pharmacol 2012 5;4:113-23. Epub 2012 Sep 5.

Department of Chemistry, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.2147/JEP.S27084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863551PMC
May 2016

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

J Am Chem Soc 2016 04 12;138(16):5426-32. Epub 2016 Apr 12.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049697PMC
http://dx.doi.org/10.1021/jacs.6b02276DOI Listing
April 2016

Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):2851-6. Epub 2016 Feb 29.

Department of Chemistry, Yale University, New Haven, CT 06520; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520

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http://www.pnas.org/content/113/11/2851.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1519846113
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http://dx.doi.org/10.1073/pnas.1519846113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801295PMC
March 2016

Non-classical selectivities in the reduction of alkenes by cobalt-mediated hydrogen atom transfer.

Chem Sci 2015 Nov 21;6(11):6250-6255. Epub 2015 Aug 21.

Department of Chemistry , Yale University , New Haven , Connecticut 06520 , USA . Email:

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http://dx.doi.org/10.1039/c5sc02476eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054054PMC
November 2015

Synthesis of 1,3-Amino Alcohols, 1,3-Diols, Amines, and Carboxylic Acids from Terminal Alkynes.

J Org Chem 2015 Sep 18;80(17):8604-18. Epub 2015 Aug 18.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/acs.joc.5b01220DOI Listing
September 2015

A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials.

Nature 2015 Sep 16;525(7570):507-10. Epub 2015 Sep 16.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/nature14902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583359PMC
September 2015

The discovery of a novel route to highly substituted α-tropolones enables expedient entry to the core of the gukulenins.

Org Lett 2015 Apr 3;17(8):2030-3. Epub 2015 Apr 3.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

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http://pubs.acs.org/doi/10.1021/acs.orglett.5b00841
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http://dx.doi.org/10.1021/acs.orglett.5b00841DOI Listing
April 2015

Substrate-modified functional group reactivity: hasubanan and acutumine alkaloid syntheses.

J Org Chem 2014 Oct 19;79(19):8937-47. Epub 2014 Aug 19.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://pubs.acs.org/doi/10.1021/jo501516x
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http://dx.doi.org/10.1021/jo501516xDOI Listing
October 2014

Analysis of diazofluorene DNA binding and damaging activity: DNA cleavage by a synthetic monomeric diazofluorene.

Angew Chem Int Ed Engl 2014 Aug 9;53(35):9325-8. Epub 2014 Jul 9.

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA) http://www.chem.yale.edu/herzongroup.

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http://dx.doi.org/10.1002/anie.201404137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206835PMC
August 2014

Broad-spectrum catalysts for the ambient temperature anti-Markovnikov hydration of alkynes.

Angew Chem Int Ed Engl 2014 Jul 25;53(30):7892-5. Epub 2014 Jun 25.

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA).

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http://dx.doi.org/10.1002/anie.201404320DOI Listing
July 2014

The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.

Nat Chem 2014 Jun 11;6(6):504-10. Epub 2014 May 11.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/nchem.1944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090708PMC
June 2014

A highly active and air-stable ruthenium complex for the ambient temperature anti-Markovnikov reductive hydration of terminal alkynes.

J Am Chem Soc 2014 May 1;136(19):7058-67. Epub 2014 May 1.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://pubs.acs.org/doi/10.1021/ja501738a
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http://dx.doi.org/10.1021/ja501738aDOI Listing
May 2014

Scope and limitations of 2-deoxy- and 2,6-dideoxyglycosyl bromides as donors for the synthesis of β-2-deoxy- and β-2,6-dideoxyglycosides.

Org Lett 2014 May 1;16(10):2776-9. Epub 2014 May 1.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/ol501101fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033630PMC
May 2014

A method for the selective hydrogenation of alkenyl halides to alkyl halides.

J Am Chem Soc 2014 May 30;136(19):6884-7. Epub 2014 Apr 30.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/ja502885cDOI Listing
May 2014

Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes.

Authors:
Le Li Seth B Herzon

Nat Chem 2014 Jan 17;6(1):22-7. Epub 2013 Nov 17.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/nchem.1799DOI Listing
January 2014

The Hasubanan and Acutumine Alkaloids.

Alkaloids Chem Biol 2014;73:161-222. Epub 2013 Dec 25.

Department of Chemistry, Yale University, New Haven, Connecticut, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-411565-1.00003-2DOI Listing
December 2013

Development of enantioselective synthetic routes to the hasubanan and acutumine alkaloids.

J Org Chem 2013 Oct 27;78(20):10031-57. Epub 2013 Sep 27.

Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/jo401889bDOI Listing
October 2013

Insights into lomaiviticin biosynthesis. Isolation and structure elucidation of (-)-homoseongomycin.

J Nat Prod 2013 Jul 26;76(7):1238-41. Epub 2013 Jun 26.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/np400355hDOI Listing
July 2013

Direct synthesis of β-N-glycosides by the reductive glycosylation of azides with protected and native carbohydrate donors.

Angew Chem Int Ed Engl 2013 Jun 22;52(23):6068-71. Epub 2013 Apr 22.

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.

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http://dx.doi.org/10.1002/anie.201301264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845733PMC
June 2013

Total syntheses of (-)-acutumine and (-)-dechloroacutumine.

Angew Chem Int Ed Engl 2013 Mar 20;52(13):3642-5. Epub 2013 Feb 20.

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.

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http://dx.doi.org/10.1002/anie.201210076DOI Listing
March 2013

Development of enantioselective synthetic routes to (-)-kinamycin F and (-)-lomaiviticin aglycon.

J Am Chem Soc 2012 Oct 3;134(41):17262-73. Epub 2012 Oct 3.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://pubs.acs.org/doi/10.1021/ja307497h
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http://dx.doi.org/10.1021/ja307497hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505684PMC
October 2012

Synthesis of (R)-(+)-4-methylcyclohex-2-ene-1-one.

J Org Chem 2012 Oct 3;77(20):9422-5. Epub 2012 Oct 3.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1021/jo3017956DOI Listing
October 2012

Regioselective reductive hydration of alkynes to form branched or linear alcohols.

Authors:
Le Li Seth B Herzon

J Am Chem Soc 2012 Oct 16;134(42):17376-9. Epub 2012 Oct 16.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1021/ja307145eDOI Listing
October 2012

Room temperature, palladium-mediated P-arylation of secondary phosphine oxides.

Org Lett 2012 Sep 20;14(17):4370-3. Epub 2012 Aug 20.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1021/ol301831kDOI Listing
September 2012

Isolation of lomaiviticins C-E, transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses.

J Am Chem Soc 2012 Sep 10;134(37):15285-8. Epub 2012 Sep 10.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://pubs.acs.org/doi/10.1021/ja3074984
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http://dx.doi.org/10.1021/ja3074984DOI Listing
September 2012

Real-time kinetics of surfactant molecule transfer between emulsion particles probed by in situ second harmonic generation spectroscopy.

J Am Chem Soc 2012 Mar 24;134(9):4264-8. Epub 2012 Feb 24.

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, USA.

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http://pubs.acs.org/doi/10.1021/ja2104608
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http://dx.doi.org/10.1021/ja2104608DOI Listing
March 2012

The diazofluorene antitumor antibiotics: structural elucidation, biosynthetic, synthetic, and chemical biological studies.

Nat Prod Rep 2012 Jan 28;29(1):87-118. Epub 2011 Oct 28.

Yale University - Chemistry, New Haven, Connecticut 06520-8107, United States.

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http://dx.doi.org/10.1039/c1np00052gDOI Listing
January 2012

Efficient entry to the hasubanan alkaloids: first enantioselective total syntheses of (-)-hasubanonine, (-)-runanine, (-)-delavayine, and (+)-periglaucine B.

Angew Chem Int Ed Engl 2011 Sep 3;50(38):8863-6. Epub 2011 Jun 3.

Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, USA.

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http://dx.doi.org/10.1002/anie.201102226DOI Listing
September 2011

11-Step enantioselective synthesis of (-)-lomaiviticin aglycon.

J Am Chem Soc 2011 May 31;133(19):7260-3. Epub 2011 Jan 31.

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja200034b
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http://dx.doi.org/10.1021/ja200034bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357143PMC
May 2011

Development of a convergent entry to the diazofluorene antitumor antibiotics: enantioselective synthesis of kinamycin F.

J Am Chem Soc 2010 Mar;132(8):2540-1

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja910769j
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http://dx.doi.org/10.1021/ja910769jDOI Listing
March 2010

Synthesis of the fully glycosylated cyclohexenone core of lomaiviticin A.

Org Lett 2009 Oct;11(19):4322-5

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

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http://pubs.acs.org/doi/abs/10.1021/ol901710b
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http://dx.doi.org/10.1021/ol901710bDOI Listing
October 2009

Hydroaminoalkylation of unactivated olefins with dialkylamines.

J Am Chem Soc 2008 Nov 21;130(45):14940-1. Epub 2008 Oct 21.

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/ja806367eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852863PMC
November 2008

Direct, catalytic hydroaminoalkylation of unactivated olefins with N-alkyl arylamines.

J Am Chem Soc 2007 May 3;129(21):6690-1. Epub 2007 May 3.

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/ja0718366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590937PMC
May 2007

Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell culture.

J Am Chem Soc 2007 Apr 31;129(16):4898-9. Epub 2007 Mar 31.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0690971
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http://dx.doi.org/10.1021/ja0690971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175819PMC
April 2007

Enantioselective synthesis of stephacidin B.

J Am Chem Soc 2005 Apr;127(15):5342-4

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja0510616DOI Listing
April 2005

Identification of a novel Michael acceptor group for the reversible addition of oxygen- and sulfur-based nucleophiles. Synthesis and reactivity of the 3-alkylidene-3H-indole 1-oxide function of avrainvillamide.

J Am Chem Soc 2003 Oct;125(40):12080-1

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja0372006DOI Listing
October 2003

Convenient preparations of 2,4-methanopyrrolidine and 5-carboxy-2,4-methanopyrrolidines.

J Org Chem 2003 Sep;68(19):7562-4

Department of Chemistry, Temple University, Philadelphia, Pennsylvania, 19122, USA.

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http://dx.doi.org/10.1021/jo0348672DOI Listing
September 2003

The rearrangement route to 2-azabicyclo[2.1.1]hexanes. Solvent and electrophile control of neighboring group participation.

J Org Chem 2003 Jun;68(13):5292-9

Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.

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http://dx.doi.org/10.1021/jo034394zDOI Listing
June 2003