Publications by authors named "Serkan Gokaslan"

17 Publications

  • Page 1 of 1

Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosis

Turk J Med Sci 2020 04 9;50(2):442-447. Epub 2020 Apr 9.

Department of Radiology, Faculty of Medicine, Afyonkarahisar University of Health Sciences, Afyonkarahisar, Turkey

Background/aim: Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination; the relapsing–remitting phase of MS is characterized by acute exacerbation of disease activity. The most commonly used noninvasive approach to assess autonomic function is the determination of heart rate turbulence (HRT) and heart rate variability (HRV). The aim of this study was to evaluate the presence of cardiovascular autonomic dysfunction using HRT and HRV parameters determined via 24-h Holter ECG monitoring in patients with relapsing–remitting MS without known heart disease.

Materials And Methods: The study included 26 patients diagnosed with relapsing–remitting MS and 22 age- and sex-matched healthy controls. HRT and HRV parameters were analyzed via 24-h Holter ECG monitoring. Magnetic resonance imaging findings were reevaluated to identify any demyelinating lesions in the brain stem.

Results: The HRV parameters of SDNNI (mean of the standard deviations of all normal sinus RR intervals in all 5-min segments), rMSSD (root–mean–square successive difference), and sNN50 (percentage of successive normal sinus RR intervals >50 ms) were significantly lower in the MS group than in the control group (P < 0.05).

Conclusion: This study revealed that the patients with MS had reduced HRV; this was demonstrated by dysfunction with regard to parasympathetic and sympathetic parameters in HRV analysis.
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http://dx.doi.org/10.3906/sag-1912-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164742PMC
April 2020

A Rare Non-penetrant Abdominal Wall Injury Caused by High-pressure Water: A Case Report.

Curr Med Imaging Rev 2019;15(6):607-609

Radiology Department, Medicine Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.

Background: High-pressure water jet injuries are an uncommon cause of trauma. Highpressure water injuries are usually seen at the extremities and less often in the thorax and abdominal areas. A review of the literature reveals a few case reports describing intraabdominal injuries due to penetrating trauma. İn this paper, we present the radiological findings of a rare case of abdominal wall injury without penetration of peritoneum caused by high-pressure water jet due to the Coanda effect. The Coanda effect is the tendency of a fluid jet to stay attached to a curved. In our case, the peritoneum also functions as flat and curved surface, causing non-penetrant abdominal wall injury.

Case Report: A 28-year-old male working at a hydroelectric terminal presented to the emergency department with abdominal pain and a two-centimeter cutaneous gap in the left lower quadrant of the abdomen caused by high-pressure water. The CT findings revealed a small entrance to left lower quadrant of the abdominal wall and extensive subcutaneous injury. There was no internal injury. The cutaneous gap was managed by primary surgical closure. Subcutaneous emphysema was diminished on the follow up physical examination. The patient was recovered without sequelae.

Conclusion: The water jet can cause a wide subcutaneous injury by following the peritoneum even though there is a small entrance. Therefore radiological imaging can help to determine their severity and planning treatment.
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http://dx.doi.org/10.2174/1573405614666181018115010DOI Listing
October 2020

Evaluation of the CT imaging findings in the diagnosis of pulmonary hypertension due to chronic thromboembolism.

Clin Respir J 2020 Mar 11;14(3):228-234. Epub 2019 Dec 11.

Department of Cardiology, Afyonkarahisar Health Sciences University, Faculty of Medicine, Afyon, Turkey.

Purpose: Chronic thromboembolic pulmonary hypertension (CTEPH) is the only pulmonary hypertension that can be treated surgically. Multidedector computerized tomography angiography (MDCTA) is considered as an important tool. In this study, the important CT findings of CTEPH and the vascular MDCTA findings of CTEPH were classified as central, peripheral, central and peripheral. The aim of this study was to investigate the relationship between these groups with parenchymal and hemodynamic findings.

Materials And Methods: MDCTA examinations of 26 patients who had been diagnosed with CTEPH were retrospectively reviewed. Vascular, cardiac and parenchymal findings were examined in MDCTA. Patients were divided into three groups as peripheral, central and peripheral and central chronic thromboembolism. The relationship between these groups with demographic, vascular, parenchymal and hemodynamic findings was investigated.

Results: The most common vascular finding was the wall filling defects attached to the lobar and/or segmental arterial walls, while the parenchymal finding was the fibrotic shrinkage. There were no statistically significant differences between the three groups compared to parenchymal findings which are mosaic pattern, brochiectasis, fibrotic changes and atelectasis, pulmonary artery diameter, right atrial diameter and RV/LV ratio. Age and sex were not different in patients between the three groups.

Conclusion: The results of the this study confirm the important role of MDCTA in the evaluation of vascular, cardiac and parenchymal findings in the patients with CTEPH and identifying patients that would most benefit from surgical treatment by visualization of the segmental and subsegmental branches of the pulmonary arteries.
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http://dx.doi.org/10.1111/crj.13120DOI Listing
March 2020

Effects of clipping endoscopic thoracal sympathectomy at Th on cardiopulmonary functions, quality of life and psychosocial functions.

Gen Thorac Cardiovasc Surg 2020 May 30;68(5):516-522. Epub 2019 Nov 30.

Department of Anesthesiology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.

Background: In this study, we evaluated the cardiopulmonary and psychosocial effects of endoscopic thoracal sympathectomy (ETS) by clipping procedure at the level of Th and effects of ETS on quality of life of patients with hyperhidrosis.

Methods: We performed a prospective study in 52 patients complaining of local sweating who applied to our clinic. Cardiac maximal treadmill stress test (CMTST), pulmonary function tests, Beck anxiety-depression inventory, Liebowitz social anxiety scale and SF-36 quality of life questionnaires were administered at preoperative period and postoperative 6th month.

Results: In the pulmonary function test, we found a minimal decrease in FEV1, and FEV1/FVC. There were no significant change in 'resting pulse rate', 'resting systolic and diastolic blood pressures' during CMTST between before and after operation. There was a significant difference in peak heart rate before CMTST, post-exercise diastolic blood pressure, and age-predictive maximal heart rate between before and after clipping procedure. In the SF-36 questionnaire, all parameters were improved. In the Beck depression-anxiety inventory and the Liebowitz social anxiety scale significant improvement was achieved in all parameters.

Conclusion: ETS by clipping procedure at the Th level is advised to be a safe and effective method for management of hyperhidrosis patients.
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http://dx.doi.org/10.1007/s11748-019-01259-4DOI Listing
May 2020

The Usefulness of Admission Plasma NT-pro BNP Level to Predict Left Ventricular Aneurysm Formation after Acute ST-Segment Elevation Myocardial Infarction.

Arq Bras Cardiol 2019 12;113(6):1129-1137

University of Health Science, Turkiye Yuksek Ihtisas Training and Research Hospital - Cardiology, Ankara - Turkey.

Background: Left ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. In this study, we investigated the role of N- Terminal pro B type natriuretic peptide level to predict the LVA development after acute ST-segment elevation myocardial infarction (STEMI).

Methods: We prospectively enrolled 1519 consecutive patients with STEMI. Patients were divided into two groups according to LVA development within the six months after index myocardial infarction. Patients with or without LVAs were examined to determine if a significant relationship existed between the baseline N- Terminal pro B type natriuretic peptide values and clinical characteristics. A p-value < 0.05 was considered statistically significant.

Results: LVA was detected in 157 patients (10.3%). The baseline N- Terminal pro- B type natriuretic peptide level was significantly higher in patients who developed LVA after acute MI (523.5 ± 231.1 pg/mL vs. 192.3 ± 176.6 pg/mL, respectively, p < 0.001). Independent predictors of LVA formation after acute myocardial infarction was age > 65 y, smoking, Killip class > 2, previous coronary artery bypass graft, post-myocardial infarction heart failure, left ventricular ejection fraction < 50%, failure of reperfusion, no-reflow phenomenon, peak troponin I and CK-MB and NT-pro BNP > 400 pg/mL at admission.

Conclusions: Our findings indicate that plasma N- Terminal pro B type natriuretic peptide level at admission among other variables provides valuable predictive information regarding the development of LVA after acute STEMI.
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http://dx.doi.org/10.5935/abc.20190226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021256PMC
December 2019

Role of aortic stiffness and inflammation in the etiology of young-onset hypertension

Turk J Med Sci 2019 12 16;49(6):1748-1753. Epub 2019 Dec 16.

Background/aim: Young-onset hypertension is a form of condition diagnosed in patients aged below 40. Cytokines such as interleukin (IL)-6 and also MCP-1 may play a role in the development of arterial hypertension. Aortic stiffness can be detected by measuring pulse wave velocity (PWV). We aimed to explore the relationship between inflammation and aortic stiffness and investigate their roles in the etiology of young-onset hypertension.

Materials And Methods: We enrolled 16 patients diagnosed with young-onset hypertension and 16 volunteers without hypertension. The plasma levels of MCP-1 and IL-6 were determined using an enzyme-linked immunosorbent assay and quantitative enzyme-linked immunoassay, respectively. Carotid-femoral PWV was measured using an arteriograph device.

Results: Compared with those in normotensive controls, the plasma levels of IL-6 and MCP-1 and the PWV values were significantly higher in patients with young-onset hypertension (P < 0.001). PWV values were also positively correlated with the levels of MCP-1 and IL-6. However, no statistically significant difference was noted in intima-media thickness between the two groups (P = 0.224).

Conclusion: In this study, increased PWVs and the levels of inflammation markers were associated with aortic stiffness and inflammation in patients with young-onset hypertension, suggesting they have a role in the etiology of hypertension.
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http://dx.doi.org/10.3906/sag-1908-137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518685PMC
December 2019

Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus.

J Infect Public Health 2018 Jan - Feb;11(1):35-38. Epub 2017 Mar 9.

Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.

Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were significantly higher in patients with HIV than control subjects (all p<0.01). In correlation analysis, there were positive correlation between Tp-e interval and disease duration (r=0.298, p=0.048). and inverse correlation between Tp-e interval and CD4 count(r=-0.303, p=0.036). Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with HIV than control subjects.
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http://dx.doi.org/10.1016/j.jiph.2017.02.008DOI Listing
July 2018

Assessment of the atrial electromechanical properties of patients with human immunodeficiency virus.

J Infect Public Health 2017 Nov - Dec;10(6):721-724. Epub 2017 Feb 3.

Türkiye Yüksek İhtisas Training and Research Hospital, Department of Cardiology, Ankara, Turkey.

The relationship between atrial fibrillation and human immunodeficiency virus (HIV) infection was evaluated. Electro-echocardiographic methods can be used to predict the development of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electromechanical delay (AEMD) parameters of HIV (+) patients. Forty-two HIV (+) patients and 40 HIV (-) healthy volunteers were prospectively enrolled in this study. The electromechanical properties of the subjects' atria were evaluated with tissue Doppler imaging. The left-AEMD, right-AEMD and inter-AEMD were increased in the HIV (+) patients relative to the controls (p=0.003, p<0.001, and p<0.001, respectively). The CD4 count was inversely correlated with the inter-AEMD (r=-0.428, p<0.001). The CD4 count was an independent predictor of the inter-AEMD (β=0.523, p=0.007). Our study demonstrated that both the inter- and intra-atrial electromechanical delays were prolonged in the patients with HIV. This non-invasive and simple technique may provide significant contributions to the assessment of the risk of atrial arrhythmia in patients with HIV.
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http://dx.doi.org/10.1016/j.jiph.2016.10.008DOI Listing
June 2018

Relation between lymphocyte to monocyte ratio and short-term mortality in patients with acute pulmonary embolism.

Clin Respir J 2018 Feb 20;12(2):580-586. Epub 2016 Oct 20.

Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Introduction: The relationship between inflammation and mortality after acute pulmonary embolism (APE) has previously been investigated with different variables (platelet/lymphocyte ratio, etc).

Objectives: We investigated the predictive value of lymphocyte to monocyte ratio (LMR) for mortality in first 30 days after APE.

Methods: The study population included 264 APE patients of which 230 patients were survivors, 34 patients were non-survivors.

Results: LMR was significantly lower in non-survivors after APE (P < .001). Neutrophil-to-lymphocyte ratio (NLR) was higher in non-survivors after APE (P < .001). Platelet-to-lymphocyte (PLR) had no significance between both groups (P: .241). Simplified pulmonary embolism severity index and LMR were independent predictors of mortality in patients with APE (P: .008 and P: .001, respectively).

Conclusion: LMR as a novel marker of inflammation seemed to be an independent predictor of short-term mortality in patients with APE.
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http://dx.doi.org/10.1111/crj.12565DOI Listing
February 2018

Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction.

Anatol J Cardiol 2017 Feb 28;17(2):119-124. Epub 2016 Sep 28.

Department of Cardiology, Turkish High Specialty Training and Research Hospital; Ankara-Turkey.

Objective: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI.

Methods: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test.

Results: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998-1.000; p=0.007).

Conclusion: Adropin could be an alternative blood sample value for predicting severity of CAD.
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http://dx.doi.org/10.14744/AnatolJCardiol.2016.7149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336749PMC
February 2017

Endocan: Endothelial Dysfunction, Inflammation, or Both?

Angiology 2017 01 13;68(1):79. Epub 2016 Jul 13.

Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319716659180DOI Listing
January 2017

Drugs That Affect the Resting Heart Rate.

Angiology 2017 02 18;68(2):174. Epub 2016 Jul 18.

1 Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319716658403DOI Listing
February 2017

Endocan to Predict Cardiovascular Events: A Promising Biomarker or a Coincidental Finding?

Angiology 2017 01 4;68(1):84. Epub 2016 Jul 4.

Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319716657224DOI Listing
January 2017

Zolmitriptan-induced acute myocardial infarction.

Cardiol J 2012 ;19(1):76-8

Ankara Numune Education and Research Hospital, Department of Cardiology, Talatpasa Bulvari, Sihhiye, Ankara, Turkey.

Triptans are an established treatment for acute migraine attacks. By activating 5HT1B/1D receptors they lead to vasoconstriction of the cerebral blood vessels which are dilated during migraine attacks. Moreover, they reduce secretion of vasoactive peptides and conduction of pain stimuli over the cerebral cortex. In up to 7% of cases of treatment with triptans, thoracic pain occurs, although this is mostly transient, mild and without lasting ischemia. We present the case of a 45 year-old woman with a history of migraine with visual aura since the age of 20. She had no history of diabetes mellitus, hypertension, smoking or any other risk factors for cardiovascular events before she was admitted to our emergency room with typical chest pain. An electrocardiogram revealed anterior myocardial infarction following her monthly dose of oral zolmitriptan. Catherization revealed a normal coronary arterial system. The laboratory indices for cardiac risk were within normal ranges. The patient was advised to avoid triptans permanently on being discharged.
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http://dx.doi.org/10.5603/cj.2012.0011DOI Listing
May 2012

Assessment of planimetric mitral valve area using 16-row multidetector computed tomography in patients with rheumatic mitral stenosis.

J Heart Valve Dis 2011 Jan;20(1):13-7

Department of Cardiology, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey.

Background And Aim Of The Study: Transthoracic two-dimensional echocardiography (TTE) is currently the 'gold standard' for the evaluation of rheumatic mitral valve disease. Multidetector computed tomography (MDCT) is a promising technique for the evaluation of heart valves. The study aim was to evaluate the planimetry of the mitral valve area (MVA) with 16-row MDCT in comparison with TTE, in patients with rheumatic mitral stenosis.

Methods: Twenty-six patients (18 females, eight males; mean age 41.7 +/- 8.7 years) with rheumatic mitral valve disease, who had been referred for 16-row MDCT for various indications, such as evaluation of the coronary arteries, assessment of pulmonary vein anatomy before catheter ablation of paroxysmal atrial fibrillation, suspicion of aortic dissection or pulmonary embolism, were recruited. All patients were in sinus rhythm. The MDCT acquisition was performed using a 16-row scanner. Echocardiographic planimetry of MVA was performed in the standard parasternal short-axis view within one week.

Results: Planimetry of the MVA with MDCT did not differ from that with TTE (1.88 +/- 0.46 cm2 versus 1.83 +/- 0.50 cm2, p = 0.242), and there was an excellent correlation between two techniques (r = 0.923, p < 0.0001). Seven patients had calcific mitral valves (mean calcium score 216.8 +/- 783.8 Agatston units). In these patients, MVA measured by MDCT was 1.73 +/- 0.39 cm2 and by TTE planimetry was 1.72 +/- 0.54 cm2 (p = 0.866; r = 0.963, p = 0.0005). When using the pressure half-time (PHT) method, the MVA was obtained in 24 of the 26 patients. MVA by PHT did not differ from the MVA calculated by TTE planimetry, nor from that obtained with MDCT planimetry (1.79 +/- 0.46 cm2 versus 1.81 +/- 0.51 cm2, p = 0.427 and 1.79 +/- 0.46 cm2 versus 1.86 +/- 0.48 cm2, p = 0.101, respectively). The correlation coefficient for the MDCT-derived MVA and PHT-derived MVA was 0.8969 (p < 0.0001). Although not statistically significant, in nine patients with moderate to severe mitral stenosis (MVA < 1.5 cm2), the MDCT tended to overestimate MVA compared to echo planimetry (1.35 +/- 0.19 cm2 versus 1.28 +/- 0.21 cm2, p = 0.059).

Conclusion: MDCT enabled accurate planimetry of the MVA in patients with rheumatic mitral stenosis, in comparison with TTE.
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January 2011

Myocardial infarction after an electric shock: a rare complication.

Cardiol J 2009 ;16(4):362-4

Numune Education and Research Hospital Cardiology, Ankara, Turkey.

Myocardial infarction is one potential outcome after an electric shock though it is seen relatively rarely. Nonetheless, an increased death rate because of cardiopulmonary arrest is of concern and merits careful scrutiny. Here, we report a man with myocardial infarction following electrical shock. Although he had frankly normal coronary arteries by coronary angiography, myocardial infarction was objectively evident by cardiac enzymes, electrocardiography and echocardiography. Oral medication with a beta-blocker and angiotensin converting enzyme inhibitor was started. He was discharged in good health after stabilization for a co-existing pelvic fracture and retroperitoneal hematoma. The patient had an uneventful follow-up one year later, with persisting non-specific electrocardiographic changes.
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October 2009

[Development of acute coronary syndrome in three patients with essential thrombocythemia or polycythemia vera].

Turk Kardiyol Dern Ars 2008 Jan;36(1):35-8

Ankara Numune Eğitim ve Araştirma Hastanesi Kardiyoloji Kliniği, Ankara.

Little is known about the management of coronary thrombosis in myeloproliferative disease. The occurrence of myocardial infarction in myeloproliferative disease is mostly attributed to coronary thrombosis due to hyperviscosity and thrombocytosis. We presented three cases of acute myocardial infarction associated with polycythemia vera in one patient (male, age 33 years) and essential thrombocytosis in two patients (male, ages 36 and 46 years). None of the patients had diabetes mellitus, hypertension, hyperlipidemia, or a positive family history. One patient with early presentation received thrombolytic therapy, and all the patients were treated with aspirin, beta-blocker, angiotensin 2 receptor blocker, statin, low-molecular-weight heparin, parenteral nitrate, and clopidogrel for acute coronary syndrome, and hydroxyurea for essential thrombocytosis. Control angiographies showed patent coronary arteries in all the cases.
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January 2008
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