Serkalem Demissie

Serkalem Demissie

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Serkalem Demissie

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Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 Feb;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.

Sci Rep 2018 Sep 13;8(1):13756. Epub 2018 Sep 13.

Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, USA.

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http://www.nature.com/articles/s41598-018-31830-7
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http://dx.doi.org/10.1038/s41598-018-31830-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137060PMC
September 2018

Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures.

J Bone Miner Res 2018 Apr 5;33(4):621-626. Epub 2017 Dec 5.

Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1002/jbmr.3338DOI Listing
April 2018

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.

J Bone Miner Res 2017 01 26;32(1):106-114. Epub 2016 Oct 26.

Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

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http://dx.doi.org/10.1002/jbmr.2915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310688PMC
January 2017

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.

Circ Cardiovasc Genet 2017 Jan;10(1)

From the Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory (Å.K.H., S.G., E.I.) and Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory (J.K.S.), Uppsala University, Sweden; Cardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden (Å.K.H.) Framingham Heart Study, MA (M.M.M., R.J., C.Y., C.L., T.H., S.D., L.A.C., D.L.); Department of Biostatistics (C.L., L.A.C., S.D.), Boston University, MA; Boston University, MA (M.M.M.); Department of Cardiology, Boston Children's Hospital, MA (M.M.M.); Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (M.M.M., R.J., C.Y., C.L., T.H., D.L.); Centre for Cognitive Ageing and Cognitive Epidemiology (R.E.M., J.M.S., I.J.D.), Medical Genetics Section, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (R.E.M.), Alzheimer Scotland Dementia Research Centre (J.M.S.), and Department of Psychology (I.J.D.), University of Edinburgh, United Kingdom; Queensland Brain Institute, The University of Queensland, Brisbane, Australia (R.E.M., A.F.M., S.S.); Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia (S.S., A.F.M.); Hebrew Senior Life, Harvard Medical School, Boston, MA (R.J.); Department of Epidemiology, School of Public Health (M.R.I.) and Department of Biostatistics, Section on Statistical Genetics (D.Z.), University of Alabama at Birmingham; Department of Biostatistics, Harvard School of Public Health, Boston, MA (L. Liang); William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (P.D.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia (P.D.); Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom (T.D.S.); Deparment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, Sweden (J.S., L.L.); Children's Hospital Oakland Research Institute, CA (R.M.K.); College of Public Health, University of Kentucky, Lexington (D.K.A.); and Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331877PMC
January 2017

Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.

PLoS One 2016 7;11(3):e0144997. Epub 2016 Mar 7.

Boston University's and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780701PMC
July 2016

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

Authors:
Elisabeth M van Leeuwen Aniko Sabo Joshua C Bis Jennifer E Huffman Ani Manichaikul Albert V Smith Mary F Feitosa Serkalem Demissie Peter K Joshi Qing Duan Jonathan Marten Jan B van Klinken Ida Surakka Ilja M Nolte Weihua Zhang Hamdi Mbarek Ruifang Li-Gao Stella Trompet Niek Verweij Evangelos Evangelou Leo-Pekka Lyytikäinen Bamidele O Tayo Joris Deelen Peter J van der Most Sander W van der Laan Dan E Arking Alanna Morrison Abbas Dehghan Oscar H Franco Albert Hofman Fernando Rivadeneira Eric J Sijbrands Andre G Uitterlinden Josyf C Mychaleckyj Archie Campbell Lynne J Hocking Sandosh Padmanabhan Jennifer A Brody Kenneth M Rice Charles C White Tamara Harris Aaron Isaacs Harry Campbell Leslie A Lange Igor Rudan Ivana Kolcic Pau Navarro Tatijana Zemunik Veikko Salomaa Angad S Kooner Jaspal S Kooner Benjamin Lehne William R Scott Sian-Tsung Tan Eco J de Geus Yuri Milaneschi Brenda W J H Penninx Gonneke Willemsen Renée de Mutsert Ian Ford Ron T Gansevoort Marcelo P Segura-Lepe Olli T Raitakari Jorma S Viikari Kjell Nikus Terrence Forrester Colin A McKenzie Anton J M de Craen Hester M de Ruijter Gerard Pasterkamp Harold Snieder Albertine J Oldehinkel P Eline Slagboom Richard S Cooper Mika Kähönen Terho Lehtimäki Paul Elliott Pim van der Harst J Wouter Jukema Dennis O Mook-Kanamori Dorret I Boomsma John C Chambers Morris Swertz Samuli Ripatti Ko Willems van Dijk Veronique Vitart Ozren Polasek Caroline Hayward James G Wilson James F Wilson Vilmundur Gudnason Stephen S Rich Bruce M Psaty Ingrid B Borecki Eric Boerwinkle Jerome I Rotter L Adrienne Cupples Cornelia M van Duijn

J Med Genet 2016 07 1;53(7):441-9. Epub 2016 Apr 1.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/jmedgenet-2015-103439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941146PMC
July 2016

Plasma Adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome.

PLoS One 2014 26;9(9):e108561. Epub 2014 Sep 26.

Center for Translational Medicine and Korman Lung Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108561PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178176PMC
January 2016

Fine mapping the region reveals a common intronic insertion associated to HDL-C.

NPJ Aging Mech Dis 2015 12;1:15011. Epub 2015 Nov 12.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/npjamd.2015.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514988PMC
November 2015

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Authors:
Gina M Peloso Paul L Auer Joshua C Bis Arend Voorman Alanna C Morrison Nathan O Stitziel Jennifer A Brody Sumeet A Khetarpal Jacy R Crosby Myriam Fornage Aaron Isaacs Johanna Jakobsdottir Mary F Feitosa Gail Davies Jennifer E Huffman Ani Manichaikul Brian Davis Kurt Lohman Aron Y Joon Albert V Smith Megan L Grove Paolo Zanoni Valeska Redon Serkalem Demissie Kim Lawson Ulrike Peters Christopher Carlson Rebecca D Jackson Kelli K Ryckman Rachel H Mackey Jennifer G Robinson David S Siscovick Pamela J Schreiner Josyf C Mychaleckyj James S Pankow Albert Hofman Andre G Uitterlinden Tamara B Harris Kent D Taylor Jeanette M Stafford Lindsay M Reynolds Riccardo E Marioni Abbas Dehghan Oscar H Franco Aniruddh P Patel Yingchang Lu George Hindy Omri Gottesman Erwin P Bottinger Olle Melander Marju Orho-Melander Ruth J F Loos Stefano Duga Piera Angelica Merlini Martin Farrall Anuj Goel Rosanna Asselta Domenico Girelli Nicola Martinelli Svati H Shah William E Kraus Mingyao Li Daniel J Rader Muredach P Reilly Ruth McPherson Hugh Watkins Diego Ardissino Qunyuan Zhang Judy Wang Michael Y Tsai Herman A Taylor Adolfo Correa Michael E Griswold Leslie A Lange John M Starr Igor Rudan Gudny Eiriksdottir Lenore J Launer Jose M Ordovas Daniel Levy Y-D Ida Chen Alexander P Reiner Caroline Hayward Ozren Polasek Ian J Deary Ingrid B Borecki Yongmei Liu Vilmundur Gudnason James G Wilson Cornelia M van Duijn Charles Kooperberg Stephen S Rich Bruce M Psaty Jerome I Rotter Christopher J O'Donnell Kenneth Rice Eric Boerwinkle Sekar Kathiresan L Adrienne Cupples

Am J Hum Genet 2014 Feb;94(2):223-32

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928662PMC
February 2014

Variations of CT-based trunk muscle attenuation by age, sex, and specific muscle.

J Gerontol A Biol Sci Med Sci 2013 Mar 17;68(3):317-23. Epub 2012 Aug 17.

Beth Israel Deaconess Medical Center, 330 Brookline Ave, RN115, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/gerona/gls168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605905PMC
March 2013

Assessment of gene-by-sex interaction effect on bone mineral density.

J Bone Miner Res 2012 Oct;27(10):2051-64

Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue CT3, Boston,MA 02118, USA.

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http://dx.doi.org/10.1002/jbmr.1679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447125PMC
October 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Authors:
Zari Dastani Marie-France Hivert Nicholas Timpson John R B Perry Xin Yuan Robert A Scott Peter Henneman Iris M Heid Jorge R Kizer Leo-Pekka Lyytikäinen Christian Fuchsberger Toshiko Tanaka Andrew P Morris Kerrin Small Aaron Isaacs Marian Beekman Stefan Coassin Kurt Lohman Lu Qi Stavroula Kanoni James S Pankow Hae-Won Uh Ying Wu Aurelian Bidulescu Laura J Rasmussen-Torvik Celia M T Greenwood Martin Ladouceur Jonna Grimsby Alisa K Manning Ching-Ti Liu Jaspal Kooner Vincent E Mooser Peter Vollenweider Karen A Kapur John Chambers Nicholas J Wareham Claudia Langenberg Rune Frants Ko Willems-Vandijk Ben A Oostra Sara M Willems Claudia Lamina Thomas W Winkler Bruce M Psaty Russell P Tracy Jennifer Brody Ida Chen Jorma Viikari Mika Kähönen Peter P Pramstaller David M Evans Beate St Pourcain Naveed Sattar Andrew R Wood Stefania Bandinelli Olga D Carlson Josephine M Egan Stefan Böhringer Diana van Heemst Lyudmyla Kedenko Kati Kristiansson Marja-Liisa Nuotio Britt-Marie Loo Tamara Harris Melissa Garcia Alka Kanaya Margot Haun Norman Klopp H-Erich Wichmann Panos Deloukas Efi Katsareli David J Couper Bruce B Duncan Margreet Kloppenburg Linda S Adair Judith B Borja James G Wilson Solomon Musani Xiuqing Guo Toby Johnson Robert Semple Tanya M Teslovich Matthew A Allison Susan Redline Sarah G Buxbaum Karen L Mohlke Ingrid Meulenbelt Christie M Ballantyne George V Dedoussis Frank B Hu Yongmei Liu Bernhard Paulweber Timothy D Spector P Eline Slagboom Luigi Ferrucci Antti Jula Markus Perola Olli Raitakari Jose C Florez Veikko Salomaa Johan G Eriksson Timothy M Frayling Andrew A Hicks Terho Lehtimäki George Davey Smith David S Siscovick Florian Kronenberg Cornelia van Duijn Ruth J F Loos Dawn M Waterworth James B Meigs Josee Dupuis J Brent Richards Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Oliver M Hofmann Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Andrew D Morris Colin N A Palmer Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Oluf Pedersen Inês Barroso Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Paul Elliott Denis Rybin Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Taina Lajunen Alex Doney Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Caroline Hayward Simon C Heath Serge Hercberg David R Hillman Aroon D Hingorani Jennie Hui Joe Hung Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Robert Mahley Massimo Mangino María Teresa Martínez-Larrad Jarred B McAteer Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Sutapa Mukherjee Silvia Naitza Matthew J Neville Marco Orrù Ruth Pakyz Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Udo Seedorf Stephen J Sharp Beverley Shields Gunnar Sigurðsson Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper Manuel Serrano-Ríos Lars Lind Lyle J Palmer Frank B Hu Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter Brenda W J H Penninx Dorret I Boomsma Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Leena Peltonen Vincent Mooser Robert Sladek Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Daniel I Chasman Christopher T Johansen Sigrid W Fouchier Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Mary F Feitosa Marju Orho-Melander Olle Melander Xiaohui Li Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Andreas Ziegler Weihua Zhang Robert Y L Zee John B Whitfield John R Thompson Ida Surakka Tim D Spector Johannes H Smit Juha Sinisalo James Scott Juha Saharinen Chiara Sabatti Lynda M Rose Robert Roberts Mark Rieder Alex N Parker Guillaume Pare Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Gavin Lucas Robert Luben Marja-Liisa Lokki Guillaume Lettre Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Inke R König Kay-Tee Khaw Lee M Kaplan Åsa Johansson A Cecile J W Janssens Wilmar Igl G Kees Hovingh Christian Hengstenberg Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Leif C Groop Elena Gonzalez Nelson B Freimer Jeanette Erdmann Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Ulf de Faire Gabriel Crawford Yii-der I Chen Mark J Caulfield S Matthijs Boekholdt Themistocles L Assimes Thomas Quertermous Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Herman A Taylor Stacey B Gabriel Hilma Holm Vilmundur Gudnason Ronald M Krauss Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt David P Strachan Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Sekar Kathiresan

PLoS Genet 2012 29;8(3):e1002607. Epub 2012 Mar 29.

Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.

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September 2012

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Authors:
Benjamin F Voight Gina M Peloso Marju Orho-Melander Ruth Frikke-Schmidt Maja Barbalic Majken K Jensen George Hindy Hilma Hólm Eric L Ding Toby Johnson Heribert Schunkert Nilesh J Samani Robert Clarke Jemma C Hopewell John F Thompson Mingyao Li Gudmar Thorleifsson Christopher Newton-Cheh Kiran Musunuru James P Pirruccello Danish Saleheen Li Chen Alexandre F R Stewart Arne Schillert Unnur Thorsteinsdottir Gudmundur Thorgeirsson Sonia Anand James C Engert Thomas Morgan John Spertus Monika Stoll Klaus Berger Nicola Martinelli Domenico Girelli Pascal P McKeown Christopher C Patterson Stephen E Epstein Joseph Devaney Mary-Susan Burnett Vincent Mooser Samuli Ripatti Ida Surakka Markku S Nieminen Juha Sinisalo Marja-Liisa Lokki Markus Perola Aki Havulinna Ulf de Faire Bruna Gigante Erik Ingelsson Tanja Zeller Philipp Wild Paul I W de Bakker Olaf H Klungel Anke-Hilse Maitland-van der Zee Bas J M Peters Anthonius de Boer Diederick E Grobbee Pieter W Kamphuisen Vera H M Deneer Clara C Elbers N Charlotte Onland-Moret Marten H Hofker Cisca Wijmenga W M Monique Verschuren Jolanda M A Boer Yvonne T van der Schouw Asif Rasheed Philippe Frossard Serkalem Demissie Cristen Willer Ron Do Jose M Ordovas Gonçalo R Abecasis Michael Boehnke Karen L Mohlke Mark J Daly Candace Guiducci Noël P Burtt Aarti Surti Elena Gonzalez Shaun Purcell Stacey Gabriel Jaume Marrugat John Peden Jeanette Erdmann Patrick Diemert Christina Willenborg Inke R König Marcus Fischer Christian Hengstenberg Andreas Ziegler Ian Buysschaert Diether Lambrechts Frans Van de Werf Keith A Fox Nour Eddine El Mokhtari Diana Rubin Jürgen Schrezenmeir Stefan Schreiber Arne Schäfer John Danesh Stefan Blankenberg Robert Roberts Ruth McPherson Hugh Watkins Alistair S Hall Kim Overvad Eric Rimm Eric Boerwinkle Anne Tybjaerg-Hansen L Adrienne Cupples Muredach P Reilly Olle Melander Pier M Mannucci Diego Ardissino David Siscovick Roberto Elosua Kari Stefansson Christopher J O'Donnell Veikko Salomaa Daniel J Rader Leena Peltonen Stephen M Schwartz David Altshuler Sekar Kathiresan

Lancet 2012 Aug 17;380(9841):572-80. Epub 2012 May 17.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419820PMC
August 2012

Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?

J Bone Miner Res 2012 Feb;27(2):319-30

Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290743PMC
February 2012

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.

PLoS Genet 2011 Dec 8;7(12):e1002393. Epub 2011 Dec 8.

Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234219PMC
December 2011

Bias due to two-stage residual-outcome regression analysis in genetic association studies.

Genet Epidemiol 2011 Nov 18;35(7):592-6. Epub 2011 Jul 18.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1002/gepi.20607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201714PMC
November 2011

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.

Nat Genet 2011 Sep 11;43(10):940-7. Epub 2011 Sep 11.

Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/ng.920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257519PMC
September 2011

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

Circ Cardiovasc Genet 2011 Aug 23;4(4):403-12. Epub 2011 May 23.

Department of Medicine II, University Medical Center Mainz, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157552PMC
August 2011

The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.

PLoS One 2011 Apr 20;6(4):e17944. Epub 2011 Apr 20.

Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080366PMC
April 2011

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Authors:
Heribert Schunkert Inke R König Sekar Kathiresan Muredach P Reilly Themistocles L Assimes Hilma Holm Michael Preuss Alexandre F R Stewart Maja Barbalic Christian Gieger Devin Absher Zouhair Aherrahrou Hooman Allayee David Altshuler Sonia S Anand Karl Andersen Jeffrey L Anderson Diego Ardissino Stephen G Ball Anthony J Balmforth Timothy A Barnes Diane M Becker Lewis C Becker Klaus Berger Joshua C Bis S Matthijs Boekholdt Eric Boerwinkle Peter S Braund Morris J Brown Mary Susan Burnett Ian Buysschaert John F Carlquist Li Chen Sven Cichon Veryan Codd Robert W Davies George Dedoussis Abbas Dehghan Serkalem Demissie Joseph M Devaney Patrick Diemert Ron Do Angela Doering Sandra Eifert Nour Eddine El Mokhtari Stephen G Ellis Roberto Elosua James C Engert Stephen E Epstein Ulf de Faire Marcus Fischer Aaron R Folsom Jennifer Freyer Bruna Gigante Domenico Girelli Solveig Gretarsdottir Vilmundur Gudnason Jeffrey R Gulcher Eran Halperin Naomi Hammond Stanley L Hazen Albert Hofman Benjamin D Horne Thomas Illig Carlos Iribarren Gregory T Jones J Wouter Jukema Michael A Kaiser Lee M Kaplan John J P Kastelein Kay-Tee Khaw Joshua W Knowles Genovefa Kolovou Augustine Kong Reijo Laaksonen Diether Lambrechts Karin Leander Guillaume Lettre Mingyao Li Wolfgang Lieb Christina Loley Andrew J Lotery Pier M Mannucci Seraya Maouche Nicola Martinelli Pascal P McKeown Christa Meisinger Thomas Meitinger Olle Melander Pier Angelica Merlini Vincent Mooser Thomas Morgan Thomas W Mühleisen Joseph B Muhlestein Thomas Münzel Kiran Musunuru Janja Nahrstaedt Christopher P Nelson Markus M Nöthen Oliviero Olivieri Riyaz S Patel Chris C Patterson Annette Peters Flora Peyvandi Liming Qu Arshed A Quyyumi Daniel J Rader Loukianos S Rallidis Catherine Rice Frits R Rosendaal Diana Rubin Veikko Salomaa M Lourdes Sampietro Manj S Sandhu Eric Schadt Arne Schäfer Arne Schillert Stefan Schreiber Jürgen Schrezenmeir Stephen M Schwartz David S Siscovick Mohan Sivananthan Suthesh Sivapalaratnam Albert Smith Tamara B Smith Jaapjan D Snoep Nicole Soranzo John A Spertus Klaus Stark Kathy Stirrups Monika Stoll W H Wilson Tang Stephanie Tennstedt Gudmundur Thorgeirsson Gudmar Thorleifsson Maciej Tomaszewski Andre G Uitterlinden Andre M van Rij Benjamin F Voight Nick J Wareham George A Wells H-Erich Wichmann Philipp S Wild Christina Willenborg Jaqueline C M Witteman Benjamin J Wright Shu Ye Tanja Zeller Andreas Ziegler Francois Cambien Alison H Goodall L Adrienne Cupples Thomas Quertermous Winfried März Christian Hengstenberg Stefan Blankenberg Willem H Ouwehand Alistair S Hall Panos Deloukas John R Thompson Kari Stefansson Robert Roberts Unnur Thorsteinsdottir Christopher J O'Donnell Ruth McPherson Jeanette Erdmann Nilesh J Samani

Nat Genet 2011 Mar 6;43(4):333-8. Epub 2011 Mar 6.

Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119261PMC
March 2011

Epidural analgesia and risks of cesarean and operative vaginal deliveries in nulliparous and multiparous women.

Matern Child Health J 2010 Sep;14(5):705-712

Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.

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September 2010

Biological, clinical and population relevance of 95 loci for blood lipids.

Authors:
Tanya M Teslovich Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Samuli Ripatti Daniel I Chasman Cristen J Willer Christopher T Johansen Sigrid W Fouchier Aaron Isaacs Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Yurii S Aulchenko Gudmar Thorleifsson Mary F Feitosa John Chambers Marju Orho-Melander Olle Melander Toby Johnson Xiaohui Li Xiuqing Guo Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Kijoung Song Jing Hua Zhao Xin Yuan Jian'an Luan Claudia Lamina Andreas Ziegler Weihua Zhang Robert Y L Zee Alan F Wright Jacqueline C M Witteman James F Wilson Gonneke Willemsen H-Erich Wichmann John B Whitfield Dawn M Waterworth Nicholas J Wareham Gérard Waeber Peter Vollenweider Benjamin F Voight Veronique Vitart Andre G Uitterlinden Manuela Uda Jaakko Tuomilehto John R Thompson Toshiko Tanaka Ida Surakka Heather M Stringham Tim D Spector Nicole Soranzo Johannes H Smit Juha Sinisalo Kaisa Silander Eric J G Sijbrands Angelo Scuteri James Scott David Schlessinger Serena Sanna Veikko Salomaa Juha Saharinen Chiara Sabatti Aimo Ruokonen Igor Rudan Lynda M Rose Robert Roberts Mark Rieder Bruce M Psaty Peter P Pramstaller Irene Pichler Markus Perola Brenda W J H Penninx Nancy L Pedersen Cristian Pattaro Alex N Parker Guillaume Pare Ben A Oostra Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Thomas Meitinger Ruth McPherson Mark I McCarthy Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Massimo Mangino Patrik K E Magnusson Gavin Lucas Robert Luben Ruth J F Loos Marja-Liisa Lokki Guillaume Lettre Claudia Langenberg Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Florian Kronenberg Inke R König Kay-Tee Khaw Jaakko Kaprio Lee M Kaplan Asa Johansson Marjo-Riitta Jarvelin A Cecile J W Janssens Erik Ingelsson Wilmar Igl G Kees Hovingh Jouke-Jan Hottenga Albert Hofman Andrew A Hicks Christian Hengstenberg Iris M Heid Caroline Hayward Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Ulf Gyllensten Candace Guiducci Leif C Groop Elena Gonzalez Christian Gieger Nelson B Freimer Luigi Ferrucci Jeanette Erdmann Paul Elliott Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Eco J C de Geus Ulf de Faire Gabriel Crawford Francis S Collins Yii-der I Chen Mark J Caulfield Harry Campbell Noel P Burtt Lori L Bonnycastle Dorret I Boomsma S Matthijs Boekholdt Richard N Bergman Inês Barroso Stefania Bandinelli Christie M Ballantyne Themistocles L Assimes Thomas Quertermous David Altshuler Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Linda S Adair Herman A Taylor Ingrid B Borecki Stacey B Gabriel James G Wilson Hilma Holm Unnur Thorsteinsdottir Vilmundur Gudnason Ronald M Krauss Karen L Mohlke Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt Jerome I Rotter Eric Boerwinkle David P Strachan Vincent Mooser Kari Stefansson Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Cornelia M van Duijn Leena Peltonen Gonçalo R Abecasis Michael Boehnke Sekar Kathiresan

Nature 2010 Aug;466(7307):707-13

Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039276PMC
August 2010

Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.

J Bone Miner Res 2010 Jul;25(7):1555-63

Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA.

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http://dx.doi.org/10.1002/jbmr.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153998PMC
July 2010

Allostatic load is associated with chronic conditions in the Boston Puerto Rican Health Study.

Soc Sci Med 2010 Jun 15;70(12):1988-1996. Epub 2010 Mar 15.

Tufts University, Boston, MA, USA; Northeastern University, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.socscimed.2010.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907654PMC
June 2010

Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe.

Bone 2010 Apr 11;46(4):1114-21. Epub 2010 Jan 11.

Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA.

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http://dx.doi.org/10.1016/j.bone.2010.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842472PMC
April 2010

Validity of self-reported rheumatoid arthritis in a large cohort: results from the Black Women's Health Study.

Arthritis Care Res (Hoboken) 2010 Feb;62(2):235-41

Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1002/acr.20073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832927PMC
February 2010

Apolipoprotein A5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in Puerto Rican older adults.

J Nutr 2009 Dec 14;139(12):2301-8. Epub 2009 Oct 14.

Jean Mayer USDA Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.

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http://dx.doi.org/10.3945/jn.109.109900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777477PMC
December 2009

The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand.

J Rheumatol 2009 Dec 2;36(12):2772-9. Epub 2009 Nov 2.

Framingham Heart Study, National Heart, Lung and Blood Institute, National Institutes of Health, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641579PMC
December 2009

APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations.

Arch Intern Med 2009 Nov;169(20):1897-906

Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111-1524, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874956PMC
November 2009

Transfers among women intending a birth center delivery in the San Diego birth center study.

J Midwifery Womens Health 2009 Mar-Apr;54(2):104-10

Institute forAging Research, Hebrew SeniorLife, 1200 Centre St., Boston, MA 02131-1097, USA.

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June 2009

Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study.

J Bone Miner Res 2009 Apr;24(4):710-8

Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1359/jbmr.081222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659513PMC
April 2009

A genome wide linkage scan of metacarpal size and geometry in the Framingham Study.

Am J Hum Biol 2008 Nov-Dec;20(6):663-70

Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts 02131, USA.

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http://dx.doi.org/10.1002/ajhb.20791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574919PMC
January 2009

Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study.

Arterioscler Thromb Vasc Biol 2008 Jun 3;28(6):1165-71. Epub 2008 Apr 3.

National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mount Wayte Avenue #2, Framingham, MA 01702-5827, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.154849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042248PMC
June 2008

Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip.

J Clin Endocrinol Metab 2008 May 26;93(5):1789-95. Epub 2008 Feb 26.

Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA.

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http://dx.doi.org/10.1210/jc.2007-2492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386280PMC
May 2008

Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women.

Arterioscler Thromb Vasc Biol 2008 Mar 3;28(3):575-9. Epub 2008 Jan 3.

Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.

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March 2008

Genome-wide association with bone mass and geometry in the Framingham Heart Study.

BMC Med Genet 2007 Sep 19;8 Suppl 1:S14. Epub 2007 Sep 19.

Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2350-8-S1-S14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995606PMC
September 2007

APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study.

J Mol Med (Berl) 2007 Feb 9;85(2):119-28. Epub 2007 Jan 9.

Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111-1524, USA.

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http://dx.doi.org/10.1007/s00109-006-0147-0DOI Listing
February 2007

LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial.

Atherosclerosis 2006 Sep 18;188(1):59-67. Epub 2005 Nov 18.

Lipid Metabolism Laboratory, JM-USDA/HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2005.10.018DOI Listing
September 2006

Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study.

J Lipid Res 2006 May 11;47(5):990-6. Epub 2006 Feb 11.

US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

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http://dx.doi.org/10.1194/jlr.M500446-JLR200DOI Listing
May 2006

Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study.

Atherosclerosis 2006 Mar 7;185(1):210-8. Epub 2005 Jul 7.

Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2005.06.008DOI Listing
March 2006

Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study.

J Hypertens 2005 Dec;23(12):2193-200

Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA.

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December 2005

Power and type I error rate of false discovery rate approaches in genome-wide association studies.

BMC Genet 2005 Dec 30;6 Suppl 1:S134. Epub 2005 Dec 30.

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866802PMC
December 2005

Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.

Am J Hypertens 2005 Nov;18(11):1388-95

Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1016/j.amjhyper.2005.05.023DOI Listing
November 2005

Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level.

Hum Mol Genet 2005 Aug 13;14(16):2405-13. Epub 2005 Jul 13.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/hmg/ddi242DOI Listing
August 2005

Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures.

J Gerontol A Biol Sci Med Sci 2005 May;60(5):574-87

Hebrew Rehabilitation Center for Aged, Research and Training Institute, 1200 Centre Street, Boston, MA 02131, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361266PMC
http://dx.doi.org/10.1093/gerona/60.5.574DOI Listing
May 2005

Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.

J Nutr 2005 Mar;135(3):397-403

Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111-1524, USA.

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http://dx.doi.org/10.1093/jn/135.3.397DOI Listing
March 2005

Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study.

J Lipid Res 2004 Nov 1;45(11):2096-105. Epub 2004 Sep 1.

Nutrition and Genomics Laboratory, Jean Mayer-United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.

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http://dx.doi.org/10.1194/jlr.M400192-JLR200DOI Listing
November 2004

High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study.

Arterioscler Thromb Vasc Biol 2004 Nov 23;24(11):2181-7. Epub 2004 Sep 23.

Lipid Metabolism Laboratory, HNRCA at Tufts University, 711 Washington Street, Boston, Mass 02111, USA.

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http://dx.doi.org/10.1161/01.ATV.0000146325.93749.a8DOI Listing
November 2004

Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs HDL Intervention Trial.

J Lipid Res 2004 Oct 1;45(10):1885-91. Epub 2004 Aug 1.

Lipid Metabolism Laboratory, Jean Mayer-United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, and Department of Medicine, New England Medical Center, Boston, MA, USA.

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http://www.jlr.org/cgi/doi/10.1194/jlr.M400152-JLR200
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October 2004

Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study.

J Bone Miner Res 2004 May 22;19(5):773-81. Epub 2003 Dec 22.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1359/JBMR.0301258DOI Listing
May 2004

Obesity modulates the association among APOE genotype, insulin, and glucose in men.

Obes Res 2003 Dec;11(12):1502-8

Nutrition and Genomics Laboratory and Lipid Metabolism Laboratory, Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.

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http://doi.wiley.com/10.1038/oby.2003.201
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December 2003

Description of the Framingham Heart Study data for Genetic Analysis Workshop 13.

BMC Genet 2003 Dec 31;4 Suppl 1:S2. Epub 2003 Dec 31.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

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http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156
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http://dx.doi.org/10.1186/1471-2156-4-S1-S2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866454PMC
December 2003

Association between estrogen receptor alpha gene variation and cardiovascular disease.

JAMA 2003 Nov;290(17):2263-70

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA.

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http://dx.doi.org/10.1001/jama.290.17.2263DOI Listing
November 2003

Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study.

J Clin Endocrinol Metab 2003 Jun;88(6):2869-79

Nutrition and Genomics Laboratory, Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1210/jc.2002-021664DOI Listing
June 2003