Publications by authors named "Sergio Rutella"

100Publications

Reverting Immune Suppression to Enhance Cancer Immunotherapy.

Front Oncol 2019 21;9:1554. Epub 2020 Jan 21.

Veana Therapeutics, Inc., Portland, OR, United States.

View Article and Find Full Text PDF
January 2020

A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study.

Blood Adv 2019 04;3(8):1330-1346

John van Geest Cancer Research Centre, College of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.

View Article and Find Full Text PDF
April 2019

Dissecting the Immune Landscape of Acute Myeloid Leukemia.

Biomedicines 2018 Nov 25;6(4). Epub 2018 Nov 25.

John van Geest Cancer Research Center, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.

View Article and Find Full Text PDF
November 2018

An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study.

Comput Struct Biotechnol J 2018 21;16:77-87. Epub 2018 Feb 21.

John van Geest Cancer Research Centre, College of Science and Technology, Nottingham Trent University, United Kingdom.

View Article and Find Full Text PDF
February 2018

Targeting Leukemia Stem Cells in the Bone Marrow Niche.

Biomedicines 2018 Feb 21;6(1). Epub 2018 Feb 21.

John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham NG11 8NS, UK.

View Article and Find Full Text PDF
February 2018

Discovery and application of immune biomarkers for hematological malignancies.

Expert Rev Mol Diagn 2017 11 25;17(11):983-1000. Epub 2017 Sep 25.

a John van Geest Cancer Research Centre, College of Science and Technology , Nottingham Trent University , Nottingham , United Kingdom.

View Article and Find Full Text PDF
November 2017

T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation.

Biomedicines 2017 Jun 21;5(2). Epub 2017 Jun 21.

John van Geest Cancer Research Centre, Nottingham Trent University, Clifton Lane NG11 8NS, UK.

View Article and Find Full Text PDF
June 2017

Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies.

J Transl Med 2016 09 1;14:252. Epub 2016 Sep 1.

Clinical Governance and International Research Activities, Fondazione Policlinico Gemelli, Rome, Italy.

View Article and Find Full Text PDF
September 2016

Granulocyte transfusions in children and adults with hematological malignancies: benefits and controversies.

J Transl Med 2015 Nov 16;13:362. Epub 2015 Nov 16.

Division of Translational Medicine, Clinical Research Center, Sidra Medical and Research Center, Out-Patient Clinic, Al Luqta Street, Education City North Campus, P.O. Box 26999, Doha, Qatar.

View Article and Find Full Text PDF
November 2015

Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies.

Front Immunol 2015 13;6:230. Epub 2015 May 13.

Clinical Research Center, Division of Translational Medicine, Sidra Medical and Research Center , Doha , Qatar.

View Article and Find Full Text PDF
June 2015

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine.

Gastroenterology 2015 Jul 17;149(1):163-176.e20. Epub 2015 Mar 17.

Inflammatory Bowel Disease Center, Humanitas Clinical and Research Center, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy. Electronic address:

View Article and Find Full Text PDF
July 2015

The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.

J Transl Med 2014 Oct 28;12:293. Epub 2014 Oct 28.

IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy.

View Article and Find Full Text PDF
October 2014

Recent advances on cellular therapies and immune modulators for graft-versus-host disease.

Expert Rev Clin Immunol 2014 Oct 8;10(10):1357-74. Epub 2014 Sep 8.

Department of Systems Medicine, IRCCS San Raffaele Pisana, Rome, Italy.

View Article and Find Full Text PDF
October 2014

Extracorporeal photopheresis for paediatric patients experiencing graft-versus-host disease (GVHD).

Transfus Apher Sci 2014 Jun 13;50(3):340-8. Epub 2014 Apr 13.

Department of Paediatric Haematology/Oncology and Transfusion Medicine, IRCCS Bambino Gesù Children's Hospital, Rome, Italy; University of Pavia, Pavia, Italy.

View Article and Find Full Text PDF
June 2014

Kindlin-3-independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III.

J Allergy Clin Immunol 2014 Apr 15;133(4):1215-8. Epub 2013 Dec 15.

Emma Children's Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

View Article and Find Full Text PDF
April 2014

At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies.

J Leukoc Biol 2013 Dec 4;94(6):1141-57. Epub 2013 Oct 4.

1.Piazza Sant'Onofrio 4, 00165 Rome, Italy.

View Article and Find Full Text PDF
December 2013

Management of relapsed acute lymphoblastic leukemia in childhood with conventional and innovative approaches.

Curr Opin Oncol 2013 Nov;25(6):707-15

aDepartment of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children's Hospital, Rome bUniversity of Pavia, Pavia, Italy.

View Article and Find Full Text PDF
November 2013

FOXP3⁺ T regulatory cell modifications in inflammatory bowel disease patients treated with anti-TNFα agents.

Biomed Res Int 2013 26;2013:286368. Epub 2013 Aug 26.

Department of Internal Medicine, Inflammatory Bowel Disease Unit, Complesso Integrato Columbus, Catholic University, Largo Gemelli 8, 00168 Rome, Italy.

View Article and Find Full Text PDF
April 2014

A novel flow cytometry-based platelet aggregation assay.

Blood 2013 Mar 9;121(10):e70-80. Epub 2013 Jan 9.

Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.

View Article and Find Full Text PDF
March 2013

Mesenchymal stromal cells in inflammatory bowel disease: conspirators within the 'colitogenic niche'?

Gut 2013 Aug 22;62(8):1098-9. Epub 2012 Dec 22.

IBD Centre, Gastroenterology, Humanitas Clinical and Research Centre, Milan 20089, Italy.

View Article and Find Full Text PDF
August 2013

Regulatory T-cell therapy for Crohn's disease: in vivo veritas.

Gastroenterology 2012 Nov 20;143(5):1135-1138. Epub 2012 Sep 20.

Pediatric Hematology/Oncology and Transfusion Medicine, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

View Article and Find Full Text PDF
November 2012

Lymphocyte proliferation specific for recall, CMV and HIV antigens in miniaturized and automated format.

J Immunol Methods 2012 Oct;384(1-2):135-42

Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children Hospital, Rome, Italy.

View Article and Find Full Text PDF
October 2012

How I treat relapsed childhood acute lymphoblastic leukemia.

Blood 2012 Oct 15;120(14):2807-16. Epub 2012 Aug 15.

Department of Pediatric Hematology-Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy.

View Article and Find Full Text PDF
October 2012

Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes.

Clin Dev Immunol 2012 11;2012:196063. Epub 2012 Apr 11.

Department of Pediatric Hematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00165 Rome, Italy.

View Article and Find Full Text PDF
September 2012

Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism.

Int J Cardiol 2013 Aug 2;167(3):910-6. Epub 2012 Apr 2.

Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy.

View Article and Find Full Text PDF
August 2013

The Yin and Yang of non-neuronal α7-nicotinic receptors in inflammation and autoimmunity.

Curr Drug Targets 2012 May;13(5):644-55

System Approaches and Non-Communicable Disease Lab, IRCCS San Raffaele Pisana, Rome, Italy.

View Article and Find Full Text PDF
May 2012

Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease.

World J Gastroenterol 2011 Sep;17(33):3761-75

Department of Pediatric Hematology/Oncology, IRCCS Children's Hospital "Bambino Gesù" 00165 Rome, Italy.

View Article and Find Full Text PDF
September 2011

Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures.

J Transl Med 2010 Dec 7;8:129. Epub 2010 Dec 7.

Department of Gynecology, Catholic University Med. School, and Department of Blood Transfusion and Cell Therapy, Azienda Ospedaliera S. Camillo-Forlanini, Rome, Italy.

View Article and Find Full Text PDF
December 2010

Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors.

J Pharmacol Exp Ther 2011 Feb 8;336(2):391-402. Epub 2010 Nov 8.

Department of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy.

View Article and Find Full Text PDF
February 2011

Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds.

Expert Opin Ther Pat 2010 Feb;20(2):229-50

Istituto Superiore di Sanità, Department of Cell Biology and Neurosciences, Rome, Italy.

View Article and Find Full Text PDF
February 2010

Function and dysfunction of dendritic cells in autoimmune rheumatic diseases.

Hum Immunol 2009 May;70(5):360-73

Department of Hematology, Laboratory of Immunology, Catholic University Medical School, and CdC San Raffaele Valletri, Rome, Italy.

View Article and Find Full Text PDF
May 2009

Treatment of Crohn's disease with colony-stimulating factors: An overview.

Ther Clin Risk Manag 2008 Oct;4(5):927-34

Department of Internal Medicine, Operative Unit of Gastroenterology and.

View Article and Find Full Text PDF
October 2008

Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors.

J Biol Chem 2008 Oct 8;283(44):30193-204. Epub 2008 Sep 8.

Institute of Internal Medicine and Geriatrics, and Haemostasis Research Centre, Catholic University School of Medicine, 00168 Rome, Italy.

View Article and Find Full Text PDF
October 2008

Granulocyte colony-stimulating factor for the induction of T-cell tolerance.

Authors:
Sergio Rutella

Transplantation 2007 Jul;84(1 Suppl):S26-30

Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A. Gemelli 8, 00168 Rome, Italy.

View Article and Find Full Text PDF
July 2007

MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle.

Proc Natl Acad Sci U S A 2006 Nov 31;103(45):16995-7000. Epub 2006 Oct 31.

Department of Neurosciences and Interdisciplinary Laboratory for Stem Cell Research and Cellular Therapy, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy.

View Article and Find Full Text PDF
November 2006

Angiogenesis as a novel component of inflammatory bowel disease pathogenesis.

Gastroenterology 2006 Jun;130(7):2060-73

Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy.

View Article and Find Full Text PDF
June 2006

Tolerogenic dendritic cells: cytokine modulation comes of age.

Blood 2006 Sep 9;108(5):1435-40. Epub 2006 May 9.

Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo Agostino Gemelli, 800168 Rome, Italy.

View Article and Find Full Text PDF
September 2006

Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance.

J Immunol 2005 Dec;175(11):7085-91

Department of Hematology, Laboratory of Immunology, Catholic University School of Medicine, Rome, Italy.

View Article and Find Full Text PDF
December 2005

Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction.

Int J Cardiol 2006 Aug 26;111(2):202-8. Epub 2005 Jul 26.

Institute of Cardiology, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy.

View Article and Find Full Text PDF
August 2006

Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications.

Immunol Lett 2004 Jun;94(1-2):11-26

Laboratory of Immunology, Department of Hematology, Catholic University Medical School, Largo Agostino Gemelli, 8, 00168 Rome, Italy.

View Article and Find Full Text PDF
June 2004