Sergio Fazio

Sergio Fazio

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Sergio Fazio

Publications by authors named "Sergio Fazio"

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The Role of the Clinical Pharmacist in a Preventive Cardiology Practice.

Ann Pharmacother 2019 Dec 25;53(12):1214-1219. Epub 2019 Jul 25.

Oregon Health & Science University, Portland, OR, USA.

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http://dx.doi.org/10.1177/1060028019864669DOI Listing
December 2019

A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice.

Exp Neurol 2019 Nov 3;321:113031. Epub 2019 Aug 3.

Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA; Department of Neurology, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2019.113031DOI Listing
November 2019

Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity.

J Clin Endocrinol Metab 2019 Oct;104(10):4793-4803

Department of Medicine, Knight Cardiovascular Institute, Oregon Health & Sciences University, Portland, Oregon.

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http://dx.doi.org/10.1210/jc.2018-02708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735736PMC
October 2019

"Taking a look under the hood"-imaging the phenotypic heterogeneity of familial hypercholesterolemia.

J Clin Lipidol 2018 Sep - Oct;12(5):1095-1098. Epub 2018 Jun 8.

Oregon Health & Science University, Knight Cardiovascular Institute, Center for Preventive Cardiology, Portland, OR, USA.

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http://dx.doi.org/10.1016/j.jacl.2018.05.020DOI Listing
September 2019

Lipoprotein Apheresis Acutely Reverses Coronary Microvascular Dysfunction in Patients With Severe Hypercholesterolemia.

JACC Cardiovasc Imaging 2019 Aug 19;12(8 Pt 1):1430-1440. Epub 2018 Jun 19.

Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458098PMC
August 2019

Coronary Microvascular Dysfunction by Myocardial Contrast Echocardiography in Nonelderly Patients Referred for Computed Tomographic Coronary Angiography.

J Am Soc Echocardiogr 2019 Jul 15;32(7):817-825. Epub 2019 May 15.

Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon. Electronic address:

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http://dx.doi.org/10.1016/j.echo.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527356PMC
July 2019

The PCSK9 revolution: Current status, controversies, and future directions.

Trends Cardiovasc Med 2019 May 21. Epub 2019 May 21.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2019.05.007DOI Listing
May 2019

The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk.

Endocr Rev 2019 04;40(2):537-557

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.

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https://academic.oup.com/edrv/advance-article/doi/10.1210/er
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http://dx.doi.org/10.1210/er.2018-00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416708PMC
April 2019

Impact of PCSK9 inhibitors on plasma lipoprotein(a) concentrations with or without a background of niacin therapy.

J Clin Lipidol 2019 Jul - Aug;13(4):580-585. Epub 2019 Apr 26.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2019.04.008DOI Listing
April 2019

Overview of Therapeutic Approaches for Cholesterol Lowering and Attenuation of Thrombosis for Prevention of Atherothrombosis.

Circ Res 2019 Feb;124(3):351-353

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland (S.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314576DOI Listing
February 2019

Relationship Between Low-Density Lipoprotein Cholesterol and Lipoprotein(a) Lowering in Response to PCSK9 Inhibition With Evolocumab.

J Am Heart Assoc 2019 Feb;8(4):e010932

1 Knight Cardiovascular Institute Center for Preventive Cardiology Oregon Health & Science University Portland OR.

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http://dx.doi.org/10.1161/JAHA.118.010932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405654PMC
February 2019

Application of PCSK9 Inhibitors in Practice.

Circ Res 2019 Jan;124(1):32-37

From the Center for Preventive Cardiology, Knight Cardiovascular Institute (T.M.K., B.A.W., J.M., J.R.M., P.B.D., J.Q.P., S.F., M.D.S.), Oregon Health & Science University, Portland.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31419
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319384PMC
January 2019

Brief Commentary: Marijuana and Cardiovascular Disease-What Should We Tell Patients?

Ann Intern Med 2019 Jan 8;170(2):119-120. Epub 2019 Jan 8.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon (T.M.K., S.F., M.D.S.).

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http://dx.doi.org/10.7326/M18-3009DOI Listing
January 2019

Biologic bases of residual risk of cardiovascular events: A flawed concept.

Eur J Prev Cardiol 2018 Nov 10;25(17):1831-1835. Epub 2018 Sep 10.

Oregon Health & Science University, Knight Cardiovascular Institute Center for Preventive Cardiology, Portland, USA.

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http://dx.doi.org/10.1177/2047487318798060DOI Listing
November 2018

Medication-based versus target-based lipid management.

J Diabetes 2018 Oct 2;10(10):789-792. Epub 2018 Jul 2.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health & Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1111/1753-0407.12789DOI Listing
October 2018

Increased Cardiovascular Risk in Hypertriglyceridemic Patients With Statin-Controlled LDL Cholesterol.

J Clin Endocrinol Metab 2018 08;103(8):3019-3027

Oregon Health & Science University, Portland, Oregon.

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http://dx.doi.org/10.1210/jc.2018-00470DOI Listing
August 2018

WITHDRAWN: Raising the Bar by Lowering the Target: Integrating PCSK9 Inhibitors Into Hypercholesterolemia Management.

Am J Cardiol 2018 Aug 16. Epub 2018 Aug 16.

Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.amjcard.2018.08.020DOI Listing
August 2018

A case of severe acquired hypertriglyceridemia in a 7-year-old girl.

J Clin Lipidol 2017 Nov - Dec;11(6):1480-1484. Epub 2017 Aug 12.

Department of Medicine, Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.08.003DOI Listing
July 2018

The Evolving Future of PCSK9 Inhibitors.

J Am Coll Cardiol 2018 07 9;72(3):314-329. Epub 2018 Jul 9.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2018.04.054DOI Listing
July 2018

Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size.

J Clin Lipidol 2018 Sep - Oct;12(5):1313-1323. Epub 2018 Jul 20.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jacl.2018.07.003DOI Listing
July 2018

Co-occurrence of heterozygous CREB3L3 and APOA5 nonsense variants and polygenic risk in a patient with severe hypertriglyceridemia exacerbated by estrogen administration.

J Clin Lipidol 2018 Sep - Oct;12(5):1146-1150. Epub 2018 Jun 1.

Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacl.2018.05.014DOI Listing
June 2018

Balanced high fat diet reduces cardiovascular risk in obese women although changes in adipose tissue, lipoproteins, and insulin resistance differ by race.

Metabolism 2018 05 31;82:125-134. Epub 2018 Jan 31.

Vanderbilt University Medical Center, School of Medicine, Department of Medicine, United States; Veterans Affairs Tennessee Valley Healthcare System, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183002
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http://dx.doi.org/10.1016/j.metabol.2018.01.020DOI Listing
May 2018

PREDICTING HYPERTRIGLYCERIDEMIC PANCREATITIS - NOT SO FAST!

Endocr Pract 2018 05 24;24(5):495-497. Epub 2018 Apr 24.

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http://dx.doi.org/10.4158/EP-2018-0121DOI Listing
May 2018

PCSK9: From Basic Science Discoveries to Clinical Trials.

Circ Res 2018 05;122(10):1420-1438

From the Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.311227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976255PMC
May 2018

Withdrawn: "Taking a look under the hood"-Imaging the phenotypic heterogeneity of familial hypercholesterolemia.

J Clin Lipidol 2018 May 30. Epub 2018 May 30.

Oregon Health & Science University, Knight Cardiovascular Institute, Center for Preventive Cardiology, Portland, OR, USA.

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http://dx.doi.org/10.1016/j.jacl.2018.05.019DOI Listing
May 2018

Diagnosing Resistance to a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor.

Ann Intern Med 2018 03 28;168(5):376-379. Epub 2017 Nov 28.

Oregon Health & Science University, Portland, Oregon (M.D.S., J.M., H.T., S.F.).

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http://dx.doi.org/10.7326/M17-2485DOI Listing
March 2018

Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism.

BMC Nephrol 2018 01 27;19(1):17. Epub 2018 Jan 27.

Departments of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, C-4204 Medical Center North, Nashville, TN, 37232-2584, USA.

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http://dx.doi.org/10.1186/s12882-018-0814-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787279PMC
January 2018

Discordant response of low-density lipoprotein cholesterol and lipoprotein(a) levels to monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9.

J Clin Lipidol 2017 May - Jun;11(3):667-673. Epub 2017 Mar 9.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.03.001DOI Listing
December 2017

Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs.

PLoS One 2017 8;12(9):e0184620. Epub 2017 Sep 8.

Department of Pathology Microbiology and Immunology; Vanderbilt University Medical Center; Nashville, TN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590986PMC
October 2017

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins.

J Clin Endocrinol Metab 2017 09;102(9):3340-3348

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239.

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http://academic.oup.com/jcem/article/102/9/3340/3869385/Thre
Publisher Site
http://dx.doi.org/10.1210/jc.2016-4043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587068PMC
September 2017

Application of PCSK9 Inhibitors in Practice: Challenges and Opportunities.

Circ Res 2017 08;121(5):499-501

From the Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311532DOI Listing
August 2017

Setting the Agenda for Preventive Cardiology.

Circ Res 2017 07;121(3):211-213

From the Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311390DOI Listing
July 2017

Dyslipidaemia: The PCSK9 adventure - humanizing extreme LDL lowering.

Nat Rev Cardiol 2017 06 4;14(6):319-320. Epub 2017 May 4.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1038/nrcardio.2017.66DOI Listing
June 2017

PCSK9 and Atherosclerosis - Lipids and Beyond.

J Atheroscler Thromb 2017 May 9;24(5):462-472. Epub 2017 Mar 9.

Oregon Health & Science University, Knight Cardiovascular Institute, Center for Preventive Cardiology.

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http://dx.doi.org/10.5551/jat.RV17003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429160PMC
May 2017

Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease.

F1000Res 2017 13;6:134. Epub 2017 Feb 13.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.

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http://dx.doi.org/10.12688/f1000research.9845.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310383PMC
February 2017

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes.

N Engl J Med 2016 12;375(22):2144-2153

From the Division of Cardiovascular Medicine, Wayne State University School of Medicine, Detroit (B.A.F.), the Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.), and Michigan State University, East Lansing (D.R.N.) - all in Michigan; the Departments of Epidemiology and Medicine, College of Public Health, University of Iowa, Iowa City (J.G.R.); the Department of Pharmacological and Biomolecular Sciences, University of Milan and MultiMedica Istituto di Ricovero e Cura a Carattere Scientifico, Milan (A.L.C.); INSERM, Pitié-Salpêtrière University Hospital, Paris (M.J.C.); the Global Genomics Group, Richmond, VA (S.V.); the Thrombolysis in Myocardial Infarction Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (R.P.G., M.S.S.); the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (G.D.S.); and the Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland (S.F.).

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http://www.nejm.org/doi/10.1056/NEJMoa1604304
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http://dx.doi.org/10.1056/NEJMoa1604304DOI Listing
December 2016

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering.

Cardiovasc Res 2016 10 5;112(1):429-42. Epub 2016 Aug 5.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy IRCCS Multimedica, Milan, Italy

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http://dx.doi.org/10.1093/cvr/cvw194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031950PMC
October 2016

HDL Particle Size and Functional Heterogeneity.

Circ Res 2016 09;119(6):704-7

From the Center for Preventive Cardiology of the Knight Cardiovascular Institute, Department of Medicine, Oregon Health & Science University, Portland.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971193PMC
September 2016

Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.

Arterioscler Thromb Vasc Biol 2016 08 30;36(8):1483-95. Epub 2016 Jun 30.

From the Division of Cardiovascular Medicine (L.Z., R.C., L.D., Y.Z., A.S.M., M.F.L.), Division of Diabetes, Endocrinology, and Metabolism (L.Z., J.M.S.), Division of Rheumatology, Department of Medicine (M.O.), Vanderbilt University Medical Center, Nashville, TN; Tennessee Valley Healthcare System, Nashville (L.Z., J.M.S.); and Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland (I.G., H.T., S.F.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.116.307736
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.116.307736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346022PMC
August 2016

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Arterioscler Thromb Vasc Biol 2016 06 21;36(6):1122-31. Epub 2016 Apr 21.

From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science University, Portland, OR (S.F.); and Department of Genetics & Complex Diseases & Sabri Ulker Center, Harvard School of Public Health, Boston, MA (G.S.H.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882236PMC
June 2016

PCSK9 Association With Lipoprotein(a).

Circ Res 2016 06 27;119(1):29-35. Epub 2016 Apr 27.

From the Department of Medicine, Center for Preventive Cardiology, Knight Cardiovascular Institute, Portland, OR (H.T., D.C., D.P., M.D.S., I.G., P.B.D., S.F.); School of Public Health, Oregon Health and Science University, Portland (J.M.); Sulpizio Cardiovascular Center, Vascular Medicine Program, University of California at San Diego, La Jolla (C.Y., S.T.); Inra UMR1280, Université de Nantes, CHU Hôtel-Dieu, Nantes, France (M.C., G.L.); Inserm UMR 1188, Sainte-Clotilde, France (G.L.); Université de la Réunion, Faculté de Médecine, Saint-Denis, France (G.L.); and CHU de la Réunion, Saint-Denis, France (G.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920709PMC
June 2016

A Systematic Review of PCSK9 Inhibitors Alirocumab and Evolocumab.

J Manag Care Spec Pharm 2016 Jun;22(6):641-653q

2 Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.

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http://dx.doi.org/10.18553/jmcp.2016.22.6.641DOI Listing
June 2016

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms.

Cardiovasc Res 2016 May 15;110(2):268-78. Epub 2016 Mar 15.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR, USA

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http://dx.doi.org/10.1093/cvr/cvw053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836631PMC
May 2016

Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.

Arterioscler Thromb Vasc Biol 2016 Apr 4;36(4):598-607. Epub 2016 Feb 4.

From the Atherosclerosis Research Unit, Department of Medicine (V.R.B., L.D., Y.Z., J.M.M., M.R.F.L.) and Pharmacology (M.R.F.L.), Vanderbilt University Medical Center, Nashville, TN; Center for Cancer Research, National Cancer Institute, Frederick, MD (P.C.L.); and Department of Medicine, Center of Preventive Cardiology, Oregon Health & Science University, Portland, OR (S.F.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306931
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http://dx.doi.org/10.1161/ATVBAHA.115.306931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808396PMC
April 2016

From Lipids to Inflammation: New Approaches to Reducing Atherosclerotic Risk.

Circ Res 2016 Feb;118(4):732-49

From the Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306471DOI Listing
February 2016

Local effects of human PCSK9 on the atherosclerotic lesion.

J Pathol 2016 Jan 13;238(1):52-62. Epub 2015 Nov 13.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR, USA.

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http://dx.doi.org/10.1002/path.4630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346023PMC
January 2016

Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.

Atherosclerosis 2015 Sep 4;242(1):56-64. Epub 2015 Jul 4.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850906PMC
September 2015

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis.

J Lipid Res 2015 Aug 9;56(8):1449-60. Epub 2015 Jun 9.

Department of Medicine, Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232.

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http://dx.doi.org/10.1194/jlr.M056689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513986PMC
August 2015

Residual Cardiovascular Risk in Chronic Kidney Disease: Role of High-density Lipoprotein.

Arch Med Res 2015 Jul 23;46(5):379-91. Epub 2015 May 23.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1016/j.arcmed.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805367PMC
July 2015

The link between lipids, statins and cancer: is there a role for cardio-oncology?

Future Cardiol 2015 Jul 4;11(4):389-93. Epub 2015 Aug 4.

Center for Preventive Cardiology, Oregon Health & Science University; 3181 Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.2217/FCA.15.32DOI Listing
July 2015

Sex-Specific Parental Effects on Offspring Lipid Levels.

J Am Heart Assoc 2015 Jun 30;4(7). Epub 2015 Jun 30.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH (R.S.S., J.B., S.M.W.).

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http://dx.doi.org/10.1161/JAHA.115.001951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608079PMC
June 2015

Smoking, sex, risk factors and abdominal aortic aneurysms: a prospective study of 18 782 persons aged above 65 years in the Southern Community Cohort Study.

J Epidemiol Community Health 2015 May 6;69(5):481-8. Epub 2015 Jan 6.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1136/jech-2014-204920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494088PMC
May 2015

PCSK9 inhibition to reduce cardiovascular disease risk: recent findings from the biology of PCSK9.

Curr Opin Endocrinol Diabetes Obes 2015 Apr;22(2):126-32

The Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Sciences University, Portland, Oregon, USA.

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http://dx.doi.org/10.1097/MED.0000000000000137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384821PMC
April 2015

Targeting PCSK9 for therapeutic gains.

Curr Atheroscler Rep 2015 Apr;17(4):499

The Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR, USA.

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http://dx.doi.org/10.1007/s11883-015-0499-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560054PMC
April 2015

Plasma lipid levels and colorectal adenoma risk.

Cancer Causes Control 2015 Apr 12;26(4):635-43. Epub 2015 Mar 12.

Florida State University College of Medicine, Tallahassee, FL, USA.

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http://dx.doi.org/10.1007/s10552-015-0555-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375726PMC
April 2015

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL.

J Lipid Res 2015 Mar 15;56(3):635-43. Epub 2015 Jan 15.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR.

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http://dx.doi.org/10.1194/jlr.M056408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340310PMC
March 2015

Carotid adventitial vasa vasorum and intima-media thickness in a primary prevention population.

Echocardiography 2015 Feb 13;32(2):264-70. Epub 2014 Jun 13.

Department of Medicine, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee; Department of Pathology, Microbiology and Immunology, VUMC, Nashville, Tennessee; Department of Radiology and Radiological Sciences, VUMC, Nashville, Tennessee.

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http://dx.doi.org/10.1111/echo.12646DOI Listing
February 2015

Dysfunctional high-density lipoproteins in children with chronic kidney disease.

Metabolism 2015 Feb 25;64(2):263-73. Epub 2014 Oct 25.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2014.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277938PMC
February 2015

On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects.

Atherosclerosis 2015 Feb 17;238(2):264-70. Epub 2014 Dec 17.

The Knight Cardiovascular Institute, Center of Preventive Cardiology, Oregon Health and Sciences University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562333PMC
February 2015

The role of PCSK9 in intestinal lipoprotein metabolism: synergism of statin and ezetimibe.

Authors:
Sergio Fazio

Atheroscler Suppl 2015 Feb;17:23-6

Cornelius Vanderbilt Professor of Medicine Professor of Pathology, Immunology, and Microbiology Chief, Section of CVD Prevention Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address:

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http://dx.doi.org/10.1016/S1567-5688(15)50006-8DOI Listing
February 2015

Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.

Arterioscler Thromb Vasc Biol 2014 Dec 2;34(12):2527-36. Epub 2014 Oct 2.

From the Department of Pathology, Microbiology, and Immunology (A.K.S., B.L., S.F., J.B.A., P.P.Y.) and Departments of Veterans Affairs Medical Center (J.B.A., P.P.Y.), Pharmacology (M.F.L.), and Medicine (Y.Z., V.R.B., S.F., M.F.L., P.P.Y.), Vanderbilt University Medical Center, Nashville, TN; Department of Neurodegenerative Diseases, Institute of Neurology, University College London, Queen Square, London, United Kingdom (P.J.); Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH (A.L.P.); and Department of Pathology, The Ohio State University, Columbus (A.L.P.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239161PMC
December 2014

Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: role of serum cholesterol and temporal effects of exposure.

PLoS One 2014 23;9(1):e84517. Epub 2014 Jan 23.

Department of Medicine, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, United States of America ; Department of Pathology, Microbiology and Immunology, VUMC, Nashville, Tennessee, United States of America ; Department of Radiology and Radiological Sciences, VUMC, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900396PMC
November 2014

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice.

J Lipid Res 2014 Nov 19;55(11):2296-308. Epub 2014 Sep 19.

Atherosclerosis Research Unit, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232.

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http://dx.doi.org/10.1194/jlr.M050633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617132PMC
November 2014

PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts.

J Neurosci 2014 Nov;34(48):16140-52

Departments of Neuroscience and Neurology, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32611, and

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1908-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.1908-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244477PMC
November 2014

Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice.

J Lipid Res 2014 Oct 2;55(10):2073-81. Epub 2014 Sep 2.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR Section of Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Departments of Medicine, Vanderbilt University Medical Center, Nashville, TN Pathology, Immunology, and Microbiology, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1194/jlr.M049874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174000PMC
October 2014

Peeking into a cool future: genome editing to delete PCSK9 and control hypercholesterolemia in a single shot.

Circ Res 2014 Aug;115(5):472-4

From The Knight Cardiovascular Institute, Oregon Health and Science University, Portland.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137455PMC
August 2014

Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

Circulation 2014 Jul 23;130(5):431-41. Epub 2014 May 23.

From the Department of Pharmacology, Dalhousie University, Halifax, NS, and Saint John, NB, Canada (S.R.); Department of Medicine, Section of Cardiovascular Disease Prevention, Vanderbilt University, Nashville, TN (H.T., M.F.L., J.H., I.G., S.F.); Oregon Health and Science University, Portland (H.T., I.G.); and Department of Biostatistics, Faculty of Medicine, University of Toronto and Cancer Care Ontario, Toronto, ON, Canada (P.E.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115295PMC
July 2014

Oral retinoids and plasma lipids.

Dermatol Ther 2013 Sep-Oct;26(5):404-10

Section of Prevention of Cardiovascular Disease, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1111/dth.12085DOI Listing
June 2014

Response to Duell et al.

Circ Res 2014 Jun;115(1):e5

Vanderbilt University Medical Center, Section of Cardiovascular Disease Prevention, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304199DOI Listing
June 2014

The severe hypercholesterolemia phenotype: clinical diagnosis, management, and emerging therapies.

J Am Coll Cardiol 2014 May 12;63(19):1935-47. Epub 2014 Mar 12.

Section of Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07351097140129
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http://dx.doi.org/10.1016/j.jacc.2014.01.060DOI Listing
May 2014

Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women.

Metabolism 2014 Apr 17;63(4):562-73. Epub 2014 Jan 17.

Vanderbilt University, Department of Medicine, Nashville, TN, USA; Tennessee Valley Healthcare System, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.metabol.2014.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306330PMC
April 2014

Association of soy food intake with risk and biomarkers of coronary heart disease in Chinese men.

Int J Cardiol 2014 Mar 8;172(2):e285-7. Epub 2014 Jan 8.

Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.ijcard.2013.12.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947738PMC
March 2014

Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis.

Circ Res 2013 Dec 11;113(12):1290-5. Epub 2013 Oct 11.

From the Section of Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Department of Medicine (H.T., I.G., M.F.L., S.F.), and Departments of Pharmacology (M.F.L.) and Pathology, Immunology and Microbiology (S.F.), Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.302655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939022PMC
December 2013

A prospective study of statin use and mortality among 67,385 blacks and whites in the Southeastern United States.

Clin Epidemiol 2014 19;6:15-25. Epub 2013 Dec 19.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA ; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA ; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.2147/CLEP.S53492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872085PMC
December 2013

Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.

Circ Cardiovasc Genet 2013 Jun 24;6(3):299-307. Epub 2013 Apr 24.

Division of Cardiovascular Medicine, Section of Cardiovascular Disease Prevention, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889706PMC
June 2013

Importance of high-density lipoprotein quality: evidence from chronic kidney disease.

Curr Opin Nephrol Hypertens 2013 May;22(3):259-65

aDepartment of Pediatrics bDepartment of Medicine cDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1097/MNH.0b013e32835fe47fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558988PMC
May 2013

When it looks like familial hypercholesterolemia...but is not.

Circ Cardiovasc Genet 2012 Dec;5(6):599-601

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http://dx.doi.org/10.1161/CIRCGENETICS.112.965137DOI Listing
December 2012