Publications by authors named "Sergio Alonso-Fernández"

6 Publications

  • Page 1 of 1

Correction: Yagüe, P., et al. Goals and Challenges in Bacterial Phosphoproteomics. 2019, , 5678.

Int J Mol Sci 2020 Dec 9;21(24). Epub 2020 Dec 9.

Área de Microbiología, Departamento de Biología Funcional, IUOPA, ISPA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain.

The authors wish to make the following corrections to this paper [1]:The author name "Gemma Fernánez-García" should be "Gemma Fernández-García" [...].
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http://dx.doi.org/10.3390/ijms21249381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764465PMC
December 2020

Impact of the implementation of best practice guidelines on nurse's evidence-based practice and on nurses' work environment: Research protocol.

J Adv Nurs 2021 Jan 15;77(1):448-460. Epub 2020 Oct 15.

Faculty of Nursing and Physiotherapy, Balearic Islands University, Palma de Mallorca, Spain.

Aim: To determine the impact of the Best Practice Spotlight Organization® initiative on nurses' perception of their work environment and their attitudes to evidence-based practice.

Design: Quasi-experimental, multicentre study. The intervention is the participation in Best Prectice Spotilight Organizations to implement Best Practice Guidelines.

Methods: The study will include seven centres in the interventional group and 10 in the non-equivalent control group, all of them belonging to the Spanish national health system. The Practice Environment Scale of the Nursing Work Index, and the Health Sciences Evidence-Based Practice Questionnaire will be administered to a sample of 1,572 nurses at the beginning of the programme and at 1 year. This 3-year study started in April 2018 and will continue until December 2021. Statistical analyses will be carried out using the SPSS 25.0. This project was approved by the Drug Research Ethics Committee of the Parc de Salut Mar and registered in Clinical Trials.

Discussion: The study findings will show the current state of nurses' perception of their work environment and attitudes to evidence-based practice, and possible changes in these parameters due to the programme.

Impact: The findings could provide a strong argument for health policymakers to scale up the Best Practice Spotlight Organization® initiative in the Spanish national health system.
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http://dx.doi.org/10.1111/jan.14598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756465PMC
January 2021

Reduction of visual and auditory stimuli to reduce pain during venipuncture in premature infants. Study protocol for a randomized controlled trial.

J Adv Nurs 2020 Apr 10;76(4):1077-1081. Epub 2020 Jan 10.

Catalan Institute of Health, Germans Trias i Pujol University Hospital. Ctra de Canyet s/n, Badalona, Spain.

Aim: To evaluate the efficacy of the reduction of visual and auditory stimuli on pain during venipuncture in premature newborns of 32-36 weeks of gestation.

Design: Open, randomized, non-blind parallel clinical trial.

Method: Study to take place at the neonatal intensive care unit of a University Hospital in 2019-2021. Fifty-six recently born babies between 32-36 weeks of gestation will participate. The dependent variable is the level of pain determined using the premature infant pain profile instrument. The intervention will be assigned randomly using the random.org software. Data analysis will be carried out using the IBM SPSS v.25 software assuming a level of significance of 5%.

Discussion: The evidence for the efficacy of reducing sensory stimulation and its effect on pain in minor procedures has not been studied in depth. There are no studies that evaluate the reduction of visual and auditory stimuli in a combined way.

Impact: It is easy to incorporate the reduction of visual and auditory stimuli into nursing practice. The results of this study could have a direct impact on clinical practice. Trial registered at clinicaltrials.gov: NCT04041635.
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http://dx.doi.org/10.1111/jan.14300DOI Listing
April 2020

Goals and Challenges in Bacterial Phosphoproteomics.

Int J Mol Sci 2019 Nov 13;20(22). Epub 2019 Nov 13.

Área de Microbiología, Departamento de Biología Funcional, IUOPA, ISPA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain.

Reversible protein phosphorylation at serine, threonine and tyrosine is a well-known dynamic post-translational modification with stunning regulatory and signalling functions in eukaryotes. Shotgun phosphoproteomic analyses revealed that this post-translational modification is dramatically lower in bacteria than in eukaryotes. However, Ser/Thr/Tyr phosphorylation is present in all analysed bacteria (24 eubacteria and 1 archaea). It affects central processes, such as primary and secondary metabolism development, sporulation, pathogenicity, virulence or antibiotic resistance. Twenty-nine phosphoprotein orthologues were systematically identified in bacteria: ribosomal proteins, enzymes from glycolysis and gluconeogenesis, elongation factors, cell division proteins, RNA polymerases, ATP synthases and enzymes from the citrate cycle. While Ser/Thr/Tyr phosphorylation exists in bacteria, there is a consensus that histidine phosphorylation is the most abundant protein phosphorylation in prokaryotes. Unfortunately, histidine shotgun phosphorproteomics is not possible due to the reduced phosphohistidine half-life under the acidic pH conditions used in standard LC-MS/MS analysis. However, considering the fast and continuous advances in LC-MS/MS-based phosphoproteomic methodologies, it is expected that further innovations will allow for the study of His phosphoproteomes and a better coverage of bacterial phosphoproteomes. The characterisation of the biological role of bacterial Ser/Thr/Tyr and His phosphorylations might revolutionise our understanding of prokaryotic physiology.
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http://dx.doi.org/10.3390/ijms20225678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888350PMC
November 2019

Intervention to reduce the incidence of surgical site infection in spine surgery.

Am J Infect Control 2020 05 7;48(5):550-554. Epub 2019 Nov 7.

Faculty of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain; Preventive Medicine Department, Germans Trias i Pujol University Hospital, Badalona, Spain.

Background: This study examines the incidence, characteristics, and risk factors of surgical site infections (SSIs) after spine surgery and evaluates the efficacy of a preventive intervention.

Methods: This was a quasi-experimental pretest/posttest study in patients undergoing spinal surgery in an orthopedic surgery department from December 2014 to November 2016. Based on the results of the study, we revised the preventive protocol with modification of wound dressing, staff training, and feedback. SSI rates were compared between the pre-intervention (December 2014 to November 2015) and post-intervention (December 2015 to November 2016) periods. The risk factors were analyzed using univariate and multivariate analyses.

Results: Of the 139 patients included, 14 cases of SSI were diagnosed, with a significant decrease in the incidence of SSIs from the pre-intervention period to the post-intervention period (19.4% vs 2.6%; P = .001). The etiology was known in 13 cases, with enteric flora being predominant in the pre-intervention group. Univariate analysis showed that age, body mass index, days until sitting and ambulation, and incontinence were statistically significant risk factors. After multivariate analysis, only body mass index and days until ambulation remained significant. When the effect of intervention was adjusted with other risk factors, this variable remained statistically significant.

Conclusions: An intervention that includes modification of wound dressing and early mobilization, as well as staff awareness training, monitoring, and feedback, allowed a significant reduction in the incidence of SSI following spinal surgery, particularly infections caused by enteric flora.
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http://dx.doi.org/10.1016/j.ajic.2019.09.007DOI Listing
May 2020

Newborn physiological immaturity: a concept analysis.

Adv Neonatal Care 2015 Apr;15(2):86-93

IDIBELL Institute of Research, University of Barcelona School of Nursing, Catalonia, Spain (Drs Juvé-Udina, Fabrellas-Padrés, and Delgado-Hito); Sant Joan de Déu School of Nursing, Catalonia, Spain (Mrs Hurtado-Pardos); Department of Nursing Informatics and Knowledge, Verge de la Cinta Community Hospital, and Rovira i Virgili University School of Nursing, Tortosa, Catalonia, Spain (Mrs Martí-Cavallé); Department of Nursing Informatics and Knowledge, Dr. Josep Trueta University Hospital, Girona, Catalonia, Spain (Mrs Gironès-Nogué); Vall d'Hebron University Hospital, Barcelona, Catalonia, Spain (Mrs García-Berman); and Germans Trias i Pujol University Hospital, Badalona, Catalonia, Spain (Mr Alonso-Fernandez).

Background: Most standardized nursing care plans for healthy neonates include multiple nursing diagnoses to reflect nurses' judgments on the infant's status; however scientific literature concerning this issue is scarce. Newborn physiological immaturity is a concept in the ATIC terminology (architecture, terminology, interface, information, nursing [infermeria], and knowledge [coneixement]) to represent the natural status of vulnerability of the healthy neonate.

Purpose: To identify the essential attributes of the concept and provide its conceptual and operational definition, using the Wilsonian approach.

Findings: The concept under analysis embeds a natural cluster of vulnerabilities and environmental interactions that enhance the evolving maturation process.

Implications For Practice: The use of this diagnosis may simplify the process of charting the nursing care plans and reduce time needed for documentation while maintaining the integrity of the information.

Implications For Research: Consistent development and use of nursing concepts is essential for knowledge building. Studies on the actual use of nursing diagnoses are needed to inform decision making.
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http://dx.doi.org/10.1097/ANC.0000000000000162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961275PMC
April 2015