Sergi Ferré

Sergi Ferré

UNVERIFIED PROFILE

Are you Sergi Ferré?   Register this Author

Register author
Sergi Ferré

Sergi Ferré

Publications by authors named "Sergi Ferré"

Are you Sergi Ferré?   Register this Author

100Publications

2067Reads

6Profile Views

Oligomerization of G protein-coupled receptors: Still doubted?

Prog Mol Biol Transl Sci 2020 12;169:297-321. Epub 2019 Dec 12.

Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.pmbts.2019.11.006DOI Listing
December 2019

Biased G Protein-Independent Signaling of Dopamine D-D Receptor Heteromers in the Nucleus Accumbens.

Mol Neurobiol 2019 Oct 27;56(10):6756-6769. Epub 2019 Mar 27.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-019-1564-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728209PMC
October 2019

Functional and Neuroprotective Role of Striatal Adenosine A Receptor Heterotetramers.

J Caffeine Adenosine Res 2019 Sep 17;9(3):89-97. Epub 2019 Sep 17.

Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine, IDIBELL, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/caff.2019.0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761580PMC
September 2019

Revisiting the Functional Role of Dopamine D Receptor Gene Polymorphisms: Heteromerization-Dependent Gain of Function of the D Receptor Variant.

Mol Neurobiol 2019 Jul 1;56(7):4778-4785. Epub 2018 Nov 1.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12035-018-1413-1
Publisher Site
http://dx.doi.org/10.1007/s12035-018-1413-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494742PMC
July 2019

Astrocytic Mechanisms Involving Kynurenic Acid Control Δ-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.

Mol Neurobiol 2019 May 27;56(5):3563-3575. Epub 2018 Aug 27.

Behavioral Neuroscience Research Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-018-1319-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393222PMC
May 2019

New Insights into the Neurobiology of Restless Legs Syndrome.

Neuroscientist 2019 04 26;25(2):113-125. Epub 2018 Jul 26.

3 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1073858418791763DOI Listing
April 2019

The Adenosine Hypothesis of Restless Legs Syndrome.

Authors:
Sergi Ferré

J Caffeine Adenosine Res 2019 Mar 14;9(1):1-3. Epub 2019 Mar 14.

Editor in Chief of the Journal of Caffeine and Adenosine Research.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/caff.2019.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444903PMC
March 2019

Adenosine A-Dopamine D Receptor Heteromers Control the Excitability of the Spinal Motoneuron.

Mol Neurobiol 2019 Feb 24;56(2):797-811. Epub 2018 May 24.

Department of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12035-018-1120-y
Publisher Site
http://dx.doi.org/10.1007/s12035-018-1120-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252157PMC
February 2019

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model.

Pharmacol Res 2019 01 22;139:337-347. Epub 2018 Nov 22.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2018.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360119PMC
January 2019

Role of placebo effects in pain and neuropsychiatric disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2018 12 14;87(Pt B):298-306. Epub 2017 Jun 14.

Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, USA; Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, USA; Department of Anesthesiology and Psychiatry, School of Medicine, University of Maryland, Baltimore, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pnpbp.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722709PMC
December 2018

New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders.

J Caffeine Adenosine Res 2018 Dec 7;8(4):121-131. Epub 2018 Dec 7.

Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/caff.2018.0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306650PMC
December 2018

α- and α-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.

Mol Neurobiol 2018 Nov 18;55(11):8438-8454. Epub 2018 Mar 18.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Triad Technology Building, 333 Cassell Drive, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-018-1004-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143434PMC
November 2018

Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer.

J Med Chem 2018 10 11;61(20):9335-9346. Epub 2018 Oct 11.

Biomaterials and Nanomedicine , Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , Barcelona Science Park , 08028 Barcelona , Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b01249DOI Listing
October 2018

Behavioral and cellular dopamine D and D receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia.

Neuropharmacology 2018 08 21;138:304-314. Epub 2018 Jun 21.

Behavioral Neuroscience Program, Department of Psychology, Binghamton University, 4400 Vestal Parkway East, Binghamton, NY 13902, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2018.06.024DOI Listing
August 2018

Fronto-striatal effective connectivity of working memory in adults with cannabis use disorder.

Psychiatry Res Neuroimaging 2018 08 8;278:21-34. Epub 2018 Jun 8.

Institute for Drug and Alcohol Studies, Virginia Commonwealth University (VCU), 203 East Cary Street, Suite 202, Richmond, VA 23219, USA; Department of Psychiatry, Virginia Commonwealth University (VCU), Richmond, VA, USA; Department of Pharmacology & Toxicology, VCU, Richmond, VA, USA; Department of Neurology, VCU, Richmond, VA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pscychresns.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953485PMC
August 2018

Luciferase complementation based-detection of G-protein-coupled receptor activity.

Biotechniques 2018 07;65(1):9-14

National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2144/btn-2018-0039DOI Listing
July 2018

The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease.

J Caffeine Adenosine Res 2018 Jun;8(2):43-58

National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/caff.2018.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049521PMC
June 2018

Treatment of restless legs syndrome/Willis-Ekbom disease with the non-selective ENT1/ENT2 inhibitor dipyridamole: testing the adenosine hypothesis.

Sleep Med 2018 05 24;45:94-97. Epub 2018 Feb 24.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13899457183004
Publisher Site
http://dx.doi.org/10.1016/j.sleep.2018.02.002DOI Listing
May 2018

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

Nat Commun 2018 03 28;9(1):1242. Epub 2018 Mar 28.

Integrative Neurobiology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-03522-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871782PMC
March 2018

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D receptor.

Nat Commun 2018 02 5;9(1):486. Epub 2018 Feb 5.

National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-02606-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799184PMC
February 2018

Adenosine A-dopamine D receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics.

Neural Regen Res 2018 Feb;13(2):241-243

Unitat de Farmacologia, DepartamentPatologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.226388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879894PMC
February 2018

Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits G and G.

J Biol Chem 2017 12 17;292(49):19989-19998. Epub 2017 Oct 17.

the Departments of Psychiatry and Pharmacology, College of Physicians & Surgeons, Columbia University, New York, New York 10032, and

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M117.800698
Publisher Site
http://dx.doi.org/10.1074/jbc.M117.800698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723988PMC
December 2017

Targeting hypersensitive corticostriatal terminals in restless legs syndrome.

Ann Neurol 2017 Dec 7;82(6):951-960. Epub 2017 Dec 7.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739944PMC
December 2017

Adenosine A-A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease.

Front Neurosci 2017 22;11:652. Epub 2017 Nov 22.

Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2017.00652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702635PMC
November 2017

Bioluminescence Resonance Energy Transfer Assay to Characterize Gi-Like G Protein Subtype-Dependent Functional Selectivity.

Curr Protoc Neurosci 2017 Oct 23;81:5.33.1-5.33.13. Epub 2017 Oct 23.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpns.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657550PMC
October 2017

Hormones and Neuropeptide Receptor Heteromers in the Ventral Tegmental Area. Targets for the Treatment of Loss of Control of Food Intake and Substance Use Disorders.

Authors:
Sergi Ferré

Curr Treat Options Psychiatry 2017 22;4(2):167-183. Epub 2017 Apr 22.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Triad Technology Building, 333 Cassell Drive, Baltimore, MD 21224 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40501-017-0109-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432584PMC
April 2017

Connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (RLS): plastic changes and neuroadaptations that may contribute to augmentation.

Sleep Med 2017 03 27;31:71-77. Epub 2016 Jun 27.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191980PMC
March 2017

In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine.

Sleep Med 2017 03 1;31:86-92. Epub 2016 Nov 1.

Sleep Research Institute, Paseo de la Habana 151, 28036 Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2016.08.019DOI Listing
March 2017

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.

J Neurosci 2017 02 22;37(5):1176-1186. Epub 2016 Dec 22.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224

View Article

Download full-text PDF

Source
http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2442-1
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2442-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296795PMC
February 2017

Targeting the equilibrative nucleoside transporter ENT1 in Huntington disease.

Oncotarget 2017 Feb;8(8):12550-12551

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.15111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355032PMC
February 2017

Key role of the dopamine D receptor in the modulation of corticostriatal glutamatergic neurotransmission.

Sci Adv 2017 Jan 11;3(1):e1601631. Epub 2017 Jan 11.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural research Program, National Institutes of Health, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.160
Publisher Site
http://dx.doi.org/10.1126/sciadv.1601631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226642PMC
January 2017

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome.

Neuropharmacology 2016 12 4;111:160-168. Epub 2016 Sep 4.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056844PMC
http://dx.doi.org/10.1016/j.neuropharm.2016.09.002DOI Listing
December 2016

Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.

Neurobiol Dis 2016 Dec 24;96:47-53. Epub 2016 Aug 24.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09699961163020
Publisher Site
http://dx.doi.org/10.1016/j.nbd.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102769PMC
December 2016

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.

J Biol Chem 2016 Jun 25;291(25):13048-62. Epub 2016 Apr 25.

the Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.715144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933222PMC
June 2016

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.

Authors:
Sergi Ferré

Psychopharmacology (Berl) 2016 05 20;233(10):1963-79. Epub 2016 Jan 20.

Integrative Neurobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Triad Technology Building, 333 Cassell Drive, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-016-4212-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846529PMC
May 2016

Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist.

Mol Pharmacol 2016 Apr 3;89(4):457-66. Epub 2016 Feb 3.

Integrative Neurobiology Section (M.S.-S., N.S.C., S.F., H.Y.) and Medicinal Chemistry Section (A.B., M.P.E., A.H.N.), Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (M.S.-S.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.115.101808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809307PMC
April 2016

Evidence for the heterotetrameric structure of the adenosine A2A-dopamine D2 receptor complex.

Biochem Soc Trans 2016 Apr;44(2):595-600

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20150276DOI Listing
April 2016

Dissecting striatal adenosine-cannabinoid receptor interactions. New clues from rats over-expressing adenosine A2A receptors.

J Neurochem 2016 Mar 25;136(5):897-9. Epub 2016 Jan 25.

Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755863PMC
March 2016

Cortico-striatal circuits: Novel therapeutic targets for substance use disorders.

Brain Res 2015 Dec 9;1628(Pt A):186-98. Epub 2015 Apr 9.

National Institute of Drug Abuse, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2015.03.048DOI Listing
December 2015

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer.

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):E3609-18. Epub 2015 Jun 22.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, and Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1507704112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500251PMC
July 2015

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.

J Neurosci 2015 Apr;35(17):6639-53

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain, School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, and

View Article

Download full-text PDF

Source
http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4364-14.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.4364-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412889PMC
April 2015

The GPCR heterotetramer: challenging classical pharmacology.

Authors:
Sergi Ferré

Trends Pharmacol Sci 2015 Mar 18;36(3):145-52. Epub 2015 Feb 18.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health (NIH), Triad Technology Building, 333 Cassell Drive, Baltimore, MD 21224, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357316PMC
March 2015

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Pharmacol Rev 2014 10;66(2):413-34. Epub 2014 Feb 10.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Department of Health and Human Services, 333 Cassell Drive, Baltimore, Maryland 21224.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/pr.113.008052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973609PMC
December 2014

Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.

Mol Pharmacol 2014 Oct 5;86(4):417-29. Epub 2014 Aug 5.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (X.G., H.Y., N.-S.C., M.S.-S., S.K.-B., Y.T.N., S.F.); Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (G.N., E.M., J.M., A.C., C.L., E.I.C., V.C., P.J.M.); and School of Pharmacy, University of East Anglia, Norwich, United Kingdom (P.J.M.)

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.114.09
Publisher Site
http://dx.doi.org/10.1124/mol.114.093096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164978PMC
October 2014

Differential effects of presynaptic versus postsynaptic adenosine A2A receptor blockade on Δ9-tetrahydrocannabinol (THC) self-administration in squirrel monkeys.

J Neurosci 2014 May;34(19):6480-4

Preclinical Pharmacology Section of Behavioral Neuroscience Research Branch and Integrative Neurobiology Section of Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.5073-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012307PMC
May 2014

Personality traits and vulnerability or resilience to substance use disorders.

Trends Cogn Sci 2014 Apr 5;18(4):211-7. Epub 2014 Mar 5.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tics.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972619PMC
April 2014

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

J Neurosci 2014 Mar;34(10):3545-58

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, 08028 Spain, Neuroscience Institute and Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitat Autónoma de Barcelona, 08193 Bellaterra, Spain, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, and School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom NR4 7TJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.4147-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942573PMC
March 2014

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.

PLoS One 2013 18;8(4):e61245. Epub 2013 Apr 18.

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630156PMC
December 2013

Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.

Nat Neurosci 2013 Nov 13;16(11):1652-61. Epub 2013 Oct 13.

1] Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. [2] Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA. [3].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.3540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835353PMC
November 2013

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology.

Methods Mol Biol 2013 ;964:95-105

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-251-3_7DOI Listing
June 2013

Caffeine and Substance Use Disorders.

Authors:
Sergi Ferré

J Caffeine Res 2013 Jun;3(2):57-58

National Institute on Drug Abuse , IRP, NIH, DHHS - Integrative Neurobiology Section, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jcr.2013.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680974PMC
June 2013

Paraxanthine: Connecting Caffeine to Nitric Oxide Neurotransmission.

J Caffeine Res 2013 Jun;3(2):72-78

Intramural Research Program, Integrative Neurobiology Section, Department of Health and Human Services, National Institute on Drug Abuse , Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jcr.2013.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680978PMC
June 2013

Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.

Neuropharmacology 2013 Apr 19;67:476-84. Epub 2012 Dec 19.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00283908120057
Publisher Site
http://dx.doi.org/10.1016/j.neuropharm.2012.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562388PMC
April 2013

Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A(2A) Antagonist in Cocaine Dependent Subjects.

Front Psychiatry 2012 28;3:44. Epub 2012 May 28.

Department of Psychiatry and Behavioral Sciences, Center for Neurobehavioral Research on Addiction, University of Texas Health Science Center at Houston Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2012.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361057PMC
October 2012

Combined effects of THC and caffeine on working memory in rats.

Br J Pharmacol 2012 Apr;165(8):2529-38

Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1476-5381.2011.01554.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423236PMC
April 2012

Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum.

Neuropharmacology 2011 Oct-Nov;61(5-6):967-74. Epub 2011 Jul 5.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2011.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156876PMC
February 2012

Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease.

Pharmacol Ther 2011 Dec 23;132(3):280-99. Epub 2011 Jul 23.

Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino", Pavia, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2011.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205226PMC
December 2011

Functional changes in postsynaptic adenosine A(2A) receptors during early stages of a rat model of Huntington disease.

Exp Neurol 2011 Nov 16;232(1):76-80. Epub 2011 Aug 16.

CNS Receptor-Receptor Interactions Unit, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S001448861100268
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2011.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190040PMC
November 2011

Alcohol and Caffeine: The Perfect Storm.

J Caffeine Res 2011 Sep;1(3):153-162

Department of Emergency Medicine, Wake Forest School of Medicine , Winston-Salem, North Carolina. ; Department of Social Sciences & Health Policy, Wake Forest School of Medicine , Winston-Salem, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jcr.2011.0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621334PMC
September 2011

Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist.

Addict Biol 2011 Jul 4;16(3):405-15. Epub 2010 Nov 4.

Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/DHHS, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1369-1600.2010.00258.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115444PMC
July 2011

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function.

Front Neuroanat 2011 17;5:36. Epub 2011 Jun 17.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnana.2011.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118889PMC
July 2011

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

J Neurosci 2011 May;31(20):7412-23

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0191-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109911PMC
May 2011

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.

J Biol Chem 2011 Feb 20;286(7):5846-54. Epub 2010 Dec 20.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.161489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037697PMC
February 2011

Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer.

CNS Neurol Disord Drug Targets 2010 Nov;9(5):596-600

National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/187152710793361603DOI Listing
November 2010

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine.

Proc Natl Acad Sci U S A 2010 Oct 18;107(43):18676-81. Epub 2010 Oct 18.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1008911107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972946PMC
October 2010

Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine.

Authors:
Sergi Ferré

J Alzheimers Dis 2010 ;20 Suppl 1:S35-49

National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2010-1400DOI Listing
September 2010

G protein-coupled receptor heteromers as new targets for drug development.

Prog Mol Biol Transl Sci 2010 ;91:41-52

National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1877-1173(10)91002-8DOI Listing
September 2010

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers.

J Biol Chem 2010 Aug 18;285(35):27346-59. Epub 2010 Jun 18.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M110.115634
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.115634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930733PMC
August 2010

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

Expert Opin Drug Discov 2010 Apr;5(4):391-403

Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain +34 94 819 4700 ext. 2033 ; +34 94 819 4715 ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17460441003653163DOI Listing
April 2010

Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers.

Curr Opin Pharmacol 2010 Feb 10;10(1):67-72. Epub 2009 Nov 10.

National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2009.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818424PMC
February 2010

Oligomerization of G-protein-coupled receptors: a reality.

Curr Opin Pharmacol 2010 Feb 16;10(1):1-5. Epub 2009 Dec 16.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2009.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825689PMC
February 2010

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

Pharmacol Ther 2009 Nov 5;124(2):248-57. Epub 2009 Aug 5.

Departament de Bioquímica i Biologia Molecular, CIBERNED (Centro de Investigación en Red de Enfermedades Neurodegenerativas) and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2009.07.005DOI Listing
November 2009

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors.

J Biol Chem 2009 Oct 24;284(41):28058-68. Epub 2009 Jul 24.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.034231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788857PMC
October 2009

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells.

J Neurochem 2009 Jun 30;109(5):1497-507. Epub 2009 Mar 30.

IDIBAPS, CIBERNED and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1471-4159.2009.06078.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2009.06078.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925975PMC
June 2009

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors.

Br J Pharmacol 2009 May;157(1):64-75

Molecular Neurobiology Unit, IDIBAPS, CIBERNED, Department of Biochemistry and Molecular Biology, School of Biology, University of Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1476-5381.2009.00152.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697789PMC
May 2009

GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors.

J Neurochem 2009 Mar 29;108(5):1208-19. Epub 2009 Jan 29.

Institute of Pharmacology and Neurosciences, Institute of Molecular Medicine, University of Lisbon, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2009.05876.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676206PMC
March 2009

Integrative action of receptor mosaics: relevance of receptor topology and allosteric modulators.

J Recept Signal Transduct Res 2008 ;28(6):543-65

Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS Lido, Venezia, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10799890802590420DOI Listing
February 2009

[Caffeine in Parkinson's disease].

Authors:
Sergi Ferré

Med Clin (Barc) 2008 Nov;131(18):710-5

Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services. Baltimore. Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1157/13129123DOI Listing
November 2008