Sergey Dikalov

Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension.

Authors:

Anna Dikalova Vladimir Mayorov Liang Xiao Alexander Panov Venkataraman Amarnath Irene Zagol-Ikapitte Aurelia Vergeade Mingfang Ao Valery Yermalitsky Rafal R Nazarewicz Olivier Boutaud Marcos G Lopez Frederic T Billings Sean Davies L Jackson Roberts David G Harrison Sergey Dikalov

Hypertension 2020 Dec 5;76(6):1980-1991. Epub 2020 Oct 5.

From the Vanderbilt University Medical Center, Nashville, TN (A.D., L.X., V.A., I.Z.-I., A.V., M.A., V.Y., R.R.N., O.B., M.G.L., F.T.B., S. Davies, L.J.R., D.G.H., S. Dikalov).

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December 2020

Cardiolipin, Perhydroxyl Radicals, and Lipid Peroxidation in Mitochondrial Dysfunctions and Aging.

Authors:

Alexander V Panov Sergey I Dikalov

Oxid Med Cell Longev 2020 8;2020:1323028. Epub 2020 Sep 8.

Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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September 2020

Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".

Authors:

Anna Dikalova Sergey Dikalov

Circ Res 2020 03 26;126(7):e33-e34. Epub 2020 Mar 26.

From the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

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March 2020

CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.

Authors:

Guillermo Flores Joel H Everett Elissa A Boguslawski Brandon M Oswald Zachary B Madaj Ian Beddows Sergey Dikalov Marie Adams Carleen A Klumpp-Thomas Susan M Kitchen-Goosen Scott E Martin Natasha J Caplen Lee J Helman Patrick J Grohar

Mol Cancer Ther 2020 05 3;19(5):1183-1196. Epub 2020 Mar 3.

Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan.

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May 2020

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.

Authors:

Anna E Dikalova Arvind Pandey Liang Xiao Liaisan Arslanbaeva Tatiana Sidorova Marcos G Lopez Frederic T Billings Eric Verdin Johan Auwerx David G Harrison Sergey I Dikalov

Circ Res 2020 02 19;126(4):439-452. Epub 2019 Dec 19.

From the Vanderbilt University Medical Center, Nashville, TN (A.E.D., A.P., L.X., L.A., T.S., M.G.L., F.T.B., D.G.H., S.I.D.).

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February 2020

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Circulation 2019 10;140(14):1205-1216

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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October 2019

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation.

Authors:

Vladimir Mayorov Peter Uchakin Venkataraman Amarnath Alexander V Panov Christy C Bridges Roman Uzhachenko Bill Zackert Christy S Moore Sean Davies Anna Dikalova Sergey Dikalov

Redox Biol 2019 09 14;26:101300. Epub 2019 Aug 14.

Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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September 2019

Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction.

JCI Insight 2019 04 23;5. Epub 2019 Apr 23.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.

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April 2019

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus.

Authors:

Ravindran Caspa Gokulan Jamie M Adcock Irene Zagol-Ikapitte Raymond Mernaugh Phillip Williams Kay M Washington Olivier Boutaud John A Oates Sergey I Dikalov Alexander I Zaika

Cell Mol Gastroenterol Hepatol 2019 8;7(2):480-482.e7. Epub 2018 Nov 8.

Department of Surgery, University of Miami, Miami, Florida; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Veterans Affairs, Miami VA Healthcare System, Miami, Florida. Electronic address:

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May 2019

Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K.

Authors:

Hanan B Elajaili Laura Hernandez-Lagunas Kalina Ranguelova Sergey Dikalov Eva Nozik-Grayck

J Vis Exp 2019 01 11(143). Epub 2019 Jan 11.

Cardiovascular Pulmonary Research Laboratories and Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado Anschutz Medical Campus;

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January 2019

Crosstalk Between Mitochondrial Hyperacetylation and Oxidative Stress in Vascular Dysfunction and Hypertension.

Authors:

Sergey I Dikalov Anna E Dikalova

Antioxid Redox Signal 2019 10 28;31(10):710-721. Epub 2019 Feb 28.

Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.

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October 2019

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension.

Authors:

Sergey Dikalov Hana Itani Bradley Richmond Aurelia Vergeade S M Jamshedur Rahman Olivier Boutaud Timothy Blackwell Pierre P Massion David G Harrison Anna Dikalova

Am J Physiol Heart Circ Physiol 2019 03 4;316(3):H639-H646. Epub 2019 Jan 4.

Division of Clinical Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee.

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March 2019

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide.

Authors:

Roxana Loperena Justin P Van Beusecum Hana A Itani Noah Engel Fanny Laroumanie Liang Xiao Fernando Elijovich Cheryl L Laffer Juan S Gnecco Jonathan Noonan Pasquale Maffia Barbara Jasiewicz-Honkisz Marta Czesnikiewicz-Guzik Tomasz Mikolajczyk Tomasz Sliwa Sergey Dikalov Cornelia M Weyand Tomasz J Guzik David G Harrison

Cardiovasc Res 2018 09;114(11):1547-1563

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.

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September 2018

Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols.

Authors:

Sergey I Dikalov Vladimir I Mayorov Alexander V Panov

Front Physiol 2017 7;8:907. Epub 2017 Nov 7.

Institute of Molecular Biology and Biophysics, Russian Academy of Sciences, Novosibirsk, Russia.

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November 2017

Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.

Authors:

Jamie L Kuck Julie A Bastarache Ciara M Shaver Joshua P Fessel Sergey I Dikalov James M May Lorraine B Ware

Biochem Biophys Res Commun 2018 01 9;495(1):433-437. Epub 2017 Nov 9.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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January 2018

Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides.

Authors:

Sergey I Dikalov Anna E Dikalova Denis A Morozov Igor A Kirilyuk

Free Radic Res 2018 Mar 3;52(3):339-350. Epub 2017 Nov 3.

b Laboratory of Nitrogen Compounds, Novosibirsk Institute of Organic Chemistry , Novosibirsk , Russia.

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March 2018

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.

Authors:

Natalia R Barbaro Jason D Foss Dmytro O Kryshtal Nikita Tsyba Shivani Kumaresan Liang Xiao Raymond L Mernaugh Hana A Itani Roxana Loperena Wei Chen Sergey Dikalov Jens M Titze Bjorn C Knollmann David G Harrison Annet Kirabo

Cell Rep 2017 Oct;21(4):1009-1020

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address:

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October 2017