Sergey Bachurin

Sergey Bachurin

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Sergey Bachurin

Sergey Bachurin

Publications by authors named "Sergey Bachurin"

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Novel Positive Allosteric Modulators of AMPA Receptors Based on 3,7-Diazabicyclo[3.3.1]nonane Scaffold.

Mol Neurobiol 2020 Jan 12;57(1):191-199. Epub 2019 Sep 12.

Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation, 119991.

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http://dx.doi.org/10.1007/s12035-019-01768-6DOI Listing
January 2020

Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.

Bioorg Chem 2020 Jan 28;94:103387. Epub 2019 Oct 28.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103387DOI Listing
January 2020

Corrigendum to "Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation". [Bioorg. Chem. 94C (2019)].

Bioorg Chem 2020 Jan 30;96:103563. Epub 2020 Jan 30.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103563DOI Listing
January 2020

Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.

Bioorg Med Chem Lett 2019 Dec 14;29(23):126716. Epub 2019 Oct 14.

Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg 620990, Russia; Ural Federal University Named After the First President of Russia B.N. Yeltsin, Ekaterinburg 620002, Russia.

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http://dx.doi.org/10.1016/j.bmcl.2019.126716DOI Listing
December 2019

Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors.

Bioorg Chem 2019 Oct 3;91:103097. Epub 2019 Jul 3.

Departments of Environmental Health Sciences and Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103097DOI Listing
October 2019

Overview of novel multifunctional agents based on conjugates of γ-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease.

Chem Biol Interact 2019 Aug 14;308:224-234. Epub 2019 May 14.

Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA; Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.05.020DOI Listing
August 2019

Implications of farnesyltransferase and its inhibitors as a promising strategy for cancer therapy.

Semin Cancer Biol 2019 06 31;56:128-134. Epub 2017 Oct 31.

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432, Russia; School of Health Science and Healthcare Administration, University of Atlanta, E. Johns Crossing, #175, Johns Creek, GA, 30097, USA; GALLY International Biomedical Research Institute Inc., 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.10.010DOI Listing
June 2019

Alzheimer's Disease - Future Therapy Based on Dendrimers.

Curr Neuropharmacol 2019 ;17(3):288-294

Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Moscow Region, Chernogolovka, 142432, Russian Federation.

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http://dx.doi.org/10.2174/1570159X16666180918164623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425077PMC
June 2019

The Possibility of an Infectious Etiology of Alzheimer Disease.

Mol Neurobiol 2019 Jun 18;56(6):4479-4491. Epub 2018 Oct 18.

I.M.Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str., 8, bld. 2, Moscow, Russia, 119991.

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http://link.springer.com/10.1007/s12035-018-1388-y
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http://dx.doi.org/10.1007/s12035-018-1388-yDOI Listing
June 2019

Chikungunya virus inhibition by synthetic coumarin-guanosine conjugates.

Eur J Med Chem 2019 Mar 21;166:136-143. Epub 2019 Jan 21.

Department of Chemistry, National Tsing Hua University, Hsinchu, 300, Taiwan; Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 300, Taiwan; Department of Chemistry, National Central University, Jhongli City, Taoyuan, 320, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193004
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http://dx.doi.org/10.1016/j.ejmech.2019.01.037DOI Listing
March 2019

New Therapeutic Property of Dimebon as a Neuroprotective Agent.

Curr Med Chem 2018 ;25(39):5315-5326

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severniy Proezd 1, Chernogolovka, 142432, Russian Federation.

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http://dx.doi.org/10.2174/0929867323666160804122746DOI Listing
February 2019

Applications of Multi-Target Computer-Aided Methodologies in Molecular Design of CNS Drugs.

Curr Med Chem 2018 ;25(39):5293-5314

Department of Biomedical and Biological Chemistry, Institute of Physiologically Active Compounds, Russian Academy of Science, 142432, Chernogolovka, Moscow region, Russian Federation.

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http://dx.doi.org/10.2174/0929867324666170920154111DOI Listing
February 2019

Nanotechnology for Alzheimer Disease.

Curr Alzheimer Res 2017 ;14(11):1182-1189

"GALLY" International Biomedical Research Consulting LLC, San Antonio, TX 78229. United States.

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http://dx.doi.org/10.2174/1567205014666170203125008DOI Listing
June 2018

Corrigendum to "Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention" [Pharmacol. Res. 129 (2018) 216-226].

Pharmacol Res 2018 06 17;132:245. Epub 2018 Mar 17.

Institute of Physiologically Active Compounds of the RussianAcademy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia; GALLY International Biomedical Research Consulting LLC., San Antonio, TX 78229, USA; School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, GA 30097, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.03.006DOI Listing
June 2018

Mitochondrial Permeability Transition Pore as a Suitable Targ e t for Neuroprotective Agents Against Alzheimer's Disease.

CNS Neurol Disord Drug Targets 2017 ;16(6):677-685

"GALLY" International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive, #330, San Antonio, TX 78229. United States.

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http://dx.doi.org/10.2174/1871527316666170424114444DOI Listing
May 2018

Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention.

Pharmacol Res 2018 03 21;129:216-226. Epub 2017 Nov 21.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia; GALLY International Biomedical Research Consulting LLC., San Antonio, TX 78229, USA; School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, GA 30097, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.11.021DOI Listing
March 2018

9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.

Bioorg Med Chem 2017 11 20;25(21):5981-5994. Epub 2017 Sep 20.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.09.028DOI Listing
November 2017

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends.

Med Res Rev 2017 09 13;37(5):1186-1225. Epub 2017 Jan 13.

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severny proezd 1, Chernogolovka, Moscow region, 142432, Russia.

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http://dx.doi.org/10.1002/med.21434DOI Listing
September 2017

Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test.

Neural Plast 2016 5;2016:5098591. Epub 2016 Jul 5.

Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, Netherlands; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1155/2016/5098591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949347PMC
August 2017

Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.

Bioorg Med Chem 2017 08 20;25(15):3997-4007. Epub 2017 May 20.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.05.045DOI Listing
August 2017

Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo.

Chem Biol Interact 2016 Nov 3;259(Pt B):332-342. Epub 2016 May 3.

Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.05.002DOI Listing
November 2016

Nanoparticles as Alternative Strategies for Drug Delivery to the Alzheimer Brain: Electron Microscopy Ultrastructural Analysis.

CNS Neurol Disord Drug Targets 2015 ;14(9):1235-42

International Biomedical Research Consulting LLC 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229 USA.

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http://dx.doi.org/10.2174/1871527314666150821102631DOI Listing
September 2016

Physicochemical property profile for brain permeability: comparative study by different approaches.

J Drug Target 2016 08 6;24(7):655-62. Epub 2016 Feb 6.

c School of Pharmacy and Biomolecular Sciences , Liverpool John Moores University , Liverpool , UK.

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http://dx.doi.org/10.3109/1061186X.2015.1132224DOI Listing
August 2016

Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.

Bioorg Med Chem Lett 2016 08 25;26(16):4092-4. Epub 2016 Jun 25.

Kazan (Volga region) Federal University, Kremlyovskaya 18, 420008 Kazan, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.06.070DOI Listing
August 2016

Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.

Bioorg Med Chem 2016 Mar 18;24(5):1050-62. Epub 2016 Jan 18.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.01.031DOI Listing
March 2016

Toxicity of nanosilver in intragastric studies: Biodistribution and metabolic effects.

Toxicol Lett 2016 Jan 23;241:184-92. Epub 2015 Nov 23.

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 33, Bld. 2 Leninsky Ave., Moscow 119071, Russia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03784274153011
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http://dx.doi.org/10.1016/j.toxlet.2015.11.018DOI Listing
January 2016

Novel Sites of Neuroprotective Action of Dimebon (Latrepirdine).

Mol Neurobiol 2015 Oct 30;52(2):970-8. Epub 2015 Jun 30.

Institute of Psychological Medicine and Clinical Neurosciences, Hadyn Ellis Building, Maindy Road, CF24 4HQ, Cardiff, UK,

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http://dx.doi.org/10.1007/s12035-015-9249-4DOI Listing
October 2015

C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population.

Neurobiol Aging 2015 Oct 9;36(10):2908.e5-9. Epub 2015 Jul 9.

Laboratory of Genetic Modeling of Neurodegenerative Processes, Institute of Physiologically Active Compounds Russian Academy of Sciences, Moscow Region, Russian Federation; School of Biosciences, Cardiff University, Cardiff, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.07.004DOI Listing
October 2015

Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet.

Brain Behav Immun 2015 Aug 21;48:42-7. Epub 2015 Feb 21.

Department of Pharmacology, Oxford University, Mansfield Road, OX1 3QT Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2015.02.015DOI Listing
August 2015

Dimebon attenuates the Aβ-induced mitochondrial permeabilization.

Curr Alzheimer Res 2014 ;11(5):422-9

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432, Russia.

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http://dx.doi.org/10.2174/1567205011666140505094808DOI Listing
February 2015

Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-thyronine T2 in mouse depression paradigms.

Biomed Res Int 2013 10;2013:565218. Epub 2013 Dec 10.

Department of Preventive Medicine, Maastricht Medical Center in Annadal, Becanusstraat 17 A0, 6216 BX Maastricht, The Netherlands ; Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 40, NL 6229 ER Maastricht, The Netherlands ; Institute for Hygiene and Tropical Medicine, New University of Lisbon, Rua da Junqueira 96, 1349-008 Lisbon, Portugal.

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http://dx.doi.org/10.1155/2013/565218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872397PMC
June 2014

Synthesis, biological activity, distribution and membrane permeability of novel spiro-thiazines as potent neuroprotectors.

Eur J Med Chem 2014 Apr 21;77:8-17. Epub 2014 Feb 21.

Institute of Solution Chemistry, Russian Academy of Sciences, 153045 Ivanovo, Russia; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.

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http://dx.doi.org/10.1016/j.ejmech.2014.02.052DOI Listing
April 2014

Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice.

Eur Neuropsychopharmacol 2014 Feb 7;24(2):309-20. Epub 2013 Aug 7.

School for Mental Health and Neuroscience, Department of Neuroscience, Maastricht University, Universiteitssingel 40, NL 6229ER Maastricht, Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2013.06.010DOI Listing
February 2014

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues.

Beilstein J Org Chem 2014 Jan 15;10:155-62. Epub 2014 Jan 15.

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severny proezd 1, Chernogolovka, 142432, Russia.

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http://dx.doi.org/10.3762/bjoc.10.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896248PMC
January 2014

Novel 1,2,4-thiadiazole derivatives as potent neuroprotectors: approach to creation of bioavailable drugs.

Mol Pharm 2012 Aug 6;9(8):2156-67. Epub 2012 Mar 6.

Institute of Solution Chemistry, Russian Academy of Sciences , 153045 Ivanovo, Russia.

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http://dx.doi.org/10.1021/mp300011rDOI Listing
August 2012

Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.

Neurotox Res 2012 Jul 17;22(1):33-42. Epub 2011 Dec 17.

Institute of Physiologically Active Compounds of RAS, 1 Severniy Proezd, Chernogolovka, 142432, Moscow Region, Russian Federation.

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http://dx.doi.org/10.1007/s12640-011-9299-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351599PMC
July 2012

Thermodynamic and structural aspects of novel 1,2,4-thiadiazoles in solid and biological mediums.

Mol Pharm 2011 Oct 10;8(5):1807-20. Epub 2011 Aug 10.

Institute of Solution Chemistry, Russian Academy of Sciences, 153045 Ivanovo, Russia.

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http://dx.doi.org/10.1021/mp2003237DOI Listing
October 2011

Quinone reductase 2 and antidepressant effect of melatonin derivatives.

Ann N Y Acad Sci 2010 Jun;1199:121-4

Department of Psychiatry, Tufts University/Tufts Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05354.xDOI Listing
June 2010

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

FEBS Lett 2009 Jul 26;583(14):2419-24. Epub 2009 Jun 26.

Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Reearch, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.

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http://doi.wiley.com/10.1016/j.febslet.2009.06.042
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http://dx.doi.org/10.1016/j.febslet.2009.06.042DOI Listing
July 2009

Neurotrophic estrogens: essential profile and endpoints for drug discovery.

Drug Discov Today 2008 Sep 15;13(17-18):734-47. Epub 2008 May 15.

Global Drug Discovery, Bayer Schering Pharma AG, Berlin, Germany.

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http://dx.doi.org/10.1016/j.drudis.2008.03.009DOI Listing
September 2008

Mitochondria as a target for neurotoxins and neuroprotective agents.

Ann N Y Acad Sci 2003 May;993:334-44; discussion 345-9

Institute of Physiologically Active Compounds, Chernogolovka, Russia.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb07541.xDOI Listing
May 2003

Structural basis for understanding structure-activity relationships for the glutamate binding site of the NMDA receptor.

J Med Chem 2002 Aug;45(18):3836-43

Department of Chemistry, Moscow State University, Moscow 119992, Russia.

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http://dx.doi.org/10.1021/jm011091tDOI Listing
August 2002