Publications by authors named "Sergey Avdeev"

48 Publications

TaGRF3-2A Improves Some Agronomically Valuable Traits in Semi-Dwarf Spring Triticale.

Authors:
Mikhail Divashuk Anastasiya Chernook Aleksandra Kroupina Milena Vukovic Gennady Karlov Aleksey Ermolaev Sergey Shirnin Sergey Avdeev Vladimir Igonin Vladimir Pylnev Pavel Kroupin

Plants (Basel) 2021 Sep 25;10(10). Epub 2021 Sep 25.

All-Russia Research Institute of Agricultural Biotechnology, Timiryazevskaya Street, 42, 127550 Moscow, Russia.

The breeding improvement of triticale is tightly associated with the introgression of dwarfing genes, in particular, gibberellin (GA)-insensitive from rye. Despite the increase in harvest index and resistance to lodging, this gene adversely affects grain weight and size. Growth regulation factor () genes are plant-specific transcription factors that play an important role in plant growth, including GA-induced stem elongation. This study presents the results of a two-year field experiment to assess the effect of alleles of the -2A gene in interaction with on economically valuable traits of spring triticale plants grown in the Non-Chernozem zone. Our results show that, depending on the allelic state, the -2A gene in semi-dwarf spring triticale plants influences the thousand grain weight and the grain weight of the main spike in spring triticale, which makes it possible to use it to compensate for the negative effects of the dwarfing allele . The identified allelic variants of the -2A gene can be included in marker-assisted breeding for triticale to improve traits.
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http://dx.doi.org/10.3390/plants10102012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537337PMC
September 2021

Large Cavitary Lung Lesions in a Patient with Severe COVID-19 Pneumonia.

Authors:
Sergey Avdeev Galia Nuralieva Galina Nekludova

Am J Trop Med Hyg 2021 Oct 20. Epub 2021 Oct 20.

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.4269/ajtmh.21-0949DOI Listing
October 2021

Asthma in older adults with severe coronavirus disease 2019: Clinical outcomes and predictors of mortality.

Authors:
Sergey N Avdeev Anna A Pozdnakova Viliya V Gaynitdinova Svetlana Yu Chikina Anna E Vlasenko

Ann Allergy Asthma Immunol 2021 Oct 17. Epub 2021 Oct 17.

Department of Medical Cybernetics and Informatics, Novokuznetsk State Institute for Advanced Training of Doctors, Novokuznetsk, Russia.

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http://dx.doi.org/10.1016/j.anai.2021.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520591PMC
October 2021

Management of Acute Exacerbation of Idiopathic Pulmonary Fibrosis in Specialised and Non-specialised ILD Centres Around the World.

Authors:
Markus Polke Yasuhiro Kondoh Marlies Wijsenbeek Vincent Cottin Simon L F Walsh Harold R Collard Nazia Chaudhuri Sergey Avdeev Jürgen Behr Gregory Calligaro Tamera J Corte Kevin Flaherty Manuela Funke-Chambour Martin Kolb Johannes Krisam Toby M Maher Maria Molina Molina Antonio Morais Catharina C Moor Julie Morisset Carlos Pereira Silvia Quadrelli Moises Selman Argyrios Tzouvelekis Claudia Valenzuela Carlo Vancheri Vanesa Vicens-Zygmunt Julia Wälscher Wim Wuyts Elisabeth Bendstrup

Front Med (Lausanne) 2021 27;8:699644. Epub 2021 Sep 27.

Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus C, Denmark.

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide. Pulmonologists working in specialised and non-specialised ILD centres were invited to participate in a survey designed by an international expert panel. Responses were evaluated in respect to the physicians' institutions. Three hundred and two (65%) of the respondents worked in a specialised ILD centre, 134 (29%) in a non-specialised pulmonology centre. Similarities were frequent with regards to diagnostic methods including radiology and screening for infection, treatment with corticosteroids, use of high-flow oxygen and non-invasive ventilation in critical ill patients and palliative strategies. However, differences were significant in terms of the use of KL-6 and pathogen testing in urine, treatments with cyclosporine and recombinant thrombomodulin, extracorporeal membrane oxygenation in critical ill patients as well as antacid medication and anaesthesia measures as preventive methods. Despite the absence of recommendations, approaches to the prevention, diagnosis and treatment of AE-IPF are comparable in specialised and non-specialised ILD centres, yet certain differences in the managements of AE-IPF exist. Clinical trials and guidelines are needed to improve patient care and prognosis in AE-IPF.
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http://dx.doi.org/10.3389/fmed.2021.699644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502934PMC
September 2021

Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure.

Authors:
Svetlana Rachina Andrey Bobylev Pavel Lazarev Vladimir Mladov Florence Carrouel Sergey Avdeev Roman Kozlov Denis Bourgeois

J Clin Med 2021 Oct 1;10(19). Epub 2021 Oct 1.

Health, Systemic, Process, EA 4129 Research Unit, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France.

The diagnosis of community-acquired pneumonia (CAP) with chronic heart failure (CHF) is associated with objective difficulties. Our case-control study aims to establish whether established serum inflammatory biomarkers are relevant to the diagnosis of CAP in patients with CHF. Seventy inpatients with previously diagnosed CHF and suspected non-severe CAP were recruited and then stratified into two subgroups with confirmed and rejected diagnosis of CAP. C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and brain natriuretic peptide (BNP) were measured. The value of biomarkers was determined using logistic regression, and their discriminatory efficacy was assessed by analyzing receiver operating characteristic (ROC) curves. Significantly higher levels of CRP 50.0 (35.5-98.5) mg/L, PCT 0.10 (0.05-0.54) ng/mL and IL-6 46.1(21.4-150.3) pg/mL in cases were identified as compared to the control group-15.0 (9.5-25.0) mg/L, 0.05 (0.05-0.05) ng/mL and 13.6 (9.5; 25.0) pg/mL, respectively. The Area Under the ROC Curve (95% CI) was the highest for CRP-0.91 (0.83-0.98), followed by PCT-0.81 (0.72-0.90) and IL-6-0.81 (0.71-0.91). A CRP value of >28.5 mg/L had an optimal sensitivity and specificity ratio (85.7/91.4%). In conclusion, the measurement of serum CRP, PCT and IL-6 levels can be useful for the diagnosis of CAP in patients with CHF. CRP showed optimal diagnostic utility in this population.
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http://dx.doi.org/10.3390/jcm10194570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509775PMC
October 2021

Correction to: Idiopathic pulmonary fibrosis in BRIC countries: the cases of Brazil, Russia, India, and China.

Authors:
Luca Richeldi Adalberto Sperb Rubin Sergey Avdeev Zarir F Udwadia Zuo Jun Xu

BMC Med 2021 Sep 5;19(1):220. Epub 2021 Sep 5.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

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http://dx.doi.org/10.1186/s12916-021-02111-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418740PMC
September 2021

A 61-Year-Old Woman With Insidious Dyspnea and Diffuse Cystic Lung Disease.

Authors:
Sergey N Avdeev Zamira M Merzhoeva Maria V Samsonova Marina A Makarova Andrey L Cherniaev

Chest 2021 Aug;160(2):e199-e203

Pulmonology Scientific Research Institute, Federal Medical and Biological Agency of Russian Federation, Moscow, Russia.

A 61-year-old woman, an ex-smoker with a 10 pack year smoking history, was referred to our clinic for the evaluation of insidious dyspnea and diffuse, bilateral infiltrates on a chest radiograph. She reported that she had been experiencing dyspnea on exertion and dry cough for the past 1.5 years. She denied fevers, chills, hemoptysis, or weight loss. Aside from a smoking history, there were no comorbidities or environmental exposures. She had no family history of lung diseases or other disorders. She worked as a school teacher and had no occupational exposures. There were no pets in the home and no prior occupational exposures.
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http://dx.doi.org/10.1016/j.chest.2021.02.044DOI Listing
August 2021

Comparative effectiveness of pneumococcal vaccination with PPV23 and PCV13 in COPD patients over a 5-year follow-up cohort study.

Authors:
Galina L Ignatova Sergey N Avdeev Vladimir N Antonov

Sci Rep 2021 08 5;11(1):15948. Epub 2021 Aug 5.

Department of Therapy, South Ural State Medical University, Vorovskogo Str. 66, building 3, Chelyabinsk, 454048, Russian Federation.

Vaccination against Streptococcus pneumoniae is among the most effective measures for preventing pneumonia and reducing the rate of chronic obstructive pulmonary disease (COPD) exacerbations. The objective of this work was to evaluate the long-term effectiveness of PCV13 and PPV23 for preventing pneumonia and COPD exacerbations. The open-label, prospective, observational cohort study involved 302 male patients aged ≥ 45 years: PCV13 group (n = 123); PPV23 group (n = 32); and vaccine-naïve group (n = 147). The primary endpoint included the frequency of pneumonia episodes and COPD exacerbations per year over a 5-year follow-up period. The secondary endpoints included the dynamics of dyspnea severity (MMRC), the BODE index, FEV1, the CAT index, the SGRQ score, and the results of 6-min walk test. Vaccination with PCV13 and PPV23 significantly reduces the total rate of pneumonia during the first year after vaccination. Starting with the second year, clinical effectiveness in PPV23 group decreases compared with both PCV13 group and vaccine-naïve patients. Pneumonia by year 5 after vaccination was registered in 47% of patients in the PPV23 group, versus 3.3% of patients in the PCV13 group (p < 0.001); COPD exacerbations-in 81.3% versus 23.6%, respectively (p < 0.001). Vaccination with PCV13 significantly reduced and maintained the BODE index over the 5-year follow-up period. Although both vaccines have comparable clinical effects during the first year after vaccination, only PCV13 is characterized by persistent clinical effectiveness during the 5-year follow-up period. Patients older than 55 years who received PPV23 have significantly higher risks of having pneumonia episodes more frequently during the long-term follow-up.
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http://dx.doi.org/10.1038/s41598-021-95129-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342495PMC
August 2021

Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19.

Authors:
Daniel Munblit Polina Bobkova Ekaterina Spiridonova Anastasia Shikhaleva Aysylu Gamirova Oleg Blyuss Nikita Nekliudov Polina Bugaeva Margarita Andreeva Audrey DunnGalvin Pasquale Comberiati Christian Apfelbacher Jon Genuneit Sergey Avdeev Valentina Kapustina Alla Guekht Victor Fomin Andrey A Svistunov Peter Timashev Vladislav S Subbot Valery V Royuk Thomas M Drake Sarah Wulf Hanson Laura Merson Gail Carson Peter Horby Louise Sigfrid Janet T Scott Malcolm G Semple John O Warner

Clin Exp Allergy 2021 09 12;51(9):1107-1120. Epub 2021 Aug 12.

Inflammation, Repair and Development Section, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK.

Background: The long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID-19 and assessed potential risk factors.

Methods: Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long-term Follow-up Study questionnaire.

Results: 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post-discharge. COVID-19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32).

Conclusions: Almost half of adults admitted to hospital due to COVID-19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms.
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http://dx.doi.org/10.1111/cea.13997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444748PMC
September 2021

How can we predict the failure of awake proning in acute hypoxemic respiratory failure associated with COVID-19?

Authors:
Sergey N Avdeev Andrey I Yaroshetskiy Galia S Nuralieva Zamira M Merzhoeva Natalia V Trushenko

Am J Emerg Med 2021 Jul 28. Epub 2021 Jul 28.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1016/j.ajem.2021.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317447PMC
July 2021

Inhaled iloprost improves gas exchange in patients with COVID-19 and acute respiratory distress syndrome.

Authors:
Natalia A Tsareva Sergey N Avdeev Djuro Kosanovic Ralph Theo Schermuly Natalia V Trushenko Galina V Nekludova

Crit Care 2021 07 21;25(1):258. Epub 2021 Jul 21.

Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya Street 8, Moscow, Russia, 119991.

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http://dx.doi.org/10.1186/s13054-021-03690-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294235PMC
July 2021

N-acetylcysteine for the treatment of COVID-19 among hospitalized patients.

Authors:
Sergey N Avdeev Viliya V Gaynitdinova Zamira M Merzhoeva Zelimkhan G-M Berikkhanov

J Infect 2021 Jul 10. Epub 2021 Jul 10.

Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1016/j.jinf.2021.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271031PMC
July 2021

Anti-IL-17 monoclonal antibodies in hospitalized patients with severe COVID-19: A pilot study.

Authors:
Sergey N Avdeev Natalia V Trushenko Natalia A Tsareva Andrey I Yaroshetskiy Zamira M Merzhoeva Galia S Nuralieva Galina V Nekludova Svetlana Yu Chikina Tatiana Yu Gneusheva Olga A Suvorova Anna E Shmidt

Cytokine 2021 10 3;146:155627. Epub 2021 Jul 3.

International School 'Medicine of the Future', I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Background: One of the main pathophysiological mechanisms underlying the severe course of COVID-19 is the hyper-inflammatory syndrome associated with progressive damage of lung tissue and multi-organ dysfunction. IL-17 has been suggested to be involved in hyper-inflammatory syndrome.

Objective: To evaluate the efficacy and safety of the IL-17 inhibitor netakimab in patients with severe COVID-19.

Study Design: In our retrospective case-control study we evaluated the efficacy of netakimab in hospitalized patients with severe COVID-19 outside the intensive care unit (ICU). Patients in the experimental group were treated with standard of care therapy and netakimab at a dose of 120 mg subcutaneously.

Results: 171 patients with severe COVID-19 were enrolled in our study, and 88 of them received netakimab. On the 3 day of therapy, body temperature, SpO2/FiO2, NEWS2 score, and CRP improved significantly in the netakimab group compared to the control group. Other clinical outcomes such as transfer to ICU (11.4% vs 9.6%), need for mechanical ventilation (10.2% vs 9.6%), 28-day mortality (10.2% vs 8.4%), did not differ between the groups.

Conclusion: In hospitalized patients with severe COVID-19, anti-IL-17 therapy might mitigate the inflammatory response and improve oxygenation, but do not affect the need for mechanical ventilation and mortality.
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http://dx.doi.org/10.1016/j.cyto.2021.155627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253694PMC
October 2021

Beneficial effects of inhaled surfactant in patients with COVID-19-associated acute respiratory distress syndrome.

Authors:
Sergey N Avdeev Natalia V Trushenko Svetlana Yu Chikina Natalia A Tsareva Zamira M Merzhoeva Andrey I Yaroshetskiy Violetta I Sopova Margarita I Sopova Oleg A Rosenberg Ralph Theo Schermuly Djuro Kosanovic

Respir Med 2021 Aug-Sep;185:106489. Epub 2021 May 29.

Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Background: We have investigated the use of nebulized surfactant as a potential therapeutic option for the patients with coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome (ARDS) undergoing non-invasive ventilation.

Methods: The patients were divided into 2 groups: surfactant (n = 33) and control (n = 32). The subjects in the surfactant group received the inhaled surfactant at daily dose of 150-300 mg. The oxygenation parameters and several clinical outcomes were analyzed.

Results: On the 5 day of therapy, PaO/FiO improved significantly in the surfactant group compared to the control group (184 (155-212) mmHg vs 150 (91-173) mmHg, p = 0.02). The inhaled surfactant significantly reduced the need for transfer of patients to intensive care units (24.2% vs 46.9%, p = 0.05) and invasive mechanical ventilation (18.2% vs 40.6%, p = 0.04). Even more, the nebulized surfactant shortened the length of non-invasive ventilation (7 (3-13) days vs 11 (5-22) days, p = 0.02) and time spent in hospital (18 (16-27) days vs 26 (21-31) days, p = 0.003) in patients suffering from COVID-19-linked ARDS.

Conclusions: Our preliminary data provided indications that inhaled surfactant therapy may represent a promising option for patients with COVID-19-associated ARDS. However, larger clinical trials are crucially needed.
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http://dx.doi.org/10.1016/j.rmed.2021.106489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163691PMC
September 2021

Self-Controlled Cleaving Method for Silicon DRIE Process Cross-Section Characterization.

Authors:
Dmitry A Baklykov Mihail Andronic Olga S Sorokina Sergey S Avdeev Kirill A Buzaverov Ilya A Ryzhikov Ilya A Rodionov

Micromachines (Basel) 2021 May 8;12(5). Epub 2021 May 8.

FMN Laboratory, Bauman Moscow State Technical University, 105005 Moscow, Russia.

Advanced microsystems widely used in integrated optoelectronic devices, energy harvesting components, and microfluidic lab-on-chips require high-aspect silicon microstructures with a precisely controlled profile. Such microstructures can be fabricated using the Bosch process, which is a key process for the mass production of micro-electro-mechanical systems (MEMS) devices. One can measure the etching profile at a cross-section to characterize the Bosch process quality by cleaving the substrate into two pieces. However, the cleaving process of several neighboring deeply etched microstructures is a very challenging and uncontrollable task. The cleaving method affects both the cleaving efficiency and the metrology quality of the resulting etched microstructures. The standard cleaving technique using a diamond scriber does not solve this issue. Herein, we suggest a highly controllable cross-section cleaving method, which minimizes the effect on the resulting deep etching profile. We experimentally compare two cleaving methods based on various auxiliary microstructures: (1) etched transverse auxiliary lines of various widths (from 5 to 100 μm) and positions; and (2) etched dashed auxiliary lines. The interplay between the auxiliary lines and the etching process is analyzed for dense periodic and isolated trenches sized from 2 to 50 μm with an aspect ratio of more than 10. We experimentally showed that an incorrect choice of auxiliary line parameters leads to silicon "build-up" defects at target microstructures intersections, which significantly affects the cross-section profile metrology. Finally, we suggest a highly controllable defect-free cross-section cleaving method utilizing dashed auxiliary lines with the stress concentrators.
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http://dx.doi.org/10.3390/mi12050534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151951PMC
May 2021

Lung ultrasound presentation of covid-19 patients: phenotypes and correlations-comment.

Authors:
Galina Nekludova Sergey Avdeev Natalia Trushenko

Intern Emerg Med 2021 08 31;16(5):1417-1418. Epub 2021 May 31.

Pulmonology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2, Trubetskaya Str., 119991, Moscow, Russia.

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http://dx.doi.org/10.1007/s11739-021-02777-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164956PMC
August 2021

Pain, Swelling and Blue Discoloration of Right Hand in a COVID-19 Patient.

Authors:
Sergey N Avdeev Galina V Nekludova Natalia A Tsareva Andrey I Yaroshetskiy Zamira M Merzhoeva Galia S Nuralieva Natalia V Trushenko

Ann Emerg Med 2021 06 6;77(6):650-657. Epub 2021 Jan 6.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1016/j.annemergmed.2021.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836820PMC
June 2021

Management of Cough in Patients with Chronic Obstructive Pulmonary Disease: Results of the Multicenter Randomized Placebo-Controlled Clinical Trial.

Authors:
Sergey N Avdeev Alexander A Vizel Vladimir N Abrosimov Andrey A Zaicev Galina L Ignatova Rustem F Khamitov Marina P Mikhaylusova Julia S Shapovalova Elena F Pavlysh Basil I Trofimov Alexander V Emelyanov Tatiana I Martynenko Vladimir A Martynenko Natalia E Kostina Danila A Chizhov Olga Yu Chizhova Natalia A Kuzubova Elena V Makova Ekaterina V Makarova

Int J Chron Obstruct Pulmon Dis 2021;16:1243-1253. Epub 2021 May 5.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

Background: Chronic cough declines quality of life and increases risk of complications in patients with chronic obstructive pulmonary disease (COPD). Reducing cough severity and associated negative effects is important therapeutic goal in COPD. Rengalin with anti- and protussive activity is based on technologically processed antibodies to bradykinin, histamine and morphine.

Aim: To evaluate efficacy and safety of Rengalin in treatment of cough in patients with COPD.

Methods: Patients (n=238, mean age 64.3±8.2 years) with stable COPD and persistent cough despite maintenance therapy (anticholinergics, beta-2-adrenergic agonists, inhaled corticosteroids) were included and randomized in the study. The severity of cough assessment (according to the "Cough Severity Score"), COPD impact on patient's life (COPD Assessment Test, CAT), and spirometry were performed at screening. Patients took Rengalin or Placebo 2 tablets 2 times daily for 4 weeks. The endpoints were proportion of patients who responded to treatment, dynamics of cough severity, and severity of COPD symptoms. Intention-to-treat (per protocol) analysis was performed.

Results: Positive response to Rengalin was recorded in 83.6 [85.7]% (vs 72.6 [72.7]% in Placebo group, p=0.0422 [p=0.0163]). Double decrease of cough severity was reported in 42.2 [43.8]% in Rengalin group (versus 32.7 [32.7]% in Placebo; p=0.1373 [p=0.0907]). The total CAT score decreased by 3.3±4.2 [3.6±3.9] points (versus 2.5±4.1 [2.5±4.2] in Placebo group); the difference between groups was 0.79±4.16 [1.04±4.02] points (p=0.0870 [p=0.0416]). The number of patients with adverse events (AEs) in Rengalin (n=13) and Placebo (n=12) groups did not have significant differences (p=1.00). No AEs with certain relationship with study drug were registered.

Conclusion: Rengalin is an effective and safe drug in patients with stable COPD and persistent cough, despite stable doses of maintenance therapy according to the GOLD guidelines. Four-week therapy decreases severity of cough by two times in more than 40% of patients.

Trial Registration: ClinicalTrials.gov (id: NCT03159091).
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http://dx.doi.org/10.2147/COPD.S292109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107011PMC
July 2021

Inhaled Treprostinil in Group 3 Pulmonary Hypertension.

Authors:
Sergey Avdeev Natalia Tsareva Galina Nekludova

N Engl J Med 2021 May;384(19):1871

Sechenov First Moscow State Medical University, Moscow, Russia

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http://dx.doi.org/10.1056/NEJMc2103465DOI Listing
May 2021

Using TAPSE (tricuspid annular plane systolic excursion) as a predictor of poor prognosis of COVID-19: is it enough?

Authors:
Galina V Nekludova Sergey N Avdeev Natalia A Tsareva Natalia V Trushenko Kirill Ataman

Int J Infect Dis 2021 06 22;107:164. Epub 2021 Apr 22.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1016/j.ijid.2021.04.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061623PMC
June 2021

Comparison of Vibrating Mesh and Jet Nebulizers During Noninvasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Authors:
Sergey N Avdeev Galia S Nuralieva Aung Kyaw Soe Viliya V Gainitdinova James B Fink

J Aerosol Med Pulm Drug Deliv 2021 Dec 13;34(6):358-365. Epub 2021 Apr 13.

Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, Chicago, Illinois, USA.

Advances in aerosol technology have improved drug delivery efficiency during noninvasive ventilation (NIV). Clinical evaluation of the efficacy of aerosol therapy during NIV in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is very limited. The aim of our study was to compare the efficacy of bronchodilators administered through a vibrating mesh nebulizer (VMN) and jet nebulizer (JN) during NIV in patients with acute exacerbation of COPD. Prospective randomized cross-over study included 30 patients treated with NIV for acute exacerbation of COPD in an acute care hospital. Patients were consented and enrolled after stabilization of acute exacerbation (3-5 days after admission). Subjects were randomly assigned into two treatment arms receiving salbutamol (2.5 mg): with VMN (Aerogen Solo) and JN (Sidestream) positioned between the leak port and the nonvented oronasal mask during bilevel ventilation with a single-limb circuit. Measurements (clinical data, pulmonary function tests [PFTs], and arterial blood gases) were performed at baseline, 1, and 2 hours after treatment. All measured PFT parameters significantly increased in both groups, but numerically results were better after inhalation with VMN than with JN: for forced expiratory volume in 1 second (FEV) (mean increase from baseline to 120 minutes-165 ± 64 mL vs. 116 ± 46 mL,  = 0.001) and for forced vital capacity (FVC) (mean increase-394 ± 154 mL vs. 123 ± 57 mL,  < 0.001). There was also a statistically significant reduction in respiratory rate and in Borg dyspnea score after therapy with VMN in comparison with the conventional JN. In both groups, there were improvements in PaCO, but with VMN these changes were significantly higher. Bronchodilator administration in patients with acute exacerbation of COPD during NIV with VMN resulted in clinically significant improvements in FVC and in Borg dyspnea score. Additional studies required to determine the impact on clinical outcomes.
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http://dx.doi.org/10.1089/jamp.2020.1665DOI Listing
December 2021

Can We Reliably Predict the Failure of Noninvasive Ventilation in COVID-19-associated Acute Hypoxemic Respiratory Failure?

Authors:
Sergey N Avdeev Andrey I Yaroshetskiy Galia S Nuralieva

Ann Am Thorac Soc 2021 09;18(9):1595

I.M. Sechenov First Moscow State Medical University (Sechenov University) Moscow, Russia.

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http://dx.doi.org/10.1513/AnnalsATS.202101-047LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489871PMC
September 2021

Therapeutic Success of Tiotropium/Olodaterol, Measured Using the Clinical COPD Questionnaire (CCQ), in Routine Clinical Practice: A Multinational Non-Interventional Study.

Authors:
Arschang Valipour Sergey Avdeev Adam Barczyk Valentina Bayer Zvi Fridlender Mariela Georgieva Ondřej Kudela Alexey Medvedchikov Ramona Miron Maria Sanzharovskaya Virginija Šileikienė Jurij Šorli Marc Spielmanns Zsuzsanna Szalai

Int J Chron Obstruct Pulmon Dis 2021;16:615-628. Epub 2021 Mar 10.

Petz Aladar County Teaching Hospital, Gyor, Hungary.

Background: The Clinical COPD Questionnaire (CCQ) is a simple patient-reported tool to measure clinical control of chronic obstructive pulmonary disease (COPD).

Objective: This open-label, single-arm, non-interventional study (NCT03663569) investigated changes in CCQ score during treatment with tiotropium/olodaterol in clinical practice.

Methods: Data were included from consenting COPD patients, enrolled in Bulgaria, Czech Republic, Hungary, Israel, Lithuania, Poland, Romania, Russia, Slovenia, Switzerland and Ukraine, who were receiving a new prescription for tiotropium/olodaterol according to the treating physician in a real-world environment. The primary endpoint was the occurrence of therapeutic success, defined as a 0.4-point decrease in CCQ score after treatment with tiotropium/olodaterol for approximately 6 weeks.

Results: Overall, 4819 patients were treated; baseline and Week 6 CCQ scores were available for 4700 patients, mostly classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) B (51.6%) or D (42.7%). After 6 weeks' treatment, 81.4% (95% confidence interval [95% CI] 80.24-82.49) of patients achieved therapeutic success; mean improvement in overall CCQ score was 1.02 points (95% CI 1.00-1.05). Improved CCQ score was seen in 92.2% of patients (95% CI 91.43-92.98), 2.5% had no change and 5.3% showed a worsening. When stratified by prior treatment, the greatest benefit was seen in treatment-naïve patients, with 85.7% achieving therapeutic success, compared with 79.5% of those pretreated with long-acting β-agonist (LABA)/inhaled corticosteroid (ICS) and 74.2% of those pretreated with LABA or long-acting muscarinic antagonist (LAMA) monotherapy. Overall, rescue medication decreased by 1.25 puffs/day (95% CI 1.19-1.31) versus baseline. In total, 29 patients (0.6%) reported drug-related adverse events and 7 patients reported serious adverse events (0.15%).

Conclusion: In 4700 COPD patients, 6 weeks' treatment with tiotropium/olodaterol, as initial treatment or follow-up to LAMA or LABA monotherapy or LABA/ICS, improved CCQ and decreased rescue medication use. The adverse event profile was consistent with the known safety profile of tiotropium/olodaterol.
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http://dx.doi.org/10.2147/COPD.S291920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956863PMC
June 2021

Can lung ultrasound predict histologic pattern of lung injury in critically ill patients with COVID‑19?

Authors:
Sergey N Avdeev Galina V Nekludova Natalia V Trushenko Andrey I Yaroshetskiy Galia S Nuralieva

Intensive Care Med 2021 05 25;47(5):629-630. Epub 2021 Feb 25.

Pulmonology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2, Trubetskaya Str., 119991, Moscow, Russia.

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http://dx.doi.org/10.1007/s00134-021-06372-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905427PMC
May 2021

SYmbicort given as needed in mild asthma (SYGMA study): a retrospective subanalysis of the Russian population.

Authors:
Zaurbek Aisanov Sergey Avdeev Vladimir Arkhipov Andrey Belevsky

J Asthma 2021 Mar 8:1-9. Epub 2021 Mar 8.

Pulmonology Department, Pirogov Russian National Research Medical University, Moscow, Russian Federation.

Introduction: While mild asthma is generally better controlled than more severe disease, patients with mild asthma may experience severe exacerbations. Definite differences between countries in terms of asthma severity and control were described previously. Since SYGMA was a global study, this sub-analysis was conducted in geographic region to investigate potential regional specificities.

Methods: The SYGMA2 trial is double-blind multicenter study involving patients ≥12 years of age with mild asthma ( = 4176), eligible for regular treatment with inhaled corticosteroid (ICS). We conducted an open-label descriptive subanalysis of the baseline characteristics of the Russian population ( = 579) comparing to rest of participants of SYGMA2 trial from other 24 countries. The subanalysis is solely descriptive and will be used for hypothesis generation.

Results: The Russian population of patients with mild asthma hardly differs from the population in other countries in terms of baseline demographic and anthropometric characteristics, smoking status, and duration of asthma. At the study entry few patients from Russia received maintenance therapy with ICS and had symptom control, but the majority was uncontrolled on short-acting bronchodilators, thus the uncontrolled/controlled ratio was 52%/48% vs 45%/55% in other countries. More patients with mild asthma in the Russian group had faced at least one severe exacerbation in the previous year (30.1% vs 20.7%).

Conclusions: The subanalysis revealed a delayed prescription of controller (ICS) therapy and overuse of short-acting bronchodilators in the Russian population with mild asthma. These factors can lead to insufficient symptom control and higher risk of severe exacerbation in the Russian population with mild asthma.
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http://dx.doi.org/10.1080/02770903.2021.1892753DOI Listing
March 2021

Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID‑19 associated acute respiratory distress syndrome.

Authors:
Sergey N Avdeev Galina V Nekludova Natalia V Trushenko Natalia A Tsareva Andrey I Yaroshetskiy Djuro Kosanovic

Crit Care 2021 01 25;25(1):35. Epub 2021 Jan 25.

Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1186/s13054-021-03472-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829618PMC
January 2021

Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale.

Authors:
Djuro Kosanovic Andrey I Yaroshetskiy Natalia A Tsareva Zamira M Merzhoeva Natalia V Trushenko Galina V Nekludova Ralph Theo Schermuly Sergey N Avdeev

Int J Infect Dis 2021 Mar 13;104:108-110. Epub 2021 Jan 13.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. Electronic address:

Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.
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http://dx.doi.org/10.1016/j.ijid.2020.12.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833717PMC
March 2021

Use of mucolytics in COPD: A Delphi consensus study.

Authors:
Alberto Papi Sergey Avdeev Peter M A Calverley Carlos R Cordeiro Milos Jesenak Vladimir Koblížek Diana Petkova Paola Rogliani Hesham Tarraf Nikolaos Tzanakis Ruxandra Ulmeanu Esra Uzaslan Yochai Adir

Respir Med 2020 12 13;175:106190. Epub 2020 Nov 13.

Pulmonary Division, Lady Davis-Carmel Medical Center, Haifa, Israel.

Background: International guidelines recommend mucolytic agents as add-on therapy in selected patients with COPD because they may reduce exacerbations and improve health status. As the evidence varies among mucolytic agents, we used the Delphi method to assess consensus amongst an international panel of COPD experts on mucolytics use in COPD.

Methods: 53 COPD experts from 12 countries were asked to complete an online questionnaire and rate their agreement with 15 statements using a 5-point scale. The mucolytic agents evaluated were carbocysteine, erdosteine and N-acetylcysteine (NAC). Data were collected anonymously and consensus presented using descriptive statistics.

Results: The 47 respondents reached consensus on the statements. They agreed that regular treatment with mucolytic agents effectively reduces the frequency of exacerbations, reduces the duration of mild-to-moderate exacerbations, and can increase the time to first exacerbation and symptom-free time in COPD patients. Consensus was consistently highest for erdosteine. The experts agreed that all three mucolytics display antioxidant and anti-inflammatory activity. Erdosteine and NAC were thought to improve the efficacy of some classes of antibacterial drugs. All three mucolytics were considered effective for the short-term treatment of symptoms of acute exacerbations when added to other drugs. The panel agreed that approved doses of mucolytic agents have favorable side-effect profiles and can be recommended for regular use in patients with a bronchitic phenotype.

Conclusions: Consensus findings support the wider use of mucolytic agents as add-on therapy for COPD. However, the differences in pharmacological actions and clinical effectiveness must be considered when deciding which mucolytic to use.
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http://dx.doi.org/10.1016/j.rmed.2020.106190DOI Listing
December 2020

Reply to Russo et al.

Authors:
Daniel Munblit Nikita A Nekliudov Polina Bugaeva Oleg Blyuss Peter Timashev John O Warner Pasquale Comberiati Christian Apfelbacher Mikhail E Politov Andrey Yavorovskiy Sergey Avdeev Valentina A Kapustina Victor Fomin Andrey A Svistunov Denis Butnaru Petr Glybochko

Clin Infect Dis 2021 06;72(12):e1159-e1160

Sechenov First Moscow State Medical University, Moscow, Russia.

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http://dx.doi.org/10.1093/cid/ciaa1746DOI Listing
June 2021

Neither earlier nor late tocilizumab improved outcomes in the intensive care unit patients with COVID-19 in a retrospective cohort study.

Authors:
Sergey Moiseev Sergey Avdeev Ekaterina Tao Michail Brovko Nikolay Bulanov Anastasiia Zykova Larisa Akulkina Irina Smirnova Victor Fomin

Ann Rheum Dis 2020 Oct 30. Epub 2020 Oct 30.

Vinogradov Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.

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http://dx.doi.org/10.1136/annrheumdis-2020-219265DOI Listing
October 2020
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