Serge Przedborski

Serge Przedborski

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Serge Przedborski

Serge Przedborski

Publications by authors named "Serge Przedborski"

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Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease.

J Control Release 2019 Jun 4;303:289-301. Epub 2019 Apr 4.

Departments of Biomedical Engineering, Columbia University, New York, NY 10032, USA; Departments of Radiology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618306PMC
June 2019

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form.

Cell Rep 2017 07;20(1):30-39

Departments of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY 10032, USA; Center for Motor Neuron Biology and Diseases, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745057PMC
July 2017

The two-century journey of Parkinson disease research.

Nat Rev Neurosci 2017 03;18(4):251-259

Departments of Neurology, Pathology, and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nrn.2017.25DOI Listing
March 2017

Axonal Degeneration: RIPK1 Multitasking in ALS.

Curr Biol 2016 10;26(20):R932-R934

Departments of Pathology & Cell Biology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; The Center for Motor Neuron Biology and Disease, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; Department of Neurology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA. Electronic address:

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http://www.cell.com/current-biology/pdf/S0960-9822(16)30997-
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http://dx.doi.org/10.1016/j.cub.2016.08.052DOI Listing
October 2016

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.

Nat Commun 2016 Mar 14;7:10943. Epub 2016 Mar 14.

Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1038/ncomms10943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793078PMC
March 2016

Identification of neurodegenerative factors using translatome-regulatory network analysis.

Nat Neurosci 2015 Sep 27;18(9):1325-33. Epub 2015 Jul 27.

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.4070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763340PMC
September 2015

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.

Lancet Neurol 2015 Aug 3;14(8):855-866. Epub 2015 Jun 3.

Institute of Neurodegenerative Diseases, University of Bordeaux, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5293, 33076 Bordeaux, France.

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http://dx.doi.org/10.1016/S1474-4422(15)00006-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217462PMC
August 2015

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.

Mov Disord 2015 Jul 7;30(8):1026-33. Epub 2015 May 7.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1002/mds.26239DOI Listing
July 2015

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis.

Cell Rep 2015 Jul 2;12(2):335-45. Epub 2015 Jul 2.

Program in Neurobiology and Behavior, Columbia University, New York, NY 10032, USA; Center for Motor Neuron Biology and Disease, Columbia Stem Cell Initiative and Columbia Translational Neuroscience Initiative, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Program in Pathobiology and Molecular Medicine, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646662PMC
July 2015

Novel subcellular localization for α-synuclein: possible functional consequences.

Front Neuroanat 2015 23;9:17. Epub 2015 Feb 23.

Departments of Pathology, Columbia University Medical Center New York, NY, USA.

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http://dx.doi.org/10.3389/fnana.2015.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337379PMC
March 2015

Parkinson's disease: animal models and dopaminergic cell vulnerability.

Front Neuroanat 2014 15;8:155. Epub 2014 Dec 15.

Department of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, Columbia University New York, NY, USA.

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http://dx.doi.org/10.3389/fnana.2014.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266040PMC
January 2015

A computational model of motor neuron degeneration.

Neuron 2014 Aug 31;83(4):975-88. Epub 2014 Jul 31.

Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032-3784, USA; Departments of Neuroscience and Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08966273140058
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http://dx.doi.org/10.1016/j.neuron.2014.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167823PMC
August 2014

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

Neuron 2014 Mar 6;81(5):1001-1008. Epub 2014 Feb 6.

Center for Motor Neuron Biology and Disease, the Columbia Translational Neuroscience Initiative, and the Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273140001
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http://dx.doi.org/10.1016/j.neuron.2014.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951532PMC
March 2014

Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy.

EMBO Rep 2014 Jan 15;15(1):86-93. Epub 2013 Dec 15.

Center for Motor Neuron Biology and Disease and the Columbia Translational Neuroscience Initiative, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1002/embr.201337294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303452PMC
January 2014

α-Synuclein is localized to mitochondria-associated ER membranes.

J Neurosci 2014 Jan;34(1):249-59

Departments of Pathology, Neurology, and Genetics and Development, and Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, Institut für Biochemie und Molekularbiologie, Universität 53115 Bonn, Germany, and Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065.

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http://dx.doi.org/10.1523/JNEUROSCI.2507-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866487PMC
January 2014

Mitophagy and Parkinson's disease: be eaten to stay healthy.

Mol Cell Neurosci 2013 Jul 2;55:37-43. Epub 2012 Aug 2.

Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.mcn.2012.07.008DOI Listing
July 2013

When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids.

Neuron 2013 Mar;77(5):801-3

Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.02.016DOI Listing
March 2013

Pathogenesis of Parkinson's disease.

Mov Disord 2013 Jan 23;28(1):24-30. Epub 2012 Aug 23.

Université Pierre et Marie Curie-Paris 06, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, Hôpital de la Salpêtrière, Paris, France.

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http://dx.doi.org/10.1002/mds.25032DOI Listing
January 2013

Neuroinflammation and Parkinson's disease.

Handb Clin Neurol 2007 ;83:535-51

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http://dx.doi.org/10.1016/S0072-9752(07)83026-0DOI Listing
October 2012

Classic and new animal models of Parkinson's disease.

J Biomed Biotechnol 2012 28;2012:845618. Epub 2012 Mar 28.

Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1155/2012/845618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321500PMC
October 2012

The Role of the Innate Immune System in ALS.

Front Pharmacol 2012 14;3:150. Epub 2012 Aug 14.

Department of Pathology and Cell Biology, Columbia University New York, NY, USA.

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http://journal.frontiersin.org/article/10.3389/fphar.2012.00
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http://dx.doi.org/10.3389/fphar.2012.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418523PMC
October 2012

Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.

J Biol Chem 2012 Jun 30;287(27):22969-87. Epub 2012 Apr 30.

Institut für Biochemie und Molekularbiologie (IBMB), Universität Bonn, Nussallee 11, 53115 Bonn, Germany.

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http://dx.doi.org/10.1074/jbc.M112.365700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391148PMC
June 2012

Mitophagy in cells with mtDNA mutations: being sick is not enough.

Autophagy 2012 Apr 1;8(4):699-700. Epub 2012 Apr 1.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.4161/auto.19470DOI Listing
April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra 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Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang 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Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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April 2012

D-β-hydroxybutyrate is protective in mouse models of Huntington's disease.

PLoS One 2011 12;6(9):e24620. Epub 2011 Sep 12.

Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York, United States of America.

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February 2012

Animal models of Parkinson's disease.

Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S183-5

Department of Neurology, Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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January 2012

Neurodegeneration and inflammation in Parkinson's disease.

Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S207-9

Department of Neurology, Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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January 2012

Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.

J Neurosci 2012 Jan;32(1):229-42

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA.

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January 2012

Can we reverse alpha-synuclein lesions?

Mov Disord 2011 Aug;26(9):1618

Center for Neurobiology and Behavior, Columbia University, New York, NY, USA.

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August 2011

Mitochondria: the next (neurode)generation.

Neuron 2011 Jun;70(6):1033-53

Department of Neurology, Columbia University, New York, NY 10032, USA.

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June 2011

A tale on animal models of Parkinson's disease.

Mov Disord 2011 May;26(6):993-1002

Insitute of Neurodegenerative Diseases, Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique, Bordeaux, France.

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May 2011

Mitophagy: the latest problem for Parkinson's disease.

Trends Mol Med 2011 Mar 9;17(3):158-65. Epub 2010 Dec 9.

Department of Neurology, Columbia University, New York, NY, USA.

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March 2011

Control of mitochondrial integrity in Parkinson's disease.

Prog Brain Res 2010 ;183:99-113

Department of Neurology, Motor Neuron Biology and Disease, Columbia University, New York, NY, USA.

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December 2010

Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins.

Ann Neurol 2010 Aug;68(2):184-92

Vall d'Hebron Research Institute and Center for Networked Biomedical Research on Neurodegenerative Diseases, Barcelona, Spain.

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August 2010

Is amyotrophic lateral sclerosis a mitochondrial channelopathy?

Neuron 2010 Aug;67(4):523-4

Department of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

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August 2010

PINK1 points Parkin to mitochondria.

Autophagy 2010 Jul 1;6(5):674-5. Epub 2010 Jul 1.

Department of Neurology, Columbia University, New York, NY USA.

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July 2010

What can pluripotent stem cells teach us about neurodegenerative diseases?

Nat Neurosci 2010 Jul;13(7):800-4

Department of Neurology, Columbia University, New York, New York, USA.

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July 2010

Inflammation and Parkinson's disease pathogenesis.

Mov Disord 2010 ;25 Suppl 1:S55-7

Department of Neurology, Pathology and Cell Biology, Columbia University, New York, New York, USA.

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June 2010

Inflammation in ALS and SMA: sorting out the good from the evil.

Neurobiol Dis 2010 Mar 13;37(3):493-502. Epub 2009 Oct 13.

Department of Neurology, New York, NY, USA.

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March 2010

PINK1/Parkin direct mitochondria to autophagy.

Autophagy 2010 Feb 13;6(2):315-6. Epub 2010 Feb 13.

Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA.

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February 2010

Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.

J Neurosci 2010 Jan;30(3):1166-75

Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA.

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January 2010

Is there a pathogenic role for mitochondria in Parkinson's disease?

Parkinsonism Relat Disord 2009 Dec;15 Suppl 3:S241-4

Department of Neurology, Columbia University, New York, New York 10032, USA.

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December 2009

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease.

Free Radic Biol Med 2009 Oct 17;47(7):1049-56. Epub 2009 Jul 17.

Department of Neurology and Department of Neurobiology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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October 2009

Intrabody and Parkinson's disease.

Biochim Biophys Acta 2009 Jul 12;1792(7):634-42. Epub 2008 Sep 12.

Department of Neurology, Columbia University, New York, NY 10032, USA.

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July 2009

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Nat Neurosci 2009 Jul 7;12(7):826-8. Epub 2009 Jun 7.

Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.

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July 2009

Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance.

Ann N Y Acad Sci 2008 Dec;1147:93-104

Department of Neurology, Columbia University, New York, NY 10032, USA.

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December 2008

A sequel to the tale of p25/Cdk5 in neurodegeneration.

Neuron 2008 Dec;60(5):731-2

Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

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December 2008

The kinase domain of mitochondrial PINK1 faces the cytoplasm.

Proc Natl Acad Sci U S A 2008 Aug 7;105(33):12022-7. Epub 2008 Aug 7.

Department of Neurology, Columbia University, 650 West 168th Street, New York, NY 10032, USA.

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August 2008

Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.

PLoS One 2008 Jul 23;3(7):e2740. Epub 2008 Jul 23.

Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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July 2008

Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.

PLoS One 2008 Jan 2;3(1):e1376. Epub 2008 Jan 2.

Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147051PMC
January 2008

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.

Proc Natl Acad Sci U S A 2007 Sep 31;104(37):14807-12. Epub 2007 Aug 31.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 731, Baltimore, MD 21205, USA.

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September 2007

Peroxiredoxin-2 links Cdk5 to neurodegeneration.

Nat Med 2007 Aug;13(8):907-9

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August 2007

Protocol for the MPTP mouse model of Parkinson's disease.

Nat Protoc 2007 ;2(1):141-51

Department of Neurology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1038/nprot.2006.342DOI Listing
June 2007

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nat Neurosci 2007 May 15;10(5):615-22. Epub 2007 Apr 15.

Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799799PMC
May 2007

Proteasome inhibition and Parkinson's disease modeling.

Ann Neurol 2006 Aug;60(2):260-4

Department of Neurology, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1002/ana.20937DOI Listing
August 2006

The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.

Proc Natl Acad Sci U S A 2006 Aug 28;103(32):12132-7. Epub 2006 Jul 28.

Department of Neurology, Columbia University, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562547PMC
August 2006

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.

J Neuroimmunol 2006 Jul;176(1-2):198-215

UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, and The Cleveland Clinic, OH, USA.

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July 2006

Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis?

Ann Neurol 2006 Jun;59(6):980-3

Department of Neurology, Columbia University, New York, NY 10032, USA.

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June 2006

Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia.

Ann Neurol 2005 Dec;58(6):858-64

Department of Neurology, Pritzker School of Medicine and Center for Comprehensive Care and Research on Memory Disorders, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

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December 2005

Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease.

Antioxid Redox Signal 2005 May-Jun;7(5-6):685-93

Department of Neurology, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1089/ars.2005.7.685DOI Listing
September 2005

Toxin-induced models of Parkinson's disease.

NeuroRx 2005 Jul;2(3):484-94

Department of Neurology, Columbia University, New York, New York 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1144492PMC
http://dx.doi.org/10.1602/neurorx.2.3.484DOI Listing
July 2005

Pathogenesis of nigral cell death in Parkinson's disease.

Parkinsonism Relat Disord 2005 Jun;11 Suppl 1:S3-7

Departmentsof Neurology, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2004.10.012DOI Listing
June 2005

Gene dosage and pathogenesis of Parkinson's disease.

Trends Mol Med 2005 Mar;11(3):91-6

Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1016/j.molmed.2005.01.001DOI Listing
March 2005

Randomized control trials in ALS: lessons learned.

Amyotroph Lateral Scler Other Motor Neuron Disord 2004 Sep;5 Suppl 1:8-13

The Eleanor and Lou Gehrig MDA/ALS Research Center, Columbia University Medical Center, USA.

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http://dx.doi.org/10.1080/17434470410019942DOI Listing
September 2004

Molecular targets for neuroprotection.

Amyotroph Lateral Scler Other Motor Neuron Disord 2004 Sep;5 Suppl 1:14-8

Departments of Neurology and Pathology, and the Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1080/1734470410019780DOI Listing
September 2004

MPTP as a mitochondrial neurotoxic model of Parkinson's disease.

J Bioenerg Biomembr 2004 Aug;36(4):375-9

Department of Neurology, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1023/B:JOBB.0000041771.66775.d5DOI Listing
August 2004

Genetic clues to the pathogenesis of Parkinson's disease.

Nat Med 2004 Jul;10 Suppl:S58-62

Department of Neurology, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nm1068DOI Listing
July 2004

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

Proc Natl Acad Sci U S A 2004 Jun 14;101(25):9435-40. Epub 2004 Jun 14.

Center for Neurovirology and Neurodegenerative Disorders and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198, USA.

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http://dx.doi.org/10.1073/pnas.0400569101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC438994PMC
June 2004

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.

Proc Natl Acad Sci U S A 2004 Jan 2;101(2):665-70. Epub 2004 Jan 2.

Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.0307453101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC327205PMC
January 2004

Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance.

Neurologist 2004 Jan;10(1):1-7

Department of Neurology, Center of Neurobiology and Behavior, Columbia University, New York, NY, USA.

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January 2004

Clarification: Pathogenic role of glial cells in Parkinson's disease.

Mov Disord 2004 Jan;19(1):118

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January 2004