Publications by authors named "Seppo Yla-Herttuala"

99Publications

Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells.

Arterioscler Thromb Vasc Biol 2020 11 17;40(11):2665-2677. Epub 2020 Sep 17.

A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, Kuopio (O.H.-F.L., M.K., M.B., S.Y.-H., J.P.L., M.U.K.).

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http://dx.doi.org/10.1161/ATVBAHA.120.315214DOI Listing
November 2020

MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy.

J Clin Endocrinol Metab 2020 Nov;105(11)

Institute of Cardiovascular Disease, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1210/clinem/dgaa538DOI Listing
November 2020

Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus.

Mol Ther 2020 08 23;28(8):1858-1875. Epub 2020 May 23.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland; Heart Center and Gene Therapy Unit, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403359PMC
August 2020

Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes.

Atherosclerosis 2020 07 10;305:64-72. Epub 2020 Apr 10.

Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland; Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland; Heart Center, Turku University Hospital, Hämeentie 11, FI-20520, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.03.029DOI Listing
July 2020

Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery.

J Extracell Vesicles 2020 17;9(1):1747206. Epub 2020 Apr 17.

Division of Pharmaceutical Biosciences and Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1080/20013078.2020.1747206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178890PMC
April 2020

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium.

Mol Ther 2020 07 19;28(7):1731-1740. Epub 2020 Mar 19.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland; Heart Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335717PMC
July 2020

Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models.

J Vasc Res 2020 7;57(2):65-75. Epub 2020 Feb 7.

A.I. Virtanen Institute for Molecular Sciences, Department of Molecular Medicine, University of Eastern Finland, Kuopio, Finland,

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http://dx.doi.org/10.1159/000505454DOI Listing
September 2020

Nucleic Acid-Based Therapies for Atherosclerosis.

Curr Atheroscler Rep 2020 02 7;22(2):10. Epub 2020 Feb 7.

A.I. Virtanen Institute, University of Eastern Finland, Neulaniementie 2, P.O. Box 1627, 70211, Kuopio, Finland.

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http://dx.doi.org/10.1007/s11883-020-0826-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007442PMC
February 2020

Nucleic Acid-Based Therapies for Atherosclerosis.

Curr Atheroscler Rep 2020 02 7;22(2):10. Epub 2020 Feb 7.

A.I. Virtanen Institute, University of Eastern Finland, Neulaniementie 2, P.O. Box 1627, 70211, Kuopio, Finland.

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http://dx.doi.org/10.1007/s11883-020-0826-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007442PMC
February 2020

Adenoviral Gene Transfer of Gremlin Modulates Vascular Endothelial Growth Factor-A-Induced Angiogenesis in Porcine Myocardium.

Hum Gene Ther 2020 02 28;31(3-4):211-218. Epub 2020 Jan 28.

A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1089/hum.2019.229DOI Listing
February 2020

Amphiphilic phthalocyanines in polymeric micelles: a supramolecular approach toward efficient third-generation photosensitizers.

J Mater Chem B 2020 01 5;8(2):282-289. Epub 2019 Dec 5.

Organic Chemistry Department, Universidad Autónoma de Madrid, 28049 Cantoblanco, Madrid, Spain. and Institute for Advanced Research in Chemical Sciences (IAdChem), 28049 Cantoblanco, Madrid, Spain and IMDEA Nanosience, Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1039/c9tb02014dDOI Listing
January 2020

Gene Therapy of Critical Limb Ischemia Enters Clinical Use.

Mol Ther 2019 12 13;27(12):2053. Epub 2019 Nov 13.

A.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904627PMC
December 2019

Isolation of fresh endothelial cells from porcine heart for cardiovascular studies: a new fast protocol suitable for genomic, transcriptomic and cell biology studies.

BMC Mol Cell Biol 2019 08 13;20(1):32. Epub 2019 Aug 13.

A.I. Virtanen Institute for molecular sciences, University of Eastern Finland, Yliopistonranta 1E, 70211, Kuopio, Finland.

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http://dx.doi.org/10.1186/s12860-019-0215-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693209PMC
August 2019

Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasis.

Curr Opin Lipidol 2019 10;30(5):370-376

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland.

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http://dx.doi.org/10.1097/MOL.0000000000000626DOI Listing
October 2019

ASGCT Annual Meeting 2019.

Mol Ther 2019 08 18;27(8):1339. Epub 2019 Jul 18.

A.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698248PMC
August 2019

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress.

Sci Rep 2019 07 17;9(1):10332. Epub 2019 Jul 17.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70210, Kuopio, Finland.

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http://dx.doi.org/10.1038/s41598-019-46841-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637125PMC
July 2019

Recent advances in novel therapies for lipid disorders.

Hum Mol Genet 2019 10;28(R1):R49-R54

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1093/hmg/ddz132DOI Listing
October 2019

Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver.

Sci Rep 2019 05 6;9(1):6934. Epub 2019 May 6.

A. I. Virtanen Institute for Molecular Sciences and Department of Medicine, University of Eastern Finland, Neulaniementie 2, FIN-70210, Kuopio, Finland.

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http://dx.doi.org/10.1038/s41598-019-43459-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502883PMC
May 2019

Gene and Cell Therapy: Success Stories and Future Challenges.

Mol Ther 2019 05 19;27(5):891-892. Epub 2019 Apr 19.

A.I. Virtanen Institute, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520518PMC
May 2019

DNA methylation processes in atheosclerotic plaque.

Atherosclerosis 2019 02 18;281:168-179. Epub 2018 Dec 18.

Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627 (Neulaniementie 2), FIN-70211, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.12.006DOI Listing
February 2019

Editorial: Vascularization for Regenerative Medicine.

Front Bioeng Biotechnol 2018 21;6:175. Epub 2018 Nov 21.

A.I. Virtanen Institute for Molecular Sciences, Univeristy of Eastern Finland, Kuopio, Finland.

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https://www.frontiersin.org/article/10.3389/fbioe.2018.00175
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http://dx.doi.org/10.3389/fbioe.2018.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258714PMC
November 2018

Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor.

Biochim Biophys Acta Gen Subj 2019 02 30;1863(2):481-490. Epub 2018 Nov 30.

A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, 70211 Kuopio, Finland; Heart Center, Kuopio University Hospital, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2018.11.012DOI Listing
February 2019

Consensus Statement of European Societies of Gene and Cell Therapy on the Reported Birth of Genome-Edited Babies in China.

Hum Gene Ther 2018 12 4;29(12):1337-1338. Epub 2018 Dec 4.

8 Société Française de Thérapie Cellulaire et Génique (SFTCG) .

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http://dx.doi.org/10.1089/hum.2018.29081.conDOI Listing
December 2018

Long Non-Coding RNA Modulation of VEGF-A during Hypoxia.

Noncoding RNA 2018 Nov 20;4(4). Epub 2018 Nov 20.

The Center for Gene Therapy, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.3390/ncrna4040034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315885PMC
November 2018

CRISPR/Cas9 and p53: An Odd Couple Requiring Relationship Management.

Mol Ther 2018 12 16;26(12):2711. Epub 2018 Nov 16.

A.I. Virtanen Institute, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277499PMC
December 2018

The development of interferon-based gene therapy for BCG unresponsive bladder cancer: from bench to bedside.

World J Urol 2019 Oct 11;37(10):2041-2049. Epub 2018 Nov 11.

Department of Urology, The University of Texas MD Anderson Cancer Center, 1220 Holcombe Blvd Floor 7, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s00345-018-2553-7
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http://dx.doi.org/10.1007/s00345-018-2553-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511323PMC
October 2019

Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants.

Arterioscler Thromb Vasc Biol 2018 10;38(10):2327-2337

From the A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.T., T.V., S.K., K.H., H.N., H.L., M.U.K., S.Y.-H.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311549
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http://dx.doi.org/10.1161/ATVBAHA.118.311549DOI Listing
October 2018

Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta.

Vascul Pharmacol 2019 01 17;112:91-101. Epub 2018 Oct 17.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Science Service Center, Kuopio University Hospital, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.vph.2018.10.005DOI Listing
January 2019

Human Vascular Endothelial Growth Factor A Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration.

Genes (Basel) 2018 Aug 31;9(9). Epub 2018 Aug 31.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70150 Kuopio, Finland.

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http://dx.doi.org/10.3390/genes9090438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162490PMC
August 2018

iPSC-Derived Cardiomyocytes Taken to Rescue Infarcted Heart Muscle in Coronary Heart Disease Patients.

Mol Ther 2018 09 16;26(9):2077. Epub 2018 Aug 16.

A.I. Virtanen Institute, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127967PMC
September 2018

All Eyes and Ears for Gene Therapy.

Mol Ther 2018 08 11;26(8):1867. Epub 2018 Jul 11.

A.I. Virtanen Institute, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183030
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http://dx.doi.org/10.1016/j.ymthe.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094487PMC
August 2018

Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits.

J Mol Cell Cardiol 2018 08 9;121:145-154. Epub 2018 Jul 9.

A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Heart Center, Kuopio University Hospital, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828183040
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http://dx.doi.org/10.1016/j.yjmcc.2018.07.007DOI Listing
August 2018

Highlighting the Field of Cardiovascular Regenerative Medicine.

Mol Ther 2018 07 19;26(7):1595. Epub 2018 Jun 19.

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036328PMC
July 2018

Differential but Complementary HIF1α and HIF2α Transcriptional Regulation.

Mol Ther 2018 07 9;26(7):1735-1745. Epub 2018 May 9.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland; Heart Centre and Gene Therapy Unit, Kuopio University Hospital, 70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036226PMC
July 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

Biodegradable coronary scaffolds: their future and clinical and technological challenges.

Cardiovasc Res 2018 07;114(8):1063-1072

Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1093/cvr/cvy097DOI Listing
July 2018

T , T and T detect early regenerative changes in mouse ischemic skeletal muscle.

NMR Biomed 2018 05 23;31(5):e3909. Epub 2018 Mar 23.

A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1002/nbm.3909DOI Listing
May 2018

Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats.

Mol Ther 2018 03 22;26(3):659-660. Epub 2018 Feb 22.

A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland; Heart Center and Gene Therapy Unit, Kuopio University Hospital, 70211 Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183006
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http://dx.doi.org/10.1016/j.ymthe.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911640PMC
March 2018

Exosomes as secondary inductive signals involved in kidney organogenesis.

J Extracell Vesicles 2018 23;7(1):1422675. Epub 2018 Jan 23.

Biocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for Cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1080/20013078.2017.1422675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795705PMC
January 2018

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.

N Engl J Med 2018 01 3;378(3):250-261. Epub 2018 Jan 3.

From the Department of Genetic Medicine and Development, University of Geneva Medical School (S.I.N., X.B., S.E.A.), Service of Genetic Medicine, University Hospitals of Geneva (S.I.N., S.E.A.), and iGE3, Institute of Genetics and Genomics of Geneva (S.E.A.) - all in Geneva; the Department of Fundamental Neurobiology, Krembil Research Institute (S.V., M.T., I.R.), Toronto General Hospital Research Institute (E.B., N.K., P.V.D., J.E.F.), the Department of Pathology (T.-R.K.), the Division of Neurosurgery, Department of Surgery (V.M.P., T.K., H.A.-B., T.T., T.V., G.Z., M.T., I.R.), and the Joint Division of Medical Imaging, Department of Medical Imaging (V.M.P., T.K.), Toronto Western Hospital, University Health Network, the Department of Laboratory Medicine and Pathobiology, University of Toronto (E.B., N.K., P.V.D., T.-R.K., J.E.F.), and the Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research (E.B., N.K., P.V.D., J.E.F.) - all in Toronto; the Department of Molecular Medicine, AIV Institute, University of Eastern Finland (S.J., B.R.J., S.S., S.Y.-H., J.F.), and the Hemorrhagic Brain Pathology Research Group, Department of Neurosurgery and NeuroCenter (S.J., B.R.J., S.S., T.R., J.F.), and the Department of Pathology (T.R.), Kuopio University Hospital - all in Kuopio, Finland; and the Cardiovascular Research Institute and the Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston (A.M.H., J.D.W.).

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http://dx.doi.org/10.1056/NEJMoa1709449DOI Listing
January 2018

The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates.

Eur J Pharm Biopharm 2018 Mar 20;124:63-72. Epub 2017 Dec 20.

Department of Pathology, Radboudumc, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands; Department of Biochemistry, Radboudumc, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2017.12.009DOI Listing
March 2018

The follow-up of progressive hypertrophic cardiomyopathy using magnetic resonance rotating frame relaxation times.

NMR Biomed 2018 02 15;31(2). Epub 2017 Dec 15.

Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1002/nbm.3871DOI Listing
February 2018

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions.

Nucleic Acids Res 2018 02;46(4):1724-1740

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.

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http://dx.doi.org/10.1093/nar/gkx1214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829566PMC
February 2018

ESGCT 2017 in Berlin: Clear Steps Forward.

Mol Ther 2017 12 28;25(12):2599. Epub 2017 Nov 28.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768661PMC
December 2017

Comparative Study of Adeno-associated Virus, Adenovirus, Bacu lovirus and Lentivirus Vectors for Gene Therapy of the Eyes.

Curr Gene Ther 2017 ;17(3):235-247

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627, 70211 Kuopio, Finland.

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http://dx.doi.org/10.2174/1566523217666171003170348DOI Listing
August 2018

Bumps in the Road for Commercial Gene Therapy for Rare Diseases.

Mol Ther 2017 10 20;25(10):2225. Epub 2017 Sep 20.

A.I. Virtanen Institute for Molecular Sciences, University of East Finland, Kuopio 70211, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628926PMC
October 2017

Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation.

Am J Pathol 2017 Dec 19;187(12):2659-2673. Epub 2017 Sep 19.

Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, Kuopio University Hospital, Kuopio, Finland; Heart Center and Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173032
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http://dx.doi.org/10.1016/j.ajpath.2017.08.023DOI Listing
December 2017

Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.

J Clin Oncol 2017 Oct 23;35(30):3410-3416. Epub 2017 Aug 23.

Neal D. Shore, Carolina Urologic Research Center, Myrtle Beach, SC; Stephen A. Boorjian, Mayo Clinic, Rochester, MN; Daniel J. Canter, Ochsner Health System, New Orleans, LA; Kenneth Ogan, Emory University, Atlanta, GA; Lawrence I. Karsh, The Urology Center of Colorado, Denver, CO; Tracy M. Downs, University of Wisconsin, Madison, WI; Leonard G. Gomella, Thomas Jefferson University, Philadelphia, PA; Ashish M. Kamat and Colin P.N. Dinney, University of Texas MD Anderson Cancer Center; Seth P. Lerner, Baylor College of Medicine, Houston; Yair Lotan, University of Texas Southwestern Medical Center, Dallas; Robert S. Svatek, University of Texas Health Science Center at San Antonio, San Antonio, TX; Trinity J. Bivalacqua, Johns Hopkins School of Medicine, Baltimore, MD; Robert L. Grubb III, Washington University, St Louis, MO; Tracey L. Krupski, University of Virginia, Charlottesville, VA; Michael E. Woods and Matthew I. Milowsky, University of North Carolina, Chapel Hill; Brant A. Inman, Duke University, Durham, NC; Alan Boyd, Alan Boyd Consultants, Cottenham; F. Peter Treasure, Peter Treasure Statistical Services, King's Lynn, United Kingdom; Gillian Gregory, David G. Sawutz, and Nigel R. Parker, FKD Therapies Oy; and Seppo Yla-Herttuala, A.I. Virtanen Institute University of Eastern Finland and Science Service Center and Gene Therapy Unit, Kuopio, Finland.

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http://dx.doi.org/10.1200/JCO.2017.72.3064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648171PMC
October 2017

Advances and Challenges in Cardiovascular Gene Therapy.

Hum Gene Ther 2017 11 15;28(11):1024-1032. Epub 2017 Aug 15.

1 A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland .

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http://www.liebertpub.com/doi/10.1089/hum.2017.129
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http://dx.doi.org/10.1089/hum.2017.129DOI Listing
November 2017

The Pharmacology of Gene Therapy.

Mol Ther 2017 08 22;25(8):1731-1732. Epub 2017 Jul 22.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542796PMC
August 2017

Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling.

Sci Rep 2017 07 17;7(1):5525. Epub 2017 Jul 17.

Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

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http://www.nature.com/articles/s41598-017-05876-y
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http://dx.doi.org/10.1038/s41598-017-05876-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514023PMC
July 2017

Activating the Chromatin by Noncoding RNAs.

Antioxid Redox Signal 2018 09 10;29(9):813-831. Epub 2017 Aug 10.

1 A.I. Virtanen Institute, University of Eastern Finland , Kuopio, Finland .

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http://dx.doi.org/10.1089/ars.2017.7248DOI Listing
September 2018

Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases.

Eur J Pharm Sci 2017 Sep 2;107:112-125. Epub 2017 Jul 2.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3508 TB Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.06.038DOI Listing
September 2017

Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs.

Adv Exp Med Biol 2017;983:195-205

A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1007/978-981-10-4310-9_14DOI Listing
April 2019

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction.

Circ Cardiovasc Genet 2017 Jun;10(3)

From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (M.U.K., P.H., O.H.-F.L., T.T., J.P., P.M., I.S., T.T., E.A., P.T., S.Y.-H.); and Heart Center and Gene Therapy Unit, Kuopio University Hospital, Finland (S.Y.-H.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001702DOI Listing
June 2017

Combined Gene Therapy Using AdsVEGFR2 and AdsTie2 With Chemotherapy Reduces the Growth of Human Ovarian Cancer and Formation of Ascites in Mice.

Int J Gynecol Cancer 2017 06;27(5):879-886

*Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, and †Institute of Clinical Medicine, Gynecology, and Pathology and Forensic Medicine, University of Eastern Finland; ‡Department of Gynecology, Kuopio University Hospital; §NMR Research Group, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland; ∥Department of Pathology and ¶Gene Therapy Unit, Kuopio University Hospital; and #Science Service Center, Kuopio University Hospital, Kuopio, Finland.

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http://dx.doi.org/10.1097/IGC.0000000000000973DOI Listing
June 2017

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [F]FDG uptake in LdlrApob mice.

Atherosclerosis 2017 08 11;263:369-376. Epub 2017 Apr 11.

Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland; Heart Center, Turku University Hospital, Hämeentie 11, FI-20520 Turku, Finland; Clinical Medicine, Turku University Hospital, Hämeentie 11, FI-20520 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.004DOI Listing
August 2017

Cardiovascular Gene Therapy: Past, Present, and Future.

Mol Ther 2017 05 4;25(5):1095-1106. Epub 2017 Apr 4.

Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1016/j.ymthe.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417840PMC
May 2017