Dr Senthilkumar Balakrishnan, PhD - Haramaya University - Associate Professor of Medical Microbiology

Dr Senthilkumar Balakrishnan

PhD

Haramaya University

Associate Professor of Medical Microbiology

Harar, Harari | Ethiopia

Main Specialties: Allergy & Immunology, Infectious Disease, Medical Microbiology

Additional Specialties: Medical Bacteriology & immunology

ORCID logohttps://orcid.org/0000-0003-4117-9695

Dr Senthilkumar Balakrishnan, PhD - Haramaya University - Associate Professor of Medical Microbiology

Dr Senthilkumar Balakrishnan

PhD

Introduction

My research interest revolves around the host - parasite interaction, molecular and microbial pathogenesis, immunology, bioprospecting of antimicrobials and bacterial metabolites. I have started my research for my Masters program on Screening of asymptomatic typhoid carriers among different food handlers and for my M.Phil program focused on Molecular characterization of Salmonella enterica serovar Typhi isolates from typhoid asymptomatic carriers. My PhD research was focused on epidemiological surveys of asymptomatic typhoid carriers, the emergence of multidrug resistant typhoid bacilli and development of the attenuated typhoid vaccine candidate. I have screened S. Typhi isolates from asymptomatic carriers including food handlers and school children. S. Typhi isolates were identified based the phenotypic and genotypic characteristics. Antibiotic resistant characteristics of the isolates and the ability of the antibiotic resistant gene transfer through conjugation by in vitro method have been determined. Molecular characterization of MDR strains have been identified. In addition TLR polymorphisms have been reported among asymptomatic typhoid reported. I have developed technologies to generate attenuated vaccine candidate against Salmonella enterica serovar Typhi and have evaluated their efficiency in mice animal model humoral immunity by adopting techniques such as agglutination, ELISA, immunoprecipitation and molecular techniques.
My post PhD research was focused on Toll like receptors and its polymorphism among the typhoid patients and asymptomatic carriers; characterization bacterial virulence factors, biopreservative efficacy of Bacteriocin, development of biological origin nanoparticles for nanomedicine, antibiofilm and multidrug resistant bacterial pathogens, prevalence of microbial diseases and associated risk factors.
I have supervised 3 PhD and 38 M.Phil research scholars and our research team focused on prevalence of typhoid and asymptomatic carriers among the school children, Cellulase and protease enzymes production form waste using statistical methods, its applications, molecular modelling and docking, antimicrobial activity of bionanoparticles, anticancer activity of medicinal plant extracts, TLR polymorphisms and bacteriocins for biopreservation. I have been supervised 3 Tamil Nadu State Council for Science and technology (TNSCST) sponsored student projects. I have also received financial assistance for MDR S. Typhi isolates nucleotide sequencing studies from Department of Biotechnology (DBT), New Delhi, Govt. of India for in the form of State Biotech Hub (BT/04/NE/2009) to Mizoram University, India.
In Haramaya University, Ethiopia I have received a major research grant and supervised 5 University granted student projects and currently supervising 3 University granted student projects in the field of Medical Microbiology and Tropical infectious diseases.
In Haramaya University, Ethiopia our research focuses on the prevalence, associated risk factors, antimicrobial susceptibility pattern on urinary tract infection among the pregnant women, childhood diarrhoea, urinary tract infection among adult HIV infected patients, Helicobacter pylori infection among HIV patients and Bacteriological Quality of Raw Cow’s Milk, dental caries, zoonotic food borne pathogens and nosocomial pathogens. Based on the research out come the recommendations have been submitted to Ministry of Health of Ethiopia, Harari Regional Health Bureau, Hiwot Fana Specialized University Hospital (Haramaya University Hospital), and non- governmental organizations for enforcing necessary steps to create awareness among the public, reduce the disease burden, appropriate antibiotics to be used for the treatment to control antibiotic resistant development.
With regard to all of this research out come have been published in the journals including
RSC Advances, Journal of Environmental Science and Polution Research, Journal of Molecular Structure, Indian Journal of Medical Microbiology, International Journal of Nanomedicine, Asian Pacific Journal of Tropical Medicine, Journal of Public Health, Egyptian Journal of Human Medical Genetics, 3 Biotech, Therapeutics and Clinical Risk Management, Food and Bioprocess Technology, Chinese Journal of Catalysis etc.,
Furthermore, I also had an opportunity to work with Salvatore Massa, Professor, Foggia University, Italy for a short-term collaboration in “Plasmid analysis and gene transfer in Salmonella sp”. Based on my experience and continues interest, I have authored 3 books entitled ‘Immunology & Immunotechnology’ (Included as a reference book / text book in many Indian Universities syllabi), ‘Practical Microbiology – A Laboratory Manual’’ and Practical Immunology – A Laboratory Manual’’ for the benefit of students and research scholars to acquire knowledge in the principles and technical aspects of Immunology and Microbiology.

Primary Affiliation: Haramaya University - Harar, Harari , Ethiopia

Specialties:

Additional Specialties:

Research Interests:

Education

Jul 2005 - Jan 2009
Periyar University
PhD/Induction of mutation on OmpR gene of Salmonella typhi isolates from typhoid asymptomatic carriers by osmolar stress to evolve attenuated strains for vaccine development

Experience

Dec 2012
Haramaya University
Member Grdulate Council
Medical Microbiology
Oct 2012 - Oct 2012
Haramaya University
Associate Professor
Medical Microbiology
May 2004 - Nov 2008
Muthayammal College of Arts and Science
Associate Professor in Microbiology and Immunology
Research Department of Biotechnology
Nov 2008
Periyar University
Member, Subject Expert Committee for providing Course Affiliations
Biotechnology
Nov 2008
Periyar University
Member, Board of Studies
Biotechnology
Oct 1999 - Apr 2004
PGP College of Arts and Science (Periyar University, Salem)
Lecturer in Microbiology
Microbiology

Publications

23Publications

731Reads

6Profile Views

78PubMed Central Citations

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

The Lancet

Abstract

Background: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea.

Methods: We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor estimates.

Findings: The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy coverage.

Interpretation: By co-analysing geospatial trends in diarrhoeal burden and its key risk factors, we could assess candidate drivers of subnational death reduction. Further, by doing a counterfactual analysis of the remaining disease burden using key risk factors, we identified potential intervention strategies for vulnerable populations. In view of the demands for limited resources in LMICs, accurately quantifying the burden of diarrhoea and its drivers is important for precision public health.

Funding: Bill & Melinda Gates Foundation.

Conflict of interest statement

Declaration of interests

C A T Antonio reports grants and personal fees from Johnson & Johnson (Philippines), outside the submitted work. S J Dunachie reports grants from The Fleming Fund at UK Department of Health & Social Care, during the conduct of the study. M Jakovljevic reports grants from Ministry of Education Science and Technological Development of The Republic of Serbia, outside the submitted work. J J Jóźwiak reports personal fees from ALAB Laboratoria and non-financial support from MICROLIFE and SERVIER, outside the submitted work. N Kissoon is the Vice President of the GSA and the Canadian Sepsis Foundation. W März reports grants from Siemens Healthineers, AstraZeneca, Bayer Vital, bestbion dx, Boehringer Ingelheim Pharma, Immundiagnostik, Merck Chemicals, MSD, Novartis Pharma, and Olink Proteomics; grants and personal fees from Aegerion Pharmaceuticals, AMGEN, Sanofi, Alexion Pharmaceuticals, BASF, Abbott Diagnostics, Numares AG, Berlin-Chemie, and Akzea Therapeutics; and other from Synlab Holding Deutschland, all outside the submitted work. M J Postma reports grants and personal fees from various pharmaceutical industries, all outside the submitted work; and M J Postma holds stocks in Ingress Health and Pharmacoeconomics Advice Groningen (PAG Ltd) and is adviser to Asc Academics, all pharmacoeconomic consultancy companies. G Remuzzi reports personal fees and non-financial support from Alnylam, Boehringer Ingelheim, Handok Ink, Inception Sciences Canada, and Achillion Pharmaceuticals, outside the submitted work. J A Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Spherix, the National Institutes of Health and the American College of Rheumatology; stock options in Amarin pharmaceuticals and Viking pharmaceuticals; and participation in the speaker’s bureau of Simply Speaking and in the steering committee of OMERACT, an international organisation that develops measures for clinical trials and receives arm’s length funding from 12 pharmaceutical companies, including Amgen, Janssen, Novartis, Roche, UCB Group, Ardea/AstraZeneca, Bristol Myers Squibb, Celgene, EliLilly, Horizon Pharma, Pfizer, and Centrexion. K Shibuya reports grants from Japan Ministry of Health, Labour and Welfare and Japan Ministry of Education, Culture, Sports, Science and Technology, during the conduct of the study. All other authors declare no competing interests.

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May 2020

Impact Factor 59.102

Analysis of salivary level Lactobacillus spp. and associated factors as determinants of dental caries amongst primary school children in Harar town, eastern Ethiopia.

BMC Pediatr 2020 Jan 16;20(1):18. Epub 2020 Jan 16.

Department of Medical Microbiology, College of Health and Medical Sciences, Haramaya University, P.O. Box: 235, Harar, Ethiopia.

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http://dx.doi.org/10.1186/s12887-020-1921-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964209PMC
January 2020
1.918 Impact Factor

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

Authors:
Christina Fitzmaurice Degu Abate Naghmeh Abbasi Hedayat Abbastabar Foad Abd-Allah Omar Abdel-Rahman Ahmed Abdelalim Amir Abdoli Ibrahim Abdollahpour Abdishakur S M Abdulle Nebiyu Dereje Abebe Haftom Niguse Abraha Laith Jamal Abu-Raddad Ahmed Abualhasan Isaac Akinkunmi Adedeji Shailesh M Advani Mohsen Afarideh Mahdi Afshari Mohammad Aghaali Dominic Agius Sutapa Agrawal Ayat Ahmadi Elham Ahmadian Ehsan Ahmadpour Muktar Beshir Ahmed Mohammad Esmaeil Akbari Tomi Akinyemiju Ziyad Al-Aly Assim M AlAbdulKader Fares Alahdab Tahiya Alam Genet Melak Alamene Birhan Tamene T Alemnew Kefyalew Addis Alene Cyrus Alinia Vahid Alipour Syed Mohamed Aljunid Fatemeh Allah Bakeshei Majid Abdulrahman Hamad Almadi Amir Almasi-Hashiani Ubai Alsharif Shirina Alsowaidi Nelson Alvis-Guzman Erfan Amini Saeed Amini Yaw Ampem Amoako Zohreh Anbari Nahla Hamed Anber Catalina Liliana Andrei Mina Anjomshoa Fereshteh Ansari Ansariadi Ansariadi Seth Christopher Yaw Appiah Morteza Arab-Zozani Jalal Arabloo Zohreh Arefi Olatunde Aremu Habtamu Abera Areri Al Artaman Hamid Asayesh Ephrem Tsegay Asfaw Alebachew Fasil Ashagre Reza Assadi Bahar Ataeinia Hagos Tasew Atalay Zerihun Ataro Suleman Atique Marcel Ausloos Leticia Avila-Burgos Euripide F G A Avokpaho Ashish Awasthi Nefsu Awoke Beatriz Paulina Ayala Quintanilla Martin Amogre Ayanore Henok Tadesse Ayele Ebrahim Babaee Umar Bacha Alaa Badawi Mojtaba Bagherzadeh Eleni Bagli Senthilkuimar Balakrishnan Abbas Balouchi Till Winfried Bärnighausen Robert J Battista Masoud Behzadifar Meysam Behzadifar Bayu Begashaw Bekele Yared Belete Belay Yaschilal Muche Belayneh Kathleen Kim Sachiko Berfield Adugnaw Berhane Eduardo Bernabe Mircea Beuran Nickhill Bhakta Krittika Bhattacharyya Belete Biadgo Ali Bijani Muhammad Shahdaat Bin Sayeed Charles Birungi Catherine Bisignano Helen Bitew Tone Bjørge Archie Bleyer Kassawmar Angaw Bogale Hunduma Amensisa Bojia Antonio M Borzì Cristina Bosetti Ibrahim R Bou-Orm Hermann Brenner Jerry D Brewer Andrey Nikolaevich Briko Nikolay Ivanovich Briko Maria Teresa Bustamante-Teixeira Zahid A Butt Giulia Carreras Juan J Carrero Félix Carvalho Clara Castro Franz Castro Ferrán Catalá-López Ester Cerin Yazan Chaiah Wagaye Fentahun Chanie Vijay Kumar Chattu Pankaj Chaturvedi Neelima Singh Chauhan Mohammad Chehrazi Peggy Pei-Chia Chiang Tesfaye Yitna Chichiabellu Onyema Greg Chido-Amajuoyi Odgerel Chimed-Ochir Jee-Young J Choi Devasahayam J Christopher Dinh-Toi Chu Maria-Magdalena Constantin Vera M Costa Emanuele Crocetti Christopher Stephen Crowe Maria Paula Curado Saad M A Dahlawi Giovanni Damiani Amira Hamed Darwish Ahmad Daryani José das Neves Feleke Mekonnen Demeke Asmamaw Bizuneh Demis Birhanu Wondimeneh Demissie Gebre Teklemariam Demoz Edgar Denova-Gutiérrez Afshin Derakhshani Kalkidan Solomon Deribe Rupak Desai Beruk Berhanu Desalegn Melaku Desta Subhojit Dey Samath Dhamminda Dharmaratne Meghnath Dhimal Daniel Diaz Mesfin Tadese Tadese Dinberu Shirin Djalalinia David Teye Doku Thomas M Drake Manisha Dubey Eleonora Dubljanin Eyasu Ejeta Duken Hedyeh Ebrahimi Andem Effiong Aziz Eftekhari Iman El Sayed Maysaa El Sayed Zaki Shaimaa I El-Jaafary Ziad El-Khatib Demelash Abewa Elemineh Hajer Elkout Richard G Ellenbogen Aisha Elsharkawy Mohammad Hassan Emamian Daniel Adane Endalew Aman Yesuf Endries Babak Eshrati Ibtihal Fadhil Vahid Fallah Mahbobeh Faramarzi Mahdieh Abbasalizad Farhangi Andrea Farioli Farshad Farzadfar Netsanet Fentahun Eduarda Fernandes Garumma Tolu Feyissa Irina Filip Florian Fischer James L Fisher Lisa M Force Masoud Foroutan Marisa Freitas Takeshi Fukumoto Neal D Futran Silvano Gallus Fortune Gbetoho Gankpe Reta Tsegaye Gayesa Tsegaye Tewelde Gebrehiwot Gebreamlak Gebremedhn Gebremeskel Getnet Azeze Gedefaw Belayneh K Gelaw Birhanu Geta Sefonias Getachew Kebede Embaye Gezae Mansour Ghafourifard Alireza Ghajar Ahmad Ghashghaee Asadollah Gholamian Paramjit Singh Gill Themba T G Ginindza Alem Girmay Muluken Gizaw Ricardo Santiago Gomez Sameer Vali Gopalani Giuseppe Gorini Bárbara Niegia Garcia Goulart Ayman Grada Maximiliano Ribeiro Guerra Andre Luiz Sena Guimaraes Prakash C Gupta Rahul Gupta Kishor Hadkhale Arvin Haj-Mirzaian Arya Haj-Mirzaian Randah R Hamadeh Samer Hamidi Lolemo Kelbiso Hanfore Josep Maria Haro Milad Hasankhani Amir Hasanzadeh Hamid Yimam Hassen Roderick J Hay Simon I Hay Andualem Henok Nathaniel J Henry Claudiu Herteliu Hagos D Hidru Chi Linh Hoang Michael K Hole Praveen Hoogar Nobuyuki Horita H Dean Hosgood Mostafa Hosseini Mehdi Hosseinzadeh Mihaela Hostiuc Sorin Hostiuc Mowafa Househ Mohammedaman Mama Hussen Bogdan Ileanu Milena D Ilic Kaire Innos Seyed Sina Naghibi Irvani Kufre Robert Iseh Sheikh Mohammed Shariful Islam Farhad Islami Nader Jafari Balalami Morteza Jafarinia Leila Jahangiry Mohammad Ali Jahani Nader Jahanmehr Mihajlo Jakovljevic Spencer L James Mehdi Javanbakht Sudha Jayaraman Sun Ha Jee Ensiyeh Jenabi Ravi Prakash Jha Jost B Jonas Jitendra Jonnagaddala Tamas Joo Suresh Banayya Jungari Mikk Jürisson Ali Kabir Farin Kamangar André Karch Narges Karimi Ansar Karimian Amir Kasaeian Gebremicheal Gebreslassie Kasahun Belete Kassa Tesfaye Dessale Kassa Mesfin Wudu Kassaw Anil Kaul Peter Njenga Keiyoro Abraham Getachew Kelbore Amene Abebe Kerbo Yousef Saleh Khader Maryam Khalilarjmandi Ejaz Ahmad Khan Gulfaraz Khan Young-Ho Khang Khaled Khatab Amir Khater Maryam Khayamzadeh Maryam Khazaee-Pool Salman Khazaei Abdullah T Khoja Mohammad Hossein Khosravi Jagdish Khubchandani Neda Kianipour Daniel Kim Yun Jin Kim Adnan Kisa Sezer Kisa Katarzyna Kissimova-Skarbek Hamidreza Komaki Ai Koyanagi Kristopher J Krohn Burcu Kucuk Bicer Nuworza Kugbey Vivek Kumar Desmond Kuupiel Carlo La Vecchia Deepesh P Lad Eyasu Alem Lake Ayenew Molla Lakew Dharmesh Kumar Lal Faris Hasan Lami Qing Lan Savita Lasrado Paolo Lauriola Jeffrey V Lazarus James Leigh Cheru Tesema Leshargie Yu Liao Miteku Andualem Limenih Stefan Listl Alan D Lopez Platon D Lopukhov Raimundas Lunevicius Mohammed Madadin Sameh Magdeldin Hassan Magdy Abd El Razek Azeem Majeed Afshin Maleki Reza Malekzadeh Ali Manafi Navid Manafi Wondimu Ayele Manamo Morteza Mansourian Mohammad Ali Mansournia Lorenzo Giovanni Mantovani Saman Maroufizadeh Santi Martini S Martini Tivani Phosa Mashamba-Thompson Benjamin Ballard Massenburg Motswadi Titus Maswabi Manu Raj Mathur Colm McAlinden Martin McKee Hailemariam Abiy Alemu Meheretu Ravi Mehrotra Varshil Mehta Toni Meier Yohannes A Melaku Gebrekiros Gebremichael Meles Hagazi Gebre Meles Addisu Melese Mulugeta Melku Peter T N Memiah Walter Mendoza Ritesh G Menezes Shahin Merat Tuomo J Meretoja Tomislav Mestrovic Bartosz Miazgowski Tomasz Miazgowski Kebadnew Mulatu M Mihretie Ted R Miller Edward J Mills Seyed Mostafa Mir Hamed Mirzaei Hamid Reza Mirzaei Rashmi Mishra Babak Moazen Dara K Mohammad Karzan Abdulmuhsin Mohammad Yousef Mohammad Aso Mohammad Darwesh Abolfazl Mohammadbeigi Hiwa Mohammadi Moslem Mohammadi Mahdi Mohammadian Abdollah Mohammadian-Hafshejani Milad Mohammadoo-Khorasani Reza Mohammadpourhodki Ammas Siraj Mohammed Jemal Abdu Mohammed Shafiu Mohammed Farnam Mohebi Ali H Mokdad Lorenzo Monasta Yoshan Moodley Mahmood Moosazadeh Maryam Moossavi Ghobad Moradi Mohammad Moradi-Joo Maziar Moradi-Lakeh Farhad Moradpour Lidia Morawska Joana Morgado-da-Costa Naho Morisaki Shane Douglas Morrison Abbas Mosapour Seyyed Meysam Mousavi Achenef Asmamaw Muche Oumer Sada S Muhammed Jonah Musa Ashraf R Nabhan Mehdi Naderi Ahamarshan Jayaraman Nagarajan Gabriele Nagel Azin Nahvijou Gurudatta Naik Farid Najafi Luigi Naldi Hae Sung Nam Naser Nasiri Javad Nazari Ionut Negoi Subas Neupane Polly A Newcomb Haruna Asura Nggada Josephine W Ngunjiri Cuong Tat Nguyen Leila Nikniaz Dina Nur Anggraini Ningrum Yirga Legesse Nirayo Molly R Nixon Chukwudi A Nnaji Marzieh Nojomi Shirin Nosratnejad Malihe Nourollahpour Shiadeh Mohammed Suleiman Obsa Richard Ofori-Asenso Felix Akpojene Ogbo In-Hwan Oh Andrew T Olagunju Tinuke O Olagunju Mojisola Morenike Oluwasanu Abidemi E Omonisi Obinna E Onwujekwe Anu Mary Oommen Eyal Oren Doris D V Ortega-Altamirano Erika Ota Stanislav S Otstavnov Mayowa Ojo Owolabi Mahesh P A Jagadish Rao Padubidri Smita Pakhale Amir H Pakpour Adrian Pana Eun-Kee Park Hadi Parsian Tahereh Pashaei Shanti Patel Snehal T Patil Alyssa Pennini David M Pereira Cristiano Piccinelli Julian David Pillay Majid Pirestani Farhad Pishgar Maarten J Postma Hadi Pourjafar Farshad Pourmalek Akram Pourshams Swayam Prakash Narayan Prasad Mostafa Qorbani Mohammad Rabiee Navid Rabiee Amir Radfar Alireza Rafiei Fakher Rahim Mahdi Rahimi Muhammad Aziz Rahman Fatemeh Rajati Saleem M Rana Samira Raoofi Goura Kishor Rath David Laith Rawaf Salman Rawaf Robert C Reiner Andre M N Renzaho Nima Rezaei Aziz Rezapour Ana Isabel Ribeiro Daniela Ribeiro Luca Ronfani Elias Merdassa Roro Gholamreza Roshandel Ali Rostami Ragy Safwat Saad Parisa Sabbagh Siamak Sabour Basema Saddik Saeid Safiri Amirhossein Sahebkar Mohammad Reza Salahshoor Farkhonde Salehi Hosni Salem Marwa Rashad Salem Hamideh Salimzadeh Joshua A Salomon Abdallah M Samy Juan Sanabria Milena M Santric Milicevic Benn Sartorius Arash Sarveazad Brijesh Sathian Maheswar Satpathy Miloje Savic Monika Sawhney Mehdi Sayyah Ione J C Schneider Ben Schöttker Mario Sekerija Sadaf G Sepanlou Masood Sepehrimanesh Seyedmojtaba Seyedmousavi Faramarz Shaahmadi Hosein Shabaninejad Mohammad Shahbaz Masood Ali Shaikh Amir Shamshirian Morteza Shamsizadeh Heidar Sharafi Zeinab Sharafi Mehdi Sharif Ali Sharifi Hamid Sharifi Rajesh Sharma Aziz Sheikh Reza Shirkoohi Sharvari Rahul Shukla Si Si Soraya Siabani Diego Augusto Santos Silva Dayane Gabriele Alves Silveira Ambrish Singh Jasvinder A Singh Solomon Sisay Freddy Sitas Eugène Sobngwi Moslem Soofi Joan B Soriano Vasiliki Stathopoulou Mu'awiyyah Babale Sufiyan Rafael Tabarés-Seisdedos Takahiro Tabuchi Ken Takahashi Omid Reza Tamtaji Mohammed Rasoul Tarawneh Segen Gebremeskel Tassew Parvaneh Taymoori Arash Tehrani-Banihashemi Mohamad-Hani Temsah Omar Temsah Berhe Etsay Tesfay Fisaha Haile Tesfay Manaye Yihune Teshale Gizachew Assefa Tessema Subash Thapa Kenean Getaneh Tlaye Roman Topor-Madry Marcos Roberto Tovani-Palone Eugenio Traini Bach Xuan Tran Khanh Bao Tran Afewerki Gebremeskel Tsadik Irfan Ullah Olalekan A Uthman Marco Vacante Maryam Vaezi Patricia Varona Pérez Yousef Veisani Simone Vidale Francesco S Violante Vasily Vlassov Stein Emil Vollset Theo Vos Kia Vosoughi Giang Thu Vu Isidora S Vujcic Henry Wabinga Tesfahun Mulatu Wachamo Fasil Shiferaw Wagnew Yasir Waheed Fitsum Weldegebreal Girmay Teklay Weldesamuel Tissa Wijeratne Dawit Zewdu Wondafrash Tewodros Eshete Wonde Adam Belay Wondmieneh Hailemariam Mekonnen Workie Rajaram Yadav Abbas Yadegar Ali Yadollahpour Mehdi Yaseri Vahid Yazdi-Feyzabadi Alex Yeshaneh Mohammed Ahmed Yimam Ebrahim M Yimer Engida Yisma Naohiro Yonemoto Mustafa Z Younis Bahman Yousefi Mahmoud Yousefifard Chuanhua Yu Erfan Zabeh Vesna Zadnik Telma Zahirian Moghadam Zoubida Zaidi Mohammad Zamani Hamed Zandian Alireza Zangeneh Leila Zaki Kazem Zendehdel Zerihun Menlkalew Zenebe Taye Abuhay Zewale Arash Ziapour Sanjay Zodpey Christopher J L Murray

JAMA Oncol 2019 Sep 27. Epub 2019 Sep 27.

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2019.2996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777271PMC
September 2019
38 Reads

Bacterial contamination of mobile phones of health professionals in Eastern Ethiopia: antimicrobial susceptibility and associated factors.

Trop Med Health 2019 27;47:15. Epub 2019 Feb 27.

2Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, P.O. box 235, Harar, Ethiopia.

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http://dx.doi.org/10.1186/s41182-019-0144-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391816PMC
February 2019
5 Reads

Prevalence, Antimicrobial Susceptibility Pattern of Bacterial Isolates, and Associated Factors of Urinary Tract Infections among HIV-Positive Patients at Hiwot Fana Specialized University Hospital, Eastern Ethiopia.

Can J Infect Dis Med Microbiol 2019 6;2019:6780354. Epub 2019 Feb 6.

Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, P.O. Box: 235, Harar, Ethiopia.

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http://dx.doi.org/10.1155/2019/6780354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381576PMC
February 2019
8 Reads
0.487 Impact Factor

Effect of Bacillus cereus peptide conjugated with nanoporous silica on inactivation of Listeria monocytogenes in apple juice, as an ecofriendly preservative.

Environ Sci Pollut Res Int 2018 Oct 18;25(29):29345-29355. Epub 2018 Aug 18.

Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India.

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http://link.springer.com/10.1007/s11356-018-2882-5
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http://dx.doi.org/10.1007/s11356-018-2882-5DOI Listing
October 2018
356 Reads
2.830 Impact Factor

Prevalence of childhood diarrhoea and associated risk factors in Dire Dawa, Eastern Ethiopia.

26(1): 29–37

Journal of Public Health

Aim Childhood diarrhea caused by enteric bacteria remains an important public health problem in the developing countries. Therefore, this study aimed to determine the prevalence of childhood diarrhea, etiological agents, antibiotic susceptibility patterns and associated risk factors in Eastern Ethiopia. Subjects and methods A total of 196 children under the age of 5 years with diarrhea were chosen for the study. Stool specimens were collected for the isolation of bacterial agents and their antibiotic susceptibility pattern using standard methods. Analysis of data was done using SPSS version 16. Results The overall prevalence of enteric bacteria observed in this study was 21.9%. The bacterial isolates identified were Escherichia coli (12.8%), Shigella species (5.6%) and Salmonella species (3.6%). Children using an unprotected spring/well source for their water supply were more likely to be infected with diarrhea-causing bacteria (AOR = 4.74, 95% CI: 1.48,15.13). None of the bacterial isolates showed resistance to ceftriaxone, while resistance to amoxicillin was observed for Shigella (100%), Salmonella (85.7%) and E. coli (56%) isolates. Resistance to ampicillin was found to be 90.9%, 71.4% and 52% for Shigella, Salmonella and E. coli isolates. All Shigella isolates were found to be multidrug resistant.Conclusion Interventions aimed to improve safe drinking water access should be strengthened/considered in the study area.

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April 2018
18 Reads

Biosynthesis of silver nanoparticles using Myristica fragrans seed (nutmeg) extract and its antibacterial activity against multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates.

Environ Sci Pollut Res Int 2017 Jun 3;24(17):14758-14769. Epub 2017 May 3.

Department of Zoology, Mizoram University, Aizawl, Mizoram, 796004, India.

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http://dx.doi.org/10.1007/s11356-017-9065-7DOI Listing
June 2017
101 Reads
2.830 Impact Factor

Bacterial profile of urinary tract infection and antimicrobial susceptibility pattern among pregnant women attending at Antenatal Clinic in Dil Chora Referral Hospital, Dire Dawa, Eastern Ethiopia.

Ther Clin Risk Manag 2016 18;12:251-60. Epub 2016 Feb 18.

Department of Medical Microbiology, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

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http://dx.doi.org/10.2147/TCRM.S99831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762443PMC
March 2016
39 Reads
5 Citations
1.343 Impact Factor

rhizome extract mediated biosynthesis of silver nanoparticles and their bactericidal activity against human pathogens.

J Genet Eng Biotechnol 2015 Dec 4;13(2):93-99. Epub 2015 Nov 4.

Department of Biotechnology, Mahendra Arts and Science College, Kalippatti, Namakkal 637501, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.jgeb.2015.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299866PMC
December 2015
3 Reads

Report: In vivo anticoccidial effects of Azadirachta indica and Carica papaya L. with salinomycin drug as a dietary feed supplement in broiler chicks.

Pak J Pharm Sci 2015 Jul;28(4):1409-15

Department of Biotechnology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India.

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July 2015
35 Reads
0.950 Impact Factor

Induction of deletion mutation on ompR gene of Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers to evolve attenuated strains for vaccine development.

Asian Pac J Trop Med 2014 Dec;7(12):933-9

Department of Zoology, Arignar Anna Government Arts College, Namakkal-637 001, Tamil Nadu, India.

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http://dx.doi.org/10.1016/S1995-7645(14)60165-6DOI Listing
December 2014
30 Reads
0.930 Impact Factor

Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity.

Int J Nanomedicine 2014 15;9:2431-8. Epub 2014 May 15.

Department of Microbiology and Botany, College of Science, King Saud University, Riyadh, Saudi Arabia.

The immense potential of nanobiotechnology makes it an intensely researched field in modern medicine. Green nanomaterial synthesis techniques for medicinal applications are desired because of their biocompatibility and lack of toxic byproducts. We report the toxic byproducts free phytosynthesis of stable silver nanoparticles (AgNPs) using the bark extract of the traditional medicinal plant Acacia leucophloea (Fabaceae). Visual observation, ultraviolet-visible spectroscopy, and transmission electron microscopy (TEM) were used to characterize the synthesized AgNPs. The visible yellow-brown color formation and surface plasmon resonance at 440 nm indicates the biosynthesis of AgNP. The TEM images show polydisperse, mostly spherical AgNP particles of 17-29 nm. Fourier transform infrared spectroscopy revealed that primary amines, aldehyde/ketone, aromatic, azo, and nitro compounds of the A. leucophloea extract may participate in the bioreduction and capping of the formed AgNPs. X-ray diffraction confirmed the crystallinity of the AgNPs. The in vitro agar well diffusion method confirmed the potential antibacterial activity of the plant extract and synthesized AgNPs against the common bacterial pathogens Staphylococcus aureus (MTCC 737), Bacillus cereus (MTCC 1272), Listeria monocytogenes (MTCC 657), and Shigella flexneri (MTCC 1475). This research combines the inherent antimicrobial activity of silver metals with the A. leucophloea extract, yielding antibacterial activity-enhanced AgNPs. This new biomimetic approach using traditional medicinal plant (A. leucophloea) barks to synthesize biocompatible antibacterial AgNPs could easily be scaled up for additional biomedical applications. These polydisperse AgNPs green-synthesized via A. leucophloea bark extract can readily be used in many applications not requiring high uniformity in particle size or shape.

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http://dx.doi.org/10.2147/IJN.S61779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035312PMC
December 2014
37 Reads
73 Citations
4.400 Impact Factor

Screening, phylogenetic analysis and antibiotic sensitivity pattern of Salmonella enterica serovar Typhi isolates from typhoid asymptomatic carriers.

Asian Pac J Trop Med 2011 Oct;4(10):769-72

Centre for Biotechnology, Muthayammal College of Arts & Science, Rasipuram -637 408, Tamil Nadu, India.

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http://dx.doi.org/10.1016/S1995-7645(11)60191-0DOI Listing
October 2011
16 Reads
0.930 Impact Factor

Effect of ompR gene mutation in expression of ompC and ompF of Salmonella typhi.

Interdiscip Sci 2010 Jun 1;2(2):157-62. Epub 2010 May 1.

Centre for Biotechnology, Muthayammal College of Arts and Science, Rasipuram, TN, India.

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http://dx.doi.org/10.1007/s12539-010-0067-0DOI Listing
June 2010
21 Reads

Multidrug resistant Salmonella typhi in asymptomatic typhoid carriers among food handlers in Namakkal district, Tamil Nadu.

Indian J Med Microbiol 2005 Apr;23(2):92-4

Department of Biotechnology, Centre for Biotechnology, Muthayammal College of Arts and Science, Rasipuram, India.

Purpose: to screen Salmonella typhi in asymptomatic typhoid carriers and to find out drug resistance and ability of the strains to transmit drug resistance to other bacteria.

Methods: Cultural characters, biochemical tests, antibiotic sensitivity test (disc diffusion), agarose gel electrophoresis, and conjugation protocols were done. Thirty five stool samples were collected from the suspected food handlers for the study.

Results: Among 35 samples, (17.14%) yielded a positive result. Out of these 4 (20.0%) were women and 2 (13.33%) were men. The isolates were tested with a number of conventional antibiotics viz, amikacin, amoxicillin, ampicillin, chloramphenicol, ciprofloxacin, co-trimaxazole, rifampicin, gentamicin, nalidixic acid, ofloxacin and tetracycline. Five isolates were having the multidrug resistant character. Four (66.66%) multidrug resistant isolates were found to have plasmids, while one (16.66%) multidrug resistant isolate had no plasmid and the chromosome encoded the resistance. Only one strain (16.66%) showed single antibiotic resistance in the study and had no plasmid DNA. The molecular weights of the plasmids were determined and found to be 120 kb. The mechanism of spreading of drug resistance through conjugation process was analyzed. In the conjugation studies, the isolates having R+ factor showed the transfer of drug resistance through conjugation, which was determined by the development of antibiotic resistance in the recipients.

Conclusion: This study shows that drug resistant strains are able to transfer genes encoding drug resistance.

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http://dx.doi.org/10.4103/0255-0857.16046DOI Listing
April 2005
17 Reads
1.037 Impact Factor

Asymptomatic typhoid carriers in Namakkal District, Tamilnadu.

J Environ Biol 2005 Jan;26(1):113-5

Department of Botany, Nehru Memorial College, Puthanampatti, Tiruchirappalli- 621 007, India.

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January 2005
10 Reads
0.553 Impact Factor

Top co-authors

Senbagam Duraisamy
Senbagam Duraisamy

Bharathidasan University

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Balakrishnan Senthilkumar
Balakrishnan Senthilkumar

Muthayammal College of Arts and Science

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B Senthilkumar
B Senthilkumar

Institute for Ocean Management

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Anbarasu Kumarasamy
Anbarasu Kumarasamy

University of Arkansas for Medical Sciences

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Selvam Kandasamy
Selvam Kandasamy

Muthayammal College of Arts and Science

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Duraisamy Senbagam
Duraisamy Senbagam

Muthayammal College of Arts and Science

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Fitsum Weldegebreal
Fitsum Weldegebreal

College of Health and Medical Sciences

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Nachimuthu Senthil Kumar
Nachimuthu Senthil Kumar

Biotechnology

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Mojisola Morenike Oluwasanu
Mojisola Morenike Oluwasanu

College of Medicine

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