Publications by authors named "Sema Yilmaz Rakici"

10 Publications

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Positron emission tomography-computed tomography use during the COVID-19 pandemic outbreak.

J Cancer Res Ther 2021 Apr-Jun;17(2):574-575

Department of Radiation Oncology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

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http://dx.doi.org/10.4103/jcrt.JCRT_683_20DOI Listing
June 2021

An urban legend: Malignant transformation caused by radiotherapy in patients with presacral ganglioneuroma. The necessity and first-time administration of radiotherapy. Case report and literature review.

J Cancer Res Ther 2021 Jan-Mar;17(1):248-254

Department of Nuclear Medicine, Recep Tayyip Erdogan University Medical School, Rize, Turkey.

Ganglioneuromas (GNs) are well-differentiated, rare benign tumors of neural crest origin and are, for the most part, considered to be the benign equivalent of neuroblastomas. There are very few cases of GN reported to be at presacral location in the literature. The standard form of treatment is the total surgical excision. However, total resection of GN is not always possible depending on the neuron, from which it originates, and its localization. Moreover, adjuvant radiotherapy (RT) or chemotherapy is not recommended even though patients are still symptomatic after subtotal resection. This view is based on the urban legend that it undergoes a malignant transformation although it is a benign tumor. Moreover, there are no data indicating that the GN cases reported in the literature have undergone RT. Therefore, articles about the suspicion that GN may undergo spontaneous or malignant transformation after RT are absolutely controversial. Based on our case, we present here, we believe that we will explain the valid necessity of application of RT that we administered for the first time and that with the clarification of this controversial topic, a significant gap will be closed in the literature.
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http://dx.doi.org/10.4103/jcrt.JCRT_380_18DOI Listing
March 2021

Method to prevent the target volume from escaping out of the field in breast irradiation: Forming a "fall-off margin".

J Cancer Res Ther 2020 Oct-Dec;16(6):1336-1343

Department of Radiation Oncology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

Objectives: We aimed to obtain data that would enable the selection of the appropriate radiotherapy technique for whole breast irradiation (WBI) based on patients' physical characteristics and to evaluate the benefit of the new fall-off (FO) margin technique.

Materials And Methods: Ten patients with left-sided breast-conserving surgery, treated for breast carcinoma between August 2016 and September 2017, were included. The FO margin was created in five different plans of which two were formed by expanding the target volume out of the skin. The dose evaluation planning was statistically compared by calculating the target volume dosimetric parameters and the doses received by the organs at risk (OARs) for each technique. The volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation therapy plans were considered ideal for WBI homogeneity and conformity indices, while the three-dimensional conformal radiotherapy (3DCRT) plan was considered nonideal.

Results: The increase in the breast x-axis length values and equivalent spherical diameter (ESD) dimension decreased the ideal value, whereas the increase in y-axis length values and ESD dimension correlated significantly with the D98 increase. The techniques were significantly correlated with OARs, such as V5, heart max, left anterior descending artery maximum, ipsilateral lung V5 and V20, and contralateral breast V5. Monitor unit values were significantly low in the 3DCRT and VMAT plans.

Conclusion: The new FO margin structure will have benefits for practical application because the head designs of linear accelerators and collimators and the target-Jaw/MLC distance are adjacent to the breast tissue, which moves during treatment.
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http://dx.doi.org/10.4103/jcrt.JCRT_823_19DOI Listing
December 2020

Do little things cast great shadows?

Indian J Cancer 2020 Jul-Sep;57(3):358-359

Department of Neurology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

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http://dx.doi.org/10.4103/ijc.IJC_683_20DOI Listing
December 2020

Interesting different survival status of musicians with malignant cerebral tumors.

Br J Neurosurg 2020 Jun 18;34(3):264-270. Epub 2019 Dec 18.

Faculty of Health, Department of Medicine, Witten/Herdecke University, Dean of Medical School Brandenburg Theodor Fontane, Neuruppin, Germany.

The education of a musician may have an effect on the neuronal functions and organization of the brain, promote brain plasticity, resulting in functional and structural changes. A variety of malign cerebral tumors have affected the musician, instrumentalist or singer, at some time during their lives. No comprehensive investigation for musicians with malignant tumors has been performed yet. The aims of the study are to investigate if there is a relationship between the performed music style (classic or pop/rock) and the malignancy of the tumor. The key words were 'neurosurgery and music' and the names of composers. We used digital catalogs like 'Pubmed' as well as the libraries of universities. We investigated a list of people with brain tumors from the English Wikipedia. (https://en.wikipedia.org/wiki/List_of_people_with_brain_tumors).We divided musicians into two groups according to their performing of classic or rock-pop music, and their gender. We found 27 classic and rock/pop musicians who suffered from malign cerebral tumors. The median survival time estimations were 18 (mean 22.33, 95% CI ranged from 7.49 to 37.17) months for pop-rock musicians and 8 (mean 8.67, 95% CI ranged from 4.13 to 12.19) months for classical music performers. However, in Cox regression analysis, performed classical music type was associated with an increased risk of early death, lesser survival time age associated with an adjusted hazard ratio (aHR) of 1.06 [95% confidence interval (CI) 1.020 to 1.111;  = .004), In musicians with malign cerebral tumors, music type performed by musician may affect the survival status, classical musicians have a worse outcome than rock-pop musicians.
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http://dx.doi.org/10.1080/02688697.2019.1701629DOI Listing
June 2020

Pelvic Radiation-Induced Testicular Damage: An Experimental Study at 1 Gray.

Syst Biol Reprod Med 2020 Apr 26;66(2):89-98. Epub 2019 Oct 26.

Department of Histology and Embryology, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey.

Therapeutic radiation of the pelvic region has been shown to cause damage to testicular germ cells. In this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on the induction of cellular and histological damage in early-stage testicular germ cells and the impact of this radiation on offspring sex ratio. Unirradiated and irradiated male rats were mated with unirradiated female rats. Female rats were followed and the sex of the offspring was determined. The male rats were sacrificed at the end of the second week, and the testicular germ cells were subjected to genetic analysis along with cytological and histopathological examination. Sperm DNA was amplified with primers specific to testis-specific Y-linked protein, rat actin beta and testis-specific X-linked genes. The resulting products were separated by capillary electrophoresis. Histopathological changes were investigated by light microscopy along with the TUNEL assay and immunohistochemical staining for caspase-3. There was no significant difference between the two groups for sex ratio and size of offspring. The number of sperm cells bearing X or Y chromosomes' did not differ significantly between these two groups. However, a 1 Gy dose of radiation caused significant cytopathological and histopathological changes in the testicular tissue. In the irradiated group, edematous regions were evident. The number of caspase-3 positive cells in the germinal epithelium of the seminiferous tubules was also significantly higher in the irradiated group. Our results showed that low-dose radiation induced apoptosis and caused significant cyto- and histopathological changes in the testicular tissue. Further research is required to fully elucidate their contribution to apoptosis and if low-dose radiation may potentially lead to long-term effects in the offspring. These results may also lead us to develop a new technique using the caspase-3 staining to monitor the susceptibility to low dose radiation.
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http://dx.doi.org/10.1080/19396368.2019.1679909DOI Listing
April 2020

Colorful Screams of Silent Emotions: A Study with Oncological Patients.

Indian J Palliat Care 2019 Jul-Sep;25(3):361-366

Department of Internal Medicine, Clinic of Medical Oncology, Training and Research Hospital, Recep Tayyip Erdogan University, Rize, Turkey.

Background: Art, as a product of human behavior, is the expression of emotions from inner states and may provide catharsis, purification, and release. Several branches of art, most notably music, dance, and painting, can be used for treatment purposes, especially in the case of psychological disorders. Cancer, which is defined as uncontrolled cell growth, has been an important health issue throughout history, but the recent increase in its frequency has made it one of the most significant public health problems. Both the physiological distress the disease subjects the body to and the accompanying emotional distress are important factors to be considered in cancer treatment.

Aims: In this study, the role of art in expressing emotions of oncological patients was investigated.

Materials And Methods: During the treatment period, patients were interviewed about their experiences, feelings, expectations and perceptions. The picture was used as an expression of emotions.

Results: Communication between the patient and doctor is one of the most important elements in the treatment process, and it has come to the fore in branches of medicine, such as oncology, because of its positive contribution to treatment compliance. In general, the study showed a pronounced positivity and expectations on the part of patients from the hope-life-healing process rather than oncological treatment.

Conclusion: In this study, we aim to demonstrate how the artistic expression of emotions, in particular, through painting, has a positive effect on healing, hope, and the interactions between cancer patients under oncological treatment and medical professionals.
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http://dx.doi.org/10.4103/IJPC.IJPC_79_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659539PMC
August 2019

Radioprotective effect of endogenous melatonin secretion associated with the circadian rhythm in irradiated rats.

Int J Radiat Biol 2019 09 29;95(9):1236-1241. Epub 2019 Jul 29.

Department of Histology and Embryology, Recep Tayyip Erdogan University , Rize , Turkey.

We investigated the radioprotective effect of endogenous melatonin release at different times associated with the circadian rhythm on head and neck radiotherapy. Two groups of animals were subjected daily to 8 Gy single fraction radiotherapy in the head and neck region from 5:00 to 6:00 (the morning group) or from 19:00 to 20:00 (the evening group). Corresponding untreated groups served as controls. Submandibular glands from rats sacrificed on the seventh day after irradiation were assessed biochemically and histopathologically. Melatonin, malondialdehyde and superoxide dismutase levels in blood collected immediately prior to irradiation were measured with rat-specific ELISA kits. In irradiated rats, melatonin, malondialdehyde and superoxide dismutase levels were significantly higher in the evening group than in the morning group. In nonirradiated rats, melatonin and superoxide dismutase levels were significantly higher in the evening group than in the morning group. The areas of seromucous acinar cells were similar between the irradiated and nonirradiated evening groups, but the area was higher in the evening irradiated group than in the morning irradiated group. Consideration of endogenous melatonin secretion associated with the circadian rhythm may offer new therapeutic solutions for the complications of head and neck radiotherapy.
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http://dx.doi.org/10.1080/09553002.2019.1642532DOI Listing
September 2019

Are there predictors that can determine neoadjuvant treatment responses in rectal cancer?

Turk J Gastroenterol 2019 03;30(3):220-227

Department of Public Health, Denizli Provincial Directorate of Health, Denizli, Turkey.

Background/aims: This study aimed to determine a predictive bioindicator that would detect the treatment response of patients diagnosed with rectal cancer and treated with neoadjuvant chemoradiotherapy (nCRT).

Materials And Methods: The data collected from 37 patients receiving nCRT were retrospectively evaluated. The p53 score and gene instability in MLH1 and MSH2, which are among the DNA mismatch repair (MMR) genes, were evaluated using immunohistochemical methods. The neutrophils-leukocytes ratio (NLR), carcinoembryonic antigen (CEA), and carbohydrate antigen (CA) 19-9 values were obtained as hematological parameters from computer records. The pathologic analysis of the therapy response after nCRT was classified according to the modified grading system by Ryan et al. Results: The changes in the NLR, CEA, and CA19-9 values before and after treatment were statistically significant (p<0.001 and p=0.005). A near significant effect of the decrease of the CEA value in the 5th week after treatment was detected on the pathological response score (p=0.075). The p53 mutation score in those patients with any residue was higher than the total response. Overall, 89.2% of the patients exhibited MMR positivity (stability), and 10.8% of the cases with MRM negativity (instability) had a macroscopic residue. Cases with pathological total response were MRM positive.

Conclusion: Consequently, in most of the patients treated with nCRT, the treatment caused tumor and nodal remission. In the prediction of this therapy response, hematological and genetic parameters, such as NLR, P53, MLH1, and MSH2, play a predictive role.
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http://dx.doi.org/10.5152/tjg.2018.18179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428507PMC
March 2019

Wernicke's encephalopathy in a patient with unresectable gastric carcinoma and literature review.

Int J Clin Exp Med 2015 15;8(1):1453-9. Epub 2015 Jan 15.

Department of Medical Oncology, School of Medicine, Recep Tayyip Erdogan University Rize, Turkey.

Wernicke's encephalopathy (WE) is a disease classically associated with nutrition deficiency. It is characterized by typical symptoms like confusion, ataxia and ophthalmoparesis, and developes due to thiamine deficieny in alcoholic patients. Recently, it has been shown that WE could ocur in patients with gastric carcinoma without a history of alcohol use. In this paper, we have made some suggestions about early diagnosis, treatment and prevention of WE by discussing the development of WE in a patient with unresectable gastric carcinoma, who had been inpatient for a long time and given radiotherapy and chemotherapy.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358609PMC
March 2015