Dr Selvaraj Miltonprabu, PhD -  University of Madras - Assistant Professor(SG)

Dr Selvaraj Miltonprabu


University of Madras

Assistant Professor(SG)

chennai, India/tamilnadu/chennai | India

Main Specialties: Biology, Cardiovascular Disease, Hepatology, Medical Toxicology, Nephrology, Neuropathology, Pharmacology


ORCID logohttps://orcid.org/0000-0003-2204-9027

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Dr Selvaraj Miltonprabu, PhD -  University of Madras - Assistant Professor(SG)

Dr Selvaraj Miltonprabu



I am working as an Assistant professor (Selection Grade) in the Department of Zoology, University of Madras,Guindy campus ,Chennai. At present, i am involving in the toxicological research about the organ toxic effects of heavy metals and their chelation by phytoconstituents. I have published more than 81 international peer-reviewed papers, 4 book chapters and 3 books with a total impact factor 122. 84 and I have organized two national conferences and workshops in environmental toxicology and complted one UGC Major research project in toxicology.
Ethnomedicine, Pharmacotherapeutics and Environmental Toxicology
The major area of my specialization is on the identification, separation and characterization of lead Phytochemicals from the Medicinal plants and to test them against heavy metals induced oxidative stress mediated multiple organ dysfunctions in rats. Medicinal plants represent the rich repository of natural products for the discovery of compounds with pharmacological properties like antoxidant, anti-hepatotoxic, antinephrotoxic, anti-carcinogenic, antibiotic, growth promoting or inhibiting, hemolytic analgesic, hypotensive and hypertensive agents. Most of the medicinal plants represent untapped resources of useful compounds or lead compounds for drugs against metal induced.
Toxicological effects of heavy metals on terrestrial animals have been extensively investigated, while scarce research has been undertaken on the chelation therapy against the metal induced toxicity in rats. Most of the antioxidant Phytochemicals like polyphenols, terphenoids, carotenoids, coumarins, proantho cyanidins, stilbenes, lignans, catechins and sulphoraphanes showing marked curative properties against heavy metals induced toxicities. Hence, the plant based Phytochemicals represents a valuable source for pharmaco-therapuetics against oxidative stress mediated pathologies and may lead to the invention of new drugs/ chelators.
?To delineate the heavy metals induced organ toxicity/cytotoxicity and their role in inducing oxidative stress, inflammation, necrosis and apoptosis in rodent model and cell lines
?To identify lead antioxidant Phytochemicals from medicinal plants used in folk medicine.
?To determine the biochemical changes induced by the heavy metals in rats at sublethal dose.
?To pharmacologically characterize the protective effects of the lead phytochemical compounds against metal toxicity in rats.
?To assess the anti-hepatoxoic, anti-nephrotoxic, cardioprotective, neuroprotective and antioxidant properties of the Phytochemicals against metal toxicity in rat model.
To analyze the protective cell signaling pathways involved in the cytoprotection antioxidant phytochemicals against heavy metals induced multiple organ toxicity

Primary Affiliation: University of Madras - chennai, India/tamilnadu/chennai , India


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Jan 2004
Annamalai University


Feb 2018
University of Madras




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8PubMed Central Citations

Naringenin in combination with vitamins C and E potentially protects oxidative stress-mediated hepatic injury in cadmium-intoxicated rats.

J Nutr Sci Vitaminol (Tokyo) 2011 ;57(2):177-85

Department of Zoology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

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http://dx.doi.org/10.3177/jnsv.57.177DOI Listing
December 2011
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Kalist Shagirtha
Kalist Shagirtha

Annamalai University