Selina Wray

Selina Wray

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Selina Wray

Selina Wray

Publications by authors named "Selina Wray"

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Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.

Cell Rep 2019 Jan;26(3):582-593.e5

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK; Alzheimer's Research UK Stem Cell Research Centre, University of Cambridge, CB2 1QN, UK; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183204
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http://dx.doi.org/10.1016/j.celrep.2018.12.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335264PMC
January 2019

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology.

Brain Res 2018 12 25;1701:75-84. Epub 2018 Jul 25.

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, United Kingdom; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, WC1N 3BG, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361106PMC
December 2018

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons.

Neuropharmacology 2018 06 2;135:1-10. Epub 2018 Mar 2.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.02.025DOI Listing
June 2018

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

Acta Neuropathol Commun 2018 05 7;6(1):37. Epub 2018 May 7.

King's College London, School of Cancer and Pharmaceutical Sciences, New Hunt's House, Guy's Campus, London, SE11UL, UK.

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http://dx.doi.org/10.1186/s40478-018-0539-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937037PMC
May 2018

Computational modelling of pathogenic protein spread in neurodegenerative diseases.

PLoS One 2018 5;13(2):e0192518. Epub 2018 Feb 5.

Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London NW1 2HE, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192518PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798854PMC
April 2018

Susceptibility of brain atrophy to in Alzheimer's disease, evidence from functional prioritization in imaging genetics.

Proc Natl Acad Sci U S A 2018 03 6;115(12):3162-3167. Epub 2018 Mar 6.

Translational Imaging Group, Centre for Medical Image Computing, University College London, London WC1E 7JE, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1706100115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866534PMC
March 2018

Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration.

J Alzheimers Dis 2017 ;56(3):885-891

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.3233/JAD-161126DOI Listing
February 2018

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration.

Redox Biol 2017 08 10;12:410-422. Epub 2017 Mar 10.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, WC1N 3BG London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357682PMC
August 2017

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Sci Rep 2017 08 21;7(1):9003. Epub 2017 Aug 21.

James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1038/s41598-017-09362-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567139PMC
August 2017

Modeling tau pathology in human stem cell derived neurons.

Authors:
Selina Wray

Brain Pathol 2017 07;27(4):525-529

Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 1PJ, UK.

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http://dx.doi.org/10.1111/bpa.12521DOI Listing
July 2017

Stem cell models of Alzheimer's disease: progress and challenges.

Alzheimers Res Ther 2017 Jun 13;9(1):42. Epub 2017 Jun 13.

Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK.

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http://dx.doi.org/10.1186/s13195-017-0268-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470327PMC
June 2017

Monoaminergic neuropathology in Alzheimer's disease.

Prog Neurobiol 2017 04 12;151:101-138. Epub 2016 Apr 12.

Fishberg Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061605PMC
http://dx.doi.org/10.1016/j.pneurobio.2016.04.001DOI Listing
April 2017

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Neuron 2017 Mar 23;93(5):1066-1081.e8. Epub 2017 Feb 23.

VIB Center for Brain and Disease Research, VIB-Leuven, 3000 Leuven, Belgium; Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology and Dementia Research Institute, University College London, Queen Square, WC1N 3BG London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.02.001DOI Listing
March 2017

Using human induced pluripotent stem cells to model cerebellar disease: hope and hype.

J Neurogenet 2015 27;29(2-3):95-102. Epub 2015 Aug 27.

a National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology , London , UK.

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http://dx.doi.org/10.3109/01677063.2015.1053478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673530PMC
August 2016

Stem cell therapy for Alzheimer's disease: hope or hype?

Lancet Neurol 2016 02 17;15(2):133-135. Epub 2015 Dec 17.

Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1016/S1474-4422(15)00382-8DOI Listing
February 2016

C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis.

Lancet Neurol 2015 Mar 29;14(3):291-301. Epub 2015 Jan 29.

Dementia Research Centre, University College London (UCL) Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(14)70233-9DOI Listing
March 2015

Comprehensive analysis of the TRPV4 gene in a large series of inherited neuropathies and controls.

J Neurol Neurosurg Psychiatry 2012 Dec 31;83(12):1204-9. Epub 2012 Jul 31.

MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

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http://jnnp.bmj.com/content/early/2012/07/30/jnnp-2012-30305
Web Search
http://jnnp.bmj.com/cgi/doi/10.1136/jnnp-2012-303055
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http://dx.doi.org/10.1136/jnnp-2012-303055DOI Listing
December 2012

Complement receptor 1 (CR1) and Alzheimer's disease.

Immunobiology 2012 Feb 23;217(2):244-50. Epub 2011 Jul 23.

Reta Lila Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1016/j.imbio.2011.07.017DOI Listing
February 2012

A tangled web - tau and sporadic Parkinson's disease.

Front Psychiatry 2010 27;1:150. Epub 2010 Dec 27.

Department of Molecular Neuroscience, University College London Institute of Neurology London, UK.

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http://dx.doi.org/10.3389/fpsyt.2010.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059613PMC
November 2011

Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies.

Acta Neuropathol 2011 Oct 21;122(4):415-28. Epub 2011 Jul 21.

Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK.

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http://dx.doi.org/10.1007/s00401-011-0857-4DOI Listing
October 2011

Tau cleavage and tau aggregation in neurodegenerative disease.

Biochem Soc Trans 2010 Aug;38(4):1016-20

Department of Neuroscience, King's College London, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1042/BST0381016DOI Listing
August 2010

Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity.

J Neurosci 2009 Aug;29(31):9665-7

Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.2234-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666583PMC
August 2009

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats.

J Neurochem 2008 Jun;105(6):2343-52

MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05321.xDOI Listing
June 2008

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

J Biol Chem 2007 Aug 11;282(32):23645-54. Epub 2007 Jun 11.

MRC Centre for Neurodegeneration Research, Department of Neuroscience, King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M703269200DOI Listing
August 2007