Publications by authors named "Sek Won Kong"

68 Publications

Genetic variation analyses indicate conserved SARS-CoV-2-host interaction and varied genetic adaptation in immune-response factors in modern human evolution.

Dev Growth Differ 2021 Feb 17. Epub 2021 Feb 17.

Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan.

View Article and Find Full Text PDF
February 2021

Two macrophages, osteoclasts and microglia: from development to pleiotropy.

Bone Res 2021 Feb 10;9(1):11. Epub 2021 Feb 10.

Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
February 2021

A two-step gas chromatography-tandem mass spectrometry method for measurement of multiple environmental pollutants in human plasma.

Environ Sci Pollut Res Int 2021 Jan 10;28(3):3266-3279. Epub 2020 Sep 10.

School of Engineering, Brown University, Box D, 184 Hope Street, Providence, RI, 02912, USA.

View Article and Find Full Text PDF
January 2021

A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populations.

Infect Genet Evol 2020 11 26;85:104507. Epub 2020 Aug 26.

Computational Health Informatics Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

View Article and Find Full Text PDF
November 2020

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease.

N Engl J Med 2020 05;382(20):1926-1932

From the Departments of Neurosurgery (J.S.S., B.S.C.), Neurology (T.M.H.), and Radiology (K.K., Q.L.), the Gordon Center for Medical Imaging (K.K., Q.L.), and the Division of Neuroradiology (O.R.), Massachusetts General Hospital, the Department of Pediatrics, Computational Health Informatics Program, Boston Children's Hospital (I.-H.L., S.-W.K.), and the Connell and O'Reilly Families Cell Manipulation Core Facility, Dana-Farber/Harvard Cancer Center (J.R.), Boston, and the Department of Psychiatry (B.M.C.) and the Molecular Neurobiology Laboratory (B.S., T.-Y.P., N.L., S.K., J.J., Y.C., H.S., J.K., T.K., P.L., K.-S.K.), McLean Hospital, Belmont - all in Massachusetts; the Departments of Neurology (C.H.) and Neurosurgery (M.K.) and the Brain and Mind Research Institute (G.A.P.), Weill Cornell Medical College, New York; the Department of Neurology, Kaiser Permanente, Irvine, CA (C.N.); and the Department of Molecular and Life Sciences, Hanyang University, Seoul, South Korea (H.S.).

View Article and Find Full Text PDF
May 2020

GenoPheno: cataloging large-scale phenotypic and next-generation sequencing data within human datasets.

Brief Bioinform 2021 Jan;22(1):55-65

Department of Biomedical Informatics, Harvard Medical School; Computational Health Informatics Program, Boston Children's Hospital.

View Article and Find Full Text PDF
January 2021

Assessment of coverage for endogenous metabolites and exogenous chemical compounds using an untargeted metabolomics platform.

Pac Symp Biocomput 2020 ;25:587-598

Computational Health Informatics Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.

View Article and Find Full Text PDF
February 2021

An Improved Prediction Model for Ovarian Cancer Using Urinary Biomarkers and a Novel Validation Strategy.

Int J Mol Sci 2019 Oct 5;20(19). Epub 2019 Oct 5.

Department of Obstetrics & Gynecology, University of Ulsan, ASAN Medical Center, Seoul 05505, Korea.

View Article and Find Full Text PDF
October 2019

Highly differentiated cytotoxic T cells in inclusion body myositis.

Brain 2019 09;142(9):2590-2604

Brigham and Women's Hospital Department of Neurology, Division of Neuromuscular Disease, and Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
September 2019

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 04 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

View Article and Find Full Text PDF
April 2019

Comparative analysis of whole-genome sequencing pipelines to minimize false negative findings.

Sci Rep 2019 03 1;9(1):3219. Epub 2019 Mar 1.

Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
March 2019

Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.

Am J Med Genet B Neuropsychiatr Genet 2019 09 6;180(6):377-389. Epub 2018 Dec 6.

Centre for Pattern Recognition and Data Analytics (PRaDA), Deakin University, Geelong, Australia.

View Article and Find Full Text PDF
September 2019

Measuring coverage and accuracy of whole-exome sequencing in clinical context.

Genet Med 2018 12 12;20(12):1617-1626. Epub 2018 Apr 12.

Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
December 2018

Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects.

Prog Neurobiol 2018 09 11;168:1-20. Epub 2018 Apr 11.

Department of Psychiatry, McLean Hospital, Harvard Medical School, United States; Molecular Neurobiology Laboratory, Program in Neuroscience and Harvard Stem Cell Institute, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA, 02478, United States. Electronic address:

View Article and Find Full Text PDF
September 2018

Comprehensive Analysis of Tissue-wide Gene Expression and Phenotype Data Reveals Tissues Affected in Rare Genetic Disorders.

Cell Syst 2017 08 16;5(2):140-148.e2. Epub 2017 Aug 16.

Computational Health Informatics Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
August 2017

Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.

Environ Pollut 2017 Dec 12;231(Pt 1):1134-1144. Epub 2017 Aug 12.

Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czech Republic. Electronic address:

View Article and Find Full Text PDF
December 2017

Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension.

Circ Res 2017 Aug 13;121(4):341-353. Epub 2017 Jun 13.

From the Computational Health Informatics Program (M.-S.O., M.D.N., A.G., S.W.K., K.D.M.), Department of Cardiology (M.P.M.), Division of Critical Care Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine (A.G.), and Department of Anesthesia (A.G.), Harvard School of Medicine, Boston Children's Hospital, MA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (E.D.A.); Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge (P.S.); Department of Pediatrics, Massachusetts General Hospital, Boston (M.D.N.); and Department of Biostatistics, Harvard School of Public Health, Boston, MA. (T.C.).

View Article and Find Full Text PDF
August 2017

Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis.

Am J Med Genet B Neuropsychiatr Genet 2017 Apr 11;174(3):181-201. Epub 2016 Nov 11.

Departments of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, Psychiatric Genetic Epidemiology and Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, New York.

View Article and Find Full Text PDF
April 2017

ksRepo: a generalized platform for computational drug repositioning.

BMC Bioinformatics 2016 Feb 9;17:78. Epub 2016 Feb 9.

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
February 2016

Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures.

Mol Autism 2015 21;6:66. Epub 2015 Dec 21.

Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA ; Children's Hospital Informatics Program, Boston Children's Hospital, Boston, MA USA ; Department of Pediatrics, Harvard Medical School, Boston, MA USA.

View Article and Find Full Text PDF
December 2015