Publications by authors named "Seema Mital"

99Publications

Genetic Diagnosis and the Severity of Cardiovascular Phenotype in Patients With Elastin Arteriopathy.

Circ Genom Precis Med 2020 Dec 22;13(6):e002971. Epub 2020 Sep 22.

Genetics & Genome Biology Program (S. Min, C.K., J.B., R.Y., S. Mital), Hospital for Sick Children, Toronto.

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December 2020

Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome.

Cell Stem Cell 2020 Oct 17;27(4):574-589.e8. Epub 2020 Aug 17.

Department of Pediatrics, Division of Pediatric Cardiology, Stanford School of Medicine, Stanford, CA 94305, USA; Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA; Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:

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October 2020

Effect of anthracycline therapy on myocardial function and markers of fibrotic remodelling in childhood cancer survivors.

Eur Heart J Cardiovasc Imaging 2020 Jun 14. Epub 2020 Jun 14.

Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave., Toronto, M5G 1X8, ON, Canada.

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June 2020

Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells.

Arterioscler Thromb Vasc Biol 2020 05 26;40(5):1325-1339. Epub 2020 Mar 26.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada (C.L., D.C.R., T.T., J.E.).

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May 2020

Predictors of Bicuspid Aortic Valve-Associated Aortopathy in Childhood: A Report From the MIBAVA Consortium.

Circ Cardiovasc Imaging 2020 03 17;13(3):e009717. Epub 2020 Mar 17.

Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Canada (M.G., R.R., C.M., S.M., Ch.-P.S.F., C.M., L.M.).

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March 2020

Quality of whole genome sequencing from blood versus saliva derived DNA in cardiac patients.

BMC Med Genomics 2020 01 29;13(1):11. Epub 2020 Jan 29.

Genetics and Genome Biology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada.

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January 2020

Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.

Circ Cardiovasc Imaging 2019 12 12;12(12):e008869. Epub 2019 Dec 12.

Division of Cardiology (M.G.S., C.F., C.S., W.H., M.K.F., C.-P.S.F., C.M., S.M., L.M.), The Hospital for Sick Children, Toronto, Ontario, Canada.

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December 2019

Return of genetic and genomic research findings: experience of a pediatric biorepository.

BMC Med Genomics 2019 11 27;12(1):173. Epub 2019 Nov 27.

Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

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November 2019

To Screen or Not to Screen, That Is the Question.

Circulation 2019 07 15;140(3):193-195. Epub 2019 Jul 15.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (S.O.).

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July 2019

Family screening for hypertrophic cardiomyopathy: Is it time to change practice guidelines?

Eur Heart J 2019 12;40(45):3672-3681

Department of Pediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.

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December 2019

Abnormal fetal cerebral and vascular development in hypoplastic left heart syndrome.

Prenat Diagn 2019 01 27;39(1):38-44. Epub 2018 Dec 27.

Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.

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January 2019

Novel Association of a De Novo CALM2 Mutation With Long QT Syndrome and Hypertrophic Cardiomyopathy.

Circ Genom Precis Med 2018 10;11(10):e002255

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada (L.Z., R.Y., S.M.).

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October 2018

Prelisting predictions of early postoperative survival in infant heart transplantation using classification and regression tree analysis.

Pediatr Transplant 2018 03 21;22(2). Epub 2017 Dec 21.

Department of Pediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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March 2018

Use of Clinical Exome Sequencing in Isolated Congenital Heart Disease.

Circ Cardiovasc Genet 2017 06;10(3)

From the Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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June 2017

Perspective on precision medicine in paediatric heart failure.

Clin Sci (Lond) 2017 Mar;131(6):439-448

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8

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March 2017

Avoiding false discovery in biomarker research.

BMC Biochem 2016 07 30;17(1):17. Epub 2016 Jul 30.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.

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July 2016

Progressive Cerebellar Atrophy and a Novel Homozygous Pathogenic DNAJC19 Variant as a Cause of Dilated Cardiomyopathy Ataxia Syndrome.

Pediatr Neurol 2016 09 4;62:58-61. Epub 2016 Jun 4.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada; Genetics and Genome Biology Research Program, Research Institute, The Hospital for Sick Children, Toronto, Canada. Electronic address:

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September 2016

Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.

Circulation 2016 Jan;133(2):226-31

From Division of Cardiology, Department of Medicine, Duke University, Durham, NC (S.H.S., G.S.G.); Duke Molecular Physiology Institute, Duke University, Durham, NC (S.H.S.); School of Public Health, University of Alabama at Birmingham, Birmingham, AL (D.A.); Division of Cardiology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Duke Center for Personalized Medicine, Department of Medicine, Duke University, Durham, NC (G.S.G.); Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (C.M., J.L.); Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada (S.M.); and Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN (J.L.H.).

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January 2016

Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome.

Mol Brain 2015 Nov 24;8(1):77. Epub 2015 Nov 24.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.

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November 2015

Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation.

Int J Cardiol 2015 Oct 18;197:209-15. Epub 2015 Jun 18.

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Division of Pediatric Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Deparment of Medical Imaging, University Health Network, Toronto, Ontario, Canada. Electronic address:

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October 2015

High throughput exome coverage of clinically relevant cardiac genes.

BMC Med Genomics 2014 Dec 11;7:67. Epub 2014 Dec 11.

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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December 2014

New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.

Circulation 2014 Jul;130(1):79-86

From the National Heart, Lung, and Blood Institute, Bethesda, MD (K.M.B., G.D.P.); University of Florida, Gainesville, FL (B.J.B.); Icahn School of Medicine at Mount Sinai, New York, NY (B.D.G.); Boston Children's Hospital and Harvard Medical School, Boston, MA (B.K.); Biofrontiers Institute, Boulder, CO (L.A.L.); Hospital for Sick Children, Toronto, ON, Canada (S.M., A.N.R.); Indiana University School of Medicine, Indianapolis, IN (M.R.); University of Pennsylvania School of Medicine, Philadelphia, PA (J.W.R.); University of Colorado School of Medicine, Aurora, CO (B.L.S.); and Cincinnati Children's Hospital Medical Center, Cincinnati, OH (M.D.T., J.A.T.).

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July 2014

Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial.

Circulation 2014 May 4;129(20):2013-20. Epub 2014 Apr 4.

From the Boston Children's Hospital and Harvard Medical School, Boston, MA (J.W.N., C.D.-M.); New England Research Institutes, Watertown, MA (L.A.S., S.C.); Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee (P.C.F.); National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (G.D.P.); Emory University, Atlanta, GA (W.T.M.); Hospital for Sick Children, Toronto, ON, Canada (S.M., S.K.); Morgan Stanley Children's Hospital of New York-Presbyterian, New York (I.A.W.); University of Michigan Medical School, Ann Arbor (C.S.G., R.G.O.); The Congenital Heart Institute of Florida, St. Petersburg (J.P.J.); Cincinnati Children's Medical Center, Cincinnati, OH (C.D.K.); Children's Hospital Los Angeles, Los Angeles, CA (A.B.L.); North Carolina Consortium: Duke University, Durham; East Carolina University, Greenville; Wake Forest University, Winston-Salem (S.K.P.); Nemours Cardiac Center, Wilmington, DE (C.P.); Primary Children's Medical Center and University of Utah, Salt Lake City (P.J.G.); Medical University of South Carolina, Charleston (A.M.A.); and Children's Hospital of Philadelphia and University of Pennsylvania Medical School, Philadelphia (J.W.G.).

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May 2014

Heart failure in congenital heart disease: a confluence of acquired and congenital.

Heart Fail Clin 2014 Jan;10(1):219-27

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

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January 2014

Risk factors for mortality or delisting of patients from the pediatric heart transplant waiting list.

J Thorac Cardiovasc Surg 2014 Jan 1;147(1):462-8. Epub 2013 Nov 1.

Labatt Family Heart Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

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January 2014

Identification of deleterious synonymous variants in human genomes.

Bioinformatics 2013 Aug 4;29(15):1843-50. Epub 2013 Jun 4.

Department of Computer Science, University of Toronto, Toronto, ON M5S 3H5, Canada.

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August 2013

Impact of prenatal risk factors on congenital heart disease in the current era.

J Am Heart Assoc 2013 May 31;2(3):e000064. Epub 2013 May 31.

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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May 2013

Pediatric transplantation: opportunities for pharmacogenomics and genomics.

Per Med 2013 Jun;10(4):397-404

Department of Pediatrics, University of Toronto, Toronto, ON, Canada.

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June 2013

Personalized medicine in the care of the child with congenital heart disease: discovery to application.

Congenit Heart Dis 2013 May-Jun;8(3):266-9. Epub 2013 Apr 22.

Division of Pediatric Cardiology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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January 2014

Stem cells in pediatric cardiology.

Eur J Pediatr 2013 Oct 5;172(10):1287-92. Epub 2013 Jan 5.

Division of Pediatric Cardiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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October 2013

Personalized medicine in pediatric cardiology: do little changes make a big difference?

Curr Opin Pediatr 2012 Oct;24(5):584-91

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

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October 2012

Cardiac transplantation in Friedreich ataxia.

J Child Neurol 2012 Sep 29;27(9):1193-6. Epub 2012 Jun 29.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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September 2012

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients.

J Heart Lung Transplant 2011 Dec 17;30(12):1352-9. Epub 2011 Sep 17.

Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.

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December 2011

Genetic counseling in the adult with congenital heart disease: what is the role?

Curr Cardiol Rep 2011 Aug;13(4):347-55

Department of Medicine, Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada.

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August 2011

Heart transplantation in children with markedly elevated pulmonary vascular resistance: impact of right ventricular failure on outcome.

J Heart Lung Transplant 2011 Jun 22;30(6):659-66. Epub 2011 Jan 22.

Division of Critical Care Medicine, Morgan Stanley Children's Hospital of New York, Columbia University College of Physicians and Surgeons, NY, USA.

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June 2011

Genomic profiling of left and right ventricular hypertrophy in congenital heart disease.

J Card Fail 2008 Nov 15;14(9):760-7. Epub 2008 Jul 15.

Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York, USA.

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November 2008

The use of mechanical circulatory support as a bridge to transplantation in pediatric patients: an analysis of the United Network for Organ Sharing database.

J Thorac Cardiovasc Surg 2008 Feb;135(2):421-7, 427.e1

Division of Cardiothoracic Surgery, Children's Hospital of New York-Presbyterian and Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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February 2008

Predicting survival among high-risk pediatric cardiac transplant recipients: an analysis of the United Network for Organ Sharing database.

J Thorac Cardiovasc Surg 2008 Jan 26;135(1):147-55, 155.e1-2. Epub 2007 Nov 26.

Division of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of New York-Presbyterian and Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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January 2008

Somatic growth in children with single ventricle physiology impact of physiologic state.

J Am Coll Cardiol 2007 Nov 23;50(19):1876-83. Epub 2007 Oct 23.

Division of Cardiology, Department of Pediatrics, University of Toronto, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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November 2007