Seema Mital

Seema Mital

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Seema Mital

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Family screening for hypertrophic cardiomyopathy: Is it time to change practice guidelines?

Eur Heart J 2019 Dec;40(45):3672-3681

Department of Pediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehz396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885133PMC
December 2019

Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.

Circ Cardiovasc Imaging 2019 Dec 12;12(12):e008869. Epub 2019 Dec 12.

Division of Cardiology (M.G.S., C.F., C.S., W.H., M.K.F., C.-P.S.F., C.M., S.M., L.M.), The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.008869DOI Listing
December 2019

Return of genetic and genomic research findings: experience of a pediatric biorepository.

BMC Med Genomics 2019 11 27;12(1):173. Epub 2019 Nov 27.

Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1186/s12920-019-0618-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882371PMC
November 2019

To Screen or Not to Screen, That Is the Question.

Circulation 2019 Jul 15;140(3):193-195. Epub 2019 Jul 15.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (S.O.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041021DOI Listing
July 2019

Abnormal fetal cerebral and vascular development in hypoplastic left heart syndrome.

Prenat Diagn 2019 01 27;39(1):38-44. Epub 2018 Dec 27.

Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pd.5395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590153PMC
January 2019

A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation.

Pediatr Transplant 2018 11 3;22(7):e13285. Epub 2018 Sep 3.

Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/petr.13285
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http://dx.doi.org/10.1111/petr.13285DOI Listing
November 2018

Novel Association of a De Novo CALM2 Mutation With Long QT Syndrome and Hypertrophic Cardiomyopathy.

Circ Genom Precis Med 2018 10;11(10):e002255

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada (L.Z., R.Y., S.M.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002255DOI Listing
October 2018

Prelisting predictions of early postoperative survival in infant heart transplantation using classification and regression tree analysis.

Pediatr Transplant 2018 03 21;22(2). Epub 2017 Dec 21.

Department of Pediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/petr.13105DOI Listing
March 2018

Use of Clinical Exome Sequencing in Isolated Congenital Heart Disease.

Circ Cardiovasc Genet 2017 06;10(3)

From the Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001581DOI Listing
June 2017

Perspective on precision medicine in paediatric heart failure.

Clin Sci (Lond) 2017 Mar;131(6):439-448

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8

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http://dx.doi.org/10.1042/CS20160414DOI Listing
March 2017

Progressive Cerebellar Atrophy and a Novel Homozygous Pathogenic DNAJC19 Variant as a Cause of Dilated Cardiomyopathy Ataxia Syndrome.

Pediatr Neurol 2016 09 4;62:58-61. Epub 2016 Jun 4.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada; Genetics and Genome Biology Research Program, Research Institute, The Hospital for Sick Children, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2016.03.020DOI Listing
September 2016

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

Nat Genet 2016 09 1;48(9):1060-5. Epub 2016 Aug 1.

Wellcome Trust Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988037PMC
September 2016

Avoiding false discovery in biomarker research.

BMC Biochem 2016 07 30;17(1):17. Epub 2016 Jul 30.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s12858-016-0073-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967310PMC
July 2016

Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.

Circulation 2016 Jan;133(2):226-31

From Division of Cardiology, Department of Medicine, Duke University, Durham, NC (S.H.S., G.S.G.); Duke Molecular Physiology Institute, Duke University, Durham, NC (S.H.S.); School of Public Health, University of Alabama at Birmingham, Birmingham, AL (D.A.); Division of Cardiology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Duke Center for Personalized Medicine, Department of Medicine, Duke University, Durham, NC (G.S.G.); Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (C.M., J.L.); Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada (S.M.); and Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN (J.L.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019475DOI Listing
January 2016

Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation.

Int J Cardiol 2015 Oct 18;197:209-15. Epub 2015 Jun 18.

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Division of Pediatric Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Deparment of Medical Imaging, University Health Network, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273150131
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http://dx.doi.org/10.1016/j.ijcard.2015.06.018DOI Listing
October 2015

High throughput exome coverage of clinically relevant cardiac genes.

BMC Med Genomics 2014 Dec 11;7:67. Epub 2014 Dec 11.

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/s12920-014-0067-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272796PMC
December 2014

New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.

Circulation 2014 Jul;130(1):79-86

From the National Heart, Lung, and Blood Institute, Bethesda, MD (K.M.B., G.D.P.); University of Florida, Gainesville, FL (B.J.B.); Icahn School of Medicine at Mount Sinai, New York, NY (B.D.G.); Boston Children's Hospital and Harvard Medical School, Boston, MA (B.K.); Biofrontiers Institute, Boulder, CO (L.A.L.); Hospital for Sick Children, Toronto, ON, Canada (S.M., A.N.R.); Indiana University School of Medicine, Indianapolis, IN (M.R.); University of Pennsylvania School of Medicine, Philadelphia, PA (J.W.R.); University of Colorado School of Medicine, Aurora, CO (B.L.S.); and Cincinnati Children's Hospital Medical Center, Cincinnati, OH (M.D.T., J.A.T.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554711PMC
July 2014

Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial.

Circulation 2014 May 4;129(20):2013-20. Epub 2014 Apr 4.

From the Boston Children's Hospital and Harvard Medical School, Boston, MA (J.W.N., C.D.-M.); New England Research Institutes, Watertown, MA (L.A.S., S.C.); Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee (P.C.F.); National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (G.D.P.); Emory University, Atlanta, GA (W.T.M.); Hospital for Sick Children, Toronto, ON, Canada (S.M., S.K.); Morgan Stanley Children's Hospital of New York-Presbyterian, New York (I.A.W.); University of Michigan Medical School, Ann Arbor (C.S.G., R.G.O.); The Congenital Heart Institute of Florida, St. Petersburg (J.P.J.); Cincinnati Children's Medical Center, Cincinnati, OH (C.D.K.); Children's Hospital Los Angeles, Los Angeles, CA (A.B.L.); North Carolina Consortium: Duke University, Durham; East Carolina University, Greenville; Wake Forest University, Winston-Salem (S.K.P.); Nemours Cardiac Center, Wilmington, DE (C.P.); Primary Children's Medical Center and University of Utah, Salt Lake City (P.J.G.); Medical University of South Carolina, Charleston (A.M.A.); and Children's Hospital of Philadelphia and University of Pennsylvania Medical School, Philadelphia (J.W.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029928PMC
May 2014

Personalized medicine in the care of the child with congenital heart disease: discovery to application.

Congenit Heart Dis 2013 May-Jun;8(3):266-9. Epub 2013 Apr 22.

Division of Pediatric Cardiology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/chd.12061
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http://dx.doi.org/10.1111/chd.12061DOI Listing
January 2014

Risk factors for mortality or delisting of patients from the pediatric heart transplant waiting list.

J Thorac Cardiovasc Surg 2014 Jan 1;147(1):462-8. Epub 2013 Nov 1.

Labatt Family Heart Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtcvs.2013.09.018DOI Listing
January 2014

Heart failure in congenital heart disease: a confluence of acquired and congenital.

Heart Fail Clin 2014 Jan;10(1):219-27

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15517136130010
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http://dx.doi.org/10.1016/j.hfc.2013.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874878PMC
January 2014

Stem cells in pediatric cardiology.

Eur J Pediatr 2013 Oct 5;172(10):1287-92. Epub 2013 Jan 5.

Division of Pediatric Cardiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00431-012-1920-4DOI Listing
October 2013

Identification of deleterious synonymous variants in human genomes.

Bioinformatics 2013 Aug 4;29(15):1843-50. Epub 2013 Jun 4.

Department of Computer Science, University of Toronto, Toronto, ON M5S 3H5, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btt308DOI Listing
August 2013

Pediatric transplantation: opportunities for pharmacogenomics and genomics.

Per Med 2013 Jun;10(4):397-404

Department of Pediatrics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.2217/pme.13.26DOI Listing
June 2013

Impact of prenatal risk factors on congenital heart disease in the current era.

J Am Heart Assoc 2013 May 31;2(3):e000064. Epub 2013 May 31.

Division of Cardiology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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https://www.ahajournals.org/doi/10.1161/JAHA.113.000064
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http://dx.doi.org/10.1161/JAHA.113.000064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698764PMC
May 2013

Genetic variations in hypoxia response genes influence hypertrophic cardiomyopathy phenotype.

Pediatr Res 2012 Dec 24;72(6):583-92. Epub 2012 Sep 24.

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://www.nature.com/articles/pr2012126
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http://dx.doi.org/10.1038/pr.2012.126DOI Listing
December 2012

Personalized medicine in pediatric cardiology: do little changes make a big difference?

Curr Opin Pediatr 2012 Oct;24(5):584-91

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOP.0b013e328357a4eaDOI Listing
October 2012

Cardiac transplantation in Friedreich ataxia.

J Child Neurol 2012 Sep 29;27(9):1193-6. Epub 2012 Jun 29.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/0883073812448229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671892PMC
September 2012

Personalized Medicine in the Genomics Era: highlights from an international symposium on childhood heart disease.

Future Cardiol 2012 Mar;8(2):157-60

Department of Molecular Genetics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.2217/fca.12.3DOI Listing
March 2012

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients.

J Heart Lung Transplant 2011 Dec 17;30(12):1352-9. Epub 2011 Sep 17.

Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.healun.2011.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640375PMC
December 2011

Genetic counseling in the adult with congenital heart disease: what is the role?

Curr Cardiol Rep 2011 Aug;13(4):347-55

Department of Medicine, Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s11886-011-0188-z
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http://dx.doi.org/10.1007/s11886-011-0188-zDOI Listing
August 2011

Personalizing medicine for the child with heart disease: a path forward.

Authors:
Seema Mital

J Cardiovasc Pharmacol 2011 Jul;58(1):1-3

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http://dx.doi.org/10.1097/FJC.0b013e3182239ed7DOI Listing
July 2011

Heart transplantation in children with markedly elevated pulmonary vascular resistance: impact of right ventricular failure on outcome.

J Heart Lung Transplant 2011 Jun 22;30(6):659-66. Epub 2011 Jan 22.

Division of Critical Care Medicine, Morgan Stanley Children's Hospital of New York, Columbia University College of Physicians and Surgeons, NY, USA.

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http://dx.doi.org/10.1016/j.healun.2010.12.007DOI Listing
June 2011

Increased short- and long-term mortality at low-volume pediatric heart transplant centers: should minimum standards be set? Retrospective data analysis.

Ann Surg 2011 Feb;253(2):393-401

Department of Cardiothoracic Surgery, Stanford University/Lucille Packard Children's Hospital, Palo Alto, California, USA.

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http://dx.doi.org/10.1097/SLA.0b013e31820700ccDOI Listing
February 2011

Relationship between a validated molecular cardiac transplant rejection classifier and routine organ function parameters.

Clin Transplant 2010 May-Jun;24(3):321-7. Epub 2009 Aug 27.

Department of Medicine, Division of Cardiology, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1111/j.1399-0012.2009.01063.xDOI Listing
October 2010

Recipient genotype is a predictor of allograft cytokine expression and outcomes after pediatric cardiac transplantation.

J Am Coll Cardiol 2009 May;53(20):1909-17

Department of Pediatric Cardiology, Columbia University, Morgan Stanley Children's Hospital of New York-Presbyterian, New York, New York, USA.

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http://dx.doi.org/10.1016/j.jacc.2009.02.027DOI Listing
May 2009

Genomic profiling of left and right ventricular hypertrophy in congenital heart disease.

J Card Fail 2008 Nov 15;14(9):760-7. Epub 2008 Jul 15.

Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1016/j.cardfail.2008.06.002DOI Listing
November 2008

The use of mechanical circulatory support as a bridge to transplantation in pediatric patients: an analysis of the United Network for Organ Sharing database.

J Thorac Cardiovasc Surg 2008 Feb;135(2):421-7, 427.e1

Division of Cardiothoracic Surgery, Children's Hospital of New York-Presbyterian and Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1016/j.jtcvs.2007.09.048DOI Listing
February 2008

Predicting survival among high-risk pediatric cardiac transplant recipients: an analysis of the United Network for Organ Sharing database.

J Thorac Cardiovasc Surg 2008 Jan 26;135(1):147-55, 155.e1-2. Epub 2007 Nov 26.

Division of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of New York-Presbyterian and Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.jtcvs.2007.09.019DOI Listing
January 2008

Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients.

J Heart Lung Transplant 2007 Dec;26(12):1270-80

Department of Pediatrics (Cardiology), Stanford University, Stanford, California 94304, USA.

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http://dx.doi.org/10.1016/j.healun.2007.09.017DOI Listing
December 2007

Somatic growth in children with single ventricle physiology impact of physiologic state.

J Am Coll Cardiol 2007 Nov 23;50(19):1876-83. Epub 2007 Oct 23.

Division of Cardiology, Department of Pediatrics, University of Toronto, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://ac.els-cdn.com/S0735109707026265/1-s2.0-S073510970702
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http://linkinghub.elsevier.com/retrieve/pii/S073510970702626
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http://dx.doi.org/10.1016/j.jacc.2007.07.050DOI Listing
November 2007

Cardiac retransplantation in high risk pediatric patients.

Pediatr Transplant 2007 Sep;11(6):615-23

Division of Pediatric Cardiology, Morgan Stanley Children's Hospital of New York Presbyterian, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1111/j.1399-3046.2007.00698.xDOI Listing
September 2007

Value of surveillance biopsy in pediatric heart transplantation.

Authors:
Seema Mital

Pediatr Transplant 2007 May;11(3):233-5

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http://dx.doi.org/10.1111/j.1399-3046.2007.00687.xDOI Listing
May 2007

Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network of Organ Sharing database.

J Thorac Cardiovasc Surg 2006 Nov;132(5):1208-12

Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.jtcvs.2006.04.054DOI Listing
November 2006

Effects of growth hormone therapy in children after cardiac transplantation.

J Heart Lung Transplant 2006 Jul 2;25(7):772-7. Epub 2006 May 2.

Division of Pediatric Cardiology, Department of Pediatrics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1016/j.healun.2004.11.317DOI Listing
July 2006

Failure of right ventricular adaptation in children with tetralogy of Fallot.

Circulation 2006 Jul;114(1 Suppl):I37-42

Division of Pediatric Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.001248DOI Listing
July 2006

Utility of post-transplant anti-HLA antibody measurements in pediatric cardiac transplant recipients.

J Heart Lung Transplant 2005 Sep;24(9):1289-96

Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1016/j.healun.2004.09.005DOI Listing
September 2005

Pediatric heart transplantation across ABO blood type barriers: a case study.

Prog Transplant 2005 Jun;15(2):161-5

Children's Hospital of New York-Presbyterian, New York, NY, USA.

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June 2005

Statins and the myocardium.

Semin Vasc Med 2004 Nov;4(4):377-84

Division of Pediatric Cardiology, Columbia University, College of Physicians and Surgeons, New York, New York.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-2004-869594
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http://dx.doi.org/10.1055/s-2004-869594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676317PMC
November 2004

Trends and outcomes in transplantation for complex congenital heart disease: 1984 to 2004.

Ann Thorac Surg 2004 Oct;78(4):1352-61; discussion 1352-61

Division of Pediatric Cardiac Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000349750400818
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http://dx.doi.org/10.1016/j.athoracsur.2004.04.012DOI Listing
October 2004