Publications by authors named "Sebnem Kargi"

18 Publications

  • Page 1 of 1

Microphthalmos: clinical and ultrasonographic findings.

Ann Ophthalmol (Skokie) 2007 ;39(2):112-22

Department of Ophthalmology, Zonguldak Karaelmas University Faculty of Medicine, Kozlu Zonguldak, 67600, Turkey.

We analyzed ocular and ultrasonographic findings of microphthalmos and associated ocular and systemic pathologies in 27 microphthalmic eyes. A high incidence of consanguinous marriages (26%) was present among the parents of patients. Associated systemic abnormalities were growth retardation, congenital rubella, cleft lip and palate, facial hemangioma, inguinal hernia, clinodactyly, Hurler syndrome, Goltz-Gorlin syndrome and Hallermann-Streiff syndrome. A variety of ocular/systemic abnormalities were encountered. Early ultrasonographic diagnosis and description of other ocular and systemic pathologies are essential.
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http://dx.doi.org/10.1007/s12009-007-0005-xDOI Listing
December 2007

The relationship of target organ damage and 24-hour ambulatory blood pressure monitoring with vitamin D receptor gene fok-I polymorphism in essential hypertension.

Kidney Blood Press Res 2006 24;29(6):344-50. Epub 2006 Nov 24.

Department of Nephrology, Zonguldak Karaelmas University School of Medicine, Zonguldak, Turkey.

Background: The contribution of genetic factors in hypertension cannot be denied.

Methods: In this study we evaluated the relationship between vitamin D receptor (VDR) gene polymorphisms (Bsm-I, Apa-I and Fok-I), and target organ damage in 74 patients (female/male 49/25, mean age 49.2 +/- 8 years) with essential hypertension. The VDR genotypes were evaluated by polymerase chain reaction and digestion of the amplified products by related enzymes. Patients with diabetes mellitus or impaired glucose tolerance and severe obesity were excluded. All patients underwent a complete physical examination, full biochemistry and urinalysis; in addition, all of them were assessed for target organ damage. Twenty-four-hour ambulatory blood pressure monitoring was performed in all patients.

Results: No significant difference was detected in biochemistry results and physical examination between groups for Bsm-I and Apa-I VDR gene polymorphisms. Patients were distributed as FF (n = 39) and non-FF (Ff/ff, n = 35) for Fok-I polymorphism. A negative correlation was present between vitamin D levels and day-time interval and early morning average by the measurement of 24-hour ambulatory blood pressure in the non-FF group. Serum cystatin-C was higher in the non-FF group (p = 0.012). In addition on retinal examination, the degree and presence of retinopathy were significantly higher in the non-FF group when compared to the FF group (p = 0.025, p = 0.018, respectively).

Conclusion: Knowing the VDR gene polymorphisms status may be helpful in preventing target organ damage in hypertensive patients.
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http://dx.doi.org/10.1159/000097409DOI Listing
February 2007

Visual acuity in children with glaucoma.

Ophthalmology 2006 Feb 10;113(2):229-38. Epub 2006 Jan 10.

Department of Ophthalmology, University of Karaelmas School of Medicine, Zonguldak, Turkey.

Purpose: To investigate the risk factors that influence outcome of visual function in children with glaucoma.

Design: Retrospective noncomparative interventional case series.

Participants: One hundred twenty-six patients (204 eyes) who had childhood glaucoma observed over 30 years, with a mean follow-up of 11.6 years.

Interventions: Full ophthalmologic examination, including measurement of corrected visual acuity (VA), slit-lamp and fundus examinations, intraocular pressure (IOP) measurement, and gonioscopic evaluation; periodic cycloplegic refraction and perimetry; and treatment of amblyopia.

Main Outcome Measures: Type of glaucoma; final best-corrected VA of good (6/6-6/12), fair (6/15-6/30), or poor (< or =6/60); patient age at time of development of glaucoma complications; and percentage of IOP measurements of < or =19 mmHg, perimetry results, and cup-to-disc (C/D) ratio during follow-up.

Results: The most recently measured VAs of children treated for glaucoma were good in 29%, fair in 24%, and poor in 47%. The most favorable outcome was for patients with primary infantile glaucoma followed by secondary glaucoma. Amblyopia and optic nerve damage due to glaucoma were the most frequent complications affecting VA. Patients with an IOP of < or =19 mmHg on 80% of determinations had stable optic nerve C/D ratios and visual fields.

Conclusions: Vision sufficient to qualify for a motor vehicle driving license was attainable in almost 30% of affected eyes. Visual acuity achieved at 6 years of age remained stable over the study period. Treatment of amblyopia is important to achieve this result.
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http://dx.doi.org/10.1016/j.ophtha.2005.10.029DOI Listing
February 2006

Acquired retraction of the eye as the first sign of myositis.

Strabismus 2005 Jun;13(2):85-8

Department of Ophthalmology, Karaelmas University School of Medicine, Zonguldak 67100, Turkey.

The authors report a patient who was diagnosed with idiopathic orbital myositis based on the findings of diplopia, worse on right gaze, globe retraction on adduction and injection at the lateral muscle tendon insertion of the left eye. Although orbital myositis as a cause of acquired retraction of the eye is rare, they wish to emphasize the importance of globe retraction with injection over the recti as an important clue for the diagnosis of orbital myositis.
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http://dx.doi.org/10.1080/09273970590935101DOI Listing
June 2005

The effects of sildenafil on ocular blood flow.

Acta Ophthalmol Scand 2005 Jun;83(3):355-9

Ophthalmology Department, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.

Purpose: To investigate the effects of sildenafil, a popular new drug in the treatment of erectile dysfunction, on ocular blood flow.

Methods: This study was designed as a prospective, double-blind, placebo-controlled study. Twenty participants with erectile dysfunction were given a single oral dose of 100 mg sildenafil, while 10 participants with erectile dysfunction were given placebo. All the participants underwent routine systemic and ophthalmological examinations. Intraocular pressure, systolic and diastolic blood pressure and ocular blood flow (ophthalmic, central retinal, short posterior ciliary arteries) were measured in both eyes before and 1 hour after the dose of sildenafil or placebo. Ocular blood flow measurements were performed using colour Doppler ultrasonography.

Results: None of the parameters were significantly different between the groups before study drug intake. Although central retinal artery velocities were not changed, ophthalmic artery and short posterior ciliary artery peak systolic velocity, end-diastolic velocity, and mean velocity values were significantly increased 1 hour after drug intake in the sildenafil group compared to the placebo group (p < 0.05).

Conclusion: Sildenafil causes a significant increase in blood flow in these arteries. A possible role of inhibition of phosphodiesterase-5 in vascular smooth muscles by sildenafil is implicated. Further studies are needed to investigate the effects of sildenafil on ocular blood flow in patients with senile macular degeneration, diabetic retinopathy and glaucoma.
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http://dx.doi.org/10.1111/j.1600-0420.2005.00422.xDOI Listing
June 2005

Capillary hemangioma of the caruncle.

Can J Ophthalmol 2004 Aug;39(5):560-2

SSK Eye Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1016/s0008-4182(04)80151-0DOI Listing
August 2004

Phototherapeutic keratectomy in Schnyder crystalline corneal dystrophy.

Cornea 2004 Apr;23(3):311-3

Department of Ophthalmology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.

Objective: To emphasize the effectiveness of phototherapeutic keratectomy (PTK) in a patient with Schnyder crystalline corneal dystrophy (SCCD).

Methods: Case report.

Results: Two eyes of a patient with SCCD underwent PTK. Best corrected visual acuity (BCVA) increased from 2/10 to 8/10 (plano/-1.50 x 10) in the right eye in a lit room. BCVA of the left eye was 4/10 (-8.00/-1.50 x 170) and did not change after treatment because of anisometropic amblyopia. No recurrence was detected after 68 months of follow-up.

Conclusion: PTK may be effective in the treatment of SCCD, especially if the crystals are the cause of visual disturbance.
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http://dx.doi.org/10.1097/00003226-200404000-00017DOI Listing
April 2004

Fine mapping of the Schnyder's crystalline corneal dystrophy locus.

Hum Genet 2004 May 19;114(6):594-600. Epub 2004 Mar 19.

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Schnyder's crystalline corneal dystrophy (SCCD) is a rare autosomal dominant eye disease with a spectrum of clinical manifestations that may include bilateral corneal clouding, arcus lipoides, and anterior corneal crystalline cholesterol deposition. We have previously performed a genome-wide linkage analysis on two large Swede-Finn families and mapped the SCCD locus to a 16-cM interval between markers D1S2633 and D1S228 on chromosome 1p36. We have collected 11 additional families from Finland, Germany, Turkey, and USA to narrow the critical region for SCCD. Here, we have used haplotype analysis with densely spaced microsatellite markers in a total of 13 families to refine the candidate interval. A common disease haplotype was observed among the four Swede-Finn families indicating the presence of a founder effect. Recombination results from all 13 families refined the SCCD locus to 2.32 Mbp between markers D1S1160 and D1S1635. Within this interval, identity-by-state was present in all 13 families for two markers D1S244 and D1S3153, further refining the candidate region to 1.58 Mbp.
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http://dx.doi.org/10.1007/s00439-004-1110-1DOI Listing
May 2004

Epiretinal membrane development during interferon treatment.

Can J Ophthalmol 2003 Dec;38(7):610-2

Ankara SSK Eye Hospital, Ankara, Turkey.

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December 2003

A rare agent of chalazion: demodectic mites.

Can J Ophthalmol 2003 Dec;38(7):605-6

Department of Ophthalmology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.

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http://dx.doi.org/10.1016/s0008-4182(03)80117-5DOI Listing
December 2003

Benign fibrous histiocytoma of the eyelid with an unusual clinical presentation.

J Dermatol 2004 Jan;31(1):27-31

Department of Plastic and Reconstructive Surgery, Zonguldak Karalemas University, Faculty of Medicine, Zonguldak, Turkey.

Benign fibrous histiocytoma is a common soft tissue tumor that can be deep or superficially located. Although the deep type of fibrous histiocytoma has a predilection for the orbit, the eyelids are an unusual location for the cutaneous type. A 42-year-old woman had bilateral yellowish nodular masses of the eyelids for two years. Pathological examination after excision revealed benign fibrous histiocytoma. Our case is an unusual clinical presentation of cutaneous fibrous histiocytoma as well as a rare location such as the eyelids.
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http://dx.doi.org/10.1111/j.1346-8138.2004.tb00500.xDOI Listing
January 2004

Bilateral Duane retraction syndrome associated with an extraordinary hand anomaly.

Strabismus 2003 Sep;11(3):157-62

Ankara SSK Eye Hospital, Turkey.

Duane retraction syndrome is an ocular motility disorder with which an increasing number of congenital abnormalities appear to be associated. In the present paper the authors report a case of bilateral Duane retraction syndrome with an extraordinary hand abnormality. Numerous theories concerning the etiology and pathogenesis of Duane retraction syndrome and its relationship to the associated findings have been proposed, but the exact mechanism is still under investigation. Further multi-centered studies and the classification of the associated clinical findings in an organized manner may help to explain this mechanism.
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http://dx.doi.org/10.1076/stra.11.3.157.16646DOI Listing
September 2003

A case of monostotic fibrous dysplasia of the maxillary sinus.

Kulak Burun Bogaz Ihtis Derg 2003 May;10(5):208-11

Department of Radiology, Medicine Faculty of Karaelmas University, Zonguldak, Turkey.

Fibrous dysplasia is an uncommon benign disease of the bone, with slow progression. Monostotic involvement of the paranasal sinuses is rare. We report a 54-year-old woman who had complaints of facial asymmetry, chronic sinusitis, recurrent headaches, and nasal obstruction for two years. Conventional radiography showed opacification and expansion of the maxillary sinus. Axial and coronal computed tomography scans showed a heterogeneous mass that expanded the right maxillary sinus, leading to nasal obstruction and cortical thickening of the maxilla. No signs of destruction or erosion in the cortical bone were identified. An endonasal endoscopic biopsy was performed and the diagnosis of fibrous dysplasia was confirmed histologically.
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May 2003

Tolerated cilium in the anterior chamber.

Ocul Immunol Inflamm 2003 Mar;11(1):73-8

Ankara SSK Eye Hospital, Ankara, Turkey.

Purpose: To describe a patient with a tolerated cilium in the anterior chamber.

Methods: A 15-year-old girl, referred with a 5-year trauma history, was examined. A cilium was noted in the anterior chamber without any inflammation during routine ophthalmological examination.

Results: The cilium was removed surgically and the prognosis was excellent.

Conclusion: The decision to remove a cilium surgically is controversial and must be based on the individual clinical examination.
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http://dx.doi.org/10.1076/ocii.11.1.73.15576DOI Listing
March 2003

Doppler measurement of blood flow velocities in extraocular orbital vessels in patients with obstructive sleep apnea syndrome.

J Clin Ultrasound 2003 Jun;31(5):250-7

Department of Radiology, Zonguldak Karaelmas University School of Medicine, Kozlu 67600, Zonguldak, Turkey.

Purpose: We used color Doppler sonography to determine blood flow velocities in the extraocular orbital vessels of patients with obstructive sleep apnea syndrome (OSAS) and compared the results with those of healthy control subjects without OSAS.

Methods: Patients with OSAS were classified according to the apnea-hypopnea index (AHI) as having mild OSAS (AHI < 20) or severe OSAS (AHI > or = 20). The peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index were measured in the ophthalmic artery (OA), central retinal artery (CRA), lateral short posterior ciliary artery, and medial short posterior ciliary artery using color Doppler sonography. Only 1 eye was measured in each study participant, and right and left eyes were chosen randomly. The blood flow velocities of patients with OSAS and those of control subjects were compared with the Kruskal-Wallis test and Wilcoxon's rank-sum test.

Results: The study comprised 30 patients (15 with mild and 15 with severe OSAS) and 20 healthy control subjects. Blood flow velocities were higher in most measured vessels in patients with OSAS than they were in the control subjects. Among patients with mild OSAS, the PSVs and EDVs in the posterior ciliary arteries were statistically significantly higher than those of the control group (p < 0.05), but those in the OA and CRA did not differ significantly between the mild OSAS group and the control group (p > 0.05). However, as the severity of OSAS increased, the PSVs and EDVs of the OA and CRA were also affected (p < 0.05).

Conclusions: Color Doppler sonographic measurements of blood flow parameters in the orbital vessels may differ significantly between patients with OSAS and those without the syndrome. Therefore, OSAS should be considered in addition to other conditions when interpreting the results of color Doppler sonography of the extraocular orbital vessels if the clinical history points toward such a diagnosis.
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http://dx.doi.org/10.1002/jcu.10171DOI Listing
June 2003