Sebastian Stintzing

Sebastian Stintzing

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Sebastian Stintzing

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Study evidence confirms current clinical practice in refractory metastatic colorectal cancer: the ReDOS trial.

Lancet Oncol 2019 Jun 28. Epub 2019 Jun 28.

Division of Hematology, Oncology and Tumor Immunology, Medical Department, Charité University Hospital Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/S1470-2045(19)30390-0DOI Listing
June 2019

Explaining the unexplainable: discrepancies in results from the CALGB/SWOG 80405 and FIRE-3 studies.

Lancet Oncol 2019 May;20(5):e274-e283

Department of Medical Oncology & Comprehensive Cancer Centre, University Hospital Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1016/S1470-2045(19)30172-XDOI Listing
May 2019

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.

Eur J Cancer 2019 Apr 7;111:138-147. Epub 2019 Mar 7.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436973PMC
April 2019

Recent advances in understanding colorectal cancer.

F1000Res 2018 24;7. Epub 2018 Sep 24.

Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.

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https://f1000research.com/articles/7-1528/v1
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http://dx.doi.org/10.12688/f1000research.14604.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173127PMC
March 2019

Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:
Stephanie L Schmit Christopher K Edlund Fredrick R Schumacher Jian Gong Tabitha A Harrison Jeroen R Huyghe Chenxu Qu Marilena Melas David J Van Den Berg Hansong Wang Stephanie Tring Sarah J Plummer Demetrius Albanes M Henar Alonso Christopher I Amos Kristen Anton Aaron K Aragaki Volker Arndt Elizabeth L Barry Sonja I Berndt Stéphane Bezieau Stephanie Bien Amanda Bloomer Juergen Boehm Marie-Christine Boutron-Ruault Hermann Brenner Stefanie Brezina Daniel D Buchanan Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Jose E Castelao Andrew T Chan Jenny Chang-Claude Stephen J Chanock Iona Cheng Ya-Wen Cheng Lee Soo Chin James M Church Timothy Church Gerhard A Coetzee Michelle Cotterchio Marcia Cruz Correa Keith R Curtis David Duggan Douglas F Easton Dallas English Edith J M Feskens Rocky Fischer Liesel M FitzGerald Barbara K Fortini Lars G Fritsche Charles S Fuchs Manuela Gago-Dominguez Manish Gala Steven J Gallinger W James Gauderman Graham G Giles Edward L Giovannucci Stephanie M Gogarten Clicerio Gonzalez-Villalpando Elena M Gonzalez-Villalpando William M Grady Joel K Greenson Andrea Gsur Marc Gunter Christopher A Haiman Jochen Hampe Sophia Harlid John F Harju Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Shu-Chen Huang Jose Maria Huerta Thomas J Hudson David J Hunter Gregory E Idos Motoki Iwasaki Rebecca D Jackson Eric J Jacobs Sun Ha Jee Mark A Jenkins Wei-Hua Jia Shuo Jiao Amit D Joshi Laurence N Kolonel Suminori Kono Charles Kooperberg Vittorio Krogh Tilman Kuehn Sébastien Küry Andrea LaCroix Cecelia A Laurie Flavio Lejbkowicz Mathieu Lemire Heinz-Josef Lenz David Levine Christopher I Li Li Li Wolfgang Lieb Yi Lin Noralane M Lindor Yun-Ru Liu Fotios Loupakis Yingchang Lu Frank Luh Jing Ma Christoph Mancao Frank J Manion Sanford D Markowitz Vicente Martin Koichi Matsuda Keitaro Matsuo Kevin J McDonnell Caroline E McNeil Roger Milne Antonio J Molina Bhramar Mukherjee Neil Murphy Polly A Newcomb Kenneth Offit Hanane Omichessan Domenico Palli Jesus P Paredes Cotoré Julyann Pérez-Mayoral Paul D Pharoah John D Potter Conghui Qu Leon Raskin Gad Rennert Hedy S Rennert Bridget M Riggs Clemens Schafmayer Robert E Schoen Thomas A Sellers Daniela Seminara Gianluca Severi Wei Shi David Shibata Xiao-Ou Shu Erin M Siegel Martha L Slattery Melissa Southey Zsofia K Stadler Mariana C Stern Sebastian Stintzing Darin Taverna Stephen N Thibodeau Duncan C Thomas Antonia Trichopoulou Shoichiro Tsugane Cornelia M Ulrich Franzel J B van Duijnhoven Bethany van Guelpan Joseph Vijai Jarmo Virtamo Stephanie J Weinstein Emily White Aung Ko Win Alicja Wolk Michael Woods Anna H Wu Kana Wu Yong-Bing Xiang Yun Yen Brent W Zanke Yi-Xin Zeng Ben Zhang Niha Zubair Sun-Seog Kweon Jane C Figueiredo Wei Zheng Loic Le Marchand Annika Lindblom Victor Moreno Ulrike Peters Graham Casey Li Hsu David V Conti Stephen B Gruber

J Natl Cancer Inst 2019 Feb;111(2):146-157

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center.

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http://dx.doi.org/10.1093/jnci/djy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555904PMC
February 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases.

Eur Radiol 2018 Nov 7;28(11):4839-4848. Epub 2018 May 7.

Department of Radiology, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00330-018-5424-0DOI Listing
November 2018

The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer.

Virchows Arch 2018 Aug 19;473(2):199-207. Epub 2018 Apr 19.

Department of Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1007/s00428-018-2360-yDOI Listing
August 2018

Synchronous colorectal liver metastases: focus on the elderly : An Effectiveness Study from Routine Care.

Langenbecks Arch Surg 2017 Dec 12;402(8):1223-1232. Epub 2017 Aug 12.

Munich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), University Hospital of Munich, Ludwig-Maximilians-University (LMU), Marchioninistr. 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00423-017-1611-8DOI Listing
December 2017

Multidisciplinary treatment of colorectal liver metastases.

Minerva Med 2017 Dec 8;108(6):527-546. Epub 2017 Sep 8.

Department of General, Visceral, Transplantation, Vascular, and Thoracic Surgery, University of Munich, Munich, Germany -

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http://dx.doi.org/10.23736/S0026-4806.17.05371-XDOI Listing
December 2017

[Personalized Treatment for Colorectal Carcinomas].

Dtsch Med Wochenschr 2017 Nov 27;142(22):1652-1659. Epub 2017 Oct 27.

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http://dx.doi.org/10.1055/s-0043-108467DOI Listing
November 2017

Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes.

Eur J Cancer 2017 10 5;84:69-80. Epub 2017 Aug 5.

USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.07.016DOI Listing
October 2017

Prevalence and influence on outcome of HER2/neu, HER3 and NRG1 expression in patients with metastatic colorectal cancer.

Anticancer Drugs 2017 08;28(7):717-722

aDepartment of Medicine III, Comprehensive Cancer Centre, University Hospital Grosshadern bDepartment of Pathology cInstitute of Medical Informatics, Biometry, and Epidemiology, University of Munich dGerman Department of Translational Cancer Research (DKTK), German Cancer Research Centre (DKFZ), Heidelberg eKlinikum St Marien, Oncology, Amberg fOncological surgery, Landshut gCentre of ambulatory treatment for oncological and haematological diseases, Kronach hKlinikum Chemnitz, Chemnitz, Germany.

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http://dx.doi.org/10.1097/CAD.0000000000000510DOI Listing
August 2017

Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials.

Eur J Cancer 2017 05 26;77:13-20. Epub 2017 Mar 26.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.020DOI Listing
May 2017

The relevance of primary tumour location in patients with metastatic colorectal cancer: A meta-analysis of first-line clinical trials.

Eur J Cancer 2017 01 29;70:87-98. Epub 2016 Nov 29.

Department of Medical Oncology, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 Munich, Germany; Comprehensive Cancer Center, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.10.007DOI Listing
January 2017

A still missing piece of the FIRE-3 puzzle - Authors' reply.

Lancet Oncol 2016 12;17(12):e516

Department of Hematology and Oncology, University of Munich, 81377 Munich, Germany; DKTK, German Cancer Consortium, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(16)30597-6DOI Listing
December 2016

A study-level meta-analysis of efficacy data from head-to-head first-line trials of epidermal growth factor receptor inhibitors versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer.

Eur J Cancer 2016 11 1;67:11-20. Epub 2016 Sep 1.

Department of Medical Oncology, Institut de Cancérologie de l'Ouest (ICO) René Gauducheau, 44805, St Herblain, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.07.019DOI Listing
November 2016

Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.

Clin Cancer Res 2016 07 2;22(13):3218-26. Epub 2016 Feb 2.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930688PMC
July 2016

Treatment of Metastatic Colorectal Cancer: Standard of Care and Future Perspectives.

Visc Med 2016 Jun 7;32(3):178-83. Epub 2016 Jun 7.

Department of Internal Medicine III, Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU), Munich, Germany, Munich, Germany; Comprehensive Cancer Center Munich, Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU), Munich, Germany.

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https://www.karger.com/Article/FullText/446052
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http://dx.doi.org/10.1159/000446052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945779PMC
June 2016

Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial: First-Line Therapy With FOLFIRI Plus Cetuximab or Bevacizumab in Patients With KRAS Wild-Type Tumors in Metastatic Colorectal Cancer.

J Clin Oncol 2015 Nov 10;33(32):3718-26. Epub 2015 Aug 10.

Dominik P. Modest, Sebastian Stintzing, and Volker Heinemann, University Hospital Grosshadern; Andreas Jung and Thomas Kirchner, University of Munich, Munich; Dominik P. Modest, Sebastian Stintzing, Volker Heinemann, Andreas Jung, and Thomas Kirchner, German Cancer Consortium and German Cancer Research Centre, Heidelberg; Ludwig Fischer von Weikersthal, Gesundheitszentrum St Marien, Amberg; Thomas Decker, Oncological Practice, Ravensburg; Alexander Kiani, Klinikum Bayreuth, Bayreuth; Ursula Vehling-Kaiser, Oncological Practice, Landshut; Salah-Eddin Al-Batran, Krankenhaus Nordwest, Frankfurt am Main; Tobias Heintges, Städtisches Klinikum Neuss, Neuss; Christian Lerchenmüller, Oncological Practice, Münster; Christoph Kahl, Staedtisches Klinikum Magdeburg, Magdeburg; Gernot Seipelt, Oncological Practice, Bad Soden; Frank Kullmann, Klinikum Weiden, Weiden; Martina Stauch, Oncological Practice, Kronach; Svantje Held, ClinAssess, Leverkusen; Markus Möhler, Johannes-Gutenberg Universität and German Cancer Consortium, Mainz, Germany; and Werner Scheithauer, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1200/JCO.2015.61.2887DOI Listing
November 2015

TAS-102, a novel antitumor agent: a review of the mechanism of action.

Cancer Treat Rev 2015 Nov 6;41(9):777-83. Epub 2015 Jun 6.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Via Taddeo Alderotti 26/N, 50139 Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624296PMC
November 2015

Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer.

Mol Cancer Ther 2015 Oct 23;14(10):2374-81. Epub 2015 Jul 23.

USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboatory, Los Angeles, California. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596768PMC
October 2015

Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC).

Eur J Cancer 2015 Sep 15;51(14):1927-36. Epub 2015 Jul 15.

Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich, Germany, Marchioninistr. 15, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.06.116DOI Listing
September 2015

[Multimodal treatment of colorectal liver metastases].

MMW Fortschr Med 2015 Aug;157(14):47-9

Klinik für Allgemeine, Viszeral-, Transplantations-, Gefäß- und Thoraxchirurgie, Klinikum der Universität München, Marchioninistr. 15, D-81377, München, Deutschland,

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http://dx.doi.org/10.1007/s15006-015-3419-1DOI Listing
August 2015

Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.

Cancer 2015 Jun 17;121(11):1898-905. Epub 2015 Feb 17.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1002/cncr.29259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441595PMC
June 2015

Sym004: Truly a New Level of Anti-EGFR Treatment?

Cancer Discov 2015 Jun;5(6):578-80

Department of Hematology and Oncology, Klinikum der Universität München, Munich, Germany.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0441DOI Listing
June 2015

Under-expression of α8 integrin aggravates experimental atherosclerosis.

J Pathol 2015 May 20;236(1):5-16. Epub 2015 Jan 20.

Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nürnberg, Germany.

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http://dx.doi.org/10.1002/path.4501DOI Listing
May 2015

Diffusion-weighted MRI Before and After Robotic Radiosurgery (Cyberknife®) in Primary and Secondary Liver Malignancies: A Pilot Study.

Technol Cancer Res Treat 2015 Apr 21;14(2):191-9. Epub 2014 Nov 21.

Department of Clinical Radiology, University Hospital Grosshadern, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.7785/tcrt.2012.500408DOI Listing
April 2015

Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.

Anticancer Drugs 2015 Apr;26(4):371-8

aDepartment of Medicine III bInstitute of Medical Informatics, Biometry and Epidemiology, University Hospital Grosshadern, Munich cDepartment of Surgery, University Hospital Magdeburg, Magdeburg dGerman Cancer Consortium (DKTK) eGerman Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1097/CAD.0000000000000196DOI Listing
April 2015

Surrogate endpoints in second-line treatment for mCRC: a systematic literature-based analysis from 23 randomised trials.

Acta Oncol 2015 Feb 14;54(2):187-93. Epub 2014 Jul 14.

Department of Medical Oncology, Klinikum Grosshadern and Comprehensive Cancer Center, University of Munich , Munich , Germany.

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http://dx.doi.org/10.3109/0284186X.2014.938830DOI Listing
February 2015

Predictive and prognostic markers in the treatment of metastatic colorectal cancer (mCRC): personalized medicine at work.

Hematol Oncol Clin North Am 2015 Feb;29(1):43-60

Sharon Carpenter Laboratory, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Room 3456, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2014.09.009DOI Listing
February 2015

Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer.

Pharmacogenet Genomics 2015 Jan;25(1):30-7

aDivision of Medical Oncology bDepartment of Preventive Medicine; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA cDepartment of Medicine, Division of Clinical Oncology, Medical University of Graz, Graz, Austria dDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://pdfs.journals.lww.com/jpharmacogenetics/2015/01000/Ge
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FPC.0000000000000101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260998PMC
January 2015

Management of colorectal cancer.

F1000Prime Rep 2014 4;6:108. Epub 2014 Nov 4.

Department of Hematology and Oncology, University Hospital Grosshadern, University of Munich Marchioninistraße 15, 81377 Munich Germany.

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http://dx.doi.org/10.12703/P6-108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229728PMC
January 2015

Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients.

Pharmacogenet Genomics 2014 Dec;24(12):588-96

aSharon A. Carpenter Laboratory, Division of Medical Oncology bDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA cDepartment of Internal Medicine, Division of Clinical Oncology, Comprehensive Cancer Center Graz, Medical University of Graz, Graz, Austria Departments of dGastroenterology eSurgery, School of Medicine, Kitasato University, Sagamihara, Japan.

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http://pdfs.journals.lww.com/jpharmacogenetics/2014/12000/Pr
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FPC.0000000000000091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218879PMC
December 2014

FOLFIRI with cetuximab or bevacizumab: FIRE-3-authors' reply.

Lancet Oncol 2014 Dec 24;15(13):e583-e584. Epub 2014 Nov 24.

Department of Hematology and Oncology, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1016/S1470-2045(14)71036-8DOI Listing
December 2014

Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent.

Pharmacogenet Genomics 2014 Nov;24(11):539-47

aSharon Carpenter Laboratory, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California bMemorial Sloan Kettering Cancer Center, New York, New York, USA cDepartment of Gastroenterology Center, Cancer Institute Hospital, Tokyo Departments of dGastroenterology eSurgery, School of Medicine, Kitasato University, Sagamihara, Japan fDepartment of Hematology and Oncology, University Hospital Grosshadern, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1097/FPC.0000000000000087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190127PMC
November 2014

So much effort, so little progress?

J Natl Cancer Inst 2014 Oct 22;106(10). Epub 2014 Sep 22.

USC/ Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory, Los Angeles, CA (HJL, SS); Department of Hematology and Oncology, University Hospital of MunichGrosshadern, Ludwig-Maximilians-University of Munich, Germany (SS).

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http://dx.doi.org/10.1093/jnci/dju282DOI Listing
October 2014

Molecular pathways: turning proteasomal protein degradation into a unique treatment approach.

Clin Cancer Res 2014 Jun 22;20(12):3064-70. Epub 2014 Apr 22.

Authors' Affiliation: USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory, Los Angeles, California

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703318PMC
June 2014

Panitumumab safety for treating colorectal cancer.

Expert Opin Drug Saf 2014 Jun 28;13(6):843-51. Epub 2014 Apr 28.

University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Division of Medical Oncology , 1441 Eastlake Avenue, Los Angeles, CA, 90033 , USA +1 323 865 3967 ; +1 323 865 0061 ;

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http://dx.doi.org/10.1517/14740338.2014.915024DOI Listing
June 2014

Panitumumab : leading to better overall survival in metastatic colorectal cancer?

Expert Opin Biol Ther 2014 Apr 5;14(4):535-48. Epub 2014 Mar 5.

University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Division of Medical Oncology , 1441 Eastlake Avenue, Los Angeles, CA 90033 , USA +1 323 865 3967 ; +1 323 865 0061 ;

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http://dx.doi.org/10.1517/14712598.2014.894502DOI Listing
April 2014

Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.

Mol Cancer Ther 2014 Feb 29;13(2):528-39. Epub 2013 Oct 29.

Corresponding Author: Heinz-Josef Lenz, Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Suite 3456, University of Southern California, Los Angeles, CA 90089.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945969PMC
February 2014

Outcome of patients with metastatic colorectal cancer depends on the primary tumor site (midgut vs. hindgut): analysis of the FIRE1-trial (FuFIRI or mIROX as first-line treatment).

Anticancer Drugs 2014 Feb;25(2):212-8

aDepartment of Medicine III, University Hospital Grosshadern bInstitute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich cKlinikum St Marien, Amberg dKlinikum Chemnitz, Chemnitz eOnkologische Praxis Landshut, Landshut fGerman Cancer Consortium (DKTK) gGerman Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1097/CAD.0000000000000041DOI Listing
February 2014

A small cog in a big wheel: PIK3CA mutations in colorectal cancer.

J Natl Cancer Inst 2013 Dec 14;105(23):1775-6. Epub 2013 Nov 14.

Affiliation of authors: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (SS, H-JL).

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http://dx.doi.org/10.1093/jnci/djt330DOI Listing
December 2013

Protein kinase inhibitors in metastatic colorectal cancer. Let's pick patients, tumors, and kinase inhibitors to piece the puzzle together!

Expert Opin Pharmacother 2013 Nov 13;14(16):2203-20. Epub 2013 Aug 13.

Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Sharon Carpenter Laboratory , 1441 Eastlake Avenue, Room 3456, Los Angeles, CA 90033 , USA

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http://dx.doi.org/10.1517/14656566.2013.828694DOI Listing
November 2013

Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States.

Mol Cancer Ther 2013 Oct 5;12(10):2261-72. Epub 2013 Aug 5.

Corresponding Author: Heinz-Josef Lenz, Sharon A. Carpenter Laboratory, Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 1441 Eastlake Avenue, Los Angeles, CA 90033.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-12
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http://dx.doi.org/10.1158/1535-7163.MCT-12-1134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810398PMC
October 2013

Percutaneous radiofrequency ablation (RFA) or robotic radiosurgery (RRS) for salvage treatment of colorectal liver metastases.

Acta Oncol 2013 Jun 14;52(5):971-7. Epub 2013 Feb 14.

Department of Medical Oncology and Comprehensive Cancer Center, Klinikum Grosshadern, LMU, Munich, Germany.

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http://dx.doi.org/10.3109/0284186X.2013.766362DOI Listing
June 2013

Early tumor shrinkage in metastatic colorectal cancer: retrospective analysis from an irinotecan-based randomized first-line trial.

Cancer Sci 2013 Jun 15;104(6):718-24. Epub 2013 Apr 15.

Department of Medical Oncology, Klinikum Grosshadern and Comprehensive Cancer Center, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/cas.12148DOI Listing
June 2013

MicroRNA-21 in colorectal cancer: "Just another brick in the wall"?

J Natl Cancer Inst 2013 Jun 23;105(12):840-1. Epub 2013 May 23.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djt128DOI Listing
June 2013

Combined resection of colorectal hepatic-pulmonary metastases shows improved outcome over chemotherapy alone.

Langenbecks Arch Surg 2013 Feb 13;398(2):265-76. Epub 2013 Jan 13.

Department of General Thoracic Surgery, University of Munich-Grosshadern, Marchioninistrasse 15, Munich, Germany.

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http://dx.doi.org/10.1007/s00423-012-1046-1DOI Listing
February 2013

Progression-free survival as a surrogate endpoint for median overall survival in metastatic colorectal cancer: literature-based analysis from 50 randomized first-line trials.

Clin Cancer Res 2013 Jan 13;19(1):225-35. Epub 2012 Nov 13.

Department of Medical Oncology, Klinikum Grosshadern and Comprehensive Cancer Center, Ludwig Maximilian University of Munich, Munich, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1515DOI Listing
January 2013

Targeted therapies: Cetuximab dosing by rash--is the scaling of EVEREST meaningful?

Nat Rev Clin Oncol 2012 Oct 14;9(10):554-6. Epub 2012 Aug 14.

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http://dx.doi.org/10.1038/nrclinonc.2012.142DOI Listing
October 2012

Myelodysplastic syndrome and histone deacetylase inhibitors: "to be or not to be acetylated"?

J Biomed Biotechnol 2011 15;2011:214143. Epub 2011 May 15.

Medical Department III, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1155/2011/214143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100562PMC
November 2011

[Colon cancer: adjuvant chemotherapy and aftercare].

MMW Fortschr Med 2011 Sep;153(35):34-6

Medizinische Klinik und Poliklinik III, Klinikum Grosshadern, LMU München.

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September 2011

Role of cannabinoid receptors and RAGE in inflammatory bowel disease.

Histol Histopathol 2011 06;26(6):735-45

Department of Medicine III, University Hospital Grosshadern, Marchioninistrasse 15, Munich, Germany.

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http://dx.doi.org/10.14670/HH-26.735DOI Listing
June 2011

Radiosurgery of liver tumors: value of robotic radiosurgical device to treat liver tumors.

Ann Surg Oncol 2010 Nov 24;17(11):2877-83. Epub 2010 Jun 24.

Department of Hematology and Oncology, University Hospital Grosshadern, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1245/s10434-010-1187-9DOI Listing
November 2010

Primary testicular lymphoma: a strictly homogeneous hematological disease?

Oncol Rep 2010 May;23(5):1261-7

Institute of Pathology, University Hospital Salzburg of the Paracelsus Private Medical University, Salzburg, Austria.

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http://dx.doi.org/10.3892/or_00000759DOI Listing
May 2010

Differentiation patterning of vascular smooth muscle cells (VSMC) in atherosclerosis.

Virchows Arch 2009 Aug 26;455(2):171-85. Epub 2009 Jun 26.

Department of Medicine III, University Hospital Grosshadern, LMU Munich, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1007/s00428-009-0800-4DOI Listing
August 2009

Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR.

Cancer Treat Rev 2009 May 30;35(3):262-71. Epub 2008 Dec 30.

Department of Hematology/Oncology, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchionini-Street 15, 81377 Munich, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S030573720800319
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http://dx.doi.org/10.1016/j.ctrv.2008.11.005DOI Listing
May 2009

The treatment of colorectal carcinoma with monoclonal antibodies: the importance of KRAS mutation analysis and EGFR status.

Dtsch Arztebl Int 2009 Mar 20;106(12):202-6. Epub 2009 Mar 20.

Medizinische Klinik und Poliklinik III, Klinikum der LMU München, München, Germany.

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http://dx.doi.org/10.3238/arztebl.2009.0202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680580PMC
March 2009