Publications by authors named "Sebastian M B Nijman"

32Publications

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.

Sci Signal 2020 Sep 15;13(649). Epub 2020 Sep 15.

Ludwig Institute for Cancer Research, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, UK.

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http://dx.doi.org/10.1126/scisignal.aba5665DOI Listing
September 2020

Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity.

Trends Cancer 2020 06 13;6(6):454-461. Epub 2020 Mar 13.

Ludwig Institute for Cancer Research and Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2020.02.016DOI Listing
June 2020

Functional genomics to uncover drug mechanism of action.

Nat Chem Biol 2015 Dec 17;11(12):942-8. Epub 2015 Nov 17.

Ludwig Institute for Cancer Research Ltd., Oxford, UK.

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http://dx.doi.org/10.1038/nchembio.1963DOI Listing
December 2015

Light-assisted small-molecule screening against protein kinases.

Nat Chem Biol 2015 Dec 12;11(12):952-4. Epub 2015 Oct 12.

Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.

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http://dx.doi.org/10.1038/nchembio.1933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652335PMC
December 2015

A thesaurus of genetic variation for interrogation of repetitive genomic regions.

Nucleic Acids Res 2015 May 27;43(10):e68. Epub 2015 Mar 27.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria

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http://dx.doi.org/10.1093/nar/gkv178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446415PMC
May 2015

Synthetic lethal vulnerabilities of cancer.

Annu Rev Pharmacol Toxicol 2015 9;55:513-31. Epub 2014 Oct 9.

CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, A1090 Vienna, Austria; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010814-124511DOI Listing
September 2015

Exploiting epigenetic vulnerabilities for cancer therapeutics.

Trends Pharmacol Sci 2014 Mar 12;35(3):136-45. Epub 2014 Feb 12.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2014.01.001DOI Listing
March 2014

Cancer. Potential of the synthetic lethality principle.

Science 2013 Nov;342(6160):809-11

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1126/science.1244669DOI Listing
November 2013

Functional drug-gene interactions in lung cancer.

Expert Rev Mol Diagn 2012 Apr;12(3):291-302

CeMM Research Center for Molecular Medicine of Austrian Academy of Sciences, Vienna, Austria.

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http://www.tandfonline.com/doi/full/10.1586/erm.12.16
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http://dx.doi.org/10.1586/erm.12.16DOI Listing
April 2012

Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.

PLoS One 2012 7;7(2):e31003. Epub 2012 Feb 7.

CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274522PMC
July 2012

p19(ARF) /p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma.

Hepatology 2011 Jul;54(1):164-72

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.24329DOI Listing
July 2011

Synthetic lethality: general principles, utility and detection using genetic screens in human cells.

FEBS Lett 2011 Jan 19;585(1):1-6. Epub 2010 Nov 19.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria.

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http://doi.wiley.com/10.1016/j.febslet.2010.11.024
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http://dx.doi.org/10.1016/j.febslet.2010.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018572PMC
January 2011

Giving Rho(d) directions.

Nat Chem Biol 2010 Jun;6(6):397-8

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http://dx.doi.org/10.1038/nchembio.373DOI Listing
June 2010

A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.

J Biol Chem 2006 Aug 31;281(31):21582-7. Epub 2006 May 31.

Division of Molecular Carcinogenesis and Centre for Biomedical Genetics, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M602312200DOI Listing
August 2006

Regulation of monoubiquitinated PCNA by DUB autocleavage.

Nat Cell Biol 2006 Apr 12;8(4):339-47. Epub 2006 Mar 12.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb1378DOI Listing
April 2006

A genomic and functional inventory of deubiquitinating enzymes.

Cell 2005 Dec;123(5):773-86

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2005.11.007DOI Listing
December 2005

Functional annotation of deubiquitinating enzymes using RNA interference.

Methods Enzymol 2005 ;398:554-67

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/S0076-6879(05)98045-2DOI Listing
December 2005

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Mol Cell 2005 Feb;17(3):331-9

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://ac.els-cdn.com/S1097276505010415/1-s2.0-S109727650501
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http://dx.doi.org/10.1016/j.molcel.2005.01.008DOI Listing
February 2005

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

Nature 2003 Aug;424(6950):797-801

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature01811DOI Listing
August 2003