Sebastian H Scharf

Sebastian H Scharf

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Sebastian H Scharf

Sebastian H Scharf

Publications by authors named "Sebastian H Scharf"

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20Publications

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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

J Pharmacol Exp Ther 2015 Apr 9;353(1):213-33. Epub 2015 Feb 9.

Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.).

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http://dx.doi.org/10.1124/jpet.114.222463DOI Listing
April 2015

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.

Curr Opin Pharmacol 2015 Feb 2;20:124-34. Epub 2014 Dec 2.

Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2014.11.004DOI Listing
February 2015

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice.

Endocrinology 2014 Jul 28;155(7):2500-10. Epub 2014 Apr 28.

Max Planck Institute of Psychiatry (C.L., C.K., J.H., C.D., A.A, P.W., J.A., C.Q., K.V.W., S.H.S., L.C., R.W-A., J.B., R.L., F.H., M.U., F.H., E.B.B., M.V.S.), 80804 Munich, Germany; Lundbeck Research USA (K.A.J.), Paramus, New Jersey 07652; and Johannes Gutenberg University Medical Center (M.B.M.), 55131 Mainz, Germany.

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http://dx.doi.org/10.1210/en.2013-1986DOI Listing
July 2014

Evidence supporting the match/mismatch hypothesis of psychiatric disorders.

Eur Neuropsychopharmacol 2014 Jun 15;24(6):907-18. Epub 2014 Feb 15.

Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2014.02.002DOI Listing
June 2014

Chronic social stress during adolescence: interplay of paroxetine treatment and ageing.

Neuropharmacology 2013 Sep 16;72:38-46. Epub 2013 Apr 16.

RG Molecular Stress Physiology, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.

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http://dx.doi.org/10.1016/j.neuropharm.2013.03.035DOI Listing
September 2013

Animal models of stress vulnerability and resilience in translational research.

Curr Psychiatry Rep 2012 Apr;14(2):159-65

Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany.

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http://dx.doi.org/10.1007/s11920-012-0256-0DOI Listing
April 2012

Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress.

Psychoneuroendocrinology 2011 May;36(4):579-87

Max Planck Institute of Psychiatry, Munich, Germany.

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http://dx.doi.org/10.1016/j.psyneuen.2010.09.007DOI Listing
May 2011

Expression and regulation of the Fkbp5 gene in the adult mouse brain.

PLoS One 2011 Feb 9;6(2):e16883. Epub 2011 Feb 9.

Research Group Molecular Stress Physiology, Max Planck Institute of Psychiatry, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016883PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036725PMC
February 2011