Sebastian D Fugmann

Sebastian D Fugmann

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Sebastian D Fugmann

Sebastian D Fugmann

Publications by authors named "Sebastian D Fugmann"

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32Publications

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AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates.

Nat Commun 2018 05 16;9(1):1948. Epub 2018 May 16.

Department of Biomedical Sciences, Chang Gung University, 259 Wenhua 1st Rd, Kwei-Shan District, Tao-Yuan, 333, Taiwan.

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http://dx.doi.org/10.1038/s41467-018-04273-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956068PMC
May 2018

Lectins identify distinct populations of coelomocytes in Strongylocentrotus purpuratus.

PLoS One 2017 10;12(11):e0187987. Epub 2017 Nov 10.

Department of Biomedical Sciences, Chang Gung University, Kwei-Shan District, Tao-Yuan, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187987PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695280PMC
December 2017

Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis.

Proc Biol Sci 2017 May;284(1855)

Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan

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http://dx.doi.org/10.1098/rspb.2017.0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454262PMC
May 2017

Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination.

Genes Dev 2016 Apr 7;30(8):909-17. Epub 2016 Apr 7.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA; Howard Hughes Medical Institute, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1101/gad.278432.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840297PMC
April 2016

Form follows function - the three-dimensional structure of antigen receptor gene loci.

Curr Opin Immunol 2014 Apr 16;27:33-7. Epub 2014 Feb 16.

Department of Biomedical Sciences, Chang Gung University, 259 Wenhua 1st Rd, Kwei-Shan, Tao-Yuan 333, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2014.01.011DOI Listing
April 2014

Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography.

Anal Biochem 2013 May 29;436(2):78-83. Epub 2013 Jan 29.

Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.ab.2013.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167792PMC
May 2013

Transcription, splicing, and release: are we there yet?

Cell 2012 Jul;150(2):241-3

Laboratory of Molecular Biology and Immunology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.cell.2012.07.004DOI Listing
July 2012

Characterizing somatic hypermutation and gene conversion in the chicken DT40 cell system.

Methods Mol Biol 2011 ;748:255-71

Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-61779-139-0_18DOI Listing
October 2011

Separation of mutational and transcriptional enhancers in Ig genes.

J Immunol 2011 Sep 15;187(6):3247-55. Epub 2011 Aug 15.

Molecular Immunology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging/National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.4049/jimmunol.1101568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169751PMC
September 2011

Targeting of AID-mediated sequence diversification to immunoglobulin genes.

Curr Opin Immunol 2011 Apr 2;23(2):184-9. Epub 2011 Feb 2.

Molecular Immunology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging/National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.coi.2010.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073656PMC
April 2011

Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.

PLoS One 2011 Apr 20;6(4):e18955. Epub 2011 Apr 20.

Laboratory of Molecular Biology and Immunology, Molecular Immunology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018955PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080390PMC
April 2011

RAG-2 unleashed: lymphocytes beware.

Immunity 2011 Feb;34(2):137-9

Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059897PMC
February 2011

The origins of vertebrate adaptive immunity.

Nat Rev Immunol 2010 Aug;10(8):543-53

Department of Molecular Genetics, All Children's Hospital, St. Petersburg, Florida 33701, USA.

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http://dx.doi.org/10.1038/nri2807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919748PMC
August 2010

The origins of the Rag genes--from transposition to V(D)J recombination.

Semin Immunol 2010 Feb 9;22(1):10-6. Epub 2009 Dec 9.

Laboratory of Cellular and Molecular Biology, National Institute on Aging/National Institutes of Health, 251 Bayview Blvd., Suite 100, Baltimore, MD 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823946PMC
http://dx.doi.org/10.1016/j.smim.2009.11.004DOI Listing
February 2010

A coming-of-age story: activation-induced cytidine deaminase turns 10.

Nat Immunol 2009 Nov 20;10(11):1147-53. Epub 2009 Oct 20.

Laboratory of Lymphocyte Biology, Rockefeller University, New York, New York, USA.

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http://www.nature.com/articles/ni.1799
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http://dx.doi.org/10.1038/ni.1799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810190PMC
November 2009

The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails.

Dev Comp Immunol 2008 8;32(10):1221-30. Epub 2008 May 8.

Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.dci.2008.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518978PMC
October 2008

AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.

Mol Immunol 2008 Apr 26;45(7):2062-8. Epub 2007 Nov 26.

Molecular Immunology Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.molimm.2007.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267867PMC
April 2008

Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus.

J Immunol 2008 Feb;180(4):2019-23

Molecular Immunology Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.4049/jimmunol.180.4.2019DOI Listing
February 2008

The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination.

Mol Cell Biol 2007 Sep 16;27(18):6288-99. Epub 2007 Jul 16.

Department of Genetics, Yale University School of Medicine, 330 Cedar St., New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1128/MCB.00835-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099602PMC
September 2007

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.

J Biol Chem 2007 Aug 5;282(35):25308-13. Epub 2007 Jul 5.

Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M704231200
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http://dx.doi.org/10.1074/jbc.M704231200DOI Listing
August 2007

The immune gene repertoire encoded in the purple sea urchin genome.

Dev Biol 2006 Dec 3;300(1):349-65. Epub 2006 Sep 3.

Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Ave., Room S-126b, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1016/j.ydbio.2006.08.065DOI Listing
December 2006

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.

J Exp Med 2006 Dec 18;203(13):2919-28. Epub 2006 Dec 18.

Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1084/jem.20061835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118177PMC
December 2006

The genome of the sea urchin Strongylocentrotus purpuratus.

Authors:
Erica Sodergren George M Weinstock Eric H Davidson R Andrew Cameron Richard A Gibbs Robert C Angerer Lynne M Angerer Maria Ina Arnone David R Burgess Robert D Burke James A Coffman Michael Dean Maurice R Elphick Charles A Ettensohn Kathy R Foltz Amro Hamdoun Richard O Hynes William H Klein William Marzluff David R McClay Robert L Morris Arcady Mushegian Jonathan P Rast L Courtney Smith Michael C Thorndyke Victor D Vacquier Gary M Wessel Greg Wray Lan Zhang Christine G Elsik Olga Ermolaeva Wratko Hlavina Gretchen Hofmann Paul Kitts Melissa J Landrum Aaron J Mackey Donna Maglott Georgia Panopoulou Albert J Poustka Kim Pruitt Victor Sapojnikov Xingzhi Song Alexandre Souvorov Victor Solovyev Zheng Wei Charles A Whittaker Kim Worley K James Durbin Yufeng Shen Olivier Fedrigo David Garfield Ralph Haygood Alexander Primus Rahul Satija Tonya Severson Manuel L Gonzalez-Garay Andrew R Jackson Aleksandar Milosavljevic Mark Tong Christopher E Killian Brian T Livingston Fred H Wilt Nikki Adams Robert Bellé Seth Carbonneau Rocky Cheung Patrick Cormier Bertrand Cosson Jenifer Croce Antonio Fernandez-Guerra Anne-Marie Genevière Manisha Goel Hemant Kelkar Julia Morales Odile Mulner-Lorillon Anthony J Robertson Jared V Goldstone Bryan Cole David Epel Bert Gold Mark E Hahn Meredith Howard-Ashby Mark Scally John J Stegeman Erin L Allgood Jonah Cool Kyle M Judkins Shawn S McCafferty Ashlan M Musante Robert A Obar Amanda P Rawson Blair J Rossetti Ian R Gibbons Matthew P Hoffman Andrew Leone Sorin Istrail Stefan C Materna Manoj P Samanta Viktor Stolc Waraporn Tongprasit Qiang Tu Karl-Frederik Bergeron Bruce P Brandhorst James Whittle Kevin Berney David J Bottjer Cristina Calestani Kevin Peterson Elly Chow Qiu Autumn Yuan Eran Elhaik Dan Graur Justin T Reese Ian Bosdet Shin Heesun Marco A Marra Jacqueline Schein Michele K Anderson Virginia Brockton Katherine M Buckley Avis H Cohen Sebastian D Fugmann Taku Hibino Mariano Loza-Coll Audrey J Majeske Cynthia Messier Sham V Nair Zeev Pancer David P Terwilliger Cavit Agca Enrique Arboleda Nansheng Chen Allison M Churcher F Hallböök Glen W Humphrey Mohammed M Idris Takae Kiyama Shuguang Liang Dan Mellott Xiuqian Mu Greg Murray Robert P Olinski Florian Raible Matthew Rowe John S Taylor Kristin Tessmar-Raible D Wang Karen H Wilson Shunsuke Yaguchi Terry Gaasterland Blanca E Galindo Herath J Gunaratne Celina Juliano Masashi Kinukawa Gary W Moy Anna T Neill Mamoru Nomura Michael Raisch Anna Reade Michelle M Roux Jia L Song Yi-Hsien Su Ian K Townley Ekaterina Voronina Julian L Wong Gabriele Amore Margherita Branno Euan R Brown Vincenzo Cavalieri Véronique Duboc Louise Duloquin Constantin Flytzanis Christian Gache François Lapraz Thierry Lepage Annamaria Locascio Pedro Martinez Giorgio Matassi Valeria Matranga Ryan Range Francesca Rizzo Eric Röttinger Wendy Beane Cynthia Bradham Christine Byrum Tom Glenn Sofia Hussain Gerard Manning Esther Miranda Rebecca Thomason Katherine Walton Athula Wikramanayke Shu-Yu Wu Ronghui Xu C Titus Brown Lili Chen Rachel F Gray Pei Yun Lee Jongmin Nam Paola Oliveri Joel Smith Donna Muzny Stephanie Bell Joseph Chacko Andrew Cree Stacey Curry Clay Davis Huyen Dinh Shannon Dugan-Rocha Jerry Fowler Rachel Gill Cerrissa Hamilton Judith Hernandez Sandra Hines Jennifer Hume Laronda Jackson Angela Jolivet Christie Kovar Sandra Lee Lora Lewis George Miner Margaret Morgan Lynne V Nazareth Geoffrey Okwuonu David Parker Ling-Ling Pu Rachel Thorn Rita Wright

Science 2006 Nov;314(5801):941-52

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http://dx.doi.org/10.1126/science.1133609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159423PMC
November 2006

An ancient evolutionary origin of the Rag1/2 gene locus.

Proc Natl Acad Sci U S A 2006 Mar 27;103(10):3728-33. Epub 2006 Feb 27.

Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1073/pnas.0509720103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450146PMC
March 2006

Immunology. UNGstoppable switching.

Science 2004 Aug;305(5687):1113-4

Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/science.1102692DOI Listing
August 2004

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination.

Int Immunol 2004 Apr;16(4):549-57

Section of Immunobiology, Howard Hughes Medical Institute and Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/intimm/dxh057DOI Listing
April 2004

Non-redundancy of cytidine deaminases in class switch recombination.

Eur J Immunol 2004 Mar;34(3):844-849

Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, USA.

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http://dx.doi.org/10.1002/eji.200324418DOI Listing
March 2004

A functional analysis of the spacer of V(D)J recombination signal sequences.

PLoS Biol 2003 Oct 13;1(1):E1. Epub 2003 Oct 13.

Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1371/journal.pbio.0000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC212687PMC
October 2003

RNA AIDS DNA.

Nat Immunol 2003 May;4(5):429-30

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http://dx.doi.org/10.1038/ni0503-429DOI Listing
May 2003

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

Immunity 2003 Jan;18(1):65-74

Howard Hughes Medical Institute, The Children's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/s1074-7613(02)00507-1DOI Listing
January 2003

DNA repair: breaking the seal.

Nature 2002 Apr;416(6882):691-4

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http://dx.doi.org/10.1038/416691aDOI Listing
April 2002

Immunology. One AID to unite them all.

Science 2002 Feb;295(5558):1244-5

Howard Hughes Medical Institute and Section of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/science.1070023DOI Listing
February 2002