Sebastian A Wagner

Sebastian A Wagner

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Sebastian A Wagner

Sebastian A Wagner

Publications by authors named "Sebastian A Wagner"

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Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification.

Authors:
Michael T Parsons Emma Tudini Hongyan Li Eric Hahnen Barbara Wappenschmidt Lidia Feliubadaló Cora M Aalfs Simona Agata Kristiina Aittomäki Elisa Alducci María Concepción Alonso-Cerezo Norbert Arnold Bernd Auber Rachel Austin Jacopo Azzollini Judith Balmaña Elena Barbieri Claus R Bartram Ana Blanco Britta Blümcke Sandra Bonache Bernardo Bonanni Åke Borg Beatrice Bortesi Joan Brunet Carla Bruzzone Karolin Bucksch Giulia Cagnoli Trinidad Caldés Almuth Caliebe Maria A Caligo Mariarosaria Calvello Gabriele L Capone Sandrine M Caputo Ileana Carnevali Estela Carrasco Virginie Caux-Moncoutier Pietro Cavalli Giulia Cini Edward M Clarke Paola Concolino Elisa J Cops Laura Cortesi Fergus J Couch Esther Darder Miguel de la Hoya Michael Dean Irmgard Debatin Jesús Del Valle Capucine Delnatte Nicolas Derive Orland Diez Nina Ditsch Susan M Domchek Véronique Dutrannoy Diana M Eccles Hans Ehrencrona Ute Enders D Gareth Evans Chantal Farra Ulrike Faust Ute Felbor Irene Feroce Miriam Fine William D Foulkes Henrique C R Galvao Gaetana Gambino Andrea Gehrig Francesca Gensini Anne-Marie Gerdes Aldo Germani Jutta Giesecke Viviana Gismondi Carolina Gómez Encarna B Gómez Garcia Sara González Elia Grau Sabine Grill Eva Gross Aliana Guerrieri-Gonzaga Marine Guillaud-Bataille Sara Gutiérrez-Enríquez Thomas Haaf Karl Hackmann Thomas V O Hansen Marion Harris Jan Hauke Tilman Heinrich Heide Hellebrand Karen N Herold Ellen Honisch Judit Horvath Claude Houdayer Verena Hübbel Silvia Iglesias Angel Izquierdo Paul A James Linda A M Janssen Udo Jeschke Silke Kaulfuß Katharina Keupp Marion Kiechle Alexandra Kölbl Sophie Krieger Torben A Kruse Anders Kvist Fiona Lalloo Mirjam Larsen Vanessa L Lattimore Charlotte Lautrup Susanne Ledig Elena Leinert Alexandra L Lewis Joanna Lim Markus Loeffler Adrià López-Fernández Emanuela Lucci-Cordisco Nicolai Maass Siranoush Manoukian Monica Marabelli Laura Matricardi Alfons Meindl Rodrigo D Michelli Setareh Moghadasi Alejandro Moles-Fernández Marco Montagna Gemma Montalban Alvaro N Monteiro Eva Montes Luigi Mori Lidia Moserle Clemens R Müller Christoph Mundhenke Nadia Naldi Katherine L Nathanson Matilde Navarro Heli Nevanlinna Cassandra B Nichols Dieter Niederacher Henriette R Nielsen Kai-Ren Ong Nicholas Pachter Edenir I Palmero Laura Papi Inge Sokilde Pedersen Bernard Peissel Pedro Perez-Segura Katharina Pfeifer Marta Pineda Esther Pohl-Rescigno Nicola K Poplawski Berardino Porfirio Anne S Quante Juliane Ramser Rui M Reis Françoise Revillion Kerstin Rhiem Barbara Riboli Julia Ritter Daniela Rivera Paula Rofes Andreas Rump Monica Salinas Ana María Sánchez de Abajo Gunnar Schmidt Ulrike Schoenwiese Jochen Seggewiß Ares Solanes Doris Steinemann Mathias Stiller Dominique Stoppa-Lyonnet Kelly J Sullivan Rachel Susman Christian Sutter Sean V Tavtigian Soo H Teo Alex Teulé Mads Thomassen Maria Grazia Tibiletti Marc Tischkowitz Silvia Tognazzo Amanda E Toland Eva Tornero Therese Törngren Sara Torres-Esquius Angela Toss Alison H Trainer Katherine M Tucker Christi J van Asperen Marion T van Mackelenbergh Liliana Varesco Gardenia Vargas-Parra Raymonda Varon Ana Vega Ángela Velasco Anne-Sophie Vesper Alessandra Viel Maaike P G Vreeswijk Sebastian A Wagner Anke Waha Logan C Walker Rhiannon J Walters Shan Wang-Gohrke Bernhard H F Weber Wilko Weichert Kerstin Wieland Lisa Wiesmüller Isabell Witzel Achim Wöckel Emma R Woodward Silke Zachariae Valentina Zampiga Christine Zeder-Göß KConFab Investigators Conxi Lázaro Arcangela De Nicolo Paolo Radice Christoph Engel Rita K Schmutzler David E Goldgar Amanda B Spurdle

Hum Mutat 2019 09;40(9):1557-1578

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1002/humu.23818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772163PMC
September 2019

Mass Spectrometry-Based Proteomics for Quantifying DNA Damage-Induced Phosphorylation.

Methods Mol Biol 2017 ;1599:215-227

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6955-5_16DOI Listing
February 2018

The experience of physicians in pharmacogenomic clinical decision support within eight German university hospitals.

Pharmacogenomics 2017 Jun 8;18(8):773-785. Epub 2017 Jun 8.

Chair of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.2217/pgs-2017-0027DOI Listing
June 2017

SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.

EMBO J 2016 09 15;35(17):1868-84. Epub 2016 Jun 15.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.15252/embj.201694300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007551PMC
September 2016

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.

Proc Natl Acad Sci U S A 2016 Apr 30;113(15):4039-44. Epub 2016 Mar 30.

Institute of Biochemistry II, Goethe University School of Medicine, 60590 Frankfurt, Germany; Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt, Germany; Institute of Immunology, School of Medicine, University of Split, 21 000 Split, Croatia

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http://dx.doi.org/10.1073/pnas.1523926113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839414PMC
April 2016

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.

Nat Commun 2015 Nov 30;6:10075. Epub 2015 Nov 30.

Ubiquitin Signaling Group, Protein Signaling Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen DK-2200, Denmark.

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http://dx.doi.org/10.1038/ncomms10075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674683PMC
November 2015

Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.

Mol Syst Biol 2015 Jun 2;11(6):810. Epub 2015 Jun 2.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501846PMC
http://dx.doi.org/10.15252/msb.20145880DOI Listing
June 2015

Acetylation site specificities of lysine deacetylase inhibitors in human cells.

Nat Biotechnol 2015 Apr 9;33(4):415-23. Epub 2015 Mar 9.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nbt.3130DOI Listing
April 2015

Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.

DNA Repair (Amst) 2015 Jan 25;25:84-96. Epub 2014 Nov 25.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, DK-2200 Copenhagen, Denmark; Molecular Oncology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.10.011DOI Listing
January 2015

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae.

Mol Syst Biol 2014 30;10:716. Epub 2014 Jan 30.

The NNF Center for Protein Research Faculty of Health Sciences University of Copenhagen, Copenhagen, Denmark.

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http://msb.embopress.org/cgi/doi/10.1002/msb.134766
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http://dx.doi.org/10.1002/msb.134766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023402PMC
September 2014

A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.

Genes Dev 2014 Sep 4;28(18):1977-82. Epub 2014 Sep 4.

The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom; The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom

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http://dx.doi.org/10.1101/gad.246272.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173157PMC
September 2014

Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation.

Cell Rep 2013 Aug 15;4(4):842-51. Epub 2013 Aug 15.

The NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.celrep.2013.07.024DOI Listing
August 2013

Acetyl-phosphate is a critical determinant of lysine acetylation in E. coli.

Mol Cell 2013 Jul 3;51(2):265-72. Epub 2013 Jul 3.

The NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molcel.2013.06.003DOI Listing
July 2013

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

J Cell Biol 2013 Jun;201(6):797-807

Ubiquitin Signaling Group, Department of Disease Biology, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1083/jcb.201212075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678163PMC
June 2013

Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.

PLoS One 2012 7;7(12):e50545. Epub 2012 Dec 7.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517600PMC
May 2013

Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.

Mol Cell Proteomics 2012 Dec 11;11(12):1578-85. Epub 2012 Jul 11.

Department of Proteomics, The NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/mcp.M112.017905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518112PMC
December 2012

Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.

Mol Cell Proteomics 2012 Nov 2;11(11):1510-22. Epub 2012 Aug 2.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/mcp.M112.017251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494197PMC
November 2012

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.

Nat Cell Biol 2012 Oct 23;14(10):1089-98. Epub 2012 Sep 23.

Ubiquitin Signaling Group, Department of Disease Biology, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://www.nature.com/articles/ncb2579
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http://dx.doi.org/10.1038/ncb2579DOI Listing
October 2012

Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.

Mol Cell 2012 Apr 15;46(2):212-25. Epub 2012 Mar 15.

The NNF Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molcel.2012.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565437PMC
April 2012

A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.

Mol Cell Proteomics 2011 Oct 1;10(10):M111.013284. Epub 2011 Sep 1.

Department of Proteomics, The NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/mcp.M111.013284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205876PMC
October 2011

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

Genome Biol 2011 Aug 18;12(8):R78. Epub 2011 Aug 18.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1186/gb-2011-12-8-r78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245618PMC
August 2011

Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.

Sci Signal 2011 Jul 26;4(183):ra48. Epub 2011 Jul 26.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2001902
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http://dx.doi.org/10.1126/scisignal.2001902DOI Listing
July 2011

[Agreement between clinical evaluation and structured clinical interviews (SCID for DSM-IV) in morbidly obese pre-bariatric surgery patients].

Psychother Psychosom Med Psychol 2010 Dec 16;60(12):469-73. Epub 2010 Apr 16.

Universitätsklinikum Erlangen, Abteilung Psychosomatische Medizin und Psychotherapie.

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http://dx.doi.org/10.1055/s-0030-1252003DOI Listing
December 2010