Publications by authors named "Sebastián Bernard"

2 Publications

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[Prognostic value of interim PET/CT in non-hodgkin lymphoma].

Rev Med Chil 2020 Nov;148(11):1558-1567

Departamento de Hemato-oncología y Jefe de Banco de Sangre, Clínica Las Condes, Santiago, Chile.

Background: The prognosis of Non-Hodgkin Lymphoma (NHL) depends on the type of lymphoma, the extension of the disease and the response to therapy.

Aim: To evaluate the prognostic value of pretreatment and interim PET/CT compared to classic prognosis factors and body composition measurement (sarcopenia, adipopenia) in patients with recently diagnosed NHL.

Material And Methods: Patients with recently diagnosed NHL who had staging 18F-FDG PET/CT performed between December 2008 and August 2018 were selected. Age, gender, weight, height, B symptoms, laboratory tests, pathology, staging PET/CT findings (Ann Arbor, number of nodal groups and extranodal sites involved, Bulky, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis), Computed Tomography findings (psoas muscle mass index, psoas area, psoas density, subcutaneous fat index (all of them at L3 level), and Deauville score (Lugano Criteria) were recorded. The prognostic value of each of these factors was assessed using Cox multivariable regressions.

Results: Of 138 NHL studied patients (median 61 y, 15-87 y, 60.4% men), 31 of them died due to the disease. The median follow-up was 39 months (1-115 months). The strongest prognostic factors were: B symptoms (p < 0.01), anemia (p < 0.01), hypoalbuminemia (p: 0.01), sarcopenia (p < 0.01), adipopenia (p < 0.01), number of node groups involved (p < 0.01), MTV (p < 0.01), and a bad response in interim PET/CT (p < 0.01). In a comparative Cox multivariable analysis, interim PET/CT was the independent variable with the highest significance (p < 0.01).

Conclusions: Early treatment response assessed by interim PET/CT is the strongest prognostic factor in NHL patients.
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http://dx.doi.org/10.4067/S0034-98872020001101558DOI Listing
November 2020

Two-part implant abutments with titanium and ceramic components: Surface modification affects retention forces-An in-vitro study.

Clin Oral Implants Res 2019 Sep 21;30(9):903-909. Epub 2019 Jul 21.

Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.

Objectives: Two-part abutments consist of titanium base and ceramic coping. Their long-term success is largely determined by the mechanical stability. The aim of the present study was to investigate the retention forces of two-part implant abutments. The study included zirconia and lithium disilicate ceramics copings, with different surface treatments and resin-based luting agents.

Material And Methods: The analysis of retention forces was based on a total of 70 test specimens. Seven surface modifications and three resin-based luting agents were employed for the bonding of components in the seven groups (n = 70). All surfaces of titanium bases-except for a control-were pretreated with aluminum oxide blasting, either alone or in combination with surface activating primers. Surfaces of ceramic copings were also treated mechanically by sandblasting, either alone or with acid etching or different primers. All specimens underwent thermal aging (10 cycles, 5°C/55°C). The retention forces between the two parts were measured with a pull-off test. The results were analyzed by two-way ANOVA statistics. Fracture patterns were evaluated by light and scanning electron microscopy.

Results: No mechanical pretreatment of the titanium (group 2) base resulted in the lowest retention. The combination with Monobond plus leads to the highest pull-off forces for both ceramic materials.

Conclusions: Surface modifications and resin-based agents influence the retention of components of two-part abutments. Lithium disilicate ceramic copings reached comparable results of retention to the typically used zirconia copings.
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http://dx.doi.org/10.1111/clr.13495DOI Listing
September 2019