Sean P Sheehy

Sean P Sheehy

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Sean P Sheehy

Sean P Sheehy

Publications by authors named "Sean P Sheehy"

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A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Nat Biotechnol 2018 10 20;36(9):865-874. Epub 2018 Aug 20.

Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.4226DOI Listing
October 2018

Traction force microscopy of engineered cardiac tissues.

PLoS One 2018 28;13(3):e0194706. Epub 2018 Mar 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194706PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874032PMC
July 2018

Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications.

Biofabrication 2018 01 16;10(2):025004. Epub 2018 Jan 16.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United States of America.

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http://dx.doi.org/10.1088/1758-5090/aa96deDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221195PMC
January 2018

Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes.

Exp Biol Med (Maywood) 2017 11 26;242(17):1643-1656. Epub 2017 Mar 26.

1 Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard Stem Cell Institute, and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1177/1535370217701006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786366PMC
November 2017

JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.

Biomaterials 2017 07 18;133:229-241. Epub 2017 Apr 18.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526340PMC
July 2017

Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model.

Biomaterials 2017 04 23;122:48-62. Epub 2016 Nov 23.

Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland; Wyss Translational Center Zurich, ETH and University of Zurich, Zurich, Switzerland; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2016.11.029DOI Listing
April 2017

Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip.

J Neurophysiol 2017 03 28;117(3):1320-1341. Epub 2016 Dec 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts; and

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http://www.physiology.org/doi/10.1152/jn.00575.2016
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http://dx.doi.org/10.1152/jn.00575.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350271PMC
March 2017

Mechanotransduction and Metabolism in Cardiomyocyte Microdomains.

Biomed Res Int 2016 4;2016:4081638. Epub 2016 Dec 4.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

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https://www.hindawi.com/journals/bmri/2016/4081638/
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http://dx.doi.org/10.1155/2016/4081638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164897PMC
February 2017

Angiotensin II Induced Cardiac Dysfunction on a Chip.

PLoS One 2016 25;11(1):e0146415. Epub 2016 Jan 25.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725954PMC
July 2016

Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

J Cell Biol 2016 Feb 8;212(4):389-97. Epub 2016 Feb 8.

Disease Biophysics Group, Wyss Institute of Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138

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http://diseasebiophysics.seas.harvard.edu/wp-content/uploads
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http://www.jcb.org/lookup/doi/10.1083/jcb.201508026
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http://dx.doi.org/10.1083/jcb.201508026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754718PMC
February 2016

Fibrous scaffolds for building hearts and heart parts.

Adv Drug Deliv Rev 2016 Jan 4;96:83-102. Epub 2015 Dec 4.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X150028
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http://dx.doi.org/10.1016/j.addr.2015.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807693PMC
January 2016

Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes.

Exp Biol Med (Maywood) 2015 Nov 23;240(11):1543-54. Epub 2015 Apr 23.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

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http://dx.doi.org/10.1177/1535370215583799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778402PMC
November 2015

Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes.

Stem Cell Reports 2013 7;1(5):387-96. Epub 2013 Nov 7.

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA ; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA ; Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(13)0009
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http://linkinghub.elsevier.com/retrieve/pii/S221367111300098
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http://dx.doi.org/10.1016/j.stemcr.2013.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841251PMC
October 2015

The structure-function relationships of a natural nanoscale photonic device in cuttlefish chromatophores.

J R Soc Interface 2014 Apr 29;11(93):20130942. Epub 2014 Jan 29.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, , Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1098/rsif.2013.0942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928930PMC
April 2014

Quality metrics for stem cell-derived cardiac myocytes.

Stem Cell Reports 2014 Mar 6;2(3):282-94. Epub 2014 Mar 6.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering and School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22136711140003
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http://dx.doi.org/10.1016/j.stemcr.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964283PMC
March 2014

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9770-5. Epub 2013 May 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1304913110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683774PMC
June 2013

Myocyte shape regulates lateral registry of sarcomeres and contractility.

Am J Pathol 2012 Dec;181(6):2030-7

Disease Biophysics Group, Wyss Institute for Biologically-Inspired Engineering, and the Harvard Stem Cell Institute, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.08.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509763PMC
December 2012

The contribution of cellular mechanotransduction to cardiomyocyte form and function.

Biomech Model Mechanobiol 2012 Nov 7;11(8):1227-39. Epub 2012 Jul 7.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Pierce Hall Rm. 321, 29 Oxford St., Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s10237-012-0419-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786397PMC
November 2012

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.

Biomaterials 2012 Aug 15;33(23):5732-41. Epub 2012 May 15.

Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute of Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2012.04.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026933PMC
August 2012

Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.

Exp Biol Med (Maywood) 2011 Mar 17;236(3):366-73. Epub 2011 Feb 17.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering & Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1258/ebm.2010.010239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501496PMC
March 2011

Self-organization of muscle cell structure and function.

PLoS Comput Biol 2011 Feb 24;7(2):e1001088. Epub 2011 Feb 24.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.

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https://dx.plos.org/10.1371/journal.pcbi.1001088
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http://dx.doi.org/10.1371/journal.pcbi.1001088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044763PMC
February 2011

Nuclear morphology and deformation in engineered cardiac myocytes and tissues.

Biomaterials 2010 Jul 10;31(19):5143-50. Epub 2010 Apr 10.

Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, 29 Oxford St (Rm 322A), Cambridge, MA 02138, United States.

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http://dx.doi.org/10.1016/j.biomaterials.2010.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416473PMC
July 2010

Biohybrid thin films for measuring contractility in engineered cardiovascular muscle.

Biomaterials 2010 May 9;31(13):3613-21. Epub 2010 Feb 9.

Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2010.01.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838170PMC
May 2010

Control of myocyte remodeling in vitro with engineered substrates.

In Vitro Cell Dev Biol Anim 2009 Jul-Aug;45(7):343-50. Epub 2009 Feb 28.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s11626-009-9182-9DOI Listing
November 2009

Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy.

Circ Cardiovasc Genet 2009 Apr 18;2(2):116-24. Epub 2009 Feb 18.

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.806935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731432PMC
April 2009

Sarcomere alignment is regulated by myocyte shape.

Cell Motil Cytoskeleton 2008 Aug;65(8):641-51

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://doi.wiley.com/10.1002/cm.20290
Publisher Site
http://dx.doi.org/10.1002/cm.20290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492320PMC
August 2008