Publications by authors named "Sean J Morrison"

100Publications

Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target.

Cell Rep 2020 Oct;33(2):108252

Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address:

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October 2020

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.

Nature 2020 02 12;578(7796):605-609. Epub 2020 Feb 12.

Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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February 2020

Evaluation of Xie et al.: Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.

Cell Stem Cell 2019 11;25(5):585-586

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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November 2019

TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling.

Cell Rep 2019 08;28(9):2293-2305.e9

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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August 2019

Metabolic Adaptation Fuels Lymph Node Metastasis.

Cell Metab 2019 04;29(4):785-786

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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April 2019

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow.

Cell Stem Cell 2019 03 17;24(3):477-486.e6. Epub 2019 Jan 17.

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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March 2019

Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.

Elife 2019 01 11;8. Epub 2019 Jan 11.

Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.

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January 2019

The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.

Sci Adv 2017 11 1;3(11):eaao5268. Epub 2017 Nov 1.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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November 2017

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.

Nature 2017 09 21;549(7673):476-481. Epub 2017 Aug 21.

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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September 2017

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.

Nat Cell Biol 2017 Aug 17;19(8):891-903. Epub 2017 Jul 17.

Department of Pediatrics and Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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August 2017

Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells.

Genes Dev 2017 06 11;31(11):1134-1146. Epub 2017 Jul 11.

Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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June 2017

Adult haematopoietic stem cell niches.

Nat Rev Immunol 2017 Sep 12;17(9):573-590. Epub 2017 Jun 12.

Children's Research Institute, University of Texas Southwestern Medical Center.

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September 2017

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients.

Neoplasia 2017 04 6;19(4):255-260. Epub 2017 Mar 6.

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX.

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April 2017

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.

Cell Rep 2017 01;18(4):947-960

Department of Internal Medicine, Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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January 2017

Cancer, Oxidative Stress, and Metastasis.

Cold Spring Harb Symp Quant Biol 2016 12;81:163-175. Epub 2017 Jan 12.

Department of Pediatrics, Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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February 2018

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.

Elife 2016 12 13;5. Epub 2016 Dec 13.

Department of Pediatrics and Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.

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December 2016

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.

Genes Dev 2016 08 4;30(15):1698-703. Epub 2016 Aug 4.

Howard Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;

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August 2016

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow.

Cell Stem Cell 2016 06 24;18(6):782-796. Epub 2016 Mar 24.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics and Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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June 2016

A perisinusoidal niche for extramedullary haematopoiesis in the spleen.

Nature 2015 Nov 16;527(7579):466-471. Epub 2015 Nov 16.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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November 2015

Oxidative stress inhibits distant metastasis by human melanoma cells.

Nature 2015 Nov 14;527(7577):186-91. Epub 2015 Oct 14.

Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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November 2015

Precise let-7 expression levels balance organ regeneration against tumor suppression.

Elife 2015 Oct 7;4:e09431. Epub 2015 Oct 7.

Children's Research Institute, Departments of Pediatrics and Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, United States.

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October 2015

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.

Nature 2015 Oct 23;526(7571):126-30. Epub 2015 Sep 23.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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October 2015

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.

Cancer Cell 2015 Jun;27(6):755-68

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address:

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June 2015

Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

Carcinogenesis 2015 Jul 4;36(7):730-8. Epub 2015 May 4.

Department of Surgery, Program in Cell and Molecular Biology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA and

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July 2015

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1.

Elife 2015 Mar 30;4:e05521. Epub 2015 Mar 30.

Department of Pediatrics and Children's Research Institute, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States.

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March 2015

Time to do something about reproducibility.

Authors:
Sean J Morrison

Elife 2014 Dec 10;3. Epub 2014 Dec 10.

Sean J Morrisonis an Investigator of the Howard Hughes Medical Institute, and Director of the Children's Research Institute at the University of Texas Southwestern Medical Center, Dallas, USA. He is also the Mary McDermott Cook Chair in Pediatric Genetics and Director of the Hamon Laboratory for Stem Cells and Cancer at UTSW, and a Cancer Prevention and Research Institute of Texas Scholar

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December 2014

Cellular differences in protein synthesis regulate tissue homeostasis.

Cell 2014 Oct;159(2):242-51

Howard Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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October 2014

Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow.

Cell Stem Cell 2014 Aug 19;15(2):154-68. Epub 2014 Jun 19.

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute. Electronic address:

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August 2014

Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling.

Cell Host Microbe 2014 Jun 29;15(6):779-91. Epub 2014 May 29.

Department of Pathology and Comprehensive Cancer Center, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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June 2014

Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.

Elife 2014 May 7;3:e02669. Epub 2014 May 7.

Department of Pediatrics, Children's Research Institute, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States

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May 2014

Haematopoietic stem cells require a highly regulated protein synthesis rate.

Nature 2014 May 9;509(7498):49-54. Epub 2014 Mar 9.

Howard Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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May 2014

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.

Nature 2014 Jan;505(7484):555-8

Howard Hughes Medical Institute, Department of Pediatrics, and Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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January 2014

The bone marrow niche for haematopoietic stem cells.

Nature 2014 Jan;505(7483):327-34

Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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January 2014

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.

Nature 2013 Dec 27;504(7478):143-147. Epub 2013 Nov 27.

Howard Hughes Medical Institute, Department of Pediatrics, and Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

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December 2013

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.

Elife 2013 Nov 5;2:e00924. Epub 2013 Nov 5.

Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, United States.

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November 2013

Tumour heterogeneity and cancer cell plasticity.

Nature 2013 Sep;501(7467):328-37

Howard Hughes Medical Institute, Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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September 2013

SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors.

Cell Stem Cell 2013 Jul;13(1):102-16

Children's Medical Center Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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July 2013

Inhibition of AMPK catabolic action by GSK3.

Mol Cell 2013 May 25;50(3):407-19. Epub 2013 Apr 25.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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May 2013

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches.

Nature 2013 Mar 24;495(7440):231-5. Epub 2013 Feb 24.

Howard Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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March 2013

Mechanisms that regulate stem cell aging and life span.

Cell Stem Cell 2013 Feb;12(2):152-65

Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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February 2013

Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice.

J Clin Invest 2013 Jan 17;123(1):418-31. Epub 2012 Dec 17.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

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January 2013

Human melanoma metastasis in NSG mice correlates with clinical outcome in patients.

Sci Transl Med 2012 Nov;4(159):159ra149

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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November 2012

Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.

Cell Stem Cell 2012 Sep;11(3):415-28

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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September 2012

Cancer stem cells: impact, heterogeneity, and uncertainty.

Cancer Cell 2012 Mar;21(3):283-96

Howard Hughes Medical Institute, Children's Research Institute, and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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March 2012

Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions.

Cancer Cell 2012 Feb;21(2):240-52

Department of Internal Medicine, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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February 2012

Endothelial and perivascular cells maintain haematopoietic stem cells.

Nature 2012 Jan 25;481(7382):457-62. Epub 2012 Jan 25.

Howard Hughes Medical Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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January 2012

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut.

J Clin Invest 2011 Sep 25;121(9):3398-411. Epub 2011 Aug 25.

Center for Stem Cell Biology, Howard Hughes Medical Institute, and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

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September 2011

Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors.

Genes Dev 2011 Aug;25(15):1613-27

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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August 2011

Integrating physiological regulation with stem cell and tissue homeostasis.

Neuron 2011 May;70(4):703-18

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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May 2011

HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells.

Cell Host Microbe 2011 Mar;9(3):223-234

Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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March 2011

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.

Blood 2011 Feb 16;117(5):1550-4. Epub 2010 Dec 16.

National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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February 2011

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

Nature 2010 Dec;468(7324):653-8

Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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December 2010

Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system.

J Neurosci 2010 Nov;30(45):15228-40

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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November 2010

mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.

Cell Stem Cell 2010 Nov;7(5):593-605

Howard Hughes Medical Institute, Center for Stem Cell Biology, Life Sciences Institute, and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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November 2010

Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress.

Nat Cell Biol 2010 Oct 12;12(10):999-1006. Epub 2010 Sep 12.

Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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October 2010

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.

Blood 2010 Dec 17;116(23):4806-14. Epub 2010 Aug 17.

Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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December 2010

Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.

Development 2010 Sep 21;137(17):2829-39. Epub 2010 Jul 21.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, Canada.

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September 2010

An in vivo model to study and manipulate the hematopoietic stem cell niche.

Blood 2010 Apr 28;115(13):2592-600. Epub 2010 Jan 28.

Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

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April 2010

Heterogeneity in cancer: cancer stem cells versus clonal evolution.

Cell 2009 Sep;138(5):822-9

Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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September 2009

Mechanisms of stem cell self-renewal.

Annu Rev Cell Dev Biol 2009 ;25:377-406

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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January 2010

Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.

Dev Biol 2009 Apr 27;328(2):257-72. Epub 2009 Jan 27.

Howard Hughes Medical Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, 5435 Life Sciences Institute, 210 Washtenaw Ave., Ann Arbor, MI 48109-2216, USA.

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April 2009

Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance.

Cell Stem Cell 2009 Feb;4(2):170-9

Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109-2216, USA.

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February 2009

Efficient tumour formation by single human melanoma cells.

Nature 2008 Dec;456(7222):593-8

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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December 2008

Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.

Blood 2009 Feb 29;113(8):1670-80. Epub 2008 Oct 29.

Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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February 2009

Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.

Cell 2008 Oct;135(2):227-39

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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October 2008

The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells.

Blood Cells Mol Dis 2008 Jul-Aug;41(1):73-6. Epub 2008 Apr 2.

Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109-2216, USA.

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August 2008

Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance.

Cell Stem Cell 2007 Aug;1(2):204-17

Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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August 2007

Uncertainty in the niches that maintain haematopoietic stem cells.

Nat Rev Immunol 2008 Apr 7;8(4):290-301. Epub 2008 Mar 7.

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan, 48109-2216, USA.

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April 2008

Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

Cell 2008 Feb;132(4):598-611

Howard Hughes Medical Institute, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI, 48109-2216, USA.

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February 2008

The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.

Cancer Cell 2008 Feb;13(2):129-40

Center for Stem Cell Biology, Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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February 2008

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.

Nature 2007 Sep 29;449(7159):238-42. Epub 2007 Aug 29.

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Centre for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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September 2007

Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells.

Cell 2007 Aug 26;130(3):470-83. Epub 2007 Jul 26.

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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August 2007

Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.

Development 2007 Jul 30;134(13):2435-47. Epub 2007 May 30.

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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July 2007

Maintaining hematopoietic stem cells in the vascular niche.

Immunity 2006 Dec;25(6):862-4

Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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December 2006

Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system.

Dev Biol 2007 Mar 24;303(1):1-15. Epub 2006 Oct 24.

Department of Internal Medicine, Center for Stem Cell Biology, Howard Hughes Medical Institute, 3435 Life Sciences Institute, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA.

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March 2007

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.

Nature 2006 Sep 6;443(7110):448-52. Epub 2006 Sep 6.

Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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September 2006

Asymmetric and symmetric stem-cell divisions in development and cancer.

Nature 2006 Jun;441(7097):1068-74

Howard Hughes Medical Institute and Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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June 2006

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.

Nature 2006 May 5;441(7092):475-82. Epub 2006 Apr 5.

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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May 2006

Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors.

Blood 2006 Jul 28;108(2):737-44. Epub 2006 Mar 28.

Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.

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July 2006

SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.

Blood 2006 Feb 11;107(3):924-30. Epub 2005 Oct 11.

Howard Hughes Medical Institute, Department of Internal Medicine, Ann Arbor, MI, USA.

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February 2006

Cancer stem cells.

Authors:
Sean J Morrison

Clin Adv Hematol Oncol 2005 Mar;3(3):171-2

University of Michigan, MI, USA.

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March 2005

Toward an understanding of the physiological function of Mammalian stem cells.

Dev Cell 2005 Aug;9(2):173-83

Howard Hughes Medical Institute and Department of Internal Medicine , 1500 East Medical Center Drive, University of Michigan, Ann Arbor, MI 48109, USA.

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August 2005

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells.

Cell 2005 Jul;121(7):1109-21

Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.

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July 2005

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

Genes Dev 2005 Jun;19(12):1432-7

Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109-0934, USA.

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June 2005