Scott T Weiss

Scott T Weiss

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Biobanks could identify medically actionable findings relevant for COVID-19 clinical care.

Nat Med 2020 07;26(7):991

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41591-020-0953-xDOI Listing
July 2020

An ecological framework to understand the efficacy of fecal microbiota transplantation.

Nat Commun 2020 Jul 3;11(1):3329. Epub 2020 Jul 3.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-020-17180-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334230PMC
July 2020

Age and morphology of posterior communicating artery aneurysms.

Sci Rep 2020 Jul 14;10(1):11545. Epub 2020 Jul 14.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-020-68276-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360743PMC
July 2020

Vitamin D Sufficiency Has a Limited Effect on Placental Structure and Pathology: Placental Phenotypes in the VDAART Trial.

Endocrinology 2020 Jun;161(6)

Department of Obstetrics & Gynecology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.

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http://dx.doi.org/10.1210/endocr/bqaa057DOI Listing
June 2020

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.

Eur Respir J 2020 Jun 1. Epub 2020 Jun 1.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1183/13993003.02347-2019DOI Listing
June 2020

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.

J Am Coll Cardiol 2020 Jun;75(22):2769-2780

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346975PMC
June 2020

Sequencing and imputation in GWAS: Cost-effective strategies to increase power and genomic coverage across diverse populations.

Genet Epidemiol 2020 Jun 9. Epub 2020 Jun 9.

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/gepi.22326DOI Listing
June 2020

Stability of developmental status and risk of impairment at 24 and 36 months in late preterm infants.

Infant Behav Dev 2020 Jun 26;60:101462. Epub 2020 Jun 26.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Partners Center for Personalized Medicine, Partners Health Care, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.infbeh.2020.101462DOI Listing
June 2020

Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth.

PLoS One 2020 29;15(1):e0227193. Epub 2020 Jan 29.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988958PMC
May 2020

Understanding the Molecular Mechanisms of Asthma through Transcriptomics.

Allergy Asthma Immunol Res 2020 May;12(3):399-411

The Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.4168/aair.2020.12.3.399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061151PMC
May 2020

Metabolome-Microbiome Crosstalk and Human Disease.

Metabolites 2020 May 1;10(5). Epub 2020 May 1.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/metabo10050181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281736PMC
May 2020

Predicting miRNA-based disease-disease relationships through network diffusion on multi-omics biological data.

Sci Rep 2020 May 26;10(1):8705. Epub 2020 May 26.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-020-65633-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251138PMC
May 2020

Determinants and Measurement of Neonatal Vitamin D: Overestimation of 25(OH)D in Cord Blood Using CLIA Assay Technology.

J Clin Endocrinol Metab 2020 Apr;105(4)

Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1210/clinem/dgz299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065842PMC
April 2020

Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes.

J Allergy Clin Immunol Pract 2020 Mar 5;8(3):1100-1102.e13. Epub 2019 Sep 5.

Division of Pediatric Pulmonary Medicine, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, NY.

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http://dx.doi.org/10.1016/j.jaip.2019.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056490PMC
March 2020

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Genome Med 2020 03 2;12(1):25. Epub 2020 Mar 2.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13073-020-0716-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050134PMC
March 2020

Gut Microbial-Derived Metabolomics of Asthma.

Metabolites 2020 Mar 6;10(3). Epub 2020 Mar 6.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/metabo10030097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142494PMC
March 2020

Real-Life Patterns of Exacerbations While on Inhaled Corticosteroids and Long-Acting Beta Agonists for Asthma over 15 Years.

J Clin Med 2020 Mar 18;9(3). Epub 2020 Mar 18.

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/jcm9030819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141292PMC
March 2020

Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction.

N Engl J Med 2020 02;382(6):525-533

From the Division of Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, NY (A.A.L.); the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital (V.J.C., N.L., B.J.S., H.M., S.T.W.), Harvard Medical School (V.J.C., H.M., S.T.W.), the Pulmonary Center, Department of Medicine, Boston University School of Medicine (G.T.O.), and the Department of Pediatrics, Boston Medical Center (M. Sandel) - all in Boston; the Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis (A.B., L.B.B.); Kaiser Permanente Southern California, San Diego (R.S.Z., M. Schatz); and the Department of Pediatrics, Medical University of South Carolina, Charleston (B.W.H.).

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http://dx.doi.org/10.1056/NEJMoa1906137DOI Listing
February 2020

Fish oil supplementation during pregnancy is protective against asthma/wheeze in offspring.

J Allergy Clin Immunol Pract 2020 01 19;8(1):388-391.e2. Epub 2019 Jun 19.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.05.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087445PMC
January 2020

Allergic disease and low ASQ communication score in children.

Brain Behav Immun 2020 01 10;83:293-297. Epub 2019 Oct 10.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.bbi.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906237PMC
January 2020

deconvSeq: deconvolution of cell mixture distribution in sequencing data.

Bioinformatics 2019 12;35(24):5095-5102

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz444DOI Listing
December 2019

Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma.

Clin Pharmacol Ther 2019 12 28;106(6):1261-1267. Epub 2019 Oct 28.

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.1646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851426PMC
December 2019

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

PLoS Genet 2019 12 23;15(12):e1008500. Epub 2019 Dec 23.

Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953885PMC
December 2019

The Association of Maternal Asthma and Early Pregnancy Vitamin D with Risk of Preeclampsia: An Observation From Vitamin D Antenatal Asthma Reduction Trial (VDAART).

J Allergy Clin Immunol Pract 2018 Mar - Apr;6(2):600-608.e2. Epub 2017 Sep 8.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass; Partners Center for Personalized Medicine, Partners Health Care, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2017.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843492PMC
November 2019

Vital Considerations for Aspirin in Prevention of Preeclampsia, a Multifaceted Pregnancy Disorder.

JAMA Pediatr 2019 Nov 4. Epub 2019 Nov 4.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamapediatrics.2019.4018DOI Listing
November 2019

DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics.

Clin Exp Allergy 2019 09 15;49(9):1225-1234. Epub 2019 Aug 15.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/cea.13447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085934PMC
September 2019

Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.

Metabolites 2019 Sep 7;9(9). Epub 2019 Sep 7.

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/metabo9090179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780678PMC
September 2019

Integrative analysis of the intestinal metabolome of childhood asthma.

J Allergy Clin Immunol 2019 08 23;144(2):442-454. Epub 2019 Mar 23.

Division of Pediatric Pulmonary Medicine, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688902PMC
August 2019

Fish-oil supplementation in pregnancy, child metabolomics and asthma risk.

EBioMedicine 2019 Aug 6;46:399-410. Epub 2019 Aug 6.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.07.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712349PMC
August 2019

Network Diffusion Approach to Predict LncRNA Disease Associations Using Multi-Type Biological Networks: LION.

Front Physiol 2019 16;10:888. Epub 2019 Jul 16.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fphys.2019.00888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646690PMC
July 2019

Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.

J Allergy Clin Immunol 2019 06 6;143(6):2263-2270.e14. Epub 2019 Feb 6.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2019.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556426PMC
June 2019

Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children.

J Expo Sci Environ Epidemiol 2019 06 26;29(4):539-547. Epub 2019 Apr 26.

Channing Division of Network Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1038/s41370-019-0136-3DOI Listing
June 2019

Remission of persistent childhood asthma: Early predictors of adult outcomes.

J Allergy Clin Immunol 2019 05 14;143(5):1752-1759.e6. Epub 2018 Nov 14.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183159
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http://dx.doi.org/10.1016/j.jaci.2018.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061344PMC
May 2019

Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children.

Clin Exp Allergy 2019 04 3;49(4):419-429. Epub 2019 Jan 3.

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1111/cea.13320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438751PMC
April 2019

Gut microbiota and overweight in 3-year old children.

Int J Obes (Lond) 2019 04 19;43(4):713-723. Epub 2018 Dec 19.

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York, NY, USA.

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http://www.nature.com/articles/s41366-018-0290-z
Publisher Site
http://dx.doi.org/10.1038/s41366-018-0290-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457121PMC
April 2019

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.

J Allergy Clin Immunol 2019 04 20;143(4):1633-1635. Epub 2018 Dec 20.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183277
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2018.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451881PMC
April 2019

Network Medicine in the Age of Biomedical Big Data.

Front Genet 2019 11;10:294. Epub 2019 Apr 11.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.

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http://dx.doi.org/10.3389/fgene.2019.00294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470635PMC
April 2019

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.

J Allergy Clin Immunol 2019 03 7;143(3):957-969. Epub 2018 Sep 7.

Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif; Department of Medicine, University of California, San Francisco, San Francisco, Calif.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183127
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2016.08.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927816PMC
March 2019

Metabolomics and Communication Skills Development in Children; Evidence from the Ages and Stages Questionnaire.

Metabolites 2019 Mar 5;9(3). Epub 2019 Mar 5.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/metabo9030042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468693PMC
March 2019

Novel Data Transformations for RNA-seq Differential Expression Analysis.

Sci Rep 2019 03 18;9(1):4820. Epub 2019 Mar 18.

Channing Division of Network Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1038/s41598-019-41315-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423143PMC
March 2019

Expression network analysis reveals cord blood vitamin D-associated genes affecting risk of early life wheeze.

Thorax 2019 02 18;74(2):200-202. Epub 2018 Jul 18.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2018-211962DOI Listing
February 2019

Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood.

J Allergy Clin Immunol Pract 2019 02 24;7(2):529-538.e8. Epub 2018 Aug 24.

Division of Pediatric Pulmonary Medicine, Golisano Children's Hospital at University of Rochester Medical Center, Rochester, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400588PMC
February 2019

Impact of Preeclampsia on the Relationship between Maternal Asthma and Offspring Asthma. An Observation from the VDAART Clinical Trial.

Am J Respir Crit Care Med 2019 01;199(1):32-42

1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1164/rccm.201804-0770OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353019PMC
January 2019

Deep Learning Methods for Predicting Disease Status Using Genomic Data.

J Biom Biostat 2018 11;9(5). Epub 2018 Dec 11.

Channing Division of Network Medicine, Brigham and Women's Hospital/Harvard Medical School, 181 Longwood Avenue, Boston MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530791PMC
December 2018

Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.

Clin Exp Allergy 2018 12 21;48(12):1654-1664. Epub 2018 Nov 21.

Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/cea.13249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659730PMC
December 2018

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.

J Allergy Clin Immunol 2018 11 9;142(5):1469-1478.e2. Epub 2018 Jan 9.

Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037620PMC
November 2018

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma.

Pharmacogenomics J 2018 09 3;18(5):665-677. Epub 2018 Jan 3.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41397-017-0006-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150906PMC
September 2018

Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: A case-control study.

Neurology 2018 09 22;91(12):e1175-e1181. Epub 2018 Aug 22.

From the Department of Neurosurgery (A.C., R.F.R., R.D.), Brigham and Women's Hospital, Harvard Medical School; Research Information Systems and Computing (V.M.C., V.G., S.M.); Department of Medicine (S.Y., S.T.W.), Division of Rheumatology, Immunology and Allergy (N.A.S.), and Channing Division of Network Medicine (S.T.W., R.D.), Brigham and Women's Hospital, Boston, MA; Center for Statistical Science (S.Y.), Tsinghua University, Beijing, China; Boston Children's Hospital Informatics Program (D.D., S.F., G.S.), MA; Department of Computer Science (D.D.), Loyola University, Chicago, IL; Department of Neurology (S.M.), Massachusetts General Hospital; and Biostatistics (T.C.), Harvard T.H. Chan School of Public Health, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161553PMC
September 2018

Elevated International Normalized Ratio Is Associated With Ruptured Aneurysms.

Stroke 2018 09;49(9):2046-2052

From the Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.C., R.D.).

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http://dx.doi.org/10.1161/STROKEAHA.118.022412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205738PMC
September 2018

Heroin Use Is Associated with Ruptured Saccular Aneurysms.

Transl Stroke Res 2018 08 4;9(4):340-346. Epub 2017 Nov 4.

Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12975-017-0582-yDOI Listing
August 2018

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.

Chest 2018 08 13;154(2):335-348. Epub 2018 Jun 13.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.chest.2018.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689076PMC
August 2018

Prenatal and early-life triclosan and paraben exposure and allergic outcomes.

J Allergy Clin Immunol 2018 07 27;142(1):269-278.e15. Epub 2017 Oct 27.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2017.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924494PMC
July 2018

Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms.

Stroke 2018 07 29;49(7):1747-1750. Epub 2018 May 29.

From the Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.C., R.F.R., R.D.)

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http://dx.doi.org/10.1161/STROKEAHA.118.020963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019530PMC
July 2018

Detecting Differentially Variable MicroRNAs via Model-Based Clustering.

Int J Genomics 2018 12;2018:6591634. Epub 2018 Jul 12.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1155/2018/6591634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079429PMC
July 2018

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus.

J Allergy Clin Immunol 2018 06 31;141(6):2282-2286.e6. Epub 2018 Jan 31.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Pulmonary Genetics Center and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2017.11.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994185PMC
June 2018

A systems immunology approach identifies the collective impact of 5 miRs in Th2 inflammation.

JCI Insight 2018 06 7;3(11). Epub 2018 Jun 7.

Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany.

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http://dx.doi.org/10.1172/jci.insight.97503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124409PMC
June 2018

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.

Sci Rep 2018 06 11;8(1):8826. Epub 2018 Jun 11.

Icahn Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41598-018-27189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995932PMC
June 2018

Circulating microRNAs and prediction of asthma exacerbation in childhood asthma.

Respir Res 2018 06 26;19(1):128. Epub 2018 Jun 26.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0828-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020199PMC
June 2018

Reply.

J Allergy Clin Immunol 2018 02 21;141(2):829-830. Epub 2017 Nov 21.

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.08.035DOI Listing
February 2018

Antihyperglycemic Agents Are Inversely Associated With Intracranial Aneurysm Rupture.

Stroke 2018 01 4;49(1):34-39. Epub 2017 Dec 4.

From the Department of Neurosurgery (A.C., R.D.), Department of Medicine (S.Y., S.T.W.), Division of Rheumatology, Immunology, and Allergy (N.A.S.), and Channing Division of Network Medicine (S.T.W., R.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Research Information Systems and Computing, Partners Healthcare, Boston, MA (V.M.C., V.G., S.M.); Center for Statistical Science, Tsinghua University, Beijing, China (S.Y.); Computational Health Informatics Program, Boston Children's Hospital, MA (D.D., S.F., G.S.); Department of Computer Science, Loyola University, Chicago, IL (D.D.); Department of Neurology, Massachusetts General Hospital, Boston (S.M.); and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA (T.C.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019249DOI Listing
January 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Emerging mechanisms and novel targets in allergic inflammation and asthma.

Authors:
Scott T Weiss

Genome Med 2017 12 4;9(1):107. Epub 2017 Dec 4.

Harvard Medical School and Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s13073-017-0501-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713157PMC
December 2017

Mapping the ecological networks of microbial communities.

Nat Commun 2017 12 11;8(1):2042. Epub 2017 Dec 11.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-017-02090-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725606PMC
December 2017

Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length.

Eur J Obstet Gynecol Reprod Biol 2017 Nov 14;218:27-32. Epub 2017 Sep 14.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejogrb.2017.09.013DOI Listing
November 2017

Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y.

Am J Clin Nutr 2017 Oct 23;106(4):1092-1099. Epub 2017 Aug 23.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and

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http://dx.doi.org/10.3945/ajcn.117.158220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611786PMC
October 2017

Association of intracranial aneurysm rupture with smoking duration, intensity, and cessation.

Neurology 2017 Sep 30;89(13):1408-1415. Epub 2017 Aug 30.

From the Department of Neurosurgery (A.C., Y.H.O., S.D., R. Du), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurosurgery (A.C., R. Dammers), Erasmus Medical Center, Erasmus MC Stroke Center, Rotterdam, the Netherlands; Research Information Systems and Computing (V.M.C., V.G., S.M.), Partners Healthcare, Boston, MA; Center for Statistical Science (S.Y.), Tsinghua University, Beijing, China; Department of Medicine (S.Y., S.T.W.), Division of Rheumatology, Immunology and Allergy (N.A.S.), and Channing Division of Network Medicine (S.T.W., R. Du), Brigham and Women's Hospital, Boston, MA; Department of Computer Science (D.D.), Loyola University, Chicago, IL; Informatics Program (D.D., S.F., G.S.), Boston Children's Hospital; Department of Neurology (S.M.), Massachusetts General Hospital; and Biostatistics (T.C.), Harvard School of Public Health, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000004419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649762PMC
September 2017

A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor.

Sci Rep 2017 08 7;7(1):7405. Epub 2017 Aug 7.

Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/s41598-017-07565-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547123PMC
August 2017