Publications by authors named "Scott Snapper"

100Publications

An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe Immunodeficiency.

J Clin Immunol 2020 Oct 24;40(7):1010-1019. Epub 2020 Jul 24.

Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.

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http://dx.doi.org/10.1007/s10875-020-00829-zDOI Listing
October 2020

Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease.

Gastroenterology 2020 Aug 16;159(2):591-608.e10. Epub 2020 May 16.

Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital, Pittsburgh, Pennsylvania; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Developmental Biology University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.04.074DOI Listing
August 2020

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Cell 2020 05 27;181(5):1016-1035.e19. Epub 2020 Apr 27.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252096PMC
May 2020

16S rRNA sequencing analysis: the devil is in the details.

Gut Microbes 2020 09 24;11(5):1139-1142. Epub 2020 Apr 24.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital , Boston, MA, USA.

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http://dx.doi.org/10.1080/19490976.2020.1747336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524321PMC
September 2020

Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center.

Gastroenterology 2020 Jun 19;158(8):2208-2220. Epub 2020 Feb 19.

SickKids Inflammatory Bowel Disease Center, The Hospital for Sick Children, Toronto, Ontario, Canada; Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, Institute of Medical Science and Biochemistry, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283012PMC
June 2020

NASPGHAN Position Paper on The Evaluation and Management for Patients with Very Early-Onset Inflammatory Bowel Disease (VEO-IBD).

J Pediatr Gastroenterol Nutr 2019 Dec 30. Epub 2019 Dec 30.

Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/MPG.0000000000002567DOI Listing
December 2019

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.

Gastroenterology 2020 03 16;158(4):1000-1015. Epub 2019 Nov 16.

SickKids Inflammatory Bowel Disease Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, Institute of Medical Science and Biochemistry, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062591PMC
March 2020

Humanized mouse models of genetic immune disorders and hematological malignancies.

Biochem Pharmacol 2020 04 18;174:113671. Epub 2019 Oct 18.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050416PMC
April 2020

Aerodigestive sampling reveals altered microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function.

PLoS One 2019 20;14(5):e0216453. Epub 2019 May 20.

Aerodigestive Center, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216453PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527209PMC
January 2020

Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.

Cell Mol Gastroenterol Hepatol 2019 9;8(2):193-195. Epub 2019 May 9.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661391PMC
July 2020

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 04 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.devcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346PMC
April 2019

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.

Nat Commun 2019 02 22;10(1):912. Epub 2019 Feb 22.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-019-08743-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385318PMC
February 2019

The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children.

Am J Gastroenterol 2018 10 28;113(10):1524-1529. Epub 2018 Sep 28.

Division of Pediatric Gastroenterology, Emory University School of Medicine, Atlanta, GA, USA. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Medical College of Wisconsin, Milwaukee, WI, USA. Department of Pediatric Gastroenterology, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH, USA. Department of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, MA, USA. Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Department of Pediatrics, Goryeb Children's Hospital, Morristown, NJ, USA. Division of Pediatric Gastroenterology, Hasbro Children's Hospital/The Rhode Island Hospital, Providence, RI, USA. Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. Department of Pediatrics, Children's Hospital of Eastern Ontario IBD Centre and University of Ottawa, Ottawa, ON, Canada. Section of Pediatric Gastroenterology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA. Department of Gastroenterology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. Children's Healthcare of Atlanta, Atlanta, GA, USA. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Department of Pediatrics, Dalhousie University, Halifax, NS, Canada. Department of Digestive Diseases and Nutrition Center, University at Buffalo, Buffalo, NY, USA. Department of Pediatrics, Nemours Children's Specialty Care, Jacksonville, FL, USA. Department of Pediatrics, University of Chicago Medicine Comer Children's Hospital, Chicago, IL, USA. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Department of Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, USA. Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. Department of Pediatrics, Mount Sinai Hospital, New York, NY, USA. Department of Pediatrics, Northwell Health, New York, NY, USA. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, CT, USA. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41395-018-0239-9DOI Listing
October 2018

The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies.

J Clin Immunol 2018 07 29;38(5):579-588. Epub 2018 Jun 29.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10875-018-0524-9DOI Listing
July 2018

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.

J Allergy Clin Immunol 2018 12 4;142(6):1932-1946. Epub 2018 May 4.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215742PMC
December 2018

The Impact of Combination Therapy on Infliximab Levels and Antibodies in Children and Young Adults With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 05;24(6):1344-1351

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1093/ibd/izy010DOI Listing
May 2018

Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier.

Cell Mol Gastroenterol Hepatol 2018 Mar 15;5(3):273-288. Epub 2017 Dec 15.

Division of Gastroenterology/Nutrition and Center for Inflammatory Bowel Disease Treatment and Research, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmgh.2017.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904039PMC
March 2018

An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning.

J Allergy Clin Immunol 2018 04 19;141(4):1354-1364.e9. Epub 2017 Dec 19.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425755PMC
April 2018

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.

Inflamm Bowel Dis 2017 11;23(11):1950-1961

1Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; 4VEO-IBD Consortium; 5Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts; 6Harvard Medical School, Boston, Massachusetts; 7Great Ormond Street Hospital London, London, England; 8Translational Gastroenterology Unit, University of Oxford, Oxford, England; 9Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida; 10Division of Gastroenterology and Nutrition, The Children's Hospital at Montefiore, Bronx, New York; 11Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 12Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan; 13Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; 14Department of Gastroenterology, Children's National Medical Center, Washington, DC; 15Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan; 16Hospital das Clınicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 17Division of Gastroenterology, McMaster Children's Hospital, West Hamilton, Ontario, Canada; 18Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany; 19Division of Pathology, Boston Children's Hospital, Boston, Massachusetts; 20Department of Pediatrics, University of Oxford, Oxford, England; 21Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; 22Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; 23Department of Biochemistry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; and 24Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000001270DOI Listing
November 2017

IL-10 induces a STAT3-dependent autoregulatory loop in T2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

Sci Immunol 2016 Oct 11;1(5). Epub 2016 Nov 11.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509416PMC
October 2016

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis.

N Engl J Med 2017 07 28;377(1):52-61. Epub 2017 Jun 28.

From the Section of Molecular Development of the Immune System, Laboratory of Immunology (A.O., W.A.C., A.R.M., H.F.M., M.J.L.), the Clinical Genomics Program (A.O., W.A.C., A.R.M., Y.Z., H.F.M., H.C.S., M.J.L.), and the Human Immunological Diseases Section, Laboratory of Host Defenses (Y.Z., H.C.S.), National Institute of Allergy and Infectious Diseases, the Laboratory of Pathology, National Cancer Institute (S.P.), and Radiology and Imaging Sciences, Clinical Center (L.R.F.), National Institutes of Health, Bethesda, MD; the Department of Pediatrics, Division of Allergy and Immunology (A.O., E.K.-A., S.B., A. Kiykim, I.O.), and the Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition (E.T., D.E.), Marmara University, Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases (A.O., E.K.-A., S.B., A. Kiykim, I.O.), and the Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, İstanbul University Cerrahpaşa Faculty of Medicine (Ö.F.B., T.E.), Istanbul, and the Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Gazi University (B.D., S.S.), the Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Başkent University (F.O., Z.B., M.G.), and the Pediatric Gastroenterology Clinic, Dr. Sami Ulus Children's Hospital (A.U.A.), Ankara - all in Turkey; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases and the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (R.C.A., C.D.C., N.K.S., A. Krolo, K.B.), Clinical Institute of Pathology (R.K.), the Department of Pediatrics and Adolescent Medicine (K.B.), and St. Anna Kinderspital and Children's Cancer Research Institute, Department of Pediatrics (K.B.), Medical University of Vienna, Vienna; Merck Research Laboratories (J.J.M.), and the Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Harvard Medical School (S.B.S.), Boston; and the Department of Pediatric Gastroenterology, University Medical Center-Wilhelmina Children's Hospital (R.H.J.H.), and the Department of Rheumatology and Clinical Immunology, University Medical Center (H.L.L.), Utrecht, the Netherlands.

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http://dx.doi.org/10.1056/NEJMoa1615887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690356PMC
July 2017

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Nature 2017 05 17;545(7655):432-438. Epub 2017 May 17.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature22370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872146PMC
May 2017

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.

Science 2017 05;356(6337):513-519

Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/science.aal3535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260791PMC
May 2017

Erratum to: Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing.

J Clin Immunol 2017 02;37(2):108

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 SWArcher Rd, PO Box 100214, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s10875-017-0368-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828329PMC
February 2017

Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice.

Gastroenterology 2017 04 11;152(5):1151-1160. Epub 2017 Jan 11.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368009PMC
April 2017

Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakin Treatment Suggests Further Mechanism for Mucosal Healing.

J Clin Immunol 2017 02 7;37(2):104-107. Epub 2017 Jan 7.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100214, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s10875-016-0365-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325838PMC
February 2017

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.

Cell Rep 2016 10;17(5):1318-1329

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106873PMC
October 2016

Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion.

Mol Hum Reprod 2016 09 11;22(9):613-21. Epub 2016 Jul 11.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China University of Chinese Academy of Sciences, Beijing 100101, P.R. China

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http://dx.doi.org/10.1093/molehr/gaw046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459223PMC
September 2016

Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2016 07;63(1):e15-7

*Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital †Department of Pediatrics ‡Department of Medicine, Harvard Medical School, Boston, MA §Division of Pediatric Hematology and Oncology ||Division of Pathology, University of Michigan, Ann Arbor, MI ¶SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute #Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada **Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany ††Division of Gastroenterology, Brigham and Women's Hospital ‡‡interNational Early Onset Paediatric IBD Cohort Study (NEOPICS), Boston, MA.

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http://dx.doi.org/10.1097/MPG.0000000000000532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605893PMC
July 2016

Very-Early-Onset Inflammatory Bowel Disease.

Authors:
Scott B Snapper

Gastroenterol Hepatol (N Y) 2015 Aug;11(8):554-6

Wolpow Family Chair in IBD Treatment and Research Director, Inflammatory Bowel Disease Center and Basic & Translational Research (Gastroenterology, Children's Hospital) Director, Inflammatory Bowel Disease Research (Gastroenterology, Brigham and Women's Hospital) Associate Professor of Medicine, Harvard Medical School Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843045PMC
August 2015

Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability.

FASEB J 2016 07 29;30(7):2557-69. Epub 2016 Mar 29.

Division of Pulmonary, Allergy, and Critical Care Medicine Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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http://dx.doi.org/10.1096/fj.201600102RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904290PMC
July 2016

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology 2016 05 4;150(5):1196-1207. Epub 2016 Feb 4.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085160012
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http://dx.doi.org/10.1053/j.gastro.2016.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842103PMC
May 2016

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.

Science 2015 Aug 13;349(6251):993-7. Epub 2015 Aug 13.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston 02115, MA, USA. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaa9420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700932PMC
August 2015

Very early-onset inflammatory bowel disease: gaining insight through focused discovery.

Inflamm Bowel Dis 2015 May;21(5):1166-75

*Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts; †Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; ‡Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany; §Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada; ‖SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; ¶Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts; **Division of Gastroenterology and Hepatology, Brigham & Women's Hospital, Boston, Massachusetts; and ††Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165626PMC
May 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

The diagnostic approach to monogenic very early onset inflammatory bowel disease.

Gastroenterology 2014 Nov 21;147(5):990-1007.e3. Epub 2014 Jul 21.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140091
Publisher Site
http://dx.doi.org/10.1053/j.gastro.2014.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376484PMC
November 2014

N-wasp is required for structural integrity of the blood-testis barrier.

PLoS Genet 2014 Jun 26;10(6):e1004447. Epub 2014 Jun 26.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072540PMC
June 2014

Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease.

Gastroenterology 2014 Oct 18;147(4):803-813.e7; quiz e14-5. Epub 2014 Jun 18.

Department of Paediatrics, University of Toronto, Toronto, Canada; SickKids Inflammatory Bowel Disease Center, Division of Gastroenterology Hepatology and Nutrition, Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2014.06.023DOI Listing
October 2014

Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease.

Gastroenterology 2014 Sep 12;147(3):680-689.e2. Epub 2014 Jun 12.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.06.005DOI Listing
September 2014

CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis.

Inflamm Bowel Dis 2014 Jul;20(7):1165-76

Divisions of *Gastroenterology/Nutrition and †Immunology, Boston Children's Hospital; ‡Department of Pediatrics, Harvard Medical School; and §Department of Pathology, Brigham and Women's Hospital & Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249688PMC
July 2014

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

Immunity 2014 May 1;40(5):706-19. Epub 2014 May 1.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS). Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513358PMC
May 2014

The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment.

Cell Microbiol 2014 Sep 2;16(9):1405-24. Epub 2014 Jun 2.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA.

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http://dx.doi.org/10.1111/cmi.12302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146666PMC
September 2014

Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.

Adv Immunol 2014 ;122:177-210

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Gastroenterology, Brigham & Women's Hospital, Boston, Massachusetts, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97801280026740
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http://dx.doi.org/10.1016/B978-0-12-800267-4.00005-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741283PMC
May 2014

Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

Clin Transl Gastroenterol 2014 Jan 16;5:e46. Epub 2014 Jan 16.

1] SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [2] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada [3] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ctg.2013.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912315PMC
January 2014