Scott P Heximer

Scott P Heximer

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Scott P Heximer

Scott P Heximer

Publications by authors named "Scott P Heximer"

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Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.

Circ Res 2018 02 22;122(3):405-416. Epub 2017 Dec 22.

From the Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada (M.C.B., R.L.E.A., Y.-Q.Z., L.-l.C., Z.M., A.Y.-L.L., R.K.K.T., H.Z., S.P.H., C.A.S.); Institute of Biomaterials and Biomedical Engineering (M.C.B., K.W., R.L.E.A., A.Y.-L.L., R.K.K.T., C.A.S.), Department of Physiology (H.Z., S.P.H.), and Department of Mechanical and Industrial Engineering (L.-l.C., Z.M., C.A.S.), University of Toronto, Ontario, Canada; and Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada (Y.-Q.Z., R.M.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311194DOI Listing
February 2018

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Mol Metab 2017 11 1;6(11):1339-1349. Epub 2017 Sep 1.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173060
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http://dx.doi.org/10.1016/j.molmet.2017.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681270PMC
November 2017

Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

PLoS One 2015 21;10(7):e0133274. Epub 2015 Jul 21.

The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133274PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510596PMC
May 2016

Gαi3-Dependent Inhibition of JNK Activity on Intracellular Membranes.

Front Bioeng Biotechnol 2015 1;3:128. Epub 2015 Sep 1.

Department of Physiology, Heart and Stroke, Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto , Toronto, ON , Canada.

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http://dx.doi.org/10.3389/fbioe.2015.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555961PMC
September 2015

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

Atherosclerosis 2015 Jul 25;241(1):111-20. Epub 2015 Apr 25.

Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.799DOI Listing
July 2015

Enhanced proliferation and altered calcium handling in RGS2-deficient vascular smooth muscle cells.

J Recept Signal Transduct Res 2014 Dec 20;34(6):476-83. Epub 2014 May 20.

Division of Experimental Therapeutics, Toronto General Research Institute , University Health Network, Toronto, Ontario , Canada and.

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http://www.tandfonline.com/doi/full/10.3109/10799893.2014.92
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http://dx.doi.org/10.3109/10799893.2014.920393DOI Listing
December 2014

Early stress prevents the potentiation of muscarinic excitation by calcium release in adult prefrontal cortex.

Biol Psychiatry 2014 Aug 28;76(4):315-23. Epub 2013 Oct 28.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640900PMC
August 2014

Rab family proteins regulate the endosomal trafficking and function of RGS4.

J Biol Chem 2013 Jul 3;288(30):21836-49. Epub 2013 Jun 3.

Department of Physiology, Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/content/288/30/21836.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.466888
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http://dx.doi.org/10.1074/jbc.M113.466888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724640PMC
July 2013

A "new twist" on RGS protein selectivity.

Authors:
Scott P Heximer

Structure 2013 Mar;21(3):319-20

Department of Physiology, Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.str.2013.02.011DOI Listing
March 2013

Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node.

Front Physiol 2012 13;3:204. Epub 2012 Jun 13.

Department of Physiology, Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fphys.2012.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374348PMC
October 2012

Amino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function.

J Biol Chem 2012 Aug 29;287(34):28966-74. Epub 2012 Jun 29.

Department of Physiology, Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M112.345629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436580PMC
August 2012

Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression.

FASEB J 2012 Jan 29;26(1):181-91. Epub 2011 Sep 29.

Department of Physiology, Heart, and Stroke, University of Toronto, Toronto, ON Canada.

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http://www.fasebj.org/doi/10.1096/fj.11-185454
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http://dx.doi.org/10.1096/fj.11-185454DOI Listing
January 2012

Metoprolol impairs resistance artery function in mice.

J Appl Physiol (1985) 2011 Oct 28;111(4):1125-33. Epub 2011 Jul 28.

Department of Anesthesia, St. Michael's Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, University of Toronto, Canada.

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http://dx.doi.org/10.1152/japplphysiol.01340.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774199PMC
October 2011

Intracellular regulation of heterotrimeric G-protein signaling modulates vascular smooth muscle cell contraction.

Arch Biochem Biophys 2011 Jun 20;510(2):182-9. Epub 2011 May 20.

Department of Physiology, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.abb.2011.05.008DOI Listing
June 2011

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse.

Mol Cell Neurosci 2011 Mar 6;46(3):563-72. Epub 2011 Jan 6.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.mcn.2010.12.005DOI Listing
March 2011

Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures.

Mol Pharmacol 2009 Jul 7;76(1):18-24. Epub 2009 Apr 7.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1124/mol.109.056127DOI Listing
July 2009

RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function.

Clin Sci (Lond) 2009 Mar;116(5):391-9

Department of Physiology, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1042/CS20080272DOI Listing
March 2009

RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.

Circ Res 2008 Aug 24;103(5):527-35. Epub 2008 Jul 24.

Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.180984DOI Listing
August 2008

The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.

Mol Pharmacol 2008 Apr 29;73(4):1037-43. Epub 2008 Jan 29.

University of Toronto, Rm 3334 MSB, 1 King's College Circle, Toronto, ON, Canada.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.04
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http://dx.doi.org/10.1124/mol.107.044214DOI Listing
April 2008

Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.

Mol Pharmacol 2008 Jan 27;73(1):1-11. Epub 2007 Sep 27.

Canada Research Chair in Cardiovascular Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario.

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http://dx.doi.org/10.1124/mol.107.036285DOI Listing
January 2008

Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.

J Biol Chem 2007 Nov 11;282(45):33064-75. Epub 2007 Sep 11.

Department of Physiology, Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M702685200
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http://dx.doi.org/10.1074/jbc.M702685200DOI Listing
November 2007

Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons.

Eur J Neurosci 2007 Jul;26(2):275-88

Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1460-9568.2007.05669.xDOI Listing
July 2007

RGS proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks.

Sci STKE 2007 Jan 23;2007(370):pe2. Epub 2007 Jan 23.

Department of Physiology and Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1126/stke.3702007pe2DOI Listing
January 2007

RGS2-mediated regulation of Gqalpha.

Authors:
Scott P Heximer

Methods Enzymol 2004 ;390:65-82

Department of Physiology, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/S0076-6879(04)90005-5DOI Listing
February 2005

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.

Nat Med 2003 Dec 9;9(12):1506-12. Epub 2003 Nov 9.

Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

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http://www.nature.com/articles/nm958
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http://dx.doi.org/10.1038/nm958DOI Listing
December 2003

Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

J Clin Invest 2003 Nov;112(9):1419-28

Laboratoire de Développement et Vieillissement de l'Endothelium, Commisarriat à l'Energie Atomique/Institut National de la Santé et de la Recherche Médicale-Equipq Mixte 0219, Université Joseph Fourier, Grenoble, France.

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http://dx.doi.org/10.1172/JCI19028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228452PMC
November 2003