Scott M Williams

Scott M Williams

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Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective.

Pharmacol Ther 2019 Apr 3;196:183-194. Epub 2018 Dec 3.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States; Department of Veterans Affairs, Nashville, TN, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258183021
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http://dx.doi.org/10.1016/j.pharmthera.2018.11.009DOI Listing
April 2019

Research to achieve a reduction in the global rate of preterm birth needs attention: Preface to the special issue by the preterm Birth International Collaborative (PREBIC).

Placenta 2019 Apr 9;79:1-2. Epub 2019 Jan 9.

Dept of Obstetrics and Gynecology, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1016/j.placenta.2019.01.008DOI Listing
April 2019

Omega-3 polyunsaturated fatty acid intake norms and preterm birth rate: a cross-sectional analysis of 184 countries.

BMJ Open 2019 Apr 20;9(4):e027249. Epub 2019 Apr 20.

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1136/bmjopen-2018-027249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527982PMC
April 2019

The Missing Diversity in Human Genetic Studies.

Cell 2019 Mar;177(1):26-31

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.048DOI Listing
March 2019

The Plight of Muntaser Ibrahim.

PLoS Genet 2019 03 25;15(3):e1008100. Epub 2019 Mar 25.

Department of Biology and the Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1008100
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http://dx.doi.org/10.1371/journal.pgen.1008100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433285PMC
March 2019

Testing the assumptions of parametric linear models: the need for biological data mining in disciplines such as human genetics.

BioData Min 2019 11;12. Epub 2019 Feb 11.

3Department of Epidemiology and Biostatistics, Case-Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 USA.

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https://biodatamining.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13040-019-0194-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371539PMC
February 2019

Non-additive effects of ACVR2A in preeclampsia in a Philippine population.

BMC Pregnancy Childbirth 2019 Jan 8;19(1):11. Epub 2019 Jan 8.

National Institute of Molecular Biology and Biotechnology, National Science Complex, University of the Philippines, Diliman, 1101, Quezon City, Philippines.

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http://dx.doi.org/10.1186/s12884-018-2152-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323705PMC
January 2019

Doubling down on forensic twin studies.

PLoS Genet 2018 12 20;14(12):e1007831. Epub 2018 Dec 20.

Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301560PMC
December 2018

Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?

Curr Genet Med Rep 2018 Dec 10;6(4):199-207. Epub 2018 Oct 10.

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/s40142-018-0153-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373874PMC
December 2018

Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth.

PLoS Genet 2018 07 12;14(7):e1007394. Epub 2018 Jul 12.

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042692PMC
July 2018

Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS.

Hum Genet 2018 May 24;137(5):413-425. Epub 2018 May 24.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00439-018-1893-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996751PMC
May 2018

The ubiquity of pleiotropy in human disease.

Hum Genet 2018 Jan 21;137(1):39-44. Epub 2017 Nov 21.

Departments of Population and Quantitative Health Sciences, Institute of Computational Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

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http://dx.doi.org/10.1007/s00439-017-1854-zDOI Listing
January 2018

Evolutionarily derived networks to inform disease pathways.

Genet Epidemiol 2017 12 25;41(8):866-875. Epub 2017 Sep 25.

Department of Genetics, The Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, United States of America.

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http://dx.doi.org/10.1002/gepi.22078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696086PMC
December 2017

Genomics of human pulmonary tuberculosis: from genes to pathways.

Curr Genet Med Rep 2017 Dec 12;5(4):149-166. Epub 2017 Oct 12.

Department of Population and Quantitative Health Sciences, Cleveland, OH.

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http://dx.doi.org/10.1007/s40142-017-0130-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965286PMC
December 2017

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.

Matrix Biol 2017 11 23;63:69-90. Epub 2017 Jan 23.

Section of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA; Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532081PMC
November 2017

A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits.

PLoS One 2013 21;8(6):e66545. Epub 2013 Jun 21.

Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, New Hampshire, United States of America ; Section of Biostatistics and Epidemiology, Departments of Community and Family Medicine, Geisel School of Medicine, Lebanon, New Hampshire, United States of America.

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http://discovery.ucl.ac.uk/1414431/1/journal.pone.0066545.pd
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http://dx.plos.org/10.1371/journal.pone.0066545
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689797PMC
October 2017

Evolutionary Triangulation to Refine Genetic Association Studies of Spontaneous Preterm Birth.

Am J Perinatol 2017 09 22;34(11):1041-1047. Epub 2017 May 22.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1055/s-0037-1603508DOI Listing
September 2017

Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.

PLoS One 2017 13;12(7):e0180471. Epub 2017 Jul 13.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180471PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509150PMC
September 2017

Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology.

PLoS Genet 2017 09 28;13(9):e1006945. Epub 2017 Sep 28.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619686PMC
September 2017

Widespread epistasis regulates glucose homeostasis and gene expression.

PLoS Genet 2017 Sep 29;13(9):e1007025. Epub 2017 Sep 29.

Department of Biochemistry, Case Western Reserve University, Cleveland, OH, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1007025
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http://dx.doi.org/10.1371/journal.pgen.1007025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636166PMC
September 2017

Genetic Effects on the Correlation Structure of CVD Risk Factors: Exome-Wide Data From a Ghanaian Population.

Glob Heart 2017 06 10;12(2):133-140. Epub 2017 Apr 10.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA; Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gheart.2017.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642993PMC
June 2017

Transdisciplinary approaches enhance the production of translational knowledge.

Transl Res 2017 04 10;182:123-134. Epub 2016 Nov 10.

Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH.

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http://dx.doi.org/10.1016/j.trsl.2016.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362296PMC
April 2017

Identifying significant gene-environment interactions using a combination of screening testing and hierarchical false discovery rate control.

Genet Epidemiol 2016 11 31;40(7):544-557. Epub 2016 Aug 31.

Departments of Biomedical Data Science and Genetics, Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1002/gepi.21997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108431PMC
November 2016

Artificial Intelligence and Amikacin Exposures Predictive of Outcomes in Multidrug-Resistant Tuberculosis Patients.

Antimicrob Agents Chemother 2016 10 23;60(10):5928-32. Epub 2016 Sep 23.

Center for Infectious Diseases Research & Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA Department of Medicine, University of Cape Town, Observatory, Cape Town, South Africa

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http://aac.asm.org/lookup/doi/10.1128/AAC.00962-16
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http://dx.doi.org/10.1128/AAC.00962-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038293PMC
October 2016

Plasminogen Activator Inhibitor-1 and Diagnosis of the Metabolic Syndrome in a West African Population.

J Am Heart Assoc 2016 10 3;5(10). Epub 2016 Oct 3.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH

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http://dx.doi.org/10.1161/JAHA.116.003867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121488PMC
October 2016

Complex Patterns of Association between Pleiotropy and Transcription Factor Evolution.

Genome Biol Evol 2016 10 23;8(10):3159-3170. Epub 2016 Oct 23.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH

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http://dx.doi.org/10.1093/gbe/evw228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174740PMC
October 2016

The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa.

Mol Genet Genomic Med 2016 Sep 14;4(5):548-56. Epub 2016 Jul 14.

Department of Molecular and Experimental Medicine The Scripps Research Institute La Jolla California.

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http://dx.doi.org/10.1002/mgg3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023940PMC
September 2016

Epigenetic and genetic variation in GATA5 is associated with gastric disease risk.

Hum Genet 2016 08 25;135(8):895-906. Epub 2016 May 25.

Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1007/s00439-016-1687-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947561PMC
August 2016

Erratum to: Epigenetic and genetic variation in GATA5 is associated with gastric disease risk.

Hum Genet 2016 08;135(8):907-908

Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, 2205 Garland Avenue, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s00439-016-1708-0DOI Listing
August 2016

Evolutionary triangulation: informing genetic association studies with evolutionary evidence.

BioData Min 2016 2;9:12. Epub 2016 Apr 2.

Department of Genetics, Dartmouth College, Geisel School of Medicine, Hanover, NH USA ; Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH USA ; Present Address: Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 USA.

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http://dx.doi.org/10.1186/s13040-016-0091-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818851PMC
April 2016

PLOS Genetics Data Sharing Policy: In Pursuit of Functional Utility.

PLoS Genet 2015 Dec 14;11(12):e1005716. Epub 2015 Dec 14.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678900PMC
December 2015

A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults.

PLoS One 2014 8;9(9):e104768. Epub 2014 Sep 8.

Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, United States of America; Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157769PMC
November 2015

Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases.

PLoS Genet 2015 Nov 5;11(11):e1005568. Epub 2015 Nov 5.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634921PMC
November 2015

Amikacin Concentrations Predictive of Ototoxicity in Multidrug-Resistant Tuberculosis Patients.

Antimicrob Agents Chemother 2015 Oct 27;59(10):6337-43. Epub 2015 Jul 27.

Office of Global Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Medicine, University of Cape Town, Observatory, South Africa

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http://dx.doi.org/10.1128/AAC.01050-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576092PMC
October 2015

Erratum to: The future of genomic medicine education in Africa.

Genome Med 2015 3;7(1):70. Epub 2015 Aug 3.

Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1186/s13073-015-0193-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522969PMC
October 2015

Meta-analysis of Randomized Controlled Trials of Genotype-Guided vs Standard Dosing of Warfarin.

Chest 2015 Sep;148(3):701-710

Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH; Department of Genetics, Dartmouth College, Hanover, NH; Institute of Quantitative Biomedical Science, Dartmouth College, Hanover, NH.

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http://dx.doi.org/10.1378/chest.14-2947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556123PMC
September 2015

The future of genomic medicine education in Africa.

Genome Med 2015 23;7(1):47. Epub 2015 May 23.

Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1186/s13073-015-0175-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526207PMC
August 2015

Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth.

BMC Med Genet 2015 Aug 11;16:59. Epub 2015 Aug 11.

Departments of Obstetrics and Gynecology and Pediatrics, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.

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http://dx.doi.org/10.1186/s12881-015-0205-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593185PMC
August 2015

Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth.

BMC Pregnancy Childbirth 2015 Aug 25;15:192. Epub 2015 Aug 25.

Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1186/s12884-015-0627-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548904PMC
August 2015

Epistasis in the risk of human neuropsychiatric disease.

Authors:
Scott M Williams

Methods Mol Biol 2015 ;1253:71-93

Department of Genetics, Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, 78 College ST, HB 6044, Hanover, NH, 03755, USA,

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http://dx.doi.org/10.1007/978-1-4939-2155-3_5DOI Listing
July 2015

Lumping versus splitting: the need for biological data mining in precision medicine.

BioData Min 2015 11;8:16. Epub 2015 Jun 11.

Department of Biostatistics and Epidemiology, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6021 USA.

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http://dx.doi.org/10.1186/s13040-015-0049-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470077PMC
June 2015

Sex-Specific Parental Effects on Offspring Lipid Levels.

J Am Heart Assoc 2015 Jun 30;4(7). Epub 2015 Jun 30.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH (R.S.S., J.B., S.M.W.).

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http://dx.doi.org/10.1161/JAHA.115.001951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608079PMC
June 2015

A systems genetics approach to dyslipidemia in children and adolescents.

OMICS 2015 Apr 11;19(4):248-59. Epub 2015 Feb 11.

1 Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth College , Hanover, New Hampshire.

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http://dx.doi.org/10.1089/omi.2014.0140DOI Listing
April 2015

Addressing population-specific multiple testing burdens in genetic association studies.

Ann Hum Genet 2015 Mar 22;79(2):136-47. Epub 2015 Jan 22.

Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.

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http://dx.doi.org/10.1111/ahg.12095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334751PMC
March 2015

Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans.

Hum Genet 2014 Dec 4;133(12):1513-23. Epub 2014 Oct 4.

Vanderbilt Epidemiology Center, 2525 West End Ave., Suite 600 6th Floor, Nashville, TN, 37203, USA,

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http://dx.doi.org/10.1007/s00439-014-1490-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334317PMC
December 2014

Association between lifestyle-related disorders and visceral fat mass in Japanese males: a hospital based cross-sectional study.

Environ Health Prev Med 2014 Nov 24;19(6):429-35. Epub 2014 Sep 24.

Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Aizubange Town, Fukushima, Japan.

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http://dx.doi.org/10.1007/s12199-014-0411-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235847PMC
November 2014

Successful MDR-TB treatment regimens including amikacin are associated with high rates of hearing loss.

BMC Infect Dis 2014 Oct 9;14:542. Epub 2014 Oct 9.

Division of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1186/1471-2334-14-542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287509PMC
October 2014

Disrupted human-pathogen co-evolution: a model for disease.

Front Genet 2014 25;5:290. Epub 2014 Aug 25.

Department of Genetics, Geisel School of Medicine, Dartmouth College Hanover, NH, USA.

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http://dx.doi.org/10.3389/fgene.2014.00290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142859PMC
September 2014

X-linked MTMR8 diversity and evolutionary history of sub-Saharan populations.

PLoS One 2013 25;8(11):e80710. Epub 2013 Nov 25.

Centre de Recherche, CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada ; Département de Pédiatrie, Université de Montréal, Montréal, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080710PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839994PMC
August 2014

Co-infection with HPV types from the same species provides natural cross-protection from progression to cervical cancer.

Infect Agent Cancer 2014 12;9:26. Epub 2014 Aug 12.

Division of Infectious Disease, University of Pennsylvania, Philadelphia, PA, USA ; Botswana-University of Pennsylvania Partnership, 214 Independence Ave, Gaborone, Botswana ; Department of Medicine, University of Botswana, Gaborone, Botswana.

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http://dx.doi.org/10.1186/1750-9378-9-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141127PMC
August 2014

A single nucleotide polymorphism in SLC7A5 is associated with gastrointestinal toxicity after high-dose melphalan and autologous stem cell transplantation for multiple myeloma.

Biol Blood Marrow Transplant 2014 Jul 4;20(7):1014-20. Epub 2014 Apr 4.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville VA Hospital, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076151PMC
July 2014

Identifying population differences in genes that affect body mass index.

Authors:
Scott M Williams

Genome Med 2013 29;5(11):102. Epub 2013 Nov 29.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1186/gm506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978763PMC
May 2014

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

Authors:
Jie Huang Jennifer E Huffman Munekazu Yamakuchi Munekazu Yamkauchi Stella Trompet Folkert W Asselbergs Maria Sabater-Lleal David-Alexandre Trégouët Wei-Min Chen Nicholas L Smith Marcus E Kleber So-Youn Shin Diane M Becker Weihong Tang Abbas Dehghan Andrew D Johnson Vinh Truong Lasse Folkersen Qiong Yang Tiphaine Oudot-Mellkah Brendan M Buckley Jason H Moore Frances M K Williams Harry Campbell Günther Silbernagel Veronique Vitart Igor Rudan Geoffrey H Tofler Gerjan J Navis Anita Destefano Alan F Wright Ming-Huei Chen Anton J M de Craen Bradford B Worrall Alicja R Rudnicka Ann Rumley Ebony B Bookman Bruce M Psaty Fang Chen Keith L Keene Oscar H Franco Bernhard O Böhm Andre G Uitterlinden Angela M Carter J Wouter Jukema Naveed Sattar Joshua C Bis Mohammad A Ikram Michèle M Sale Barbara McKnight Myriam Fornage Ian Ford Kent Taylor P Eline Slagboom Wendy L McArdle Fang-Chi Hsu Anders Franco-Cereceda Alison H Goodall Lisa R Yanek Karen L Furie Mary Cushman Albert Hofman Jacqueline C M Witteman Aaron R Folsom Saonli Basu Nena Matijevic Wiek H van Gilst James F Wilson Rudi G J Westendorp Sekar Kathiresan Muredach P Reilly Russell P Tracy Ozren Polasek Bernhard R Winkelmann Peter J Grant Hans L Hillege Francois Cambien David J Stott Gordon D Lowe Timothy D Spector James B Meigs Winfried Marz Per Eriksson Lewis C Becker Pierre-Emmanuel Morange Nicole Soranzo Scott M Williams Caroline Hayward Pim van der Harst Anders Hamsten Charles J Lowenstein David P Strachan Christopher J O'Donnell

Arterioscler Thromb Vasc Biol 2014 May 27;34(5):1093-101. Epub 2014 Feb 27.

From National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (J.H., A.D.J., C.J.O.); Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (J.H., A.D.J., C.J.O.); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom (J.E.H., V.V., A.F.W., C.H.); The Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY (M.Y., C.J.L.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.d.C., R.G.J.W.), and Molecular Epidemiology (P.E.S.), Leiden University Medical Center, the Netherlands; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands (F.W.A.); Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands (F.W.A.); Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom (F.W.A.); Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine (M.S.-L., L.F., P.E., A.H.), Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden; INSERM UMRS 937, Pierre et Marie Curie University, Paris, France (D.-A.T., V.T., T.O.M., F.C.); ICAN Institute for Cardiometabolism and Nutrion, Paris, France (D.-A.T., V.T., F.C.); Departments of Public Health Sciences (W.M.C., B.B.W., F.C.) and Biochemistry and Molecular Genetics (M.M.S.), Center for Public Health Genomics, University of Virginia, Charlottesville, VA; Departments of Epidemiology (N.L.S., B.M.P., B.M.), Medicine (B.M.P., J.C.B.), and Health Services (B.M.P.), University of Washington, Seattle, WA; Group Health Research Institute, Group Health Cooperative, Seattle, WA (N.L.S., B.M.P.); Seattle Epidemiologic Research and Information Center, VA Office of Research and

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009733PMC
May 2014

G6PD A- deficiency and severe malaria in The Gambia: heterozygote advantage and possible homozygote disadvantage.

Am J Trop Med Hyg 2014 May 10;90(5):856-9. Epub 2014 Mar 10.

Centro di Ricerca, Ospedale San Pietro Fatebenefratelli, Rome, Italy; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland; Medical Research Council Laboratories, Fajara, Banjul, The Gambia.

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http://dx.doi.org/10.4269/ajtmh.13-0622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015578PMC
May 2014

The multiscale backbone of the human phenotype network based on biological pathways.

BioData Min 2014 Jan 25;7(1). Epub 2014 Jan 25.

Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1186/1756-0381-7-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924922PMC
January 2014

Human and Helicobacter pylori coevolution shapes the risk of gastric disease.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):1455-60. Epub 2014 Jan 13.

Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Divisions of Gastroenterology and Infectious Diseases, Department of Medicine, and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.

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http://dx.doi.org/10.1073/pnas.1318093111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910595PMC
January 2014

Multi-locus candidate gene analyses of lipid levels in a pediatric Turkish cohort: lessons learned on LPL, CETP, LIPC, ABCA1, and SHBG.

OMICS 2013 Dec 29;17(12):636-45. Epub 2013 Aug 29.

1 Department of Cardiology, Marmara University School of Medicine , Istanbul, Turkey .

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http://dx.doi.org/10.1089/omi.2013.0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837502PMC
December 2013

Signatures of natural selection on genetic variants affecting complex human traits.

Appl Transl Genom 2013 Dec 7;2:78-94. Epub 2013 Nov 7.

Department of Genetics and Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121263PMC
December 2013

Big Data analysis on autopilot?

BioData Min 2013 Dec 6;6(1):22. Epub 2013 Dec 6.

Department of Genetics and Institute for Quantitative Biomedical Sciences, The Geisel School of Medicine, Dartmouth College, One Medical Center Dr,, Lebanon, Lebanon, NH 03756, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878969PMC
December 2013

Recurrent tissue-specific mtDNA mutations are common in humans.

PLoS Genet 2013 Nov 7;9(11):e1003929. Epub 2013 Nov 7.

Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820769PMC
November 2013

An information-gain approach to detecting three-way epistatic interactions in genetic association studies.

J Am Med Inform Assoc 2013 Jul-Aug;20(4):630-6. Epub 2013 Feb 8.

Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721169PMC
September 2013

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

Authors:
Nora Franceschini Ervin Fox Zhaogong Zhang Todd L Edwards Michael A Nalls Yun Ju Sung Bamidele O Tayo Yan V Sun Omri Gottesman Adebawole Adeyemo Andrew D Johnson J Hunter Young Ken Rice Qing Duan Fang Chen Yun Li Hua Tang Myriam Fornage Keith L Keene Jeanette S Andrews Jennifer A Smith Jessica D Faul Zhang Guangfa Wei Guo Yu Liu Sarah S Murray Solomon K Musani Sathanur Srinivasan Digna R Velez Edwards Heming Wang Lewis C Becker Pascal Bovet Murielle Bochud Ulrich Broeckel Michel Burnier Cara Carty Daniel I Chasman Georg Ehret Wei-Min Chen Guanjie Chen Wei Chen Jingzhong Ding Albert W Dreisbach Michele K Evans Xiuqing Guo Melissa E Garcia Rich Jensen Margaux F Keller Guillaume Lettre Vaneet Lotay Lisa W Martin Jason H Moore Alanna C Morrison Thomas H Mosley Adesola Ogunniyi Walter Palmas George Papanicolaou Alan Penman Joseph F Polak Paul M Ridker Babatunde Salako Andrew B Singleton Daniel Shriner Kent D Taylor Ramachandran Vasan Kerri Wiggins Scott M Williams Lisa R Yanek Wei Zhao Alan B Zonderman Diane M Becker Gerald Berenson Eric Boerwinkle Erwin Bottinger Mary Cushman Charles Eaton Fredrik Nyberg Gerardo Heiss Joel N Hirschhron Virginia J Howard Konrad J Karczewsk Matthew B Lanktree Kiang Liu Yongmei Liu Ruth Loos Karen Margolis Michael Snyder Bruce M Psaty Nicholas J Schork David R Weir Charles N Rotimi Michele M Sale Tamara Harris Sharon L R Kardia Steven C Hunt Donna Arnett Susan Redline Richard S Cooper Neil J Risch D C Rao Jerome I Rotter Aravinda Chakravarti Alex P Reiner Daniel Levy Brendan J Keating Xiaofeng Zhu

Am J Hum Genet 2013 Sep 22;93(3):545-54. Epub 2013 Aug 22.

Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769920PMC
September 2013

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Authors:
Keri L Monda Gary K Chen Kira C Taylor Cameron Palmer Todd L Edwards Leslie A Lange Maggie C Y Ng Adebowale A Adeyemo Matthew A Allison Lawrence F Bielak Guanjie Chen Mariaelisa Graff Marguerite R Irvin Suhn K Rhie Guo Li Yongmei Liu Youfang Liu Yingchang Lu Michael A Nalls Yan V Sun Mary K Wojczynski Lisa R Yanek Melinda C Aldrich Adeyinka Ademola Christopher I Amos Elisa V Bandera Cathryn H Bock Angela Britton Ulrich Broeckel Quiyin Cai Neil E Caporaso Chris S Carlson John Carpten Graham Casey Wei-Min Chen Fang Chen Yii-Der I Chen Charleston W K Chiang Gerhard A Coetzee Ellen Demerath Sandra L Deming-Halverson Ryan W Driver Patricia Dubbert Mary F Feitosa Ye Feng Barry I Freedman Elizabeth M Gillanders Omri Gottesman Xiuqing Guo Talin Haritunians Tamara Harris Curtis C Harris Anselm J M Hennis Dena G Hernandez Lorna H McNeill Timothy D Howard Barbara V Howard Virginia J Howard Karen C Johnson Sun J Kang Brendan J Keating Suzanne Kolb Lewis H Kuller Abdullah Kutlar Carl D Langefeld Guillaume Lettre Kurt Lohman Vaneet Lotay Helen Lyon Joann E Manson William Maixner Yan A Meng Kristine R Monroe Imran Morhason-Bello Adam B Murphy Josyf C Mychaleckyj Rajiv Nadukuru Katherine L Nathanson Uma Nayak Amidou N'diaye Barbara Nemesure Suh-Yuh Wu M Cristina Leske Christine Neslund-Dudas Marian Neuhouser Sarah Nyante Heather Ochs-Balcom Adesola Ogunniyi Temidayo O Ogundiran Oladosu Ojengbede Olufunmilayo I Olopade Julie R Palmer Edward A Ruiz-Narvaez Nicholette D Palmer Michael F Press Evandine Rampersaud Laura J Rasmussen-Torvik Jorge L Rodriguez-Gil Babatunde Salako Eric E Schadt Ann G Schwartz Daniel A Shriner David Siscovick Shad B Smith Sylvia Wassertheil-Smoller Elizabeth K Speliotes Margaret R Spitz Lara Sucheston Herman Taylor Bamidele O Tayo Margaret A Tucker David J Van Den Berg Digna R Velez Edwards Zhaoming Wang John K Wiencke Thomas W Winkler John S Witte Margaret Wrensch Xifeng Wu James J Yang Albert M Levin Taylor R Young Neil A Zakai Mary Cushman Krista A Zanetti Jing Hua Zhao Wei Zhao Yonglan Zheng Jie Zhou Regina G Ziegler Joseph M Zmuda Jyotika K Fernandes Gary S Gilkeson Diane L Kamen Kelly J Hunt Ida J Spruill Christine B Ambrosone Stefan Ambs Donna K Arnett Larry Atwood Diane M Becker Sonja I Berndt Leslie Bernstein William J Blot Ingrid B Borecki Erwin P Bottinger Donald W Bowden Gregory Burke Stephen J Chanock Richard S Cooper Jingzhong Ding David Duggan Michele K Evans Caroline Fox W Timothy Garvey Jonathan P Bradfield Hakon Hakonarson Struan F A Grant Ann Hsing Lisa Chu Jennifer J Hu Dezheng Huo Sue A Ingles Esther M John Joanne M Jordan Edmond K Kabagambe Sharon L R Kardia Rick A Kittles Phyllis J Goodman Eric A Klein Laurence N Kolonel Loic Le Marchand Simin Liu Barbara McKnight Robert C Millikan Thomas H Mosley Badri Padhukasahasram L Keoki Williams Sanjay R Patel Ulrike Peters Curtis A Pettaway Patricia A Peyser Bruce M Psaty Susan Redline Charles N Rotimi Benjamin A Rybicki Michèle M Sale Pamela J Schreiner Lisa B Signorello Andrew B Singleton Janet L Stanford Sara S Strom Michael J Thun Mara Vitolins Wei Zheng Jason H Moore Scott M Williams Shamika Ketkar Xiaofeng Zhu Alan B Zonderman Charles Kooperberg George J Papanicolaou Brian E Henderson Alex P Reiner Joel N Hirschhorn Ruth J F Loos Kari E North Christopher A Haiman

Nat Genet 2013 Jun 14;45(6):690-6. Epub 2013 Apr 14.

The Center for Observational Research, Amgen, Inc. Thousand Oaks, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694490PMC
June 2013

Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.

Circ Cardiovasc Genet 2013 Jun 24;6(3):299-307. Epub 2013 Apr 24.

Division of Cardiovascular Medicine, Section of Cardiovascular Disease Prevention, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889706PMC
June 2013

Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.

PLoS One 2012 21;7(11):e49464. Epub 2012 Nov 21.

Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504028PMC
May 2013

High body mass index is an important risk factor for the development of type 2 diabetes.

Intern Med 2012 15;51(14):1821-6. Epub 2012 Jul 15.

Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Japan.

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http://dx.doi.org/10.2169/internalmedicine.51.7410DOI Listing
January 2013

Diagnostic tools for hypertension and salt sensitivity testing.

Curr Opin Nephrol Hypertens 2013 Jan;22(1):65-76

Department of Pathology, The University of Virginia, Health Sciences Center, Charlottesville, Virginia, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724405PMC
January 2013

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Blood 2012 Dec 18;120(24):4873-81. Epub 2012 Sep 18.

National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA 01702, USA.

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December 2012

Gene ontology analysis of pairwise genetic associations in two genome-wide studies of sporadic ALS.

BioData Min 2012 Jul 28;5(1). Epub 2012 Jul 28.

Institute for Quantitative Biomedical Sciences, Department of Genetics, Dartmouth Medical School, One Medical Center Dr,, Lebanon, NH 03756, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463436PMC
July 2012

Neighborhood socio-economic characteristics, African ancestry, and Helicobacter pylori sero-prevalence.

Cancer Causes Control 2012 Jun 21;23(6):897-906. Epub 2012 Apr 21.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 6th floor, Nashville, TN 37203-1738, USA.

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http://link.springer.com/10.1007/s10552-012-9960-7
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475203PMC
June 2012